Fibrinolytics or Thrombolytic (Part-01) | Classification & Mechanism of Action of Fibrinolytics

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Thrombolytic drugs are used to dissolve (lyse) blood clots (thrombi). Blood clots can occur in any vascular bed; however, when they occur in coronary, cerebral or pulmonary vessels, they can be immediately life-threatening - coronary thrombi are the cause of myocardial infarctions, cerebrovascular thrombi produce strokes, and pulmonary thromboembolic can lead to respiratory and cardiac failure. Therefore, it is important to rapidly diagnose and treat blood clots.
Thrombolytic drugs dissolve blood clots by activating plasminogen, which forms a cleaved product called plasmin. Plasmin is a proteolytic enzyme that is capable of breaking cross-links between fibrin molecules, which provide the structural integrity of blood clots. Because of these actions, thrombolytic drugs are also called "plasminogen activators" and "fibrinolytic drugs."
There are three major classes of fibrinolytic drugs: tissue plasminogen activator (tPA), streptokinase (SK), and urokinase (UK). While drugs in these three classes all have the ability to effectively dissolve blood clots, they differ in their detailed mechanisms in ways that alter their selectivity for fibrin clots.
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sir if patient take thrombolytic drugs
and bleeding out continuesely what should to do for stop bleeding

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[@mbbslovers9572]

One more point ,,, Streptokinase ( stK )
Can not be used in 2nd time because it is neutralized by the antibodies which are generated in ist time Dose ,
Also earlier dose , result Fever , Hypotension & Arrhythmia,,,
Thanks sir ,,💝💝💝💝💝💝💝

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Sir in case of acute MI within how much time streptokinase should be given

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Sorry i have to follow the sequence of syllabus. I am not able to accept individual request

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Maza aaya 😅

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Sir u can add English translation so it will helpful for other state students to understand easily, ike me.

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Harshadha mahesh Really sorry. I am not able to do that

[@kushseth]

What is the different between thrombolytic & anticoagulant?

[@laxmikantbanthanale8856]

The basic difference is that, Anticoagulants are those agent which avoid the clotting of blood but can't destroy existing clots...
And Thrombolytic agents lyse or destroy the clot by activating the plasminogen..

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[@mdshahzad5355]

Sir what is the difference between anticoagulant and fibrinolytic

[@solutionpharmacy]

Good question. Anticoagulant drugs prevent blood from making clot but fibrinolytic drugs breck the fibrin which is present in already clotted blood. Means one act before clotting to reduce this and another act after clotting to dissolve it.

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[@shahzadalam8703]

Sir, what is the difference between thrombolytics and anti-coagulants ?

[@solutionpharmacy]

Anticoagulant will prevent from being clot but thrombolytic will break thrombus once clotted

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@@solutionpharmacy Thank you sir

[@lakshyajeetnath5227]

Sir, difference between thrombolytics and anti-coagulant

[@solutionpharmacy]

Thrombolytuc will brek the throbmin when blood is already clotted. And anticoagulant will inhibit the cascade of reaction responsible for clotting (Before and after)

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Sir anti coagulant, anti Platelet, anti thrombotic drugs me different kya hai?

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Nahi

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If you really want to know then please watch this video till end - czcams.com/video/sRc9T3fvSY8/video.html

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Sir whats the difference between anti coagulants and thrombolytics?

[@solutionpharmacy]

Explained in video. Please have a look to all parts. Thrombolytics are examples under anticoagulants

[@laxmikantbanthanale8856]

The basic difference is that, Anticoagulants are those agent which avoid the clotting of blood but can't destroy existing clots...
And Thrombolytic agents lyse or destroy the clot by activating the plasminogen..

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Sir how can we diagnose a patient is having clot in his body ??

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Radiology

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Sir procedure???

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Watch next part

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Can u please explain in English

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