Prostate Tumors: Kurt’s Notes

In this video , we use amazing Kurt’s notes (kurtsnotes.net) to break down prostate tumors.
• #acinar adenocarcinoma and how its more commonly located in posterior/posterolateral peripheral gland.
• Cancer morphology: architecture, nuclear features, cytoplasmic and luminal contents.
• Features specific to malignancy including glomerulations, perineural invasion, mucinous fibroplasia.
• Variants of acinar adenocaricnoma: atrophic, pseudohyperplastic, foamy
• Rare variants of acinar adenocarcinoma: microcystic, mucinous, signet ring-like, sarcomatoid, hypernephroid, pleomorphic giant cell
• Gleason grading and Gleason Scoring
• IHC stains including NKX3.1 and PSA
• Tips for differentiating cancer v benign glands
• What ASAP and ATYP is and when to use it.
• Biopsy reporting and extraprostatic extension
• Genetics of prostate cancer
• Changes of benign and malignant glands after treatment
• What Active surveillance entails
• Intraductal tumors: HGPIN and intraductal carcinoma
• Other tumors: Ductal adenocarcinoma, basal cell carcinoma, urothelial carcinoma, squamous neoplasms, neuroendocrine tumors
• Mesenchymal tumors: STUMP, stromal sarcoma
• Seminal vesicle, amyloidosis, adenocarcinoma, MEST
• Mimics of cancer: basal cell hyperplasia, central zone sampling, adenosis, atrophy, Cowper’s glands, clear cell hyperplasia, sclerosing adenosis.