Pharmacology for Anesthesia 02 IV Anesthetics Part 1

Recorded lectures for a 2-semester course on Pharmacology for Anesthesia
TOPICS:
01 - Fundamentals of Clinical Pharmacology: Pharmacokinetics, pharmacodynamics
02- IV anesthetic agents, benzodiazepines, sedatives
03 - Opioids, infusions, context-sensitive half-time
04 - Principles of uptake and distribution of inhalational anesthetics
05 - Clinical Pharmacology of Inhalational Anesthetics, MAC, malignant hyperthermia
06 - Local anesthetics, toxicity
07 - Neuromuscular blocking agents and reversal drugs, phase II blockade;
neuromuscular diseases
08 - Autonomic Nervous System: Physiology, neurotransmitters, cholinergic
agonists / antagonists (Lectures 1-2); Adrenergic agonists (Lectures 3-4); Adrenergic antagonists (Lecture 5)
09 - Cardiovascular System: Vasodilators & Antihypertensives (Lectures 1-2); Antiarrhythmics and Ca-Channel blockers
(Lectures 3-4)
10 - Renal System: Diuretics
11 - Antimicrobial Therapy
12 - Vitamins & Herbal Supplements
13 - Coagulation System
14 - GI System and Antihistamines
15 - The Brain & CNS
16 - Endocrine: Thyroid, Steroids, NSAIDs, acetaminophen (Lectures 1-2); Insulin, oral hypoglycemics; OB drugs (Lectures 3-4)

[@aimanadil1317]

How does rhabdomyolysis and metabolic acidosis occur

[@AltoseAnesthesia]

I don't think we know for sure, but the theory is that propofol impairs free fatty acid use and mitochondrial activity, resulting in cardiac and peripheral muscle necrosis.