The "Movers and Shakers" Rory and Nick are back to discuss what it means to cure Parkinson's, when that might happen, and some of the challenges in getting there.
I think we are closer than 30 yrs away from a cure. My gosh, that’s very long. Let’s hope that gene editing can help edit this out of the DNA chain either before birth or after. We have got to get more attention on getting Parkinson’s cured! Alzheimer’s gets alot more attention for some reason and it’s not fair! Parkinson’s is impossible to live with…very hard on patient and spouse, family, etc… so hard to live a normal life. God bless the patients.
I hope you're right but my personal view is we're still some way from properly understanding the disease and completely preventing or curing it. But there will likely be a lot of progress in the meantime. Firstly I think it is likely that some drugs will be approved in the next 10 years that slow the progression of the disease for some people. Secondly I think cell replacement will become a viable option in the next 10-20 years. Thirdly I think we will start to find therapies for genetic forms of PD (which account for 10-20% of cases) in the next 10-20 years. Maybe there will be a major breakthrough soon but the reality today is that Parkinson's was first described over 200 years ago and don't yet have a therapy that actually slows or stops the its progression, only ways of treating the symptoms. Fingers crossed that 30 years turns out to be overly pessimistic! Jodie
Thanks for your comment. This is indeed an interesting hypothesis (czcams.com/video/k703Shlgkhw/video.html) and in general the No Silver Bullet CZcams channel is excellent. However, as I understand it, Dr Sackner-Berstein's theory has not yet been proven and remains one of many theories about the pathology of Parkinson's. It is also possible that the toxicity of cytosolic dopamine is just one piece of the jigsaw. Even if Metyrosine is shown to slow the progression of Parkinson's I think there is still a long way to go to fully understand the biochemistry underlying Parkinson's and to actually develop a cure. Jodie.
I absolutely love the questions you ask in this video Jodie and really looking forward to the episode of movers and shakers.
I think we are closer than 30 yrs away from a cure. My gosh, that’s very long. Let’s hope that gene editing can help edit this out of the DNA chain either before birth or after. We have got to get more attention on getting Parkinson’s cured! Alzheimer’s gets alot more attention for some reason and it’s not fair! Parkinson’s is impossible to live with…very hard on patient and spouse, family, etc… so hard to live a normal life. God bless the patients.
I hope you're right but my personal view is we're still some way from properly understanding the disease and completely preventing or curing it. But there will likely be a lot of progress in the meantime. Firstly I think it is likely that some drugs will be approved in the next 10 years that slow the progression of the disease for some people. Secondly I think cell replacement will become a viable option in the next 10-20 years. Thirdly I think we will start to find therapies for genetic forms of PD (which account for 10-20% of cases) in the next 10-20 years. Maybe there will be a major breakthrough soon but the reality today is that Parkinson's was first described over 200 years ago and don't yet have a therapy that actually slows or stops the its progression, only ways of treating the symptoms. Fingers crossed that 30 years turns out to be overly pessimistic! Jodie
and buntanetap in phase 3
See Johnathan sackler bernstaeins piece on no silver bullet.
Thanks for your comment.
This is indeed an interesting hypothesis (czcams.com/video/k703Shlgkhw/video.html) and in general the No Silver Bullet CZcams channel is excellent. However, as I understand it, Dr Sackner-Berstein's theory has not yet been proven and remains one of many theories about the pathology of Parkinson's. It is also possible that the toxicity of cytosolic dopamine is just one piece of the jigsaw. Even if Metyrosine is shown to slow the progression of Parkinson's I think there is still a long way to go to fully understand the biochemistry underlying Parkinson's and to actually develop a cure. Jodie.