How We're Reverse Engineering the Human Brain in the Lab | Sergiu P. Pasca | TED
Vložit
- čas přidán 27. 07. 2024
- Neuroscientist Sergiu P. Pasca has made it his life's work to understand how the human brain builds itself -- and what makes it susceptible to disease. In a mind-blowing talk laden with breakthrough science, he shows how his team figured out how to grow "organoids" and what they call brain "assembloids" -- self-organizing clumps of neural tissue derived from stem cells that have shown the ability to form circuits -- and explains how these miniature parts of the nervous system are bringing us closer to demystifying the brain.
If you love watching TED Talks like this one, become a TED Member to support our mission of spreading ideas: ted.com/membership
Follow TED!
Twitter: / tedtalks
Instagram: / ted
Facebook: / ted
LinkedIn: / ted-conferences
TikTok: / tedtoks
The TED Talks channel features talks, performances and original series from the world's leading thinkers and doers. Subscribe to our channel for videos on Technology, Entertainment and Design - plus science, business, global issues, the arts and more. Visit TED.com to get our entire library of TED Talks, transcripts, translations, personalized talk recommendations and more.
Watch more: go.ted.com/sergiuppasca
• How We're Reverse Engi...
TED's videos may be used for non-commercial purposes under a Creative Commons License, Attribution-Non Commercial-No Derivatives (or the CC BY - NC - ND 4.0 International) and in accordance with our TED Talks Usage Policy (www.ted.com/about/our-organiz.... For more information on using TED for commercial purposes (e.g. employee learning, in a film or online course), please submit a Media Request at media-requests.ted.com
#TED #TEDTalks #brain - Věda a technologie
In the not so distant future, the phrase "I've changed my mind" could have a literal meaning
Best Of Luck
I think it already is literal. Changes are always happening. I know my thoughts have changed my actions and my day to day life. I know my day to day life has a effect on my body and brain. So 🤷♂️
I want to change my mind to be healthier with this science
But then might not be accurate to say "I've". Maybe by the time then the deeper illusion may be that you think you had ownership over changing your mind when yet someone else has done it covertly
Bruh imagine a weapon that make your brain mush then used the materials to make a new brain and thus having a new mind inside of it.
This has been one of the most true to form ted talks in years. Brilliant 👏.
Yes because big leaps take time to make, a program with monthly talks like TED easily outpaces advancements hehe
It is so exciting to know that we're almost getting to science fiction levels of technology right now! This is all so amazing.
we have been there for quite some time friend. most normies just don't realise it yet.
That’s what you think now, just wait, I’m sure we will come to regret playing in the realm of the gods.
@@yourmommashouse What?
@@yourmommashouse so you regret having medicine, you’d rather die of easily preventable diseases instead of “playing god”? I genuinely hate Luddites
Look up the history of neonard neemoy as spok and notice how much he hated his character until he went to a high society party and everyone in the room was drooling over the fact he was there, because he inspired every single scientist and big wig in the room to pursue what they were pursuing (like teleporters)
It's fascinating how much we can do now with bio-engineering that we are finally getting to the frontiers of understanding brain mechanisms especially since despite the developments in science we never knew how we do the things we do. The fact that it's even happening in our age and time is just mind blowing. I think bio-engineering and genetics is about to go supernova in the near future but people seem to still be sleeping on these discoveries....
Yeah , polishing the chromeware on the Titanic, fascinating work.
Absolutely amazing how far we have come in so little time.
Very informative video..the level of work they are doing is source of awe.
this is crazy. absolutely crazy. the first time i got hooked in neurotransmitter was in high School after i saw a movie about ALD disease (lorenzo's oil). and lately im studying abt personality disorder (dsm 5), and these disorder can be genetics bc of lack of neuron in the brain. he is so right. this is huugeee, amazing. lots lots of people with disorders will get benefit form this. i cannot wait to know more in the future!
This is fascinating! Scientists are doing amazing experiments. Glad to be in the world of internet with easy access to such brilliant Ted talks. Full of gratitude! 🙏
That is so facsinating! It really blew me off and I'm happy to live in such a great time.
This is absolutely jaw-dropping!
Wow. this moved me to tears. please fund this!
I was wondering about this the other day. So happy it’s happening.
Felicitari domnule Pasca !!
The innovative research by Dr. Pasca’s lab is truly awe-inspiring and pioneering. Utilizing this organoid and assembloid technology may afford a not-so-distant future where our understanding of neurodegenerative diseases and other devastating neurologic conditions can be enriched and the prospect of identifying feasible treatments or meaningful improvements could become a reality. I appreciate how Dr. Pasca acknowledged the important ethical considerations inherent to his research. At this juncture, the ongoing research does not seem to overtly violate ethical principles. This is considering that the skin samples are obtained under consent and with understanding that these cells are engineered neural tissue capable of organizing, responding physiologically, and resemble part of the brain, but are not sophisticated enough to have perception or feeling. While Dr. Pasca mentioned the scientific community’s obligation to operate carefully, and communicate ethical questions, societal implications, and potential regulations, the future application of this technology should be subject to diligent ethical evaluation, particularly use in transplantation of these organoids or assembloids into humans or animals. Furthermore, as the science continues to develop, these stem cells will likely be utilized in ways that may not be envisioned right now. With this in mind, the scientific community as a whole needs to hold researchers accountable in order to comply with the ethical principle of non-maleficence or do no harm to all involved. According to bioethicist, Sarah Chan of the Usher Institute of Population Health Sciences at the University of Edinburgh, the benefits of brain organoid research are many and the risks are few at this stage. But, per her account, “if we ever start using brain organoids directly in therapy, as a form of tissue transplantation, then we’ll have to think again about what the risks are.” Ultimately, I believe that with the evolving science involved in this research, we must ensure that ethical considerations and implications are maintained during the research process and match future scientific advancements.
This is insane, I wish this can help us understand more about consciousness as well.
how could something physical help us with something metaphysical. this is what go us into the whole SSRI debauchle.
@@1goldinga Consciousness is just as metaphysical as temperature. Both are emergent properties of very physical things, and their influence is physical. It's all physical.
@@acpwnd2020 you just compared consciousness to temperature...lol okay friend. You keep believing that.
@@1goldinga our consciousness is our brain why isnt it as real as temperature?
@@isaack5601 no...no it is not. You are the type of people who would sign up to be uploaded to a computer brain. Thoughts and consciousness are not just electrical signals. You both have clearly not actually looked into this topic or you would not be speaking so ignorantly right now. Again the thought that personality disorders could be fixed by drugs is what got us into the SSRI debauchle. Maybe you both should actually do some research before you try and speak about the topic. Obviously this is not the platform for this conversation, for at anytime for any phrase your comment can be censored. So I bid you two a good day. Maybe you have ears to listen, I hope that's the case.
Truly amazing work
Brilliant presentation, Sergiu, thank you 🙏🏽😃🧠
It's almost heartbreaking to me that we won't see the full long term fruits of this labor in our lifetimes. I mean there will be developments and insights but the complete combating of certain diseases will be mostly for future generations to benefit from.
We don’t know that. History shows that as tech improves it accelerates learning and development.
We could make huge improvements by 2045 with AI that can function at a higher level than humans. This could lead to numerous ground breaking discoveries and treatments in different aspects of life.
The Atoms that are performing you, will perform something else
Also remember there is a lot of money in the medical industry.
It's more profitable to not cure cancer.
I don't want to get all conspiracy like by any means.
But i'll just say that, you'd be surprised how many times lab findings are altered as to have different findings to limit advancements.
I know of one case personally from a family member regarding medical marijuana at one of the big unis.
It's a real worry, let alone what will and wont be in our lifetime. However we are born in one of the best time periods the world has seen. Technological and world standing.
All the damage caused to the world and bloodlines through our forefathers and establishments before that.
We are in a far better position than the industrial age for example, however paying for it now in our lifetimes.
Its ok. We are benefiting from those before us. We must carry the torch. And preserve the world as best we can
So what? 100 billion people before paved the path for us to get this to this stage and we have had better lives than all of them in every considerable way.
it's absolutely fascinating... what a nice time to be alive 👍🏻👍🏻👍🏻
Speechless...and in awe...love the future
Thank you for the presentation
Fascinating. Reminds me of the other Organoid work that was used to find a cure for the common variety of Cystic Fibrosis. Interesting you refer "The work I do" rather than the work you and your team do. :p
That was a little bit on the narcissistic side; but the work that they do truly is remarkable.
He says the word "we" 71 times in this Ted Talk.
This Ted Talk blew my mind.
I am in awe!!!
Thank you ....👏👏👏👏
Umbrella Corp got a TED talk!? 😂 No really, this is pretty amazing to watch.
This isn't only the future of curing mental disease, but might be the key to fixing the aging process altogether
I just wish I'd still be alive and able to access it when we reach this point
How far away are we now before we can start using these organoids/asseenoids?
Ted is back!
Fascinating
Brilliant!
Thanks 🙏
Amazing
amazing... amazing... Amazing!!!
So when this project a succes one, can they give person another personality or control your personality?
10:20 did not show the actual video, can he show it next time? Thanks.
I hope this research can help people with cerebral palsy and other developmental disabilities.
Very cool.
Astounding, inspiring and primitive, in posterum
This has blown my mind! I think we should focus More on bio-engineering and Upgrade humanitiy befor building AI and lose the top of the food chain.
Polio powoduje horoby umysłowe ?
Free Energy Principle proponents like Karl Friston should check out immediately the data associated w/ the auto(ish) connections created inside the (connected) organoids
This.. is amazing. This is the kind of research which will save my entire generation.
it would be interesting to rewire our brains toward thinking, since thinking is very costly for our body we developed to not think.
with the amount of easy accesibble food now we could change this.
2:36 he pause there a little hoping for an applause, but the audience was stll sceptical about it. 😅
I'm studying neuroscience so of course I'm in awe. I would like people to understand that autism can be debilitating, but not always. I think autism is my superpower. I wouldn't care so much about neuroscience if not for my hyperfocus and lack of friends
how does it feel when you hyperfocus?
@@zerikogania665 I feel on top of the world. I feel at one with the universe. I feel at peace. I feel complete and full of joy. In a way my ego dissolves and I become one with the tasks I set. I focus on science a lot. It can make me lose track of time and friends which is an issue, but it also makes me learn really quickly and I remember everything I learnt really easily.
I'm actually a high school drop out but I'm now in university. I knew nothing of basic biology before last year and now I'm a top student. I taught labs by the end of first year and I'm friends with all my lecturers and joined a research advisory board. It sounds like I'm showing off, which is kind of true, but I'm also trying to illustrate a point. This is due to my hyperfocus. Imagine the rabbit holes neurotypicals fall down on tiktok and other social media or binge watching Netflix but instead it is studying. I spent the entire summer holiday studying biology, chemistry and mathematics for neuroscience. To me, this is how I relax, how I feel safe. It's like an endless source of dopamine and energy.
Wow!
The function of the brain being understood by the brain, not sure if thats a paradox. If the brain is complex enough to understand its own function, is it really that complex? (can we ever really understand it completely?)
I think that’s projecting our own consciousness/self awareness onto it, it’s more like a natural intelligence (aka genes) that cause all the cells to work in harmony and do stuff like heal itself be self aware of when it’s damaged etc
Logic is relative
If you listen really closely to the neural organoids you'll hear a faint _"What is this? Why am I hear? Life is suffering. Kill me!"_
people are awesome!
I wish he mentioned that to turn cell into a stem cell you basically use anti-aging technique which can be used in any cell, in any body and will make soon human immortal.
Imagine using these in our computers in the future. Or using it to build robots.
Yep...hopefully I'm dead by the time this really gets going.
i wish he would help me
Graph theory is gonna be big here
On the human cortical motor pathway. Your study may time into future transhumant or cyborg study and creation. This is something I’m looking forward to.
It’s silly to even think robots could take over the world.
Can you build a A.I. brain model through full cognitive movements and motor functionality is that a posability
I suggest that you let elon musk try your organ oids out on his robots Optimus for development in his time scape and see how grateful he may help fund your work it wont hurt to ask him its posible to make a synthetic A.I. for DoJo a even use them in the event of neuralink for making better connectivity in aid around the human host open reign to heal faster and have them firing at all synopsis
In the same way stem cells van ordered can form any organ anywhere in the human body so can you then take the representative keyed organoids put them in a pill 💊 and swallow growth cycle needed to make Said cortical pathways fit to anywhere in the human body say new lungs hearts liver or Brain technology is this a plausible thing making the noids synthesized-aid to medicine 💊 a reality
pretty crazy stuff lol. hopefully it is used for good only.
Very good
Wow
The Singularity is approaching pretty soon
What ever it takes 2 make us immortal
He’s in the historical cloud library
I'm interested in the chemical soup he mentioned
did he say infecting them with polio virus ?? 11:54
I believe science will create a human being someday though it may not happen in our generation.
11:11 they made a homunculEYE
Stem Cells are amazing. I have nerve damage and something tells me stem cells could cure this damage. The problem is, here in the USA, stem cells are for the rich.
For now
Omg, soon I can change my brain to rocket scientist
What if we and our entire universe are all part of one single consciesness in a brain organoid just like those in that lab?
Does this mean we've finally reached the future?
Staggering
Could we put them back into the brain to extend our brain mass? 😂
Might be a good cure for some people as well 🤪
Would it be ethical to grow a conscious brain?
Not at all
@@ryanelam4472 But isn't that sort of what they are doing? How do we know when a set of neurons become conscious?
@@awesome0sour Honestly, I really don't know, it just seems irresponsible to assume unconsciousness if there is a decent possibility something is.
@@awesome0sour But I suppose I'm not really consistent, because I don't mind lab animals nor animal brains being experimented with (with good reasons). It's just when they cross over to humans it gets worrying to me.
Nations belongs to its scientists.
but does it have consciousness?
This vidio is goat
Absolutely phenomenal science!!! But, it's so sad to me that any scientific advance ALWAYS becomes WEAPONIZED :(
Questions: How large and complex can we make the 'human' brain? Would it even still be 'human'?
Let me get my brain extension and think about it some more.
New treatments or new diseases. It depends in which hands it fall's
That still doesn’t explain why some people don’t seem to use their brain.
That's sociology and psychology. Not neurology.
This is amazing!
wow...
Funny how i already knew about stem cells from reading mangas
How isn't it a miniature Frankenstein's monster?
This is so radically simplified, it’s unclear what he does or how legitimate the work is.
no way
"Reverse engineering"
There was an Engineer who may not like His work to be a lab experiment
3d print a cyborg brain with braincells attached to cyborg materials and wow you got a cyborganic brain
Great
There are two ways to study the human brain. One, by engineering it in the lab or use of animal models. Two, by looking within and experimenting with your own brain in a holistic way. I leave it to you to decide which way is the most effective.
That’s scary af
I hope this power is used for good, and not evil. Watch out, because the AI researchers are listening.
I think we're pretty close to actually making artificial consciousness.
The Matrix explained!
But would a robot with a real brain still have to sleep?
Very insightful but scary
Holy efffff! This is some insane PR. This is beyond speculative and riddled with misleading ideas.
Finally, Frankenstein's monster is on the way muaahahahahha
That is the future but
Still far from now.
He looks like Peter Parker in spiderman