Highly Successful Weight Loss Drug Semaglutide Explained
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- čas přidán 31. 05. 2024
- A transcript of this podcast and more information about Tom Wadden is available on the website of the Duke World Food Policy Center at wfpc.sanford.duke.edu/podcast...
Much attention has been paid recently in both scientific circles and in the media to a drug for weight loss newly approved by the FDA. A flurry of articles in the media hailed this drug as a breakthrough. This was prompted by the publication of a landmark article in the New England Journal of Medicine addressing the impact of this medication in a large clinical trial. Today's guest is one of the authors of that paper. Another flurry of media attention occurred as the drug became available, with news that supply couldn't keep up with demand. Dr. Thomas Wadden is the Albert J. Stunkard Professor and former Director of the Center for Weight and Eating Disorders at the University of Pennsylvania School of Medicine. He is one of the most highly regarded experts on treatments for obesity, having done some of the most important research on very low-calorie diets, a variety of medications, bariatric surgery, intervention in primary care settings, and more.
This talk was a miracle explanation for me. I have Celiac disease (small intestine) and pernicious anemia and I’m always hungry. I cannot eat carbs at all, all carbs turn directly to body fat. I struggled for two decades to stay thin and post menopause it’s impossible.
I did my first shot this morning. I’ll probably need to stay on this for life.
I’ve lost 40lbs on Wegovy, and there is a delay in filling prescriptions - usually a day or two. I started at 237lbs. last December and today I’m 195lbs. at the 2.4mgs with only some occasional nausea. It’s an amazing drug.
in my area theres a huge shortage
@@sasfishadventures9729 East coast shortage too - and it's affecting the availability of Ozempic as well. Semaglutide is a safe efficacious medication, hang in there, the company will get the supply back up - it's good for them - they make money - and good for patients - we reduce all the obesity-caused diseases and conditions - and good for payors - the drug is cheaper than all the healthcare costs of those obesity-caused diseases and conditions. If the powers that be recognize this, this medication may rescue the economies of the west.
@@anthonyhawthorn2960 yea im on ozempic most places are out
08/11/22: I have Aetna Medicare and they filled my Ozempic on the 1st try. Wegovy I fought them on and they still denied. So maybe something has changed. There was NO shortage in NC where I live.
that is just great! I like what this doctor says about getting rid of the stima of obesity and looking at it as a health condition like heart disease and diabetes. People need to understand that it is way more than just " eat less, exercise more, "
I've been on Ozempic for 3 months and have lost 17 pounds. And my glucose checks are amazing! No problems with my insurance.
Its amazing congratulationo
What dosage are you on?
I've been on it too for 3 months but didn't loose as much.
I am a 60 year old male who has struggled with weight loss for the past two decades. On Mounjaro for seven weeks and I am down 29 lbs. Exercise (Cardio) 6 days a week, 65 minutes daily, light weights twice a week, eating about 1,200 calories daily. Great medicine with a strong appetite suppressant. Only side effect has been some constipation.
Way to go brother! Keep it up!
Way to go brother! Keep it up!
Thanks for this podcast. I was prescribed Wegovy in May and took a month to get approved. After approval it was and still is on back order till mid August. My doctor then prescribed Ozempic which was approved right away. Fast forward 4 weeks and I have lost 8 lbs. I do hope more Drs. will try to help those who have struggled their whole lives with obesity. There is such a stigma around those of us who have trouble maintaining a healthy weight.
You are speaking nothing but the truth. It isn’t easy just to lose weight. Even exercising I still don’t lose weight.
Can I ask what your dosage is and how much is your prescription? I looked at prices from from my pharmacy and Good RX; it’s very expensive, between $300-800. Thank you.
@@teresap6055 I'm on 2mg dose per week. The cost to me with my insurance is $25 a month. Since mid June of this year I am down 30lbs.
It’s only 5 days my first dose of ozempic and I feel good. I can see am losing weight but I have to see next week. I am really grateful to scientists.
Thanks for your comment...I don't see much information about how ozempic is helping glucose levels.
I’ve been on ozempic for 5 days and down 6lbs. This is a game changer for a ton of people
This was great - especially the discussion about the stigma of obesity as a disease. I just took my 3rd shot @.25 and didn't know that it takes four months to start to get the best affect. It really does work - it is amazing really. Thanks again and I will recommend this to others so they can have a better understanding of the drug and how it works. On the FB groups, it seems like nausea and constipation are the biggest challenges.
I've upped my dosing about every 6 wks. I've done well. Only minimal side effects
Thank you
It's an amazing podcast. Really helped explain something complicated in such a way that anyone can understand it. Sounds like a pioneer drug that will help so many people. I pray that he becomes more affordable so the people who really need it may benefit.
I have lost 18 lbs after 2 months on semigutide I have no side effects I walk for 2 hrs 6 days a week 13,000 steps over 5 miles daily
this was so good! Can you comment on compounding pharmacies creating semaglutide for a lower cost and reducing some of that cost barrier?
For now, genetically engineered peptides such as semaglutide cannot be made in compounding pharmacies.
I know a few people using it from compound pharmacies and it works.
@@ChristiantoWitchin I am taking compounded and doing well
@@bannedinfinity5789 wrong
@@bannedinfinity5789 lol what do you base this on? Lyophilized semaglutide, ipamorelin, bpc157 and any peptide one desires can be found rather easily. Compounding pharmacies have no issues providing these products at a fraction of the cost.
I wonder what will happen if I drink semagglutin and do not apply it to the muscle? will it have the same effect but much weaker or none at all? thank you (when applying to the muscle, I had extremely undesirable effects with 1 ml and I would need to carefully reduce the dose)
I started today.
Good luck!
Good luck!
Cigna does not cover it. I’m getting ready to pay out of pocket. My BMI is 29.
So the amount keeps increasing until you get to the suggested amount? I am on 6th week. Now at .5 level. Feeling great.
Ozempic costs 102€ (~100$) per month on Belgium
He mentioned the small intestine. People who have had roux and y that had a portion of that removed will this still work
Yes I have.
I added Dr Berg gallbladder formula and that was huge relief to the gallbladder situation! Miraculous …
Who paid for the research?
Im on week 2 of I think .5 lowest dose… no results… Im hoping they will increase dosage.
Where would you get coupon's from
Just Google that question. You can't be on Medicare. And coupon is only good for so long.
The med is $50/week at certain weight-loss clinics!
I had a prescription of semaglutide/ozempic filled last month...I didn't get it at $1035.oo. 😑
Pharmaceutical companies are making a fortune.
It cost me $25. Maybe get a job and get health insurance?
@@Danlovestrivium nothing like being rude. Some insurance won't pay and some doctors don't want you on diabetes drugs because of how it reflects on your future insurance.
My doctor just makes sure you get a month for $200 apparently the nifty little applicator is what they make you pay the extra $1000 for.
I got it from Dr for $200/month in vial w syringe instead of the applicator
Some private insurance companies consider it an anti-diabetic drug. And many will not pay for it if you are not diabetic! They are not interested in preventing anything! They will offer some support once you have the disease!
@@Danlovestrivium just Soo you know some people have jobs like me I have to reach $3,000 or $4,000 before my insurance would kick in so think before you start leaving comments and I work full-time it should be a law for insurance companies to be able to do that
Do you except Medicare and Medicade insurance
08/11/22: Aetna Medicare approved my Ozempic 1st try. My appetite...GONE. It cost me $10.
My PA offered it when my weight was at a stand still. Im at 254...which is horrible for me after living at 185 x 20 years. I am a RNY gastric bypass survivor since 1992. I lost 212 pounds via the surgery PLUS walking 10,000 steps a day. I kept it off til I was in a car accident and back surgery in Aug 2017 and no longer able to walk 1000 steps much less 10,000 steps. My Aetna Medicare denied Wegovy twice but I could not have paid the $1300. price out of pocket. I live with mild diarrhea since RNY so must watch what I eat normally. If taking Semaglutide halts that I would be thrilled. I chose to pass on conversion of my RNY to Duodenal Switch via Duke's Dr. Fornier back in 2019 due to high risk of diarrhea. I have one comorbidty, mild HTN, caused by Fibromuscular Displasia in my renal system; found when I had a SCAD heart attack 6 yrs back. My appetite is pretty much GONE. I'm a huge skeptic but this is not a complaint. Im on 0.25mg to start. My PA says she will increase the dose as needed.
I found this video to be informstive and EZ for the lat population to understand. Thanks Dr. Wadden.
Medicaid is paying for my Ozempic. Took about a year, jumping through their hoops. So far, so good
I am type 2 diabetic and I had a horrible experience with Ozempic. I made a video on that if any body wants to watch. It's on my channel. I will NEVER take this drug again.
Semaglutide is still under brand name patent, so it can't be compounded. Though Ive heard some pharmacies in the US are illegally getting the compounding powder from China.
Ugh, I would NOT trust such powders from China!
False. Compounding pharmacies are legally allowed to produce their own version of semaglutide because of supply issues. Their semaglutide isn’t FDA approved, but all the ingredients in the vial are.
@@gymjake7619 exactly, due to shortages they can legally produce and sell nice little loophole
Wrong
Not true, I’ve been on it for 3 mos and get it at Compound Pharmacy of America and have lost 15 pds plus cholesterol numbers dropped and A1c so I’m confident in the drug from CPA.
I paid $450 for four injections The first week is .1 second week is . .2, 3rd week is .3.. fourth week is .4
Then next month is a bit more $550... But it's 4 weeks at .5
I'm paying $150 a month in Kansas for it as well as a second injection of vitamins
I pay $80 a month. Get them through my doc and not pharmacy. Taking twice weekly divided .25 so I don’t have as much of the headaches and nausea side effects. Maybe people can shop around to find a better doc. One that’s not in a big conglomerate corporate setting.
I stopped using ozympic after 5 weeks because my hair was falling out in handfuls.
Damn
Oh that's awful! I'm sorry you experienced that. Fortunately for myself, I've always had really thick hair. I always fill a hairbrush when I brush my hair, always have. So I'm not noticing any issue with that, thankfully. Of course my hair has thinned out a lot. Used to be I could barely get an elastic to go around. my pony tail twice. Now I have half as much hair but still have more than plenty.
I've been on ozempic for almost 4 weeks. I'll be starting the increased dose of 0.5 in 2 days. I haven't checked my weight in a few days but on November 11th I had lost 10.2lbs. I'm so grateful for this drug. I am a diabetic with a thyroid disorder as well as a number of other comorbid disorders. I anticipate being on this for the rest of my life, just as I am going to be on all my other medications.
Is there any possibility that one of the other medications might help you without the hair loss?
I wonder, do you have hyper or hypothyroidism? Have you ever had your thyroid checked? Hair loss is associated with both of these disorders. There's also the possibility that your diet after starting the medication could have some impact here. Taking a vitamin pill could potentially help to offset that effect... If you wanted to try the medication again.
Weird! No issues with that. As a matter of fact my already thick hair has gotten thicker! 😬
I believe that is part of any quick weight loss unfortunately.
My
How much does it cost
In the suburbs of Houston: Month 1=$200, Month 2=$200, Month 3=$300, Month 4=$300 and Month 5+ is $350 but in month 5 and over it is a maintenance dose so that $350 lasts 3 months each.
@@loriconsidine7164 are these cash prices ? Is this for the real stuff or the compounded one?
Can a person still inject Semaglutide when pregnant? 👀
no no no
ABSOLUTELY NOT!!!
Definitely not
You can get off blood pressure and cholesterol drugs by changing what you shove in your mouth, fasting, and walking. Typical medical industry answer. Use the drug for a jump start change your habits and get off it. Take responsibility for your health
Unless you have walked the path you can’t judge.
Agreed. Most Don't have the information though. They listen to the standard advice and have no idea what actually works. I've been on this journey for a while. It has been a decade now and I finally understand what works and why it workst. Waterfasting has been excellent. Healthy Keto diets and low carb diets are the best ways to eat. Intermittent fasting every day. I've added this drug because I was having trouble complying with my waterfasting schedule. I couldn't make myself restart my fasts. I wanted something for that extra push. But you absolutely do have to take control of what you put in your mouth. It feels like you cannot do it because you are legitimately addicted to food and the chemicals that they put into it. Once I completed the 7 day fast, I literally broke all addictions and found my power. Even still, it is very difficult for me to restart fasting. I'm adding every tool in the arsenal to get this excess weight off.
Absolutely true. I hired a trainer 3X a week and started walking about 2.5 miles a day. Also cleaned up my diet, eliminated junk foods, cookies, etc. within 3 months my lipid panel was all normal and my blood pressure dropped about 30 points. My doctor had been telling me to do this for years but I just ignored him.
Agree, use it only for a jump start to help change habits.
Yes this is the way to do it you're right
My question is what happens when they go off Semaglutide, longer term. And also the Thyroid cancer risks are scary..
What if we don’t have issues with eating too much and just need to make our metabolism faster..
Current thinking is semaglutide will be life long therapy - like insulin for diabetics and blood pressure medicine for hyerptension. The thyroid cancer risk is very specific - and very low. The risks of obesity are serious and life thtreatening - and nearly 100% inevitable
@@anthonyhawthorn2960 But I see a lot of people taking who need to lose 10-30 pounds or so. What if it’s being used to shed a few pounds, not for serious obesity(?) Is “risk vs reward” worth it?
Are you sure making your metabolism faster would solve the issue? If your metabolism is faster you would be more hungry, so you would eat more. Unless a metabolic rate increase reduces hunger levels. But I don't think it does. If that were the case, we'd have solved the problem, because we can increase metabolic rate.
I thought saying someone eats too much is exactly the same as saying someone's metabolism is too slow.
I am entirely open to being wrong about it, and would rather I was wrong, but I think "your metabolism is too slow" is like "you need a low fat diet" or "calories in calories out" in that they SOUND right, and make sense on the surface, but don't work.
@@dellgilliam6431 Making your metabolism faster isn't the issue. The root cause of why people develop obesity is because they have high insulin levels because they consume excessive amounts of Glucose. Once you lower your insulin levels, your body can access stored fat for fuel. It is physiologically impossible to burn fat when your insulin levels are over 10.
The rate at which you burn calories is calories is somewhat irrelevant to this issue. It only comes into play if you increase your exercise and then decrease the amount of food you consume, your body will freak out, think it's starving, and to a starvation mode. It will then down regulate your metabolism. You will burn a 1000 calories but eat 1200. You will gain weight even though you think you are in a deficit.
The 1st thing you need to do in order to lose weight is to lower your insulin levels. Going on a 72 hour water fast is an immediate way to drastically lower your insulin levels and tap into stored fat for fuel. Keto It is another tool that allows you to empty out the carbohydrate in your body, lower insulin, and tap into stored fat for fuel. Intermittent fasting for 20 hours in A-day, is another way to lower your insulin levels. You have to be careful about what you eat when you refuel. You want to eat in a manner that does not trigger insulin. Fat does not trigger insulin. Protein triggers insulin at a moderate level. Look up the insulin index of food. You'll see that red meat triggers just as much insulin as pasta.
Lowering your insulin levels will lower your body's set point. You will adjust to the lower weight, instead of trying to defend the old weight.
Insulin is everything.
The reason why people drop weight on keto or a very low carb diet is because carbs draw water into the cell. When you lower carbs, you lower water. Insulin is not the enemy. Obviously if your glucose levels are out of control then that needs to be addressed but insulin itself is not this evil entity people make it out to be.
Also, the calories DO matter and the reason why people lose weight on keto is because they are cutting out an entire food group (carbs) from their diet, which in turn lowers caloric intake. Keto is all fine and dandy if people can adhere to it. The issue becomes that people will not stay keto for the rest of their lives nor is the diet sustainable. So then what happens? 95% of people will rebound and shoot past the weight and body fat levels they were at before.
The true key is to make lifestyle and diet changes you can adhere to and be consistent with and maintain. THATS the key.
Wow..that sounds like a horrible drug. Long term drugs for cholesterol and blood pressure are also terrible
Why?
LOL then don't take it.
@Mat Lepak: to each their own. Nobody is forcing you to take this med. I'd take it 1000 times over any Statin/Cholesterol med, MY CHOICE.
That's ridiculous! Should I also just toss out my insulin and thyroid medications, along with my cholesterol and BP meds based on your expert opinion?
My medications and health conditions are followed by a top notch endocrinologist and a diabetic team.
Ozempic is the latest medication that I'm trying. So far it's been doing wonders for my health and I'm only just finishing up week 4 at the low dosage. It's helping me to wean off, reduce, the amount of insulin that I take.
I wear a flash cgm (continuous glucose monitor) that records my glucose levels graphing them each day. So far I've gone from 120 units of my long acting insulin to 90 units per day. The graph is showing me that this medication is helping me maintain my sugar levels. That's pretty darned impressive for someone with brittle diabetes.
My cgm is showing me how well this drug is working. Other than fighting my sugar lows, because I predicted eating more than my body could handle, it's showing that my sugars are actually leveling out. It used to be, if I didn't get to eat for 2 or 3 hours after waking my sugar level would climb to excessively high levels. Now because the drug is causing my pancreas to produce and use insulin more effectively my sugar readings are now stable. I will be working to bring it to a stable lower level.
Because ozempic is causing me to feel satiated faster and lasting longer, I have very little interest in food. At 3 weeks, at the very lowest dose of 0.25mg, I'd lost 10.2lbs.
My biggest problem right now? Is estimating how much food I'll actually be able to eat so that I can safely administer my short acting insulin to accommodate how many carbs are in my meal. But I'm on a learning curve with this and clearly I'm going to continue to need to learn to accommodate this medication. For the first time, in my 60 years, since I was a young child I actually have hope and a medication that is effective for me in my journey.
LOW carb eating is the treatment for obesity.
So many low carb dieters struggling with thyroid issues. It works for a while till it doesn’t
DO what works, for you...Coloring & Doodling.
I lost a ton of weight on low carb eating but my cholesterol went up to 455 so now I have to take a statin. My leg cramps were terrible. Introduced 100 net grams of carbs back into my diet and put on 20 pounds. Just started
Ozempic and my cravings are calmed.
Calories in calories out idiot. Doesn’t matter what makes up the calories. Carbs are not bad for you.
Putting less food in your mouth than your body needs to maintain weight and being active is the treatment for obesity. Carbs are not the enemy for most.