Psilocybin Induces Long Lasting Modifications to Brain Connections
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- čas přidán 16. 07. 2021
- A recent study investigated the effects of psilocybin, the active ingredient in magic mushrooms, in mice and demonstrated its long lasting effects on the growth and structure of dendritic spines. The authors suggest these changes may underlie the putative rapid and sustained antidepressant effects of psychedelic drugs. In this video, I will give a brief overview of these very interesting results!
I'd be happy to hear your thoughts about this study and continue the discussion down below in the comments section.
For more in-depth videos related to neuropharmacology, subscribe to my channel!
IG: @neuropharmacist
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Also check out my video on Psilocybin and 5HT2A receptors:
• Psilocybin and 5HT2A r...
Original study
Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Ling-Xiao Shao, Clara Liao, Ian Gregg, Pasha A Davoudian, Neil K Savalia, Kristina Delagarza, Alex C Kwan
PMID: 34228959 DOI: 10.1016/j.neuron.2021.06.008 - Věda a technologie
Research has shown psilocybin to have potential to treat a range of psychiatric and behavioral disorders.
Taking shrooms was 100% one of the most important experiences in my life. Everything has changed since my trip - I perceive - things differently.
Where do I get nice shrooms from?
magic mushroom are the safest antidepressant medication to take.. I wish it was easy to source for those who would really need it.
It's hard to put the transformation in words. Incredible amounts of healing occurred. I'm still processing the beauty.
I'm currently dealing with him, My buddies get from him as well. His products are pure and amazing.
I have been depressed for a long time, but after taking shrooms few months ago, l feel much happier and highly motivated and my ADHD gone , lost a ton of anxiousness and had a few epiphanies about how I should live my life. I decided to buy an ounce for backup, but haven’t yet felt the need to take any more since then.
One of the uses of psychedelics is administering psilocybin to cancer patients, it allowed them to confron their mortality, remove fear and anxiety and to die with peace and equanimity. What a gift this is.
I've been microdosing on the batch of mushrooms I got from one guy online for the last few months for depression and the results have been immeasurable. The world has beauty again whereas before it was grey and painful.
Some of the first trials were in cancer patients, and I think the results have been promising.
Ive not had cancer, but I used to obsess about death, the prospect of total annhilitation, and turning to nothing terrified me greatly. After trying pcylocibin, i stopped. While under the influence, i became fire and light, then i started to move away from this world, and went to a place that felt like home, it was warm and peaceful, like ive been there before, and felt full of love, i felt as if i was given all the love that i had wanted and didnt get in my life after that i stopped being afraid of death. It felt like being born again. The medicine told me life is a sacred mission that justifies all the pain and suffering we experience.
The ones who have sold their minds to a foreign installation of evil and sick ways of beings, who are unaware of their mortality and being confronted by it have an increase ego and self importance. They are the worst types of humans that exist.
Hallucinations are our brain connections using new parts of the brain instead of our ordinary habitual small brain connection we use for our routine that Have becomed dormant. Shamans call these visions, signs and seeing 👁️. Yet western and the settlers culture and society laughs at them calls them insane while oblivion following a lost culture and world goverments who just fight, consume, destroy, invade ect. psychedelics reminds us how powerful our minds really are and that the great mystery is all around. That All is one and conmected. That is highten awareness, you feel and exist difrent, suddenly nature becomes difrent than in your ordinary awareness, you are able to see beyond the human conditioning of the modern day rat societies eich and poor people fighting, chasing happiness and materialism. While never knowing reality. The rest is illusion and are asleep. Led by others at the top via a cultural foreign installation. So free your mind from a scinzophrenia foreign installation he who can 👁️
I tried micro-dosing yesterday for the first time, and I had wonderful experience. I'm someone who suffers from chronic depression, and I was simply happy, not overly ecstatic, but genuinely happy and active with my friends and family. I was even excited to get out of bed this morning.
Psilocybin saved my life. I was addicted to heroin for 15 years and after Psilocybin treatment I will be 3 years clean in September. I have zero cravings.
This is something that truly needs to be more broadly used in addiction treatment.
Yes, bergwilly11_
A lot of people have testified about this and I really want to give it a shot. I put so much on my plate and it definitely affects my stress and anxiety levels
The Trips I've been having have really helped me a lot,I finally feel in control of my emotions and my future and things that used to be mundane to me now seem incredible and full of nuance on top of that I'm way less driven by my ego and I have alot more empathy as well
Is he on instagram?
Anybody who has undergone intend psilocybin therapy will understand that trying to get life changing therapeutic benefits of psychedelics without the trip is laughable.that’s what rattles you out of depression.
That’s true mate.
The trips I’ve been having really helped me a lot. I finally feel in control of my emotions. The things that used to be mundane to me now seem incredible and full of nuance and on top of that I’m way less driven by my ego and I have a lot more empathy as well.
Psilocybin trips happen to be some of the greatest experiences of my entire life.
Psilocybin is an ancient and powerful medicine. It is amusing that “modern” medicine is only now trying to understand what Indigenous people have know for a millennia.
I’ve been trying to get my hands on some of em but is kinda hard, I haven’t got the time to grow them. Where can I get them?
How do I get across is he on insta or something?
This is the power of psychedelics. I used DMT hoping to get rid of some chronic pain associated with a mowment disorder.
I got so much more. My brain learned to stop creating pain and then find abstract ways to turn those sensations into useable signals. Not even a year later im not even the same person and dont think a neurologist could even see abything wrong at all. I had previously been told physical therapy wasnt even worth trying.
I have been finding microdosing psilocybin very useful for fatigue and ADHD. The fatigue which is psychosomatic seems to be eradicated by psilocybin. It's literally incredible. For the first time in years I can work physically all day and still have enough energy to do sport after. I can also focus on tasks, work systematically, and be very focused. I also stack with Lions Main, Reishi and Siberian ginseng.
bullshit, there are many more factors to it, people claim psilocybin does everything these days, misinformation, alot of people are gona be dissappointed with all the false information. It makes you trip, and if you are not ready for what it shows you well take caution.
Glad to hear it... do you mind sharing your formula and body mass? cheers. I had some pleasant results with a Stamets Stack of 0.2g of Liberty cap/ 500mg 20:1 Lions mane extract/ 100mg Niacin. Improved curiosity and concentration.
You're doing it right. 🍄💚
I find that mushrooms help with my chronic fatigue as well. Interesting. However, it only works when I’m high so maybe it’s not that effective overall? Happy it’s working for you 😊
How often do you have it? Im new to this, but I'd think having to be tripped out of your mind every few days to sustain energy might not be worth it imo. But if its a monthly thing i'd be willing.
I was more than a year in the pain clinic for back pain. extremely painful attacks in my back. Had many injections in my back, several treatments nothing helped. Most of time a was in extreme pain and couldn't do anything. After one session psilocybin my pain was gone. In that session a owl took me to walk through my spine and I saw that it was clean en healthy and strong. Somehow my brain had made this information to reality.
Fascinating
My last trip kicked my ass. The shrooms had enough of me abusing them. They sat me down and had scolded me like never before. I saw all my flaws, all the wrongs I’ve done. My body felt old, frail, damaged. My nerves were damaged. I was alone, felt alone. They showed me that staying in isolation away from friends and family will not lead to happiness. I have been pushing life away for too long and it was time to pay consequences. Normally I have fun, light, wild trips. Like a vacation from life. This time, no vacation, no fun. It was time to sort myself out. It was very difficult. Now a few days later I feel like I am glad it happened. First couple days were not easy. I felt broken and alone. Now I have begun talking to my family again and am starting to feel like myself. Shrooms can have a great impact, but I would not say it’s easy !!! Have a plan !!! Trip alone is okay but have a safety plan or someone to call. Good luck friends 👍
Broooo you're post is fear-mongering. Like why don't you understand we're trying to get people to understand that these things are a wonderful plant.
@@thehobbyisthub8180 they aren’t plants
@@thehobbyisthub8180 people need to understand it isn’t without risks
That’s an ego death love
Mushrooms helped me get of opiates. Truly magical. They helped me connect with the past, present, and future. I was able to build new and rebuild old bridges. These connections allowed me to remap my mind and life. It gave me the inspiration to break through a massive barrier that was controlling my life. 1.5 years later now, my life has changed in wonderful ways.
As unfortunate as it sounds, a family passing is what let me to do psychedelics again.
And i couldnt be any more happier that i decided to do so. 🙂
I’m glad you guys are here today ❤
Me and a friend had our Psilocybe Cubensis up for the first time in 1978. What I noticed early on was how the mushroom built its threads and created a network in the jar, which was completely snow white. It glistened from the small drops of moisture that the medium created. It was a powerful experience and the network really resembled what is in the brain. I was struck by the beauty of the image and you could clearly feel a great intelligence present within this network. A biological internet of the highest kind. We knew it early on, and now the facts are finally on the table! It has been with me for over thirty years, opening unimagined doors to paying attention to the great world, beyond the horizon of the five senses. Thanks for passing on this important knowledge!
I have server ptsd spent 3 years in and out of a hospital for self check out reasons. I friend gave me an oz and said eat this. I didn’t know anything so I ate it all. Hard night but I have never wanted to self check out since then and it’s been 13 years. I owe a lot to mushrooms and teaching me about how beautiful the world could be again.
You ate an ounce?
Its changed my life. Its given me feelings i havent had in years back
Its also made my brain quiet
A lobotomy would do the same.
same
How long did the brain quietness last for
Made your brain quiet... I have tinnitis so loud I can't hear people... Can microdosing fix this?
@@fusion9619 No, it can't fix tinnitis. It just makes your interior monologue disappear, because, through brain-damage, you are turning into a lower animal.
I was searching for a non vulgarizing video about psilocybin effects on the brain, finally found it! Thank you mate, it was very interesting.
The main effect is permanent brain-damage, which will only be obvious to you if you do advanced mathematics daily at a professional level. Do not take these drugs, they are like a concussion, even worse. You will not notice the damage until it is far too late to recover.
In india they climb mountains to temples of shiva and others. Here in native land. My dream is to go to the amazon and so Ayahuasca.
@@GOne-vj6no Ayahuasca is equally brain-damaging.
I have never used psilocybin for depression, but I have used LSD for spine pain management when my pain is so severe, nothing touches it. It works! Another friend who has similar spine pain from a deformation in the spine tried it and it worked for her as well. We definitely need to explore unconventional treatments like these more and change our thinking about pharmacological treatment options.
Hanna Somatic Educational
exercises done correctly.
= THE ANSWER.
Your welcome 🙏
My spine hurts so bad 😢😢 where can I find this lsd?
have you looked at what is causing the pain? for most its just inflammation from their diets rich in gluten, sugars and alcohols and for others injuries and incorrect yet repetitive stress from mechanical loads from incorrect bedding, posture and more. Past cultures avoided anything fungal, its invasive and warned in many texts as long term infiltrating its consented host. This also means no supermarket foods containing penicillin and other anti-biotics or anti-life fungal hybrids. Chametz and its varieties will do anything to take over the host specially their will. Enzymes from bacteria are the proper relationship of symbiosis for mankind while its fungal opponents only infiltrate and sure will help your ailments at first but lead hosts into the wrong direction, its proven historically and still ignored. Good luck
Never heard it used for that before !
Why do you think it works...?
Quite a leftfield therapy.
Can you explain briefly how you use LSD for spine pain? I was in a car accident, and already know that can be really hard to treat. I'm wondering if that could be right for me, and would like to know how to proceed.
I stopped taking anxiety medication, had 2 mushroom trips 1 week apart, and I have to say I feel so much better. Happier, more confident, more engaged, I am certain that the mushrooms helped. I also believe that they may have played a role in human brain evolution.
During a singular occasion, I decided to embark on a profound journey by consuming what is commonly known as a heroic dose of mushrooms. Little did I know that this extraordinary experience would transport me to a realm of surreal enchantment. As the effects of the mushrooms began to take hold, I found myself standing atop a verdant hill, surrounded by an ethereal landscape that seemed to pulsate with vibrant life.
It was there, in that magical place, that I encountered a majestic being-a gryphon of immense stature and elegance, known by the name of "The Hornigan." The Hornigan's regal presence was accentuated by an intricate golden helm that adorned its noble head. With wings outstretched and a commanding gaze, it exuded an aura of wisdom and transcendence.
Engulfed in a mix of awe and wonder, I engaged in a captivating conversation with The Hornigan. Its words resonated deep within me as it expounded upon the wonders and majesty of conscious existence. The Hornigan spoke of the interconnectedness of all living beings, the intricate tapestry of the universe, and the boundless potential that lies within each of us. That is the reasons governments the world over try to criminalise its use because it is very useful and directly contradicts that which the governments the world over would have us believe.
👆You want some?
For the best psilocybin 💊🍄 products and use guide.
Look up to the handle 🔌
Was he demonic at all or you think purely angelic?
I just tried mushrooms recently and after 50 of trying various hallucinogens this was only one mushroom, I felt the effects in a matter of minutes, and it is the first time I've tripped with visuals. Very first time. I could have done less I think. But no fantasy visuals. I saw auras around my cat tree. And then saw them elsewhere. My front lawn became checkerboard patterned. That annoyed me. The trees across the street moved their branches menacingly. They moved like black ink poured into water towards me. Had a very nice conversation with my granddaughter who was also doing shrooms. I wish I could have listened to music because when I have tripped before it really enhanced the music. I recommend you never listen to a brand new song you never listened to before, because it will never sound as good. I am still disappointed when I hear Edgar Winter's Frankenstein after all these years. The first time I heard it it was the best. Drum solo in the middle was much longer when I first heard it.
@@susanfarley1332great song~~~
da da da da da dant da dee....
love the song but its a bit gimeky sounding at times.
They provide the only “great reset” of any true value! ❤
When I was 14 years old I was diagnosed with traumatic scoliosis resulting from a car accident. For years my orthopedist would tell me it's irreversible and surgery was my only option. The pain and nausea were so unbearable I was willing to try anything but refused surgery time and time again. And by pure happenstance, I took about 5 grams of mushrooms ONE time with some friends and I was CURED the next morning. Went to get xrays done a week later and the look of perplexity on my doctor's face when he saw the results, I'll never forget it. And needless to say I've been taking them ever since. Now mushrooms aren't for everybody, but I encourage anyone to try it at least once in their life. Especially those suffering with chronic back pain. But I'm also not a doctor so do your own due diligence.
😱😱😱😱amazing
this is amazing the promotion of these connections is literally the science of consciousness
Whoa dude
The promotion of these drugs is a crime, as it is an attempt to cause brain damage to as large a number of people as possible. These drugs are permanently brain damaging, there is no safe dose.
And that's why cops say drugs turn your brain to mush, but they're fine with alcohol doing just that.
And that's why everyone in law enforcement is either an idiot or a psychopath or are too cowardly to do anything about the ones who are worse.
Because they only care about their paycheques.
Morals, intelligence, and compassion be damned.
But sure, lets trust a gang of psychopaths to protect us from other gangs even though they wait for crime to happen before doing anything... and often ignore repeat offenders and those who have warrants out for their arrest.
They have to be ordered to do that, by a different institution. New program for some of Canada... gotta tell cops to do their job or they won't.
Also, they're not allowed to do their own autopsies anymore because they can't be trusted to not fudge the results in order to convict an innocent person. And they still lie to the court/judge to this very day.
@@aliensarerealttsa6198 This has nothing to do with police, this is about brain damage. Alcohol DOES NOT cause permanent brain damage (in normal doses), neither does marijuana. Neither do opiates. Unlike those, cocaine, lsd, and psilocybin cause permanent irreversible serious damage.
Enough to literally change who we are and change our world. But the cultures and their internal dialogs. They hate reality and chose to live in meterims thinking thats the epoc of living or existing. Of being. Or the reason we are all human beings and came to pacha mama mother earth. Its a scared place and no ones in control. Youll see. They die just like the rest of them.
I suffer from Bipolar 2, and Borderline Personality disorder. I spent many years in counselling, and still see my psychiatrist on a regular basis. I take my meds regularly for many years now and have found the combination that works best for me. I have done both CBT and DBT therapy a number of times. A couple of years ago I started experimenting with micro dosing and have gone through a number of off/on cycles now. I tried short lengths of time taking it, I tried longer times and different breaks in between etc. I can say beyond a reasonable doubt that it makes a very noticeable difference for me. My depression and anxiety are pretty much non existent and I am far more motivated and interested in things. I cant praise them enough for the changes they have helped me make in every aspect of my life.
Psilocybin was a key factor in regaining control of my mental health, it got rid of the anxiety and depression in me. I'll refer you to this online specialist I got mine
Mycotenn_
I have BPD and am wanting to try microdosing because I want to be better so badly. I have heard negative things about people with BPD doing such things, but I am willing to try.
I need a change and you gave me some hope.
Thank you for your comment!
@@GoodFencesMakeGoodNeighbors You are very welcome. Remember everyone is different so if you do start trying it start at very low levels and take your time to find the right dosage for you. Good luck and I wish you the very best. I hope it gives you some of the relief and help it's given me.
I micro dosed for a different reason than my spinal issues I had. I kept noticing my micro dosing regimens was helping my back pain. I did a longer than normal micro session for around a month, normally did 2 weeks stents. My back feel so good right now. I broke my L5 and T12 and has disc damage afterwards on 3 different occasions. I feel really good and it somewhat surprising. I really think my micro dosing did something to help repair my muscle tissue in my attached muscles and it helped with nerve pain a lot.
You might be interested in neuroplasticity and the work of Moshe Feldenkrais and F M Alexander. Also Bowen therapy.
bullshit
Hi I would be interested in trying and micro dosing on this. Where can you get this please?
@@canterburybell8435 microdose, do a proper trip son, stop fluffing around in the puddles
That's the hard part, You can grow your own or find them through a friend. If you can find them buy them and store them properly for when you're ready. You're not getting high off this, It's more like a real happy pill.. @@canterburybell8435
40 yrs of the regular toxic meds i really need to try this. blessings on everyone in here and their journey to health
Brings new meaning to the old saying "Grow a spine!"
Lol or you got a lotta nerve
Mushrooms saved my life, overnight.
I went from several suicidal thoughts every day, down to zero.
That was 18 months ago, and I'm still alright.
@@adams9871 Winter is coming and the woods are my friend, thanks for the offer though.
God loves you personally. Its true. Knowing that I can face anything and you can too.
Mushrooms cured my depression and led me into my autism diagnosis. I'm glad they exist.
Psylocybin micro dosing cured my anxiety. Got me over opioids and gave me my life back. I am now a very social person. It really cured my nervousness when it comes to public speaking too. This stuff should be legal everywhere.
I definitely feel like my nervous system gets a reboot. I have a lot of neurological damage so its nice to know shrooms are actually good for you in moderation. Its as if the mushroom wants you to know how beautiful it thinks the universe is. You instantly feel cosmic connection and realize life is a presentation for you to give and receive and simply make the universe a warmer place. I say if everyone could try it, we could find forgiveness without God because we would find it in ourselves to make every day count. If I feel sad I just remember what I learned. Sadly it also requires a place to feel safe and secure or you feel the opposite.
I know what you are saying, but we cannot find forgiveness without God, only Jesus Christ can be the atoning substitute for sin that God accepted and for those who repent and believe in Christ and His finished work on the cross can be forgiven and redeemed. 🤍✝️
Your careful way of speaking, makes your words so clear, and easy to understand. Thank you. Your pronunciations are very helpful. I’m so glad you take time. Thank you for the useful synopsis!
Thank you!
Finnish people cant usually speak fast in english because our mouth starts lagging if i my self for example try
He is speaking slowly because he is advocating for drugs that cause serious brain-damage. This means it is likely he took these drugs a few times, and has some minor damage already. He is already damaged enough that will never be able to learn advanced mathematics in his entire remaining life.
I concur. The presenter obviously has a European accent but his enunciation is very good. My own son doesn’t speak so clearly.
His voice is synthesized electronically, no human being speaks like that.
I use just over threshold ammounts before doing something im not necessarily good at. I find that my progress at learning tasks is improved when i do this and the growth in that skill is measurable.
What is a just over threshold amount?
From first hand experience I will say that after "experimenting" with psylocibe cubensis mushrooms I noticed my own capacity for learning and adapting to situations grew, I'm not exactly sure how to explain what it was like before it's as if that was me but I didn't know that I had such a deficiency in my own intellect or abilities but after I can't learn enough I have a thirst for knowledge that I wish I had when I was in school. I was in my mid twenties and was a bit of a cold I enjoyed drinking and good times with friends. As it would happen the friends had told me about mushrooms and the good time it was, had some and I tried it. Not scientific in any way and I wanted more because I really enjoyed the intoxication they provided I procured them a few times from various sources and decided that I'd make my own to be sure if what I was getting and quickly found my self reading and seeking out more info on almost every subject that I came across. I never microdosed I was going after profound experiences, and found them eventually it seemed to slowly lack in the psychedelic experience and I would have to wait longer and longer between trips to even get a experience at all first 3 days then 5,7,10,15 days till I could get the psychedelic effect, as it got to be too much of a stretch and larger amounts to achieve the results I lost the desire to continue and gave it up. I still find and consume cubies but I still don't get the mind bending introspective moments I remember but I enjoy what I do get which is only a watered down version of the experience. The change in my personality is positive and I feel like my mind plasticity is that of a toddler. I adapt to horrible situations so quick it seems like there is nothing I can't handle. I have seen the new micro dosing trend and I'm intrigued. I'm curious if there would be benefits to persons with brain injuries the ability to regain or gain in general better cognitive reasoning and motor skills. Increases eye hand coordination (I learned to juggle when I was 12 after my mushroom experimenting I learned to do it with one hand, in a day) theres going to be a lot of new ground covered with psychedelics in the near future, I hope the others out there like myself can contribute to the good that will come.
Seriously? I bought all the stuff to grow them just for the cognitive effects, I don’t really care about the high or whatever I just want to assist in neuroplasticity and neurogenesis.
I've see improvements in me.
I bartend and I have noticed that I consolidate my time effortlessly especially multitasking behind the bar. I had long covid and my brain was fried from it.
I honestly feel like a different person. But like everything use with extreme caution I can see experiences going down hill in every way.
You didn't gave long civud, you gad vaccine side effects - vaccines have heavy metals in them - that's fact - magic mushrooms remove heavy metals from your brain - that's a known action of psilocybin
Are there any dose levels you recommend or even something like a FB group for people experimenting with them for long covid? Have had it a couple years compounded on top of a preexisting neurological issue.
@@DeltaUpsilonTug I would love to know as well.
Everyone is different. I took 3-5 grams and that's when everything started to really light up in my head. Out of desperation I tripped 2-3 times a month for about 2 months and every now and then I give it another go.
You're going to find out a lot about yourself too so please use caution. If you have anxiety you're going to face your fears for REAL. I'm a different person now a better, resilient, fearless version of me.
Please do your own research.
@@iammadeinthecreatorsimage.8295 Really appreciate you responding. Will use caution ❤
I experienced the anxiety and depression relief that mushrooms bring. It was a good and bad experience as I had a bad trip too. I have to say exercising such as walking also had a tremendous effect on my anxiety and depression. I was on pills for a few months so I know a little bit about this topic. I quit the pills due to the lowered sex drive and the panic it would cause when I was out of pills. Never again.
Bad trip could be bc youre alergic to the micotoxins neurotoxins and biotoxic mold fungus. One in four people have a gene on the 6th chromosome that doesn’t detox mold! They wont tell you this btw! ❤
@@hopefaithstarlight1207 that’s interesting. Thank you.
Kratom might help you too.
When you have a bad trip it's the mushrooms bringing your trauma to the surface to heal its not a bad trip its something that you needed to deal with.
visit the ocean. immerse yourself in the replenishing mother three times a week and specifically breathe deeply the air and salt mist made by crashing waves. walk in nature and micro dose. your anxiety, skin issues and mental fog will dissapear within 21 days. no pills, no doctors, nothing. even if you cant microdose, your brain and body will benefit greatly. the microdosing is only to help your focus.
Ah, so that's why it felt like I became more intelligent while under the influence of shrooms.
I love it when science catches up to intuition/common sense.
What a great work. Your accent is very interesting, and your pace and pronunciation is excellent. A pleasure to listen to.
Subscribed.
Thank you!
Very interesting, thank you so much for explaining things, I would love to check out more of the publications you suggest. But , despite my best efforts at teaching myself as much physiology and anatomy as I can I am always amazed at the fact I don't really understand anything. As soon as I think I have a grasp on things I realize there are so many more, deeper levels to it, that I just can't keep up. It would take lifetimes to understand wtf is going on inside me every second.
@Adams sorry brother thank you for the offer, but I got more p envy than my brain knows what to do with
The more you learn, the more you realize how little is understood. That's what keeps experts interested in their specialties- the rabbit hole has no end.
Please keep going on in study of depression treatment, i need your help! Thank you for work!
Since it’s believed the mechanism that produces psychotropic effects for ketamine and psilocybin is from binding to NMDA and 5HT2A receptors, respectively. Does this suggest a single common receptor for binding that stimulates dendritic growth or is it through binding to their respective receptors (mentioned above) that initiates or stimulates additional cascade pathways that drives growth? Or did the authors speculate?
Maybe there are two different "triggers" to glutamatergic signaling (NMDA and 5HT2A receptors) which result in similar growth of dendritic spines. What about psychosomaticism?
There was a recent Cell paper suggesting that ketamine directly binds to neurotrophin TrkB receptors to facilitate plasticity, but I don't believe any of that.
I believe that some psychedelics and dissociatives, mind the dose, have the ability to facilitate glutamate release and cortical excitability, which can lead to the facilitation of synaptic plasticity (e.g. see the disinhibition hypothesis video).
Words can’t describe how much microdosing helped my anxiety & MDD the benefit are endless. Thanks to @dodge_shroomtips on IG for guiding me
👆👆 he's got shrooms, LSD, bars, Dmt he's got a lot of good trippy stuffs, you can order from him 🍄 💊🍄🍫💯🔌
This would mean that psilocybin is a anti-dissociative being a NMDA agonist. Very interesting.
First time on your channel. Well done. Thank you.
Thanks, I hope you enjoy the content!
Fascinating and uplifting. Thanks.
I appreciate your presentation style & articulate content. Very 👍🏾. Immediate subscriber. I check your videos list I didn’t not see anything on MDMA/MDA & brain 🧠 from your neuro pharma perspective. Would very much like to see that.
Interesting video, kiitos! I wonder if there's any studies / data on possible treatment some ASD symptoms and eating disorders with psilocybins.
Thanks! Not any studies I can recall from the top of my head.
All i Wana do now on shrooms is lay comfy in bed put loud meditaing music and have fun moving matter, at the wall. I was playing with it while on shrooms and it began to vortex. Thats how powerful the human mind is when we use more of our awareness than the ordinary one. Funny how they think the ordinary one is all there is to life or reality. Theres more to us human beings and this not so material world. But yah choose to sleep instead. I manipulated matter and thats what we as luminouse beings in this luminouse world came to do. The most human thing ever. Sad we have forgoten.
Im not surprised. Psilocybin is here to help
Good to see clean science about this
I have no idea what a " dendritic spine " is , but I have eaten so much psilocybin in the last 35 years that I should have them growing out of my head !
@thehairywoodsman5 I wonder if you'll find out what a dendritic spine is next time you go foraging now that you've heard those words.
What a class, good quality content, explain very well the points, news dendrites can increase the neurotransmitters connections.
Explains very slowly, because brain damaged.
You are so right Dr Sage. Thank you for being open and caring. Very spportive in getting people to realise that they are entitled to have there real thoughts and feelings.
👍👍👍🤞🤞
I healed my spine by microdosing a strain of cubensa with lionsmane. I had a compressed disc due to dehydration and moved incorrectly so I torn my spinal column. Worst pain ever in my life.
It took months to heal my spinal chord injury with microdosing, What I learned during the process is to eat alot of clarified oils with the microdosing: Ghee, omega 3&6 oils. This speeds up the process.
Here I was, hoping magic mushrooms would make me taller.
I took it a few times last year and I had 4 months of intense visual snow and tinnitus. The effect is almost gone, but I can still feel it sometimes. I hope the someone tries to study the side effects as well. Remodelling is not always good.
Yup glad you spoke on this I experienced this exact affect with acid which I get is different but still people just recklessly try to make everyone take shrooms and not everyone is built the same
@@couchmayne4351 Exactly. Everyone around me recommended it. It cured my depression and I had spiritual experiences, but the side effects, especially the annoying tinnitus, were not worth it. I don’t know what it has done to my brain. Even after almost a year sometimes I experience tinnitus and visual snow at night.
Did you guys have tinnitus after taking it the first time already? Or did it appear only after taking it a couple times?
@@TranscendentII I experienced some tinnitus the first time but it became noticeable in my daily life after 4 or 5 experiences.
Tripping and micro dosing are different things
Fascinating mushroom health benefits information. Sending love and warm greetings from Missouri.
Thanks for the info!
Erittäin mielenkiintoinen ja valaiseva video.
Kiitos!
Mora
Try the fadiman protocol around 100 mg and you'll see positive changes. Increased empathy, more clarity in your thinking, calmer thinking, sudden light bulb moments and insights you weren't aware of before (on all kinds of things), and stronger memories of your childhood as if it was yesterday and all positive that give you happiness and joy being thankful for all the wonderful things that made you into who you are today.
Lions mane mushroom has similar effects too.
Not much evidence for that.
In the mid 70s when I was 15 years old, I picked a bread bag full of psilocybin shrooms and ate most of them and survived. Since then, in '74 and '77, I had powerful and very real telepathic encounters and countless metaphysical "miracles" happen but not sure if there's a correlation, as I'm hyper-spiritual anyway and live an amazing flowing life.
Took a dose of shrooms soon after a near death experience. Said fuck it. After the psychedelic experience I felt a lot better about it. It helped me process how I feel about myself and my life in that time. I still feel awful about nearly dying but the improvement was noticeable.
I confirm that mushrooms are affecting spine cord condition from my own experience,, but would like to mention that it's not only related to psylocibin mushrooms, Medicinal strains like Lion's Maine, Reishi, Chaga etc. will make your cord dance like that cobra )))
@@Boyhowdy875 You know, those steroids you're on there weaken your heart and make you far more prone to heart failure... along w causing B tits, shrunken peepee, and so on.
But, you're on here whining about naturally derived mushrooms that are less toxic to the body per use than a cup of coffee?
Funny stuff.
😉
Utterly fascinating.
That's awesome because I've had to do it the old fashioned way.
The Psilocybin mushroom might taste awful, but it actually made my depression better.
👆You want some?
For the best psilocybin 💊🍄 products and use guide.
Look up to the handle 🔌
I like to see real data like this.
Yep. Made it much easier bro. Thanks!
👆You want some?
For the best psilocybin 💊🍄 products and use guide.
Look up to the handle 🔌
So this with Lion's Mane Mushroom combined could reduce and or reverse dementia???
Every time I’ve taken psilocybin I’ve felt that I have much better posture and I feel taller. I wonder if this has anything to do with that
:D
I feel like I’m floating 😊
SAME
Ate so much psilocybin and mushrooms when I was younger maybe that's why I'm awesome
Great video, great channel! Subbed!
Thank you!
Does it grow presynaptic nmj
I am not being hyperbolic when I say it saved my life when nothing else worked
I definitely believe it. I've eaten this stuff now and then since I was like 15 years old. I can definitely say without sounding super egoic that my brain developed beautifully. Doing shrooms now and then and smoking weed definitely helped me evolve mentally. Its abusing the hard stuff that becomes an issue ( Mostly because hard drugs compromise the immune system, making You susceptible to chronic disease infection ) . I believe the body is fully capable of repairing damage done by drugs and replacing dead cells with healthy ones, but when the body becomes infected with chronic disease, it's no longer able to do so efficiently, so its very important to be careful when doing drugs. For instance, say You are doing cocaine or sniffing some sort of chemical, You dont want to put a finger in Your nose and touch any potential scar tissue, because it could get infected with whatever bacteria You might have on Your finger. Then of course theres the more obvious ways to contract infection like STD's. Dont believe people who say smoking weed makes You dumb. I knew a guy who smoked all day everyday, but he also studied all day and He was beating out all the other kids in his college with a grade of like 99.8% and I think second to Him was like 99.3% . I believe diet plays a huge factor as well as overall mood and of course, habitual daily lifestyle choices.
iboga is one i suggest researching thoroughly in regards to this sort of benefit and more
My mother has nerve damage along her neck legs and hips and doctors cannot figure out what is wrong. She had what seemed to be “mini strokes” last year and has foggy memory along with the body nerve symptoms. They’ve told her they just want to put her on “pain management”. Do you think that microdosing could help with her body nerves as well? She has numbness and sharp pain occasionally.
No. There is no evidence of microdosing having any medical benefits.
There is nothing wrong in trying..psilocybin heal nerves
@@GodisGreat...89 For all I know, there could be risks involved in giving psilocybin to someone suffering from stroke and cognitive decline.
Furthermore, there is no evidence of psilocybin healing nerves in any meaningful capacity.
Please do not promote reckless drug use.
@@Neuropharmacist she doesn’t have cognitive decline. It’s all physical. I’ve researched it, and it says that the chemical works atleast for depression. Which she has because of the hopelessness since Mississippi doctors are useless. Idk. She’s desperate at this point for any kind of relief.
Try Lions Mane. It helps restore Myelin in the nerves. Its none-psychoactive. It can be supplemented into your meals. It won't fix all your problems but combined with micro dosing it might help your mother manage her mental health, along with the lion's mane potentially giving some relief for mental fog. Obviously look it all up for yourself, just an idea, but one you should thoroughly look through yourself. Good luck mate.
Het i started smoking weed, wax, and tobacco products at age 13, and only quit about 7 months ago, (18 now) ive been reading studies on how much cannabis use in adolescence fucks with your brain, learning, memory, and development, and behavior overall. It's made me super scared and neurotic over my memory, I'm working on my emotions and psychology interally, but is there any way I can treat my brain? Supplements that would reverse the detrimental effects of my stunted development? Restore memories? Gain a better learning capability?
Don't worry about it too much, stress is no good for the brain. The best treatment is to have a long abstinence, eat healthy, do regular exercise and try to get better at learning and studying. You're still young and will likely recover very well.
👆👆👆 he's got mushrooms, LSD, bars, psilocybin, Dmt, Ayahuasca, nbomes, he's got all psychedelic products, you can order from him💊🍄🍫💯🔌
@@Neuropharmacist thanks
take lion's mane mushroom extract from NootropicsDepot to repair your brain. Don't take magic mushrooms for your case.
Saturated animal fats. They're what made the human brain so big
I love how he sats dendritic spines!
Wow, thank you.
It works.
Can anyone recommend a safe source for psylosybin capsules in the UK?
Thank you, are they on Instagram?
Never used telegram
Thank you!
Thanks for posting, any bit of accurate, breakthrough scientific data helps me understand my anecdotal knowledge better.
Thanks!
4:29 It can last 34 days... Could this explain why some people experience a month-long lasting psychosis if we interpret psychosis as a long lasting increase in Glutamate activity? What about people who "trigger their schyzophrenia" with drugs by (maybe) permanently unbalancing their GABA/Glutamate balance? And now, maybe a stupid and uninformed question but could the lasting anti-anxiety/depression effect from psilocybin be the result of the brain "remapping itself" during a glutamate storm, thus learning to manage such an overload of stress?
I have so many questions and I have no idea on how to do my own research.
Hypothetically, there could be a connection. At this time, I think we just don't know enough to draw any conclusions based on spine data. It could also be that the spine changes are mediated by something other than we think - e.g. a novel experience. I'd love to see a psychoactive control group in studies like this.
The remapping idea is a complex topic but I've discussed something like that in a recent hypothesis paper pharmrev.aspetjournals.org/content/72/2/439
@@Neuropharmacist I will check it, thanks.
My cousin is in psychiatric hospital cus of these shrooms.
I first used psychedelics when I was 15 years old. I did them a lot. And I think it actually damaged my brain. Initially it enhanced my brain. The first two or 3 times, I gained the ability to draw spontaneously and became extremely organized and my grades in school increased. I don't know if it was the shrooms, alcohol, or marijuana, but eventually I lost all of these gains and have been confused ever since with memory and recollection issues. I would say kids should not do drugs or alcohol. Perhaps once your brain is developed try it a few times.
The human brain is still in development and slows down around the age of 25. there are study's from a doctor online from Standford university who talks about the effects of Mushrooms at a young age and when it actually benefits to those who are older adding more seritonin to the brain! among other key factors of benefits. so.. in your early comment.. i'd say.. "I did them a lot". that's on you!. nothing wrong with experimenting at a young age, I did. but never in crazy amounts. ...
My opinion is that alcohol does a whole lot more damage than the other two substances mentioned. I'd blame it on the alcohol first.
As a teen, I took LSD a few times, but the last time it affected my brain negatively. Possibly a stroke. But my thinking was never as sharp. I eventually grew out of it, but it handicapped me for a time.
Great explanation, tank you.
👆You want some?
For the best psilocybin 💊🍄 products and use guide.
Look up to the handle 🔌
I'm growing my dendritic spines all day today!
I doubt it
Do you know if someone who has been on ssri's for years can get off of them? I believe my brain became addicted to this anti-depressant and now my brain doesn't want to work properly making dopamine and other natural chemicals without this unnatural drug.
Sure it is possible, but tapering the dose needs to be done slowly and will take time.
I came off Lexapro and subutex. Trying to quit cigs but I microdosed.
I've been on Paxil since 2000. I used psilocybin to quit. No brain zaps, no migraines, no dizziness but I did it slowly. I mean one month from a 60 mg daily dose (which is high) to about 20 mg per day. I wean down in the summer (more sunlight) to a 40 mg in winter. I would like to quit entirely and take psilocybin say once on the weekend and once mid week to stay off of the Paxil and maybe help my brain build its own positive networks so I never have to take pharma again. I will be growing mushrooms this summer and hopefully have enough to last me for a while.
I have been for about 15-16 months.
Took 2 months lower dose until i reached 0.
Long term use changes brain but you can get back to normal. I think there is a youtube channel called life after SSRIs or antidepressants.
@@NordeggSonya how much of psilocybin per day or per week do you use to get off ssri?
I had a gram of mushrooms two days in a row… I didn’t take any for the next 5. I noticed that my brain seemed to be permanently different. The baseline of my mood has shifted.
Cured my PTSD
A large number of people I talk to about this believe microdosing with LSD will have the same time effects despite it being derived from ergot . Are there any study's to support this or is it just a public misconception that's becoming widely believed?
Given the results of this study and the existing body of work done on Psilocybin, would you personally ingest it if you were suffering from depression? Just curious 🙂
The best is to go through the actual therapy, not just to automedicate by ingesting a psychedelic since there is little to no research paper speaking about depression healing by taking magic mushrooms alone and in an uncontrolled setting. Psilocybin therapy offers great results, but keep in mind the substance is not fully responsible of the final result. There are protocols, therapists, sets and settings which are both playing a role.
Now if anyone had treatment-resistant depression and can participate to a psychedelic/dissociative therapy, it's one of their best one-way ticket to healing.
www.nature.com/articles/s41598-017-13282-7
As my professional opinion: if it was available in a therapeutic setting, and I would fulfill the criteria, I'd be open to it.
Nearly all psilocybin research has been done with psychedelic dose levels. My personal experience has been that microdosing can be effective, though this is obviously anecdotal. Results may vary. I was diagnosed with major depression and generalized anxiety disorder a few years ago. I was taking Effexor (venlafaxine) at 300mg a day, which is nearly 30% higher than the FDA max dose. I had also tried 4 other antidepressants without relief. I began microdosing (0.4 to 0.7g) every 3 days using the Stammets protocol. I started drawing down my Effexor 3 days after my first microdose and was completely off Effexor 6 weeks later.
@@Neuropharmacist as a novice who sufferers from depression would you use
@@garysimone4977 It cured a friend's wife's drug-resistant depression. You can either have a full dose or just microdose but with microdosing the effect will happen after a few weeks. Full dose will have instant result. The follow up to a full dose can be another full dose after 2 months or just microdosing.
Psychedelics have so much potential.
Golden teacher 🍄 👍
Would psilocybin be a good or bad idea to take for someone who has autism and/or ADHD ? What do we know about that?
Not much at this time, unfortunately.
Noticed the Finnishness immediately
The Finnishness is strong in this one.
Counteracts:
* PTSD ("shell shock" - constant nerve firing caught in an endless feedback loop)
* Nerve Entrapment (again, constant firing)
It does this by:
*Increasing connections of nerves.
*Increased connections to allow communication bypassing compromised neurons
And / Or
*Allows compromised neurons to brake the feedback loop.
- Both causes over a prolonged period will rewire the brain
- A rewired brain will produce body chemistry chemicals (estrogen, testosterone, seretonin, etc.)
- If you treat chemical shortages without fixing the "overloaded feedback loop", its not a fix, just a "band aid"
- When fixed, the chemical balance will be off again and need revaluate to rebalance with correct medication.
(1) This will not resolve PTSD - Survivors Guilt
(2) Selling you a band aid is more profitable for pharmaceutical companies than the fix
(3) Finding a good doctor that is more concerned with your total health and not just a quick $$$ will be the hardest part in today's age
I had the same effects doing the Gateway Tapes.
Hope it helps you all
Here we go again, the materialists will not talk about psilocybin's benefit to spiritual growth, if you took psilocybin you would realize that indeed there is a spiritual component to the human and to the world .
Do you have personal experience with this? I'm looking to find some sort of spirituality again
I’ve been battling with alcoholism for over 15 years.
I grew my own mushrooms and with microdosing and 2 medium trips I got 75 days.
During that time I got into hiking. One of my hikes was the best day of my life, absolutely amazing.
I stopped taking mushrooms because of the stigma from others and started drinking again.
Later I was diagnosed with ADHD and prescribed Ritalin.
I was honest with my psychologist about my history of drug abuse and alcoholism and he still gave it to me, and now I am totally f’d. Like everything it started of Ok, but enough is never enough for me.
I’m trying my best to get the strength to grow them again.
I can say first hand that mushrooms worked for me. But do your own research and make sure it is right for you and know what you’re getting into.
I think mushrooms could be beneficial for most but it’s not for everyone, if you have a slippery grasp on everyday reality just do your homework first.
I wish us all the best 🙏🍄🌅
I think you should try out Microdosing capsules, it really helped with my anxiety, Fibromyalgia,depression, chronic pains,OCD,PTSD and ADHD, autism, insomnia, arthritis and FND alot. I have been coping well since I started micro-dosing psychedelics I usually get the capsules from nelly_psychie❤.....He's a mycologist he guided me through the journey of getting better I think you should try it would be worth your time.
He's on instag
Would it help with stroke recovery?
greatest video ever LMAO gonna get some shrooms right away
Check out ⬆️⬆️🔌👆 the above handle, he's got nice mushrooms and other trippy products like LST, DMT, chocolate bars, MDMA, ketamine, gummies and more, he ships, gives free guide on me dedications, growing and tripping