Blood, Part 2 - There Will Be Blood: Crash Course Anatomy & Physiology #30

Sdílet
Vložit
  • čas přidán 30. 06. 2024
  • It's time to start talking about some of the terrible things you can do to your own body, like blood doping. We'll start by explaining the structure and function of your erythrocytes, and of hemoglobin, which they use to carry oxygen. We'll follow the formation and life cycle of a red blood cell, including how its levels are regulated by EPO and its signaling molecules. We'll wrap up by looking at how blood doping works and how it is truly a recipe for disaster.
    Pssst... we made flashcards to help you review the content in this episode! Find them on the free Crash Course App!
    Download it here for Apple Devices: apple.co/3d4eyZo
    Download it here for Android Devices: bit.ly/2SrDulJ
    Chapters:
    Introduction: Blood is Powerful Stuff 00:00
    Form and Function of Erythrocytes (Red Blood Cells) 1:34
    Hemoglobin 2:30
    Formation of a Red Blood Cell: Hematopoiesis 4:11
    How Erythropoietin (EPO) Regulates Blood Oxygen Levels 5:43
    How Red Blood Cells Die 6:54
    Don't Dope Your Blood! 7:53
    Review 9:00
    Credits 9:35
    ***
    Crash Course is on Patreon! You can support us directly by signing up at / crashcourse
    Thanks to the following Patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
    Mark, Jan Schmid, Simun Niclasen, Robert Kunz, Daniel Baulig, Jason A Saslow, Eric Kitchen, Christian, Beatrice Jin, Anna-Ester Volozh, Eric Knight, Elliot Beter, Jeffrey Thompson, Ian Dundore, Stephen Lawless, Today I Found Out, James Craver, Jessica Wode, Sandra Aft, Jacob Ash, SR Foxley, Christy Huddleston, Steve Marshall, Chris Peters
    --
    Want to find Crash Course elsewhere on the internet?
    Facebook - / youtubecrashcourse
    Twitter - / thecrashcourse
    Tumblr - / thecrashcourse
    Support Crash Course on Patreon: / crashcourse
    CC Kids: / crashcoursekids

Komentáře • 516

  • @crashcourse
    @crashcourse  Před 4 lety +88

    Pssst... we made flashcards to help you review the content in this episode! Find them on the free Crash Course App!
    Download it here for Apple Devices: apple.co/3d4eyZo
    Download it here for Android Devices: bit.ly/2SrDulJ

  • @Chiller-pc1dv
    @Chiller-pc1dv Před 7 lety +1818

    The art in Crash Course is so cute. I mean, never before have I ever wanted to hug a cell.

  • @speedstacker51
    @speedstacker51 Před 8 lety +449

    Although I was watching this in preparation for a test.... it just blew my mind how complex the life of a single component of your body is. Crazy.

  • @TheFireflyGrave
    @TheFireflyGrave Před 8 lety +282

    All these videos are great, but this one was dope.

  • @therambler3713
    @therambler3713 Před 7 lety +146

    I love the way he just chucks in a funny quip or metaphor every here and there, hilarious, makes the lesson all the more interesting and fun to learn

  • @DanThePropMan
    @DanThePropMan Před 9 lety +444

    1:54 Sounds like a Shakespearean insult, but with biology.
    "You glorified, protein-filled, phospholipid bilayer sac!"

  • @DuckyoftheNorth
    @DuckyoftheNorth Před 9 lety +367

    Poor Squidward at 3:20 was good. +1 for your graphics team for keeping it fun by being graphic.

    • @jiayilim1986
      @jiayilim1986 Před 9 lety +2

      yasss!

    • @dvddvd8719
      @dvddvd8719 Před 8 lety +1

      +Douglas Gerlach no no no, we have gay people needing therapy because of that little soundless animation.....

    • @briannacasillas2052
      @briannacasillas2052 Před 6 lety

      Douglas Gerlach ddddddfecce

    • @khardstaff
      @khardstaff Před 6 lety +4

      You're a real musculus sphincter ani externus, eh Dvd Dvd?

    • @khardstaff
      @khardstaff Před 6 lety +3

      A glorified, protein-filled, phosopholipid bilayer sac, y'know?

  • @MstMannerz
    @MstMannerz Před 8 lety +411

    Watching this makes me want a blood cell plushie...

    • @eggrollsoup
      @eggrollsoup Před 6 lety +3

      Dulliest get someone to have their period on a plushie, there ya go..

    • @besyt.9676
      @besyt.9676 Před 5 lety +1

      THIS! @Andrianna Lu

  • @Etienne.D.
    @Etienne.D. Před 7 lety +172

    Sometimes when I feel down, I come back to this video and watch Hank say
    "THE RED BLOOD CELL GRAVEYARD"
    about ten times, then I remember that life is good

  • @moonfaire460
    @moonfaire460 Před 7 lety +54

    I got so emotionally invested in the red blood cell's life and now I'm crying :(

  • @suheimahmateus8220
    @suheimahmateus8220 Před 7 lety +144

    These videos are the only reason I pass any of my Bio Tests.

  • @raashidabdullah8941
    @raashidabdullah8941 Před rokem +11

    WHY IS THIS SO FREAKIN HELPFUL
    Like I’m learning more in 10 minutes than I could learn in a week

  • @damiansilva2491
    @damiansilva2491 Před 8 lety +235

    "Tiny, bloody breath mint"

    • @TheRealVivia
      @TheRealVivia Před 8 lety +3

      That made me actually laugh out loud :)

    • @sonja4164
      @sonja4164 Před 5 lety +2

      😂😂😂😂😂

  • @SSmith-di8xi
    @SSmith-di8xi Před 8 lety +116

    *Swishes about a glass of water* "This is your blood."
    "And this is your blood..." *dumps in a bunch of cornstarch* "ON DRUGS."

  • @isectoid9454
    @isectoid9454 Před 8 lety +507

    I'm flagging this video for violence... too much blood.

    • @benscholer4022
      @benscholer4022 Před 8 lety +4

      +isectoid youre joking right the video is about blood what the heck did you expect. And a child wont watch this because it is much to complex. you need to be at least 13+ to understand this.

    • @isectoid9454
      @isectoid9454 Před 8 lety +54

      Ben Scholer Yes, I'm joking. I'm not stupid.

    • @WeridGirlJP
      @WeridGirlJP Před 8 lety +18

      +Ben Scholer I think isectoid is joking

    • @benscholer4022
      @benscholer4022 Před 8 lety +2

      in that case its all fine
      LOL

    • @rupalishankerarthub
      @rupalishankerarthub Před 6 lety +7

      i am a child watching this (using my mother's account)

  • @many3440
    @many3440 Před 7 lety +53

    this erytrocytes are incredibly cute!!!!

  • @rawanmohammad3356
    @rawanmohammad3356 Před 4 lety +11

    BLESS YOU!! I can’t imagine my life without crashcourse. Don’t ever stop please

  • @cheeseenthusiast6549
    @cheeseenthusiast6549 Před 4 lety +14

    3:19 that animated Squidward looks super cool, and you might wanna take him to the hospital.

  • @totaleNonale
    @totaleNonale Před 9 lety +7

    wow this is great! now that I actually follow and always watch the newest episodes I was wondering about some stuff with red blood cells and before I even get to look it up it gets explained in the next video! If only schools were that effective and entertaining...
    Great job everybody!

  • @isaacrigel9231
    @isaacrigel9231 Před 6 lety +11

    I loled at the *Red Blood Cell Graveyard* scene, poor old cell ...lol

  • @Ana-fq9to
    @Ana-fq9to Před 7 lety +33

    I love the crash course episodes. It helps me learn. If it is possible, please make more

    • @nikki4592
      @nikki4592 Před 7 lety +1

      I'm amazed too, especially with his speech rate!

  • @alangebhardt8286
    @alangebhardt8286 Před 9 lety +57

    Ok, had to pause to type this. That image of Squidward at 3:20? WOW. That's pretty graphic. Wasn't expecting that.

    • @GentrifiedPotato
      @GentrifiedPotato Před 9 lety +7

      chazz30000 You are mad. Is not big surprise.

    • @Koltronn
      @Koltronn Před 9 lety

      Alan Gebhardt I paused there too, they could have had him donating blood or something

    • @alangebhardt8286
      @alangebhardt8286 Před 9 lety +8

      chazz30000
      Yeah, nice try. I'm not ashamed that I find a character with their hand cut off and spurting blood a little disturbing. Especially for a family friendly educational series.
      You did get the tumblr part right, though. I love that website.

    • @goprolikeapro
      @goprolikeapro Před 9 lety +17

      Alan Gebhardt I'm offended that you found this graphic.

    • @blacktommer3543
      @blacktommer3543 Před 9 lety +7

      liampgc
      Let's be honest, for this show it's pretty graphic, you know, with Squidward screaming and all.
      For rest of the internet it's nothing but I agree it felt a little out of place here.
      Inbefore you're offended. I'm not offended cause you know, the internet and stuff.

  • @parynejatbakhsh7242
    @parynejatbakhsh7242 Před 7 lety +12

    I probably would've failed my assignment without you guys... keep up the good work❤️

  • @YJ4
    @YJ4 Před 8 lety +2

    THanks for being my favorite thing on youtube. I recommend you every chance I get. Chemistry, Biology, World History, Economics, American History, Astronomy, my personal favorite Big History, and the rest... I love them all. THanks for them all :)

  • @jillstgeorge7254
    @jillstgeorge7254 Před 5 lety +8

    I have been *trying* to work on a research paper in regard to blood during decomposition stages. I suggest a CrashCourse discussing how blood 'dies' when a person dies. There is very little information on this subject

  • @daryakabushka
    @daryakabushka Před 7 lety +8

    I love these crash courses! Thanks for making them!

  • @madelinedasilva6784
    @madelinedasilva6784 Před 5 lety +4

    your videos always help me out in college in nursing thanks so much and keep going!

  • @vanshitagoyal8149
    @vanshitagoyal8149 Před 5 lety +5

    Hey there! Your videos are truly amazing, helping and are really comprehensive...Please make a video on BLOOD TYPES AND RH GROUPING..that would be a great help!!

  • @nicoarias5863
    @nicoarias5863 Před 8 lety +85

    with out this channel i would have probably failed my finals for collage

  • @digiexploration530
    @digiexploration530 Před 4 lety +3

    that was a good journey for me to understand how the cardiovasc works. I am currently prepping to write about Viagra, so now I understand the big picture behind the science working in this specific medicine. Thanks, CC.

  • @mstluv1101
    @mstluv1101 Před 4 lety +3

    Thank you for having this channel. Needed this to go over some things before Quiz. 👍🏽👍🏽

  • @jackheltect359
    @jackheltect359 Před 7 lety +2

    thank you all those on patreon i really appreciate you guys. These videos are awesome

  • @meryemlahbara9669
    @meryemlahbara9669 Před 7 lety +11

    You made me laugh when said, "The hemoglobine run away naked in your blood" I watched like 4 times for this sentence ... So funny ...

  • @burnettfitness1468
    @burnettfitness1468 Před 7 lety +3

    This is one of your funniest videos so far! Very enjoyable and educational. Thanks!

  • @MrNotThatFamous
    @MrNotThatFamous Před 9 lety +15

    thanks for teaching me random stuff bro! was bored and came here just in time.

  • @csharon82
    @csharon82 Před 5 lety +3

    love this videos! Quality, content and humour are amazing!

  • @wbedard
    @wbedard Před 9 lety +26

    Wow, I thought that this was a really "standout" video in this series. Maybe it was just my personal interest in the content or some extra work on the part of your team. Whatever it was, thank you so much for a thoroughly enjoyable video!

  • @potzysk2
    @potzysk2 Před 5 lety +3

    Wow, awesome video. So many terms, can't remember them all, but we get the general picture very well.

  • @kinkychickenugget9849
    @kinkychickenugget9849 Před 9 lety +4

    I love these videos! Especially since history and science are my favourite subjects xD

  • @rebeccalane7883
    @rebeccalane7883 Před 4 lety +1

    the early erythroblast is so cute that it made me giggle and rewatch the development of an erythrocyte just to see all the cuteness. props to the animation team :) 5:00

  • @paulgarza2921
    @paulgarza2921 Před 9 lety +7

    I love how no matter or energy is wasted in most things in nature :).

  • @miaroberta18
    @miaroberta18 Před 8 lety +3

    I love learning how our body functions!! I felt sorry for the red blood cell that got eaten.

  • @benscholer4022
    @benscholer4022 Před 8 lety +1

    great video you make learning fun and nourishing at the same time which is very special . keep on doing that.

  • @denizsinaci6137
    @denizsinaci6137 Před 8 lety +1

    i love your videos! thanks they help me understand concepts much better! cheers

  • @jeneecole1486
    @jeneecole1486 Před 5 lety +4

    I love this !! I passed A&P1 with a B ! Thank you ❤️

  • @dewshifernando6969
    @dewshifernando6969 Před 6 lety +1

    Every video in crash course is so informative and helpful

  • @SkyfutureRN123
    @SkyfutureRN123 Před rokem

    Thanks you! This helps me when I am in class and It makes learning so much fun.

  • @shallbetterdj
    @shallbetterdj Před 9 lety

    Good job on hematopoesis. That was much better than than the errors I found in last weeks episode. Congrats on a successful well written episode.

  • @publiusdg
    @publiusdg Před 7 lety +1

    OMG this video is so informative and helpful!!!

  • @bmanfox
    @bmanfox Před 6 lety

    I love the little Strong Mad figurine on Hank's desk, quite appropriate ;-)

  • @junemalcolm-evans7409
    @junemalcolm-evans7409 Před 5 lety +1

    GREAT. I CAN ACTUALLY LEARN HERE. Why did they not teach science and biology so effectively, back in the day?

  • @markvale8168
    @markvale8168 Před 5 lety +1

    I have binge watched so many crash course videos and I feel quite confident when I say; your hair is different in this one

  • @marnierogers3931
    @marnierogers3931 Před 6 lety +1

    I love these videos. Thank you!

  • @heatherburdette-roberts8113

    loved Rasputin on the shoulder when speaking of hemophilia 😆

  • @maryannwhatuira5582
    @maryannwhatuira5582 Před 7 lety

    I love watching your presentations!!!😍

  • @Jess-pe6vh
    @Jess-pe6vh Před 4 lety

    I owe so much to this series it's insane

  • @jiinjung1445
    @jiinjung1445 Před 6 lety +1

    wow this lectures are fantastic. It's the first time I have ever left a comment on You tube.

  • @ichangednametoamorecringyo1489

    you know I always knew I needed Red Blood Cell in my life ^_^
    she's best waifu!
    *reference to the anime Cells at Work*

  • @LetsTakeWalk
    @LetsTakeWalk Před 9 lety +4

    7:17
    That just cracked me up.

  • @tiffanystone5514
    @tiffanystone5514 Před 8 lety +1

    This is helping pass anatomy ! 😁 thanks

  • @kimvaso6557
    @kimvaso6557 Před 7 lety +1

    thanks that was helpful
    and i want an ep about platelets

  • @lawrencecalablaster568
    @lawrencecalablaster568 Před 5 lety +4

    This reminds me of when Hank explained erythropoiesis while giving blood during an old Vlogbrothers video :)

  • @alejandrobugarin9146
    @alejandrobugarin9146 Před 5 měsíci

    Thank you, for this video.

  • @chrisbcreem
    @chrisbcreem Před 8 lety

    Hey Crash Course,
    I research hemoglobin based oxygen carriers. I enjoyed the show, however modern research on the subject suggests that hemoglobin cannot be put directly in the blood because it would extravasate through the capillary wall and 1)scavenge NO and 2) cause oxidative stress. loved the show!

  • @hannahzang2369
    @hannahzang2369 Před 4 lety

    okay with the erythroblast chucks out the nucleus that is just the cutest little sound ever

  • @ndroo1014
    @ndroo1014 Před 9 lety

    These videos are AWESOME !!!

  • @alyyyxxxx
    @alyyyxxxx Před 9 lety +22

    So, blood dopers poop more?
    Thanks, CrashCourse.

  • @MissLilThanggg
    @MissLilThanggg Před 8 lety +1

    perfectly explained jst awsm..... thnx a lot sir...

  • @ursulapebble7063
    @ursulapebble7063 Před 8 lety +2

    Hank is so saltyyy in this. Love it.

  • @PuffyWuzHere
    @PuffyWuzHere Před 8 lety

    YAY!!!! I FINALLY underdtand the notes my prof gave me!! Thank you so much~♥ I want to hug you guys * squeeze~*

  • @r302112
    @r302112 Před 8 lety

    Brilliant as always crash course

  • @cambaopa
    @cambaopa Před 9 lety

    Excellent episode!

  • @dehfuzz33
    @dehfuzz33 Před 8 lety

    7:06 AAAHHH WHY ITS SO CUTE Q-Q I DON'T WANT TO BELIEVE 2 MILLION OF THOSE ADORABLE THINGS DIE EVERY SECOND

  • @nathanhanson5324
    @nathanhanson5324 Před 5 lety +1

    Hematopoiesis is not the process of forming RBCs, it's the process of blood formation in general. Erythropoiesis is the process on RBC formation specifically.

  • @mickeysuri
    @mickeysuri Před 6 lety

    Another awesome video!!!

  • @jeremyspensieve
    @jeremyspensieve Před 9 lety +1

    could you please make some videos explaining the wide world of autoimmune diseases (rheumatoid arthritis, MS, crohns, neuromyelitis optica, etc..) there is a whole world of people experiencing these things that would like to have some it illuminated in the way you do.

  • @PsychoDiesel48
    @PsychoDiesel48 Před 8 lety +4

    1:03 I like the fact that we have a little bit of Weird Al in all of us . . . XD

  • @1DogoArgCali
    @1DogoArgCali Před 8 lety

    Love it!! thank you!!!

  • @ursuladuffin6692
    @ursuladuffin6692 Před 4 lety +1

    fun fact, "The intense color of the protein stems from the extended conjugation of the protoporphyrin ring, not the iron, as is commonly misconceived." - B.Reeder 2010, The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms

  • @muqi_hameed
    @muqi_hameed Před 4 lety

    Im doing GSCEs but thanks for the extra info

  • @samanthagreen1428
    @samanthagreen1428 Před rokem

    Can you do a video about how hyperbaric oxygen therapy with the pressure and oxygen helps heal your tissues etc

  • @titania642
    @titania642 Před 9 lety

    SO interesting! Yay!

  • @meh4177
    @meh4177 Před 9 lety +1

    Could you please do a series on crash course physics?

  • @tropicaltundra6409
    @tropicaltundra6409 Před 8 lety

    you should make merch for that plush fish. if you agree plz spread it around it around to other parts of the channel

  • @caseylee9146
    @caseylee9146 Před 8 lety

    Tiny, bloody breath mint -- Oh Hank, you are too funny!

  • @Nate303
    @Nate303 Před 9 lety

    this episode is dope

  • @ghaythabd4869
    @ghaythabd4869 Před 4 lety +1

    Thanks ❤️

  • @waelwm4331
    @waelwm4331 Před 9 lety

    thank you for reminding me why you're awesome

  • @ChiquittasBasketsBowsandThings

    Thanks Hank

  • @deysisanchez361
    @deysisanchez361 Před rokem

    Thank you

  • @DocFlareon
    @DocFlareon Před 9 lety

    There is something else about blood that's really cool and was not mentioned for some strange reason. Mature avian RBCs still have nuclei.

  • @oluwatoyinogunkanmi2989

    Thank you very informative

  • @deborahmeredith6411
    @deborahmeredith6411 Před 7 lety

    Good job!

  • @Thirst-4knowledge
    @Thirst-4knowledge Před 7 lety

    You are the BEST!

  • @DemiRonin
    @DemiRonin Před 9 lety

    I Love your videos!!

  • @kassadymcbride5419
    @kassadymcbride5419 Před 9 lety

    awesome video!

  • @DadandBubs
    @DadandBubs Před 6 lety

    Thank you!

  • @jailene8086
    @jailene8086 Před 9 lety +1

    Please make a respiratory video !

  • @hikaru8050
    @hikaru8050 Před 7 lety

    i like this!! at least I've learned sumthin!

  • @davidwallace4537
    @davidwallace4537 Před 7 lety

    You are amazing!