Ketosis & Parkinson's Disease: Improving Symptoms with a Ketogenic Diet
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- čas přidán 24. 07. 2024
- If you feel like you are hearing about more and more about Parkinson's Disease in the media lately, you shouldn't be surprised. Cases are being presented with more and more frequency, such that Parkinson's rate of incidence is now somewhere between 2% and 4% of the population over 60 in the US.
Of course, Parkinson's is impacted by man factors, such as genetics and environment, but at its core Parkinson's is an energy issue, characterized by the failure of mitochondrial activity in cells, the location where cellular energy is produced. This paves the way for the subject of today's discussion, and how a ketogenic diet may lead to symptomatic improvement in Parkinson's patients. Let's take a look at the latest science, presented in the journal Neurology. - Věda a technologie
I'm involved in answering regular questionaires from the Miachell J Fox foundation regarding Parkinson's. They regularly ask about mood, sleep, exercise, medical diagnoses, but not ONE question about nutrition.
No money to be made in diet and lifestyle changes. So sad.
Too much sugar is inflammatory, dangerously so. But doctors actively avoid talking about it Its too profitable treating the wide range of problems that too much sugar in all its forms(Carbs) for them to warn against it.
Thanks for making these videos, Dr. Perlmutter. I pass them on to friends, family, and patients.
Thank you Dr. Perlmutter, the results you showed are powerful. I really like this review format as well, hope to see more in the future! Thanks for all your work.
Thank you doctor for this amazing video.
Thanks Doc, God Bless You.
Well explained.Thanks. God bless U.
Thanks, David! This is just what I was looking for: some well-explained science to convince my family to stop feeding Dad carbs. Keep up the great work.
Did you convince them?
@@66gtb No, Dad and Mom have both passed away, without ever changing their diets. My sisters are next :(
Very nice presentation. Would like to see an update and more extensive supportive information. I believe the Keto diet offers benefits in protecting the brain. Much of this is also addressed in Dr. Perlmutter's various books, including the Brain Maker.
Please add subtitles. your information could also greatly impact those who are deaf with Parkinson's
You can turn on closed captioning. On the top right-hand press CC. Of course deaf sufferers of PD should have this info. 😊
Sir help me...
For my husband...hez 44 yrs and ve Tremors in right hand.
Want an appointment with Dr...if possible... PlZ HELP
seems like an amazing idea but why aren't there more robust and current studies on this topic?
My guess is that there is no money in it.
😄 Big Pharma, my friend.
@@mkshffr4936makes sense
2:29 nombre del studio
My mother was on ketogenic diet and instantly stopped it and turned to standard diet. Since then her Parkinson began. How can this correlate?
Did she reverse parkinsons?
It would be beneficial if you would give examples of what a ketogenic diet consists. How much wheat vegetables or meat should create the desired result.
Philip Stineburg Dr Berg ( here on CZcams ) is a very good source of info on the Ketogenic diet. He has several books on the Ketogenic diet as well.
Philip Stineburg Dr. Berry, Dr. Darren Schmidt, and Primal Edge Health are good resources.
Go and have a look at Dietdoctor.com
Agree with other recommendations. NO wheat or grains. Dr. Ken Berry has a Keto 101 playlist
@blobmonster9494- but he still has an entire CZcams playlist for keto, and advocates for what he calls the “proper human diet,” which is low carb/keto/ketovore/carnivore. The reason I like him is he doesn’t tell you which one is best for you; he helps you figure it out for yourself.
Is there a diet we can view that was used for this study. I’d like to follow for my husband
keto is keto so just get rid of carbs and eat proteins and fat
There is a researcher out of New Zealand that might provide more interest specifically in the field of Parkinson's. His name is Dr Matthew Phillips. There are others about as well but it isn't a topic I am looking into for someone's health so isn't as much on my radar currently.
What is is ketogenic diet. Pl let me know.
More here: www.drperlmutter.com/how-a-keto-program-helps-parkinsons-disease/
and here: www.drperlmutter.com/focus-area/ketogenic/
google it
Anyone trying coconut oil and mannitol? Coconut oil is a good way to get fat on board too.
I tried the generally recommended dose of mannitol for two months and experienced no noticeable benefits. The downside was that I did experience an unpleasant amount of abdominal gas.
..yes it does have that side effect. Shame. Others have noticed that it improves their sense of smell, which does suggest some brain improvement. It seems that there are different types of Parkinson's and most people react in different ways.
Parkinson's is a very individual disease and different people react better to different approaches, though as much exercise as possible is always beneficial. Hopefully you can find something else that works.
If you are using the mannitol as a sweetener, try Erythritol and Stevia instead. Although it is also a sugar alcohol, Erythritol very rarely produces gas in anyone. Almost never. Because it passes through the gut, undigested. Combining Erythritol with Stevia produces a synergistic effect: erythritol removes some stevia products' bitter aftertaste, while stevia removes the cold mouthfeel of erythritol. Having said that, I kind of enjoy the cold mouthfeel. Also, if you get NOW brand stevia, there is no aftertaste at all. Both the Erythritol and the NOW brand stevia can be found in certified organic (as such, non-GMO) versions.
MCT Oil is better because it contains more ketones.
I wonder if it was full blown carnivore if it would be even better.
There are videos addressing this here on CZcams and seem very positive. I like the video information, but I especially like the comments with those videos.
Well; let's be clear on what we are discussing: a higher level of Ketones in the blood: is that the same as having your metabolism shifted to burning only on ketones? I REALLY doubt that. With all due respect: Measuring your blood on the level of Ketones and being able to talk about hyperketonemia, doesnot ensure that cells of the patients are in ketone-burning state; NOT TO SAY ANYTHING ABOUT the level of insulin in the blood. What it comes down to is: does the system get the time for getting rid of the INFLAMMATION ( and mitochondrial damage that's been there for years and years ) in there???
+Noel van der Mullen, Sugar and insulin cause inflammation, but they are not sure if that's actually what's causing Parkinson's or not. In other words, you might be barking up the wrong tree. In any case, here are a few scientific articles that might interest you.
Neuroprotective and disease-modifying effects of the ketogenic diet
www.ncbi.nlm.nih.gov/pmc/articles/PMC2367001/
The Ketogenic Diet as a Treatment Paradigm for Diverse Neurological Disorders
www.ncbi.nlm.nih.gov/pmc/articles/PMC3321471/
Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases
www.ncbi.nlm.nih.gov/pmc/articles/PMC4101992/
The Nervous System and Metabolic Dysregulation: Emerging Evidence Converges on Ketogenic Diet Therapy
www.ncbi.nlm.nih.gov/pmc/articles/PMC3312079/
Hi Noel,
If by dietary intervention only, your ketone levels rise to a certain desired level and glucose is low enough (test and diet) not to stimulate insulin and you don't overeat protein (diet) to also keep insulin low, you usually don't have to test insulin levels (more expensive, less regular) unless you're not sure if your test subjects keep to their diet.
Your right about how long it can take before some effects like inflammation take to fully vanish. My blood-pressure normalized within a week but inflammation of my hip and knee joints took over 6 weeks to vanish while my shoulders (both hurting only during sleeping) took more than a year and I only noticed it by analyzing the benefits of Ketosis much later. Even after 2 1/2 years, I'm still losing weight although just a little.
The idea that insulin resistant cells can starve from lack of energy (glucose) and that it is possible to bypass that by supplying ketones while restricting glucose, so your ketones are not turned into fat on insulin signaling seems to be at par with our evolutionary past of eating mostly bone marrow (from femurs from African Buffalo) leftovers from fresh kills by other predators. That's why biologists misinterpret our lack of predator claws and teeth as proof for mostly vegetarian life. It took other predators to kill and these bones are untouched by even Hyena's as they are just too strong and heavy to handle. Only stone tools gave access to these precious resources (fat and protein). After the kill, they would only have had to keep sight of the vultures to see when they left and quickly remove these two leftover femurs that were of no interest to any other animal and take them to their safe sites where they had simple stone tools. Most primates also understand tool use but behind an office desk that is hard to wrap your head around. So only the lack of claws and canines was always interpreted as proof of not eating animal food. Only much later in human evolution did the hunting and fishing get effective and only for about 8000 years did some of us start eating grass-seeds for our staple foods all year round. Most plants protect their progeny from being eaten by thick husks and spines but also by poisons, so if we didn't evolve along with that it is wise to be cautious. Eat like an Inuit (or Eskimo) or like a Massai. Lots of saturated fat, enough protein and no carbs, especially when you turn ill from this modern lifestyle.
+Herman de Jong, When in ketosis, ketones are not the only fuel available to your cells. Most of the cells in your body can still metabolize fatty acids directly. Ketones are only necessary for those few cells that can not metabolize fatty acids.
I know fat cells can turn on heat production but when the liver makes ketones from fat in a very efficient way that is preferred for most cells, especially nerve cells and ganglion cells. All cells utilize fatty acids for membranes. In case of hunger cells will cannibalize on fats and protein to survive, but it is not a preferred energy source. We do share a common mechanism for turning glucose into ETP the general cellular energy of most living things, and it's combination with insulin but our 'recent' evolution specialized us for fat metabolism.
Glucose (fruit and starch) signaled the end of monsoon and a period of scarcity for which it was good to have a fat supply in the body. Survival depended on it so eating starch or fruit all year round every day each meal is always preparing the body for scarcity forcing to eat more by inducing a feeling of hunger and no satiety, turning fructose into fat and storing it in or around the liver.
The incidence of PD is rising not only because we get older but fundamentally and if you only look at PD it is hard to see the big picture, we are avoiding fat and overeating carbs all the time like we've never done before. Results in uncontrollable inflammatory diseases. Just like Alzheimer's, MS, ALS, cancer (depends exclusively on anaerobic glucose metabolism), rheumatism of joints, Krohn's all on the rise. You can therapy for free, (no drugs) and at no risk, It will not cure PD but you will get significant improvement and stabilization. No official research has been done for PD with the Ketogenic diet but 2 pilot tries were don with 5 and 6 subjects for only 4 weeks (which is really short) and they all improved. Of course nobody pays for that type of research as there is no profit for anyone , no patent-able medication or treatment method so it will take a long time if ever for this research to get done. Here David Perlmutter MD explains the research:
www.drperlmutter.com/ketogenic-diet-dramatically-improves-parkinsons-disease/?DrPerlmutter.com+Newsletter&EMAIL_CAMPAIGN_2017_07_10&mc_cid=950524c686&mc_eid=d1fd24613d
Ketogenic Diet Dramatically Improves Parkinson’s Disease.
It seems that many people are "edicted to grass (wheat, barly, rye, oats)" and so they have a hangover from grass deprevation. It helps if you get help from a supportive dieticien who understands "nutritional ketosis" and not just low carb as some paleo diets or Atkins. For most people low/no alcohol is an even bigger problem, but it does help not to drink alcohol. with an average alcoholoc consumption you have to count 5 grams for the alcohol alone and then many whines and bears have a lot of extra sugar/carbs. Only Wodka seems to be almost pure alcohol and water. For many of these alcoholic drinks there is no relevant nutritional information on the label.
With all due respect, a sample of five does not make for "powerful findings". Promising, maybe, but one would have to replicate the findings using the gold standard. Without this rigour, one has junk science being promoted as a breakthrough. And by the way, it has been 13 years since this "study" was published. Where are the replication studies?
Daniel Day Don’t understand your hostility to the doctor’s comments. He was clear two different times that this was a small five person study. I don’t think anyone heard his “powerful” statement as “the Keto diet will cure all Parkinson’s patients.” It’s powerful for what it is, a small study with 100% positive results. You calling it junk science without the “gold standard” replication is just wrong. It may end up being junk science. It also may end up helping a large percentage of patients. If you do have a friend with Parkinson’s, maybe you could do a little research. Search “Keto Diet & Parkinson’s Disease with William Curtis” from the CZcams channel “High Intensity Health”. Sure it’s anecdotal, but it is a direct conversation with a Parkinson’s patient on Keto.
66gtb, With all due respect, one cannot use "powerful" when referring to a sample of five. This kind of language is "plain wrong" because of its inherent bias. The MD should know better than to promote this as science. Sprinkle the presentation with as many histograms and cross-tabs as you like. The bottom line is that this pre-post design, using five patients, who likely were not randomly selected, is at best - a promising result. But I digress. The study probably uncovered a placebo effect or bias on the part of the medical staff who rated the patients at pre and post intervention. This brings me back full circle. One needs to apply a gold standard to make the "powerful" claim. Given the limitations of this study, one cannot make the claim that these are powerful results. As for the suggestion that my criticism equates to hostility toward the MD. You're sadly mistaken. I take umbrage with his claims. That's it. Seriously, if these five patients experienced powerful benefits from the intervention, why hasn't anyone else replicated the researchers' findings? The Internet is rife with this type of nonsense. But, hey, people will believe what they want to believe, no matter how flimsy the evidence. And, no, I won't be going to another CZcams channel to hear more anecdotal information. The sad thing is that these types of "protocols" can be dangerous. And this is why I posted the original comment. I firmly believe that Hitchen's razor applies here. Show me compelling and defensible evidence. If not, refrain from posting this junk under the guise of knowledge translation.