Autophagy & Fasting: when it all starts
Vložit
- čas přidán 21. 08. 2024
- Science says eating just one meal per day can improve your health.
Learn more at highintensityh...
-----
There’s a lot of speculation about when autophagy starts and stops.
“Fast for 18 hours and autophagy kicks-in,” the guru says.
The truth is, autophagy is occurring at different rates in different tissues for different people.
Today at 5:00 PM, we’ll add some clarity to this topic that’ll help you figure out how long and frequently you should fast to enhance autophagy.
➢New eClass: courses.highin...
New Optimized Collagen Formula: myoxcience.com
Buy 2 get one 50% off w/ code Summer19
New Essential Fatty Nutrient Blend (Vitamin D3 + K2): bit.ly/2WNMxkf
New Mini eCourse Plus Fasting Guide & Recipes: bit.ly/2VxYmLO
----------------------------------------Lets Connect-------------------------------------
➢ Listen in iTunes: itunes.apple.c....
➢ Instagram / metabolic_mike
➢ Facebook / mikemutzelms
------------------------------------ VIDEO GEAR & TOOLS----------------------------------------------
Gravity Blanket (use code HIH10 to save): shrsl.com/1o7wi
A Metabolism Book Should Have:amzn.to/2jUiAh5
Best iPhone Stabilizer: amzn.to/2IuCFFw
Vlog Cam Canon M50: amzn.to/2jRBTEd
Sony Vlog Cam: amzn.to/2DhRV4j
Interview Cam C100 ii: amzn.to/2EC5NE8
Best Lens Ever: amzn.to/2IJ9WZC
Vlog lens: Canon EF-S 17-55mm f/2.8 IS: amzn.to/2IGlfSo
Good Audio: Rode VMPRPLUS Videomic Pro: amzn.to/2v9W9cm
------------------------------------- Key Timestamps---------------------------------
We’ll address more about:
-Insights from human fasting studies about autophagy and fast duration
-Herbs and foods that may enhance autophagy
Here's a good Brain Story for you Mike. My Grandmother at the age of 70 had a Brain Aneurysm, after being operated on by one of the best Brain Surgeons in the country at the time (Nicknamed "Christ" by fellow doctors and nurses for the miracle like surgeries he could perform). She ended up in the hospital for 5 months, nearly dying a few times. "Christ" said she would never recover and be herself that her brain must have been damaged. She made a full recovery, her personality was exactly the same and she lived to be 90. Even at an older age the Brain can fully recover.
Wishing your Dad well.
Raw Bacon Thank you for sharing such a beautiful outcome
Wow! Amazing!
@@faybelle2991 I understand there is a reason to hate your mom, and she likely deserves the comments laid upon her, but you are also your own person, and you have control over your own behaviours. I know there is a spectrum of shit and you might have a massive pile of shit, but always remember, if you want change, YOU must change. If you decide to let your feelings over your mom affect your own personal behaviour, that's on you. I grew up with a sister with a severe, untreated mental health disorder and she was used as punishment for me. She was severely abusive and I was an emotional mess and no one defended me. My mom and sister picked on my weight to manipulate me once I hit early puberty and my weight skyrocketed. It was a cold, isolating home. Ironically, I became a nurse and saw the suffering, and I mean really, really realized; there are a shit ton of people who suffer. Most people will never see the severity of the suffrage and nor would they want to. I wouldn't wish it upon my worse enemies-- not even my own sister who I hate to my very core. Alas everyone has their own huge pile of shit and a level as to which they can control. My suffering didnt stop when my chronic pain issues started a few short years after university. I'm no longer able to work full time and I'm a financial disaster in the vicious cycle that I can't control. But I'm still trying and not giving up on me. Most people just make their pile worse because of their own behaviours and they believe their own BS coming out of their own mouth, to justify their destructive behaviours. Mental health is so important but it is sacrificed. "it won't happen to me", up until it IS you. So you get to decide to burn in the flames like everyone else, or will you rise above and take ownership of the life that is yours? I really hope you will choose to fight and die trying your very best. I am really sorry that whatever she did, it hurt you so much. But just know there are people rooting for you. There are people that will take the time to write this because they care. And when you put the effort into the right place, you very well might be able to have a little control over something in your life, even if it's merely your attitude. Be well.
@@dana102083 Very, very well stated.
@@LordStanley94 thank you. It was a tough month.. But we all need to cut the BS and wake up to our own self-destruction. We are a work in progress. Xo
*Changed my life. I will never eat the same ever again. "Unless you physically trip and your face lands in a box **weightlose.fitness** of donuts, there is no such thing as a 'slip'." Get that mind set and you'll win again and again.*
:)))) accidentally trip and land on a bag of donuts 😂hilarious 👍
I am 190 I always been 145 my whole life at one point lower than that I've gained over 50 lbs in the last 4 years and now that I am engaged I am wanting more to be healthy again. czcams.com/users/postUgkx5VQ5nUzHu6i0O5_u7ipyLnCz0lbsSvr0 I am not fat but I am thick and have muscle. I am very close to how you were but a lil smaller but I am so sick people making comments to me like I'm huge or like you said having shorts that used to be so cute on me and now I can't even find a pair to fit me. I used to love shopping now I don't even want to go to the store and if I do I pick the biggest size don't even try it on and deal with it. I went from size 5 to size idk because I don't even want to know the real number. I hate looking at pics of myself now or me before. Thank you for your video it's time to make a change.
Am 66 years and have been exercising on and off since my teens. I hit on IM after reading about it and am now on 5/19 routine for a year now. All my relatives,including those 15 years younger than me are diabetic and hypertensive while I'm not.
It is downright scary the state of medicine is in. The fact is, we can't trust conventional medicine. A lot of doctors are just not trained in nutrition. The pharmaceutical companies are in charge of medical text books.
The only doctors I trust are those who went to med school before 1973, but most are now retired.
The best approach is to be educated and stay up to date on the latest science and find a doctor who is willing to listen to you and will even take a look into the latest published research.
I have one child with mosaic Turner syndrome and another with autoimmune issues. I found doctors who were willing to listen and take an integrative approach that went a long way to optimizing their treatments. I don't dismiss conventional medicine, but I also do not fully embrace it when there are other less dangerous approaches that not only treat disease, but restores health.
Late to the party here but I will tell you this having recently gone through postgrad (engineering, not medicine, although I knew medical students and this was a top 100 university in the world)
Many med students today are dumb as bricks, engineering students too. Sure they can regurgitate textbooks and crunch numbers but they completely lack critical thinking, and if you ask to many questions they just go "you don't understand cause you don't study it".
We are deeply in trouble in the future. BUT remember this. Your health is in your hands, the best way to stay healthy is through PREVENTATIVE (think eating well, exercise, proper rest, etc. etc.) care and actions, versus REACTIVE (modern medicine).
Gosh isn’t it terrible that conventional medicine is saving his father’s life…
I only trust functional med docs and naturopaths
czcams.com/video/NAMYAoiCSsI/video.html says exactly what you said.
I am 73 and have been fasting for 24 hrs a day..doing OMAD... doing great..I am losing weight slowly and that’s good with me..
Fasting for 24 hrs a day???
@@urflofit2010 I'm guessing she breaks her fast with one meal a day then starts another 24 hr fast.
@@paulalumbra6274 I guess you are right but that's a really weird way to put it.
@@urflofit2010 weird for whom?
My goal is to fast at least for 72 hours in a row then do OMAD on all other days. I want to give my body time to really heal and repair. I recently tried the 72 hour fast and only made it to 63 hours. This week is a new start. I started my fast last night at midnight. I am a nurse and work crazy hours. I am so happy to see a woman at the age of 73 doing this. So many women just give up and WE are not going to be one of them :)
After two months of a light OMAD I lost 12 kilos. It Is simple , cheap and you are never hungry....and I feel full of energy!
My husband and I have been doing IM fasting for 14 hours for last 8 months,and from 30 units of insulin he took before he is now on only 4 unitsperday.its really working.and we walk 8kms daily too.
Some good insights:
Autophagy is always occurring; it’s a sliding scale of intensity and efficacy.
Intermittent fasting (compressing the feeding window) alone favorably affects autophagy.
As you get older, autophagy lessens so you need to fast longer.
Autophagy is intracellular. The cleanup occurs within the cell. It is not a process of eating whole cells.
At 36 hours and 72 hours of fasting, autophagy intensifies in muscle cells.
Alice in wonderland. Is 24 hours enough
Got 10 hours remaining on my 5 day water fast and I’ll be honest it’s been hard... Thanks so much for this video - you’ve motivated me to go all the way!
Looking forward to eating tonight and a good night’s sleep!
I fast for 72 hours from Monday to Wednesday and 24 hours fast from Thursday to Sunday then repeat that for almost 4 months.. Also on carnivore diet and doing tabata workout daily.. and feeling super active everyday...
Is it hard for you to start up your 72 hour fast each week?
@@citronmonet294 Yes! It took me two weeks for my body to adjust.. once it done abopting to my new normal. The rest was history...
I have 33 hrs left on my 72 hr fast. So far feeling good, and hoping it helps. Normally do 20/4 but I've been stuck.
Fuck that! Enjoy life dude. Eat eat eat
@@paulalumbra6274 I'm doing 20/4 some days I have sugar drop cant get to 200
Thinking it will improve
I am using bio-kinesiology (muscle testing) to determine my optimum fasting/restricted eating regimen. Best practices are often less severe than we think. I am getting consistent positive results with routines that are not difficult to maintain... daily 6 to 8 hour eating window, monthly 36-45 hour fast. Weight loss, energy levels and autophagy are all at optimum levels. It is worth noting that I am 69, have no major health issues, eat mostly paleo (I do love my daily dark chocolate fix), walk regularly, take supplements, and use herbs and essential oils to maintain my health. But I've been 20 to 60 pounds overweight my whole adult life, and tried all kinds of diets, including a brief fling with prescription diet pills. Intermittent fasting is working for me like nothing else. I feel great, and for the first time, in control of my weight management. I love how naturally flexible and compatible with all my lifestyle choices this practice is. Finding our own best routines is a personal journey, and using muscle testing can be an invaluable tool
I am a neophyte at all this. Recently dumped massive amount of fat when I inadvertently triggered a spontageous great rendering of lipid xenobiotic toxins...specifically obsenegens. I went from a size 22 pants to a size 4 within less then a week...
A WEEK! I am in need of autograghy, even though it has like I unzipped a Sumo Wrestler's fat suit custome and step out the tiny me I was when I started bare handling (sans masks or any known precautions-- flourides decades ago)
I am 65 years old and have been exercising all my life. I have found that the 8 16 mid fast during the week works well for me maintaining my weight. One day of the week I have one meal for the day (soon I will do two days week). I also run 3 miles 3 to 4 times a week. I find or feel that i hit autophagy on the days I run. Now after seeing this video I will need to increase fasting but remain hydrated. Thank You
You mentioned having a cold. I have not actually come down with one single cold or sore throat in 5 years, since I began taking simple acidophilus. It's a miracle.
I'm turning 75. Until a month ago I hadn't experienced a cold in more than 20 years. When I recently experienced a mild cold, it took me a day to understand what it was. I don't do anything special to avoid colds.
Camera tips, don't have auto focus on. You don't need it and your slight moving back and forward won't be noticed. I've seen so many videos where you are out of focus. Try it, set to manual and focus yourself at the start and you will have a nice clear shot!
And thanks for the great content you always provide!
My new studio should help fix this--issue is my current set up is too close to camera (I think). But thank you
High Intensity Health thanks for your advice, I did a 16 day water fast 4 months ago, I got rid of a virus I had. Thanks.
@@Highintensityhealth The problem is that the camera goes out of focus when you raise your hands into the frame.
XRP Paul 16 days? Wo this is long how ho did you feel those 16 days?
I almost lost it trying to watch, ended up just listening.
I would imagine the fasting time required to achieve autophagy is going to be very individualistic given variation in genetics and rates of metabolism.
Anyone here have heart issues and fibromyalgia? If you have IF experiences to share I’d love to listen. Thank you for this channel. I’m glad I found you.
I'm a T2 and fasted 11 days to begin; I went from 100 u before to 30 u after with better control. My second fast was 4 days and I went down to 20 u. Third fast was 3 days and went to O. Am now doing 3 days a week, OMAD the other 4 days; no insulin.
The whole thing took me under 2 months so far. I've been a T2 for over 3 decades; on insulin over 12 years.
@Jackie Patti Awesome. I am on day 8 today. Pure Water Fast.
What are 'u' s ?
@@tubetime39 Units
@@lunarminx lol, thanks !
My mom: Same, basically. (Although, she didn't go over a few days at a time.) She went from being poorly managed on insulin+ to healthy numbers in a few months. Neither of us will ever be diabetic again. Sure, my mom and Jackie are bad asses, but y'all can all be healthy bad asses, too.
I’m 71 and fasting 22-24 hours...feeling great..
My guess is the body prioritizes and uses autophgy to move nutrients around to where they're needed.
I love your raw honesty!! Your dad is blessed to have you for a son.❤️
Wow I've seen one or two of your other videos and this one made me subscribe to you. I was hit by a car while I was on my bike once and my brain swelled up for weeks. It was so scary. I really appreciate you talking about the personal things. You are hella real, love that. Keep it up.
I am so sorry about your dad. Hope he feels better soon, Not to worry meanwhile we will watch your old videos which are real gems
Thank you Mike. I am so sorry about your dad. Ugh. Pray he’s better now. You and family stay awesome!
Just saw this video now, I hope your father is better; awesome that he is out there enjoying life!
As an epileptic I hit my head quite a bit, thanks for telling us about your father.
Autophagy is an intracellular process. I've been laboring under the false impression that lymphocytes are going around eating old and damaged cells, but that isn't true, based on this information. How fun to learn something new!
Best way to think of it is autophagy is like demolishing an house and moving the remnants into a steel waste bin. The lymph system is the truck that fetches the steel bin and transports it to the dump for disposal (bowls and bladder)...
If the bin is empty when the truck comes...not much gets done by the lymphatic system. If the truck doesn't come regularly...you get a lot of debris spilling over...and maybe autophagy slows.
So ideally a healthy system of both is best.
One thing we know for sure, the vast majority of what we eat is garbage, so every hour you don't eat is another hour you know that no garbage is going into your body.
I am 64 and doing variant fasting . My body and mind is returning to when I was 17 yrs of age . Feel love very in my clothes & all the tiny spots on my arm and upper legs all cleared up and I am now 7 stone 6 pounds ; I was 8 stone 5 lbs . First couple of weeks was truly tough , however by understanding Autophagy I managed to keep going - cheated occasionally when I felt really low ( ate an odd date or too ). This is my 4th week and truly , I can’t eat back the way I did 4 weeks and beyond . Please try it - simply cut down about 25% of your daily meals and then skip a meal and then slowly move into a little more restrictions with the amounts abd frequency of eating .
I keep asking why am I shoving so much food down my oesophagus and you not my tiny stomach .
Thank you for re-educating us & sharing your knowledge with us all humans . With respect and gratitude.
@21:17 OMG I just got TBI last month from a concussion (angry Liberal assaulted me over coronavirus politics).
Wow! Your info is fascinating (even though lots goes over my head, I hope to understand some day),... yes, I'm suffering double vision, blurry vision, cognitive difficulty in understanding, organizing, and remembering.
I didn't know autophagy helped with that... SUBSCRIBING!
Your past is like mine. Then I had a TBI, had seizures daily, brain surgery 20 yrs later I’m interested in Keto and fasting
Do it your mind will improve
Thanks for sharing your background - I have even more respect for you than before. I’m pretty sure you have recovered your cognition.
You should go and talk to kids in school about health, fasting etc as they would listen to you
I just stumbled upon this video! Wow!! Mind blowing. I did not know autophagy was an intracellular process! The majority of medical or health gurus perpetuate the idea that it is a “packman” effect, kind of like phagocytosis, and that after a certain amount of time the whole body undergoes this process. Anyways, thank you for the clarification. I appreciate all the info you put out on here. I know you said that autophagy occurs at different rates in different tissues for different people, but I was wondering if there was a “general” guideline that indicates at approximately what time tissue cells undergo autophagy. For instance, bone and muscle start at around the 17 hour mark, liver at 18... and so on. (I just made up those numbers). Thank you 🙏🏻💕
Just found you about two weeks ago as I continue on my health journey. I appreciate you and subscribed to your channel! Keep the information coming!😁
Intermittent fasting is not just good for weight loss. I'm currently bodybuilding on a 18/6 fast and I'm in a caloric surplus, slowly putting on weight. I do intermittent fasting for all the other benefits that come with it (increase HGH, increase testosterone, insulin sensitivity, anti-inflammation benefits, improved energy levels, staying lean and maintaining lean muscle,...). Feels great and it's convenient for me personally. At first it wasn't eating getting enough calories in with a 6 hour eating window, but giving it some time I have become accustomed to it and have no problem reaching my caloric surplus now.
Praying for your dad's wellness and healing. Love your show!
Thank you!
Been doing hardcore IF while losing weight. Monday to Thursday I eat at 1PM and 6PM. Friday and Sunday I eat at 3PM. I was astonished how fast I adapted to this.
3 months I lost 6 inches off my waistline.
Hi, do you eat on Saturday or skip a day?
@@nicola4594 nothing on Saturday. I'm going IF for another round of this for a few months this winter. I like doing diet sprints where you go as hard as you can for 1 to 3 months and then take a break to maintain and learn how to eat for your new size. I needed to get from 370 to 200 and didn't have the willpower to do it all in one go. Right now I am about 240 so I am getting close.
Your focus point is set to the center of the screen which is why it goes out of focus every time you lean to your right :) Thanks for the video!
So sorry about your Dad. Pray he fully recovered.🙏
I CAN read all the book titles on da bookshelf! OK I will just listen. I'm fasting 12 hours in and going strong. It works!
I'm so sorry your dad is in the hospital. Hope he's out soon.
He's out now and doing great, but thank you!!
@@Highintensityhealth Excellent news. I'm very interested in hearing more about how you're helping him treat his TBI.
I needed to hear this! I had so many questions in relation to Autophagy and you answered them all! Thank you!
Autophagy starts around 18h-20h I do omad 23/1 and I start weightlifting around 18h doing total body workouts x3 a week to help increase autophagy.
You’re a great interviewer. Have you considered interviewing Dr. Sten Eckberg?
Day 5!
Going for 14.. Maybe 21.....
Cheers👍
Did you make it to 21?
How did it go!? Even if you didn’t complete it! Every day is a victory! :) every hour is.
This is starvation, what is going one, 21 days? Are you trying to die?
I'd love to hear more about testosterone and fasting and how they interact ...
I have too much T as a female.
@Michael Bertrand,
I can tell you that high levels can happen when fasted. About a year ago I did a T and insulin test. I was about 18 hours fasted when blood was drawn.
Insulin:
@@faybelle2991,
I'd say that is a symptom of insulin resistance. It has the reverse effect in women. Too much insulin in the blood will lower estrogen and increase testosterone.
Go low carb and fast. Get insulin down.
@@faybelle2991 how much is too much?
@@martinirving3824 Thank you, I took a SS to remind myself.
I don't have $ to get blood work done 🔬👩🔬⚕️
Re your dad's hospital experience: emerg doctors are great a acute care; they are not so good at chronic care. They will save your life but you need to care for it afterwards if you want to be healthy.
slow down, relax, that energy goes into the viewers.
I appreciate your studies, and information and stories. So sorry to hear about your dad.
I hope he heals fast! God Bless..
A trick I can advise with your camera focus issue: use autofocus to begin with as you would normally do. Once you are in focused, TURN OFF autofocus, so your camera wouldn't find some other area in the frame to focus on. Assuming you are not going to move back towards your bookshelf or move your head towards the camera.
I really enjoy your videos on autophagy and Intermittent fasting. I am vegan and it does benefit vegans too.
Autofocus: off
If it's only you in the picture there's no reason to use autofocus. That will solve the problem.
We need to talk about how too much protein raises insulin and glucose too.
Great idea--let's do!
Probably then need to talk about how it is the most satiating of the macros, how low-fat and low-carb diets result in equal weight loss when protein is equated, how people need MUCH more protein as they age, and the effect of specific gluconeogenic and ketogenic amino acids.
Joda Gordon, not disputing anything you have written. Protein can definitely be very satiating, but that is part of the problem... it’s easy to over consume. Therefore, raising insulin and glucose. On a low carb or ketogenic diet, it's not just the carbohydrates that need to be monitored.
Folks are way over estimating their daily protein intake. It is causing a myriad of health issues as people get older and they tend to treat each symptom independently instead of looking at the root cause which is spiking insulin too frequently of a daily basis. All chronic diseases lead back to insulin.
Ken Jay, Agree!
'Inter cellular homeostasis housework'.....Champion👍😁. Don't worry about the focus, because I am super focused on what you have to say. Great info as always. Big hug to 'Dad' hope he much better very soon. xx
Thanks!! Awesome and informative as always. Any chance you could link that podcast with Fung & Attia you mentioned??
Most likely this one from a couple of weeks ago: peterattiamd.com/jasonfung/
Bravo! Your passion transpires in a very nice, contagious way. You seem to have very nice personality for doing the videos. You come across as humble person. I learn tons from you.
Thank you! Please, do some very simple videos for people who can't handle complex medical approach like my daughter. YOu'll see many new followers coming if you do a series like this.
Our youth has attention span of a fish. Please, help!
Thank you Sir for this video , this video answered a lot of questions I've been thinking about lately
Thank you for these insights into these autophagy studies Mike, really enjoyed this stream! :)
I became more flexible with my fasting and I achieved a better balance for myself.
Monday I do two meals a day, morning and afternoon with no snacking between, Tuesday-Wednesday-Thursday I do 22/23 hour fasts, Friday I do a 18/6 or 20/4 fast and after that I go into a 36-48 hour fast until Sunday when I break my fast with a small meal high in protein, 0 carbs and low in fat and go back again to fasting.
And at the end of every month I do a 72 hours fast.
I don't advise others to do it like this, I just wanted to give an example of what works for me, but I encourage people to experiment for themselves and make their own schedule. I train 6 times/week gym+ cardio and feel great.
You got it, John! Cheers
"Cured" myself of 'irreversible' brain damage, not verified by a 'pro'. Almost 7 months of fasting, some mistakes tho. There is hope.. * from b12 deficiency, not verified by a pro, self-diagnosed, knew my symptoms. Hope 2 go 2 Pro soon tho, and document? Ty..
Woah!! Really?
What I've read is that ketosis starts in a healthy immune system at 14 to 17 hour of fasting. However, when the immune system is impacted by metabolic syndrome/Type 2 diabetes then ketosis may take up to 3 days of fasting to trigger. ... Ketosis is required to trigger autophagy ... another method is to test for ketosis is to measure the ketone levels with a ketone meter - the mildly annoying aspect of this is that ketone level may vary over time as the body adjust to fasting levels so ketone levels drop over multiple attempts of fasting.
Oooooo exciting!! I am healthy and eat either 16/8 or 18/6 🙌🙌
I did 65 hours fasting !! I do 17,18,20 horas on daily basis
Mike I love to listen to you.You are incredibly knowledgeble and really great speaker.Thank you!!!
Love the content! This question has been plaguing me. Super interesting and informative. Definitely sharing this video.
Prayers for yours dad.
I knew alpha fetoprotein sounded familiar! I had a child with neural tube defect years ago:
“Your doctor will most likely check for spina bifida by first performing these tests: Maternal serum alpha-fetoprotein (MSAFP) test. ... But abnormally high levels of AFP suggest that the baby has a neural tube defect, such as spina bifida, though some spina bifida cases don't produce high levels of AFP.”
Just FYI
Thank you!
Seems like the word of the day is "invagination"! thanks so much Mike for another great video. Keep up the superb content.
Doc Goreblot also... phagosome...
lolz! Good cocktail party trivia
I hope that your Dad gets better....prayers for you and your family Mike......and that your sickness goes away soon! 😊
This was really beyond briiliant,,,GREAT GREAT STUFF!
Thanks! I felt a little scattered but hopefully it was a little helpful!
I am 73 in very good health, No meds, on Carnivore 3 months 4 hour eating windo., lost 24 pounds need to lose about 25 more yet.Walk 4 miles 5 days a week, thinking of adding 36 hour fast once a month just because i was a yo-yo dieter for about 50 years, so I thought that might be a good plan for me????
If you are fat adapted and comfortably OMAD I am envious. I started keto with a 48 hour fast and man was it hard. After 5 weeks I am at 20 gr, carb , 18/6, and walking everyday. My sleep is good too . I need to lose 30 lbs. I am 67 and on no meds. My diet was always organic but way too many carbs and snacking. I am not doing a longer fast for a few more months.
I never get colds. When you feel a cold coming on take some good quality eucalyptus oil and put a drop on a Q-tip. Then run the q-tip on the inside of each nostril. Do this morning and night. I haven’t had a cold since I started doing this years ago.
Explain how this works?
I use gymnema and it supports liver ,, pancreas, and insulin resistance. It also helps with fasting because it helps stop that hunger feeling.
Autophagy does not necessarily kill a cell but the removal of cellular waste material. High insulin hormone levels decreases autophagy and low insulin hormone can increase higher levels of autophagy. The only way to decrease the level of insulin is to avoid eating protein and carbohydrates - essential one needs to fast.
The number of advertisements on this video is ASTOUNDING. Very difficult to watch.
Worry and Fear are from unloving spaces. Heal emotions and they go away.
Lol @23:00 wow I really connect with you... love how vulnerable and open you are with your life... you're awesome Mike! 😊👍
Mike - firstly, I like you have a MSc in Nutrition - although I think the USA abbreviate it as MS (?) - I really enjoy your presentations they are very professional and more importantly they are not dumbed down and you are not afraid to hit the Biochemistry etc head on - or more importantly treat your audience like 5 yr olds ...thank you for that ...
I would like to ask when you present the studies could you either link or reference them in the show notes below and possibly annotate if they behind a paywall please ?
Also, Like me when you get revved up / excited about a subject you tend to fire off at 90 miles an hour - I am the same and often leave my friends staring at me glassy eyed wondering what the hell I am talking about lol...so could you please try and consciously slow down a little as sometimes it becomes too overwhelming and important things are missed so need to be replayed several times ...not a criticism but just a gentle request ... don’t get me wrong I couldn’t present info like you even if I wanted too...lol
Please keep going with your show it’s deffo one of the best and although in some areas I have drawn some slightly different perspectives to you, I do feel that you and I could comfortably sit in the same room reading from the same hymn sheet ...
Best
Ric
No matter how fast or slow Mike talks I will always note a place I want to revisited when I play it again for any note taking.
Debbie J. you can slow it down with the playback speed. i find this helps when people are talking too fast or when i am taking notes.
The goal is to live longer correct? At a cost of not enjoying food a lot of the time? Quality of life for me includes healthy great tasting food whenever my body says its hungry. Exercise and portion control will give you the body you desire.
I've been mostly 16:8 IF-Keto and had good success with it, but have been wanting to supercharge it somehow and also settled on 36 ish hours once a week, 3-4 days straight once per quarter. Very happy to hear this format validated by someone else!
Mike,
Is there a list of which tissues benefit from autophagy at what duration of fast?
eg musculoskeletal (24 hrs); liver (36 hrs); GI tract...
Miracles can happen in treating TBI. Omega3, protein, zinc, coline, bone marrow broth and avoiding inflammation causing food. Positivity and healing energy.
For those asking how long do you need to fast the answer is: Are you just looking to increase autophagy or are you looking to cure your diseases? Because if you're just looking to increase it, do what he said. If you're looking to cure your diseases then you need to fast until your disease is gone.
For me personally I did a 2 week fast, which made my hyperthyroidism and myasthenia gravis disappear, but it did not make my type 1 diabetes disappear. However, after about a few years they reappeared again, showing that I didnt actually fast for long enough to completely cure myself. Id say probably a month to cure yourself, but after all my research 3 months seems to be the perfect amount of time to completely cure everything. It all comes down to you and what you'e willing to do.
However do not fast as a type 1 diabetic without medical supervision. I tried to fast many times as a type 1 diabetic without medical supervision and ended up going into DKA and nearly dying every time except for 2 times, so its very dangerous. If you are a type 1 diabetic test your sugars regularly dont just assume you're fine because DKA can happen out of no where. Also test your ketones regularly, test before your fast to see what your normal ketone levels are and then check your ketones around every 4-6 hours while fasting. If you do end up going into DKA, sodium bicarbonate (baking soda) its great for lowering your acidity but putting a half teaspoon into half a glass or 4 ounces of water(read the back of the box / bag of baking soda, it gives you directions for homeopathic use. Its actually what they use in hospitals to treat acidosis, they put DKA patients in the ICU on a sodium bicarbonate saline solution via IV drip. They also put you on an insulin drip, so to simulate that you can use long acting insulin. Using these two things while going into DKA are how I was able to stay out of the hospital and remove the acidosis at home. I would however not try any of this yourself and do this with medical supervision, but if you go against my suggestion there's something you can do to keep you out of the hospital.
Everyone else should be fine as long as you dont have some form of acidosis that could kill you like with diabetes.
What's DKA ??
Great content Mike!! Always learning more every time you log on!! Thanks so much!! I’m 57 post menopausal doing IF 16/8 or 18/6 & lift heavy every day ...yourself and Deanna are the best 👍💙💪🏿
Thanks for the educational and well presented video.
I just found this page today while reading a Facebook page. Oh my goodness... this information is more important that focus of camera etc. smh
Mike, love what you are doing and love more you and Deanna, you bounce off each other in a really entertaining way ' your content is massively Educational and that's what attracted me in the first place. I will say I'm concerned about how hard you are working. May I humbly suggest that when you want to help other people sometimes you need to look after yourself first to better help them. Thank you again for your content, I'm learning so much.
If your main goal with autophagy is to reduce excess/saggy/loose skin after significant weight loss what is the ideal fasting period for that kind of autophagy?
Re: 24:46 Hi Mike. Alex did not specify whether he or she was type 1 or type 2, but from my own experience as a type 1 who fasts without difficulty, the answer is yes. Of course, do not just dive staright in, and do discuss this with your physician. However, Dr Richard K. Bernstein (who has been type 1 since developing the condition at age 12) mentions in his book "Diabetes Solution" how when he was training in medicine, he'd sometimes go as long as 36 hours without eating with no problem. His CZcams series "Dr Bernstein's Diabetes University" provides a lot of useful insights into many different aspects of (primarily, but not exclusively, type 1) diabetes. As well as Dr Bernstein's book (and his shorter version of it "Diabetes Diet"), I can recommend Volek and Phinney's "The Art and Science of Low Carbohydrate Living" and Davis and Runyan's "The Ketogeneic Diet for Type 1 Diabetes".
I’m at 24 hours fasted, aiming for 36 hours. Came here to find out what’s happening inside me now. I mainly wanted to find out if I was fat adapted following a ketogenic diet, I think I have my answer as I’m not hungry 😋
At 36 hrs fasting going for 120hrs or 5 days.
That is on big answer. When the hunger goes away.
Just don't be afraid of calories keep them up so you don't slow down your matabolism.
I'm in the middle of a 48 hour fast:
I normally do OMAD for 23 with a one hour feeding window.
strong content overall, and it could be strengthened with preparing an outline of your thesis with key- and sub- points. the hedges, editorial self-talk, and digressions can distract a listener's capacity to sustain attention...
You’re not paying for this information so I’m not sure why you’re critiquing it
36 hours but how long does autophogy continue and by what volume
I am shocked, such a important question is not snswered if that person really wanted to help others.
I think he is also one like others who wants money made on CZcams. Just another fox.
@@crisprcrispr229 listen again...he answered it
@@centerfornaturallanguage9871 Respected sir, I am dibetes diagnosed and I am really looking for help and when I can not find help and it really annoyed me. So sorry for my earlier message. But I will certainly listen to whe video again for the or four times to find the answer and to help myself. I will be happy to find some useful information again. Thank you bro. Good day. Ifbyhere any other important video link to to autocracy and to revers insulin resistance. Please give the link. Your help is much appreciated.
@@centerfornaturallanguage9871 okay. I will listen again
Not exactly what you're looking for maybe but I was shocked that Peter Attia had insulin resistance...both these guy, Mutzel and Attia, both strive for objectivity, knowing it's a bit elusive.
I can fast forever, but damn what do i hate the muscle cramps that comes together with it. Even on magnesium for 2months every day and on L carnitine and allot of sea salt with iodine in it on my food i'll still get it
Great content; thank you for sharing your experience and personal practice!
Okay, so mediocre forms of autophagy are occurring concurrently all over body. So the question now changes to: When does the most ""meaningful"" autophagy start? Or, we need to now shift our focus on differentiating b/t ""qualitative'' vs ""quantitative"" perspectives on autophagy....and their respective efficacies. Maybe mitophagy is king.
Hope your Dad has a full recovery. Better make certain he wears a quality bike helmet.
Thank you! He sure does wear a helmet! (He was wearing the MIPS that seemed to really help minimize impact.)
I had been comatosed for 11days, lost sight and hearing on left eye and ear after being run down by a truck. Brain was haemorrhaged despite an expensive Arai helmet and it was shattered, held together by the stickers and glue. Cut long story short, are our lives shortened by going through this kind of head injury? Wish your dad speedy full recovery
I appreciate you sharing your depth of knowledge and experience with us but would really appreciate if you could focus your mind and stay on topic, not commenting on every thought or observation that pops into your head. Can live with the camera but the rambling talk is hard to keep up with.
Love the hair Mike!
Watching this Oct 2021, and you said "head cold," and I immediately thought "Oh, he got sick with it two years ago" LOL
Dr. Yoshinori Ohsumi (won the Nobel prize for discovering autophagy) research shows that too much autophagy causes cancer. How do you avoid the "too much" and the cancer risk??
Great information Mike. Need to listen again. I loved your interview with Ask Nurse Cindy. Thank you and God's Speed as your Dad heals. Blessings.
Thank you, Debby! Nurse Cindy is so amazing!
excellent video. my interest in autophagy is rooted in my ulcerative colitis.
Thank you so much fr imparting your knowledge much appreciated sorry about Yr dad hope he makes a full recovery god bless