Cause of High B12 Level Without Supplementation
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- čas přidán 26. 06. 2024
- In this article we will discuss the causes of high B-12 without supplementation. In a previous video we talked about What Does A High B-12 Level Mean and some things to think about with that. In this article we will explore this topic in a little bit more detail.
The basis of this article is to discuss some of the more serious or problematic things that could be causing your high vitamin B-12 and the information is based a research paper. If you are having persistent elevated B-12 levels, this information will b helpful. So keep watching we're gonna get into the detail.
MY NEW B12 BOOK: geni.us/rTQTvd (Amazon)
The causes of high B-12 levels without supplementation are numerous. Before we get into this, we have to take first things first. Even though the title is "cause of high B-12 without supplementation," my experience helping people figure this out, they are taking B-12 but they are not aware of it. It maybe in a multivitamin, a workout drink, a protein powder, or something like this. So double-check you are not getting B-12 from various sources that you're not aware.
Now in a previous video we talked about how liver disease and cell membrane issues can be implicated in elevated B-12 levels. This still can be the cause of high B-12 without supplementation but there could be other, more serious, reasons for this as well. Most of these more serious causes are altering the transportation of B-12 via the transcobalamin transport proteins (more on this below). Both the cell membrane and transcobalmin proteins can be a part of the issue and solution. As you will see below look at some of the problems that can come up with the trans cobalamin the various transcript a'lamin transport proteins and various diseases that can cause elevated B-12 when you're not supplementing with B-12
most often when there is elevated B-12 levels whether or not you're taking be extra B-12 it has nothing to do with alterations in these transport proteins called transcobalmin. This is why most often when you have an elevated B-12 level that shows up on your laps it's ignored, pushed to the side, or explained away. Essentially if you remain having persistently elevated B-12 levels in the absence of supplementation you should explore this further. High B-12 levels could be an epiphenomenon or related to a deeper issue with B-12 transportation.
Role of Transcobalmin in High B-12 Level Without Supplementation
So how is B-12 transported? The chemical name for B-12 is cobalmin and it has to be bound to a carrier protein to move through the blood and more importantly into the cell. B-12 uses three different carrier proteins to do this TCN 1, TCN 2, and TCN 3. However only one of these transporters is actually functionally useful in delivering B-12 into its target cells. It is the TCN 2 transporter that is the main transporter for B-12. Therefore, anything that raises TCN 1 and TCN 3 will lower the functional activity of B-12 by limiting the binding of B-12 to the TCM 2. In this case all the B-12 is getting bound up by these other transcobalmins that don't really work well for getting B12 into the cell. Now this doesn't necessarily explain the elevated B-12 levels but it does explain how one can be deficient in B-12 in the presence of higher serum B-12 levels. So what is actually causing the high B-12 levels? Let's look at that next.
In the case that you've ruled out excess consumption of B-12 makes sense to explore some of these other things. This does not necessarily mean you have these things but problems that could be going on to cause elevated B-12. First thing to consider is solid tumors can cause elevated B-12 levels. Most commonly it would be liver tumors, hepatocellular carcinoma in particular. This can lead to elevated B-12 levels due to poor uptake of B-12 in the liver cells. With liver cancer some of the liver cells are damaged as a result the liver cell are are not expressing as many B-12 receptors. The same thing happens with liver disease whether it is acute or chronic hepatitis.
Hepatitis and Hepatocellular Carcinoma can also lead to increase release of B-12 from the cells being damaged. B-12 can be released from the cells because basically it is where most of the B-12 is stored. B12 is stored in the body. So solid tumors are a cause of high B12 and there are probably other cases of solid tumors outside of Hepatocellular carcinoma but this was the focus of the research paper.Blood cancers in general can lead to an increase in B-12 levels due to an increased production of these TCN 1 and TCN 3 trans cobalamin proteins. These particular transport proteins are made more commonly in certain cell lines like the granulocytes in the white blood cells. High B12 levels are found in many myloproliferative disease. These are disease of the bone marrow where the white blood cells come from. These disease states result in an increased production of white blood cells including Granulocytes. - Krátké a kreslené filmy
Check out my book that goes into details on high B12 levels and more:
"Don't B12 Deficient" amzn.to/35TQBWt
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Ok I’ll check out your book ! Thank you again I like all your videos !
Great content, thank you!!
Glad you liked it!
amazing and very useful video!
Glad it was helpful!
Thank you so much for this video , many people are still asking about elevated levels of vitamin b12 in comments of your first video on this, this complement informations will be very helpful !!! In my case, the last blood test show normal level of b12, the value has decreased gradually in about 10 months, I hope that means i don't have the source issue any more !
Hi Samira, I know I am surprised how many people are having this issue. Glad to hear yours is getting better.
@@swintegrative Thank you so much 🙏
Thank you Doctor from the UK.
you are welcome.
After listening to you . I purchased your book and made some changes with diet and vitamin. My b12 went from 1390 to 918 within one month. Thank you doctor . I'm still going to read your book as you recommended and make more changes in my lifestyle to fix my liver.
Great to hear this! An Amazon review would be really helpful 👍😉
@@swintegrative will do after I read the content.
I appreciate it.
Oh, I need this book!
@@kayjay4014 I hope it helps you and please leave a review if appropriate.
Very good information.
Glad it was helpful!
Thank you, very good video
Glad you liked it!
Thank you for your videos!
Your welcome!
Can you write down the research paper : Title & authors please as well as the year? Thank you.
Hi Dr. I am a 45 yr old female. I was diagnosed with lupus 2½ yrs ago.
It was all good as far as symptoms. I was very stable however this past months have been a bit hectic.
I was told i have gastritis 3 weeks ago. My lipase is at 130. Last week a had lab work from a follow-up appointment. My labs came back normal, except my vitamin b12 @1643, a1c at 5.7, bad cholesterol at 127, Eos absolute 0.7,
I'm Worried about the b12 mainly. I have health anxiety whem 4 urs ago a had a pericardial effusion with cardiac tamponade. I think by then i already had lupus but it took forever to get a diagnosis. I wont see my Dr until next week so my mind is all over the place.
Hi Doc and anyone else who might be reading this. I have elevated levels of B12 of 1300 and GGT:226 U/l , ALT:279 U/l, AST:435 U/l and i was tested for ana which is positive, I have an enlarged Liver 21cm and have an adrenal gland mass that is 35mm. I recently have an ultrasound done which they say the liver show no lesions. I am on a cocktail. of drugs to try to control my bp tried many different tablets . My question is can these drugs cause the liver to secret B12 and be enlarged ? Thank you for reading this and thanks for sharing some of your knowledge with us
Most bP meds do not have a major impact on the liver.
Starts at 1:56
My b12 was over 1 000 years ago. A couple of doctors said it was nothing to worry about. Haven't had it retested
Thanks for the video. 4 Years ago I had 1100. However, the doctor at the time associated it with a pre workout that contained lots of B12. I have now been tested again and I have 900. However, I occasionally took creatine, pre workouts( BCAA) and use a hair lotion which shows B vitamins (B3, B6, biotin). My last ultrasound results last month show everything is normal. Should I still be concerned. Thx
Hi Nick, 900 (pg/ml) does not seem high .
@@swintegrative I was also surprised about this. Thx for replying
Hi my moms albumin is high and b12 1300 she doesn’t take supplements and she’s vegetarian please suggest
Can you do a video on low transcobalmin levels? I had very low b12 serum levels so so I did methylcobalamin b12 subcutaneous injections for 8 months, after 8 months b12 serum levels were elevated as expected but I also got transcobalamin tested for the first time and it was low.
Video on transcobalmin coming soon.
@@swintegrative Awesome!
I have Hashimotos and autoimmune gastritis. My b12 levels have ranged from 1500-over 2000 since 2017. I am on a pretty restrictive diet trying to eliminate all triggers of my autoimmune but I have not felt well, pale skin, cold, fatigue, dry hair, itching, pain in arms and legs at night . My doctors really don’t seem to put too much concern with my b12 levels but I certainly know it’s contributing to my not feeling well. My hematologist who called me and never met me told me to stop taking b12 supplements which I told him I didn’t and haven’t, he just dismissed me. Could my high b12 levels actually be a deficiency?
Hi Shar, there are multiple things that can cause high B12. It is possible that you have low intracellular B12 despite high serum number. There are test you can do to determine this. I have a book coming out in the fall (hopefully) that goes into some detail on this. If you hematologist is not concerned, I would not be either. It is hard to say though since they were "dismissive" . Hope that helps.
did your problem solve?
Have you gotten any help yet?
Hello doctor, ive got a blood teat done yesterday which showed B12 as 1089,it was 580 4 months before. CBC, Kidney, liver everything else is normal and iam not having any medications. Will it resolve?
Hi Doctor, I know it’s an old video but recently did blood w. Had high homocysteine, high B12 , Hb is lower by one degree 12.9 . The rest is normal wether kidney or liver . But I do have numbness in my legs not severe. Should I be worried? Btw I have MTHFR mutation
Thank you 🙏🏼
I would like to knwo the optimal range?
Thanks for the follow up video. do you think there is a permanent cure if the cause was the carrier protein or the cell membrane? if the LDH is normal and blood smear as well (except for larger blood cells and low platelets which am facing for the last 2 years). appreciated .
Yes the next video (coming tomorrow) will go into this in more detail. It is not a one size fits all kind of thing.
@@swintegrative thanks for those, i did learn a lot from them. waiting for your next one now :-)
My dad showed my his results. B12, 1738. Range is 232-1245. His Dr wasn't concerned!
He doesn't take anything with B12 in it?
@@swintegrative
No supplement, not a big meat eater. Folate was normal, platelets were a little high. if I remember correctly, liver results were normal. Urine color was abnormal. Rest of urine test was normal.
The easiest thing to do is re-check it in a month. It is very inexpensive test. If you have not done so watch the other two videos I did on this topic. There are a few other tests to consider as well.
What about RNY surgery? I know that this sx can cause malabsorption issues, but could it be a cause of high B12? Mine was 2000. I was taking B12 inj weekly (instead of monthly) and taking B Complex or am I just taking too much....
Color Colorwad, No I don't think this would cause high B12 levels. There are some case reports of high B12 levels with digestive microbial imbalances. Microbial imbalance is common with digestive surgeries.
My test results show a level of 1800, which is twice the normal range. I am on keto diet, eat lots red meat , eggs and nuts.
Is it possible that MTHFR mutation results in elevated serum B12 test?
No I don’t think so
What's the range Doctor for safe b-12 numbers? thanks. I have 968 pg/ml. is that number serious?
Sounds normal or close to it. Every lab is slightly different though.
Hi Doctor 👋. My B12 level is over 8,000 without any supplementation of any kind for weeks. I've had elevated liver enzymes in the oast but my doctor didn't seem concerned. I'm having all the symptoms of pernicious anemia most recently nerve pain in all limbs and head. My Dad had pernicious anemia and his life span was shorted by it going undiagnosed for many many years. I was diagnosed with hashimoto's about 5 years ago and had fibroids until my recent hysterectomy. Any suggestions or guidance you can give me would be greatly appreciated. 🙂
Hi Tanya Get your urinary methylmalonic acid checked and re-check that B12 level away from B12.
Icelandic Sea Kelp (Iodine) you should be tsking on hashimoto's. Keto would help. "Neisha loves it" CZcams channel her husband is Dr. Berry both have channels- she has hashimoto's. Also potassium levels cream of Tartar is a natural choice for it
did your problem solve?
@@shubhanshujain9827 yes, it did. The best way to get Iodine is by way of a sea Kelp. It has the most iodine of any living plant in the world
@@hello_sunshine4875 thanks :) do you know any way to reduce high B12?
thanks for your great video, i have sibo and candida and dysbiosis battles. one note might be worth adding to the stack, along with my elevated b12, (1500pgml), my bilirubin has climbed steadily 5 points above ref. liver ultrasounds turned up nothing, i'll have repeat scans soon
did your problem get resolve?
@@shubhanshujain9827 strangely enough i've had recent bloodwork and bilirubin and b12 came bavk within range. i don't feel much better but i won't complain about stats normalising. as to what i did or changed: i've been on a steady regime targetting candida overgrowth in my gut. organic acid tests and stool tests revealed it reached drastic levels and left me rock bottom with pain, no energy, broken krebs cycles, muscle and connective tissue wasting and pain. i'm not finished yet but i've taken it away from rock bottom. i have a suspicion bilirubin is an adaptation; it's one of the body's natural antioxidents
@@johnline i am glad that your levels of decreased! but i think your inflammation is still high maybe due to factors other than candida like high cortisol from stress or from high blood sugar levels or overactive immune system due to autoimmunity or infections/cancer, as chronic inflammation can impair the cell membranes and weaken their B12 retention capability, also did you check on your liver and kidney function?
Hi doctor, my mother is taking medication of giant cell Arteritis. She is not taking any medication of b12. From last 3 months, she stopped taking medication. But still B12 is greater than 2000. Can you please guide? Due to GCA, her wbc looks always high but
Hi Krittika, sounds like there are a lot of moving parts so talk this through with your doctor. In this case I think the high B12 is a symptom of high inflammation and WBC count. Resolve that and the B12 likely goes into normal too.
Hello
I got my gall bladder removed before 14ys but i have my b12 level around 644.4 i some times take b12 and i have vit d deficiency so what i can doto decrease b12 levels?
Hi Manjot, this levels does not look high to me but could be different units. Each person is unique so there are many variables to consider I have a book coming out on everything related to B12 in a month or two. If you still need help at that time it will go into all the details on this topic.
Hello doc .I recently did a blood test and found out I have high b12 levels but low folic acids levels .Is there any way these are related ?
Folate and b12 are definitely related in how they work in the body. I don't think that one will cause the other however.
I’m a 23 year old woman. My kidney and liver function is well. But my b12 was 753pg/mL last year and this year it went up to 1597pg/mL. It hasn’t regularly been included in my blood work till more recently as I’ve been given a few iron infusions and my wbc count has been wavering between low and on the normal end of low with a high ESR. I don’t take any supplements except vitamin D. Can iron infusions raise B12 levels?
Not typically Bee.
How r u now plllllzzz pllllzzzzz reply facing same problem
I am having high vit. B12 as well .. since 2019 up to now .. I didn’t pay attention the first time I knew it because I felt perfectly well. But this 2022, my doctor just ordered me B12 for an overall lab check up. It makes me feel anxious that B12 remains high until now, >1000. I consulted a Hematologist, did blood works , kidney and liver fx, carcinoembyonic exam , cbc, whole abdominal ultrasound , pelvic ultrasound and even chest xray.. all are normal except for fatty liver. Hematologist told me nothing to be concerned. Some people are like that but it does not always mean that you have cancer or so. We have different body structures and genes. We are uniquely created. And those cancer pts does not always have a high B12. One of our doctor’s daughter also have high B12 and also did all the labs but is completely normal and okay. Just my two scents .. hope to lessen others anxiety 👌 by the way I have a very strong immune system I guest ?. Seldom to have flu or fever and even covid 😇 and take note,I’m always exposed to patients.
It's been really high for years in fact my neurologist got a copy of my blood test & called regarding this, it appears this time my folate is high also I'm Italian American & don't eat meat could it be that Mediterranean blood disorder where you have to much iron in your blood and they need to remove some once a month? He supposedly took a more sensitive B12 test 6mth back but I asked for the results & I keep getting the exact same test? I've had pancreatitis many times & due to the fact I don't have anyone to take me to the hospital for the temporary stent I just ride out the pain!
Sounds like you have a lot going on. Good luck to you
I tested my B12 is 927 and i am not taking any supplement exept iron because i have deffieciency and i have Sibo could it be the reason? I have MPV 12 and some blood cloting and some swelling under my eyes does any of these syptoms relate to some issue in the liver? What tests i should do?
Not sure 927 is all that high could be just good absorption. SIBO has been shown to increase b12
Thanks a lot for the video.
I went in for general blood work and tested high in B12, 941 pg/mL. My general doctor told me to stop taking a multivitamin I had been taking for a year that had very high levels of B12 in it. A week later, I test again and B12 levels were even higher, 1131 pg/mL. Any idea what's going on? I was expecting levels to drop after getting off the vitamin.
Can what you eat the night before a B12 test skew the results at all? I did eat a meal high in dairy the night before both tests.
It's probably just going to take longer than one week for the levels to come down. I don't think what you eat will greatly affect it unless it is like organ meat or something like that.
did your problem solve?
940 is not high! American lab references are a disgrace - based on sick people. You should get a test for methylmalonic acid and homocystine to get an accurate picture of your B12 levels. Serum B12 is useless.
How r u now plllllzzz pllllzzzzz reply facing same problem
Did they ever go down. Mine are still high after stopping a supplement for 9 months 1132.
I'm concerned now my level fluctuate from 4000-7000. Has been 6 yrs. I hope is the cell membrane..kidneys are ok , I've had GERD and IBS for 13 yrs. Recently gallstones and fattyliver. Hematogist said I'm ok no cancer, but she said it's not harmful and I will excrete it. How cam this be normal? Im havin a lot of digestive issues I can only eat some vegetables and some fruits plus other few things.
Hi Djjulie, it sounds like you have a lot going on. You might want to get a test for SIBO.
Hello, how are you doing? I have Similar results and symptoms as you
Hello Dr , I know you do not refer particularly about kids, but would still have a question. Could it be that the high B12 (1500) could come from a several repetitive infections, colds, otitis for 2.5 years old kid. He is having as well erythrocytes at about 5.7 Mio and he presented lymph nodes around neck? Thank you.
Hi Florian, Children have different reference ranges for many things than adults, so I am not sure on that level. Because of the immune involvement in infections, multiple infections could theoretically cause elevated b12. It would have to be going on for a while. Ongoing swollen lymph nodes should be followed by a doctor.
Hello Dr. Very much appreciated your feedback and your passion to help people by providing this information. We have been repeating the B12 test to another laboratory and observed it's within the given limits by the laboratory(870), but we will keep an eye on it and repeat it regularly.
Thank you very much.
Great good idea.
I've had three b12 tests over a period of 5 months and they all came back at >1500 ng/L, normal range is 150-750 (same as pg/ml, I believe). I also recently did a holotranscobalamin test, which came back as 150, normal lab values are 37-188. What could be the cause of High total b12 serum, with a normal/high holoTC result? My other blood tests, including liver panel are normal, except ferritin, which is low. I am not supplementing, and even tried eliminating all b12 from my diet for 2 months with no effect. I appreciate your time if you read and answer. thank you.
Hi DudetChic, I can't give you specific advise but a hematologist would be the best option given that it is so high. They will do more in depth testing on white blood cells. It might be best to do this first.
did your problem solve?
@@shubhanshujain9827 no, my b12 is still high with no reasoning behind it.
@@DudetChic i believe your inflammation is high maybe due to factors like high cortisol from stress or from high blood sugar levels or overactive immune system due to autoimmunity or infections/cancer, as chronic inflammation can impair the cell membranes and weaken their B12 retention capability, also did you check on your liver and kidney function?
also high Eosinophil levels on a blood test can confirm your high inflammation.
@@shubhanshujain9827 my eosinophil levels are normal. My kidney and liver function are also normal. My blood sugar levels are normal. Thank you for the extra information though 🙂
Hello Doctor ,
My B12 came back 776 pmol/L and I am soooo worried after Googling . All I can think about is "cancer". All my blood work is normal . Liver and kidneys blood work looks normal. I am 33 years old female. I do drink daily whey isolate powder from Costco . I do not supplement .
What do you think could be the cause ? Thank you so much for your show ! I subscribed and love all your other topics as well !!
Pusha I don't use those units but I don't think that number is high?The units we use here are pg/ml.
How r u now plllllzzz pllllzzzzz reply facing same problem
I had increased b12 levels after having the flu (1000)Could that be a correlation?
@@idabullgrn5322I just tested high for b12 after having a respiratory virus wonder if it’s related
I have been tested several times and each time my b12 blood level is flagged as high. Im wondering, is anyone here having symptoms that you might suspect is being caused by your high B12 ? If so what symptoms are you having ? I am having tingling, numbing, coldness and stabbing sensations in my feet. I have had several tests done to rule out nerve damage and blood circulation issues but all came back normal. Basically Im trying to find out if there is any link between my symptoms and high B12 levels. Thanks.
Hi Edward, I think a better way to ask this question is when you have high B12, do you have symptoms. If you have symptoms, the second question is, do those symptoms correspond to a problem that commonly causes high B12. For instance, one cause of high B12 is making too much binding protein (TCN-3) this can lead to low intracellular b12. Low intracellular B12 can cause all the same things as low B12 in general. High b12 and your symptoms are associated but the high B12 is not the cause of the symptoms. Hopefully that makes sense.
Same symptoms
I have these symptoms as well
Hey Edward ,,, how are you doing now ... Any updates ?!
Gotta say this video lost me. I came here because I recently had some bloodwork and when it came back, the nurse called and wanted to know if I took b12. I told her no and she said it was ok. I asked if it was high and she said it was on the high end of normal. This concerns me because I have chronic gastritis and most with this have low b12. I don't eat healthy at all and actually don't eat much. I also don't take any supplements with b12. With it on the high end of normal and given my circumstances, should I be concerned?
Hi Miranda, No it does not sound like it.
Hi doc, my B12 levels are 974 and I’ve been complaining about burning in my flank and abdomen area. The sensation is off & on. I read that elevated levels could also be caused by gut bacteria. Do you have any knowledge on complaints of burning in stomach and flank? I am having MRI done soon of brain, cranial and cervical/thoracic.
Hi Diamond Bush, there are several case reports of elevated B12 being caused but gut bacteria. It makes logical sense as well. There is no one test that can you tell you this 100% certainty but several that can clue you in (OAT, SIBO etc)
did your problem solve?
hello,my mom 65 years old came with a high b12 result knowing that all her labs came perfect the CBCD and the SGOT and SGPT with a creatinine level of 1.25 and BUN of 49.Should i worry about the result ?
forgot to mention that she's not on b 12 supplements and the result came higher than 2000
Hi Alaa, 2000 is pretty high make sure she is not taking it in any drinks or multivitamin. If not then you should track it down.
I’ve had I onset of mild achy, pin pricking sensations intermittently over past year and a half. Blood cell count was normal but b12 around 1300, and several months later tested around 1400. Before both tests I was taking a supplemant that had biotin and also protein powder which I don’t think has b12, both of which I have since stopped. I have an appointment with a hemotologist soon. Are there certain things I should make sure I ask? Abdominal ultrasound, brain/Cervical and thoracic MRI Normal
@iphyth
Hi; I’m wondering if any doctor ever resolved or explained any correlation between elevated high B-12 levels and neurological symptoms. (tingling/pins and needles sensations). I’ve ready many comments to this video, including yours detailing these symptoms. I’m struggling with something similar.
@@Alex-ml2hb hi, no they haven’t. I saw a hematologist oncologist and had a few rounds of bloodwork. Honestly nobody seems to be able to give me any information or useful feedback regarding these symptoms. Neurologist brushed it off too.
If you do get any useful info just reply to this comment, might help me as well
@@iphyth thank you for your response/sharing. I’m going to see a neurologist soon. I’ll share any information here! Thanks again.
I am an 18 yo women and my b12 is at 679pmol/L it says the reference levels are between 150-599. I have low iron could this contribute to my high levels?
Not likely.
Seems a lot of females are here with high b12 and long term gastro issues. I am one too. What test do I need to find out if I am actually absorbing b12? My CRP levels are low. White blood cell count 3.1 (low). Stopped high dose multi vits 9 months ago and still have b12 over 1500. Docs don’t seem bothered about the b12 at all. I have chronic fatigue. Eat mostly healthy vegan diet. I’m dying without my supplements which I only stopped to see what my baseline is. Can I just carry on taking them and stop worrying?
I cannot give you an answer to this without a lot more information. As for testing MMA and homocysteine. check out my book "don't B12 deficient" if you want a better understanding of this. New video coming out in a few weeks on "high b12 as well"
Hi Dr my b12 1807 and ferritin 255. My iron is normal as is liver and diabetes. Do you have any idea what may cause this? Thanks
Check out the other videos and the link in the comments for book. There are several answers to the cause there.
My ferritin is 11 only. What you eat to increase ferritin please?
My Vitamin B12 Level was tested to be ">2000" with normal range between "213 - 816" for the past 2 months now (I was tested two months ago and again just a few days ago). I don't take any supplementation or have any foods with really any B12 in them at all. My ALT/SGPT was "73" (about 2 months ago) with normal range between "0-55 U/L" and when I tested again a few days ago my AST-SGOT was 36 with normal range between "5-34" and my ALT/SGPT was "69" with normal range between "0-55". It's interesting my AST-SGOT was "33" 2 months ago and is now higher 2 months later (up to 36). I haven't drank or had anything with B12 in it for about 2 months now. Any ideas on what could be happening?
Hi Fahim Anwar, the B12 does not cause high liver enzymes but high liver enzymes could be the cause of high B12. I doubt yours are high enough to cause this but it could (optimal is less than 25 so even at 36 it is a little high). It's hard to say if they are connected without having the full picture. You probably need to keep testing and possibly get a deeper look at the liver.
did your problem solve?
@@swintegrative they've ran a lot of liver tests and done other blood work but haven't found the cause yet. Any ideas on what could be the case? No hepatitis or anything on the liver. Or could I have naturally high levels of B12?
@@shubhanshujain9827 sadly no
@@fahimanwar94 do you feel energetic and healthy otherwise? too much blood sugar can create inflammation as well, which could perhaps damage the cell membranes.
Thank you for your informative video. My mom's b12 came twice high: 1440+ over a period of 2 months. She does not take any supplements. She is on warfarin, plavix and betaloc medications and had an aortic valve replacement a year ago. Doctors could not really figure out the resson why B12 level was high. I would be grateful if you give your insight into this issue. Thank you in advance
Hi Lynx, I have posted several videos on this and wrote in a lot of detail about this in my book. too much to cover in a response like this.
Hello, I have Mthfr 677tt. I was supplementing with methylfolate & methyl B12 for a few years. B12 blood serum lab was 1200 in July. I cut off the methyl B12 in August. Retested in October: B12 over 1900. I have history of hashinotos. Any ideas of what I should do next?
That does seem odd. make sure it is not in anything else you are taking. If you are worried about it being high then retest because the b12 is stored in body specifically in liver. Even though you stopped it, the b12 could be released from storage in the liver (theory). I would retest before getting too concerned.
Nurse for nearly 40 years long, long complicated history congenital heart disease JRA which appear to go into remission with my first pregnancy but appear to come back but was diagnosed with fibromyalgia. Now with type 2 diabetes, hashimoto's, and autoimmunity of a questionable nature . My total compliment is quite high but c3 and c4 are normal . In the last year underwent full genetic testing which found the source of my endocardial cushion defect and of my long-term open severe allergies both to foods, medications, chemicals and environmental sources. I suffered a heart attack in 2011 not diabetic related and cardiac or diabetes related and catheterization showed totally clear coronary arteries except for the LED which is where the clot was. Initially thought to be from my MVR mechanical mitral, which, on catheterization was clean and functioning as the day was put in over 10 years prior. (I am now 22 years on my original St Jude, we joke because I hold the record at Penn medicine for longest time on the original valve without a redo LOL) it was determined that because we were trying to switch from Coumadin to one of the newer drugs I threw a clock from my horrible varicose veins in my right leg. BUT immediately after the heart attack I began having worsening of my muscle function in my proximal large muscles particularly upper arms thighs and hip/girdle. A roller skater for years since childhood, my legs would now no longer hold me up for certain maneuvers and the cramping and pain was horrendous. Had a full genetic muscular workout and essentially they did not find anything genetic. Several years ago maybe five or so my B12 was low and my primary was thinking my muscle issues were from low B12 because in addition I had some neurologic things going on. We tried po supplementation with very little results. She wanted me to start taking shots and I said that there's something wrong with this and I really felt like they were trying to put a Band-Aid over this while what was really causing it would be raging on/getting worse. I realized I had switched to mainly chicken and fish because doctor says got to reduce your amount of red meat well that's precisely when my B12 started to go low. So I started eating organic meat from the Amish market boom couple months B12 is fine period stays fine for quite a while then all of a sudden when the compliment went out of whack I had to go on steroids for a while and wham bam the B12 starts going up. Now I have been off all steroids for about 6 months now but the B12 is climbing I just had one drawn Wednesday and it was over 1400 I will edit when I can go to quest and get the result now we understand that autoimmunity normally goes along with low complement, high compliment? And also a sky high B12. I have for quite some time had the nephronic syndrome, you know microalbuminuria and such but it's been pretty under control seems to be a little linear with how well I control my sugar. Right now I am totally normal at 0.2 random urine microaluminum. See a neurologist regularly suspected this is lupus however I have things that overlap with rheumatoid and I get skin rashes so now she is saying which I agreed with that this sounds like mixed connective tissue disease sometimes my lupus will be elevated other times not sometimes the rheumatoid will be elevated and other times not. I see my primary on Monday and I'm not sure which tree to ask her to bark up next period And I don't know what is the best way to approach this high B12 level. I did read however that metabolic syndrome which is where all this mess began before the diabetes may cause the high B12 and right now my cholesterol triglycerides are high but I cannot take statins with these muscle issues and trust me I've been on three different ones and could not get out of bed it made my muscles so bad. Oh latest A1C 5.7 3 months ago 5.8 before that I was a little up at about 6.6 but I knew what that was about and fixed it. I'm trying to wrap my brain around the bigger picture here like how does this high B12 relate to everything else. I also have many other physical issues, trigeminal neuralgia on the left, familial hemiplegic migraine, asthma just to name a few.
@@elizabethclarkson979 how are you now? 🙏🤗
Hey did you ever figure this out? In the same boat 😩
I have primary biliary cholangitis and high b12 and starting to have kidney issues but have not been to a urologist
Hi Jessica, that may be related since there is more inflammation in your liver.
Hi doc can you have elevated b12 from eating excess sea foods
Hi The Urban Pandit, I don't think do.
@@swintegrative
How about eating high protein meals with 1200-1300 b12 le els?
Hi Dr, my b12 is 1546 and I was sick with a cold then the next day after the blood test I was positive with Covid, could be the case of a higher b12? Please reply.
yes possibly.
Hello Dr, thanks for the very informative vedio. I am 57, my B12 level is 932 (the range is 138-652), my WBC is a little low (3.3, range should be 4-11), my LDL is a little high 3.91, is there anything I should be converned? What kind tests should I do to rule out any serious issues? Before the blood test, I was taking Amoxicillin for my tooth infection, is it possible the high B12 level could be related to my tooth infection?
Did you ever find out the cause?
Did you find out?
Hi can very high dose of biotin effect the b12 result and make it high?
Hi Naomi, I don't think so. Biotin can skew many blood tested though.
I have a 1216 ng/l b12 level. All other tests are normal and no symptoms. Don’t supplement directly but to take a protein shake occasionally (once or twice a week) with 400% recommended vit d levels. Should
I go ahead and do and mma test and active b12, do you think it can be serious wi Tb no other symptoms?
Sorry I meant to write vit b12 levels not bit d. But I heard our body flushed out extra vitamins?
It might be from my protein shakes because when I drink them my peengoes fluorescent yellow which I hear is flushing of excess b vitamins. My pee is normal otherwise
Hi Jacq Al, maybe you should re-test with no protein shake for 3 days.
b vitamins are water soluble but that does not mean you will urinate them all out. Some (like B12) are stored. High B12 levels are not a problem in and of themself but what it might say about your health.
did your problem solve?
ok so i had mild alcohol poisoning which prompted me to get an IV with a free B12 shot added to it, and then i had my blood drawn a week later … my b12 number is 1341 which is showing as higher than normal. do you think the shot has anything to do with the elevated numbers?
more than likely it is from the shot/IV
@@swintegrative i watched the other b12 videos you have on your channel, i was put to ease after what you said about the b12 shots .. thank you so much for the comment back!
My last few b12 test have all come back between 1750-2000, I also have been having what I can only describe as a feeling of nerve damage in my feet and lower limbs as well as my finger tips for the past year. I have went to a neurologist who told me nothing was wrong, and have recently had a skin biopsy to test my nerve endings.. I am awaiting the results. Could kidney or liver issues be causing this?
Liver and kidney issues can cause high B12 but not the other things.
What did you ever find out?
Been having neurological and cognitive issues for 3 years. Now my b12 is high. All pther tests normal. Awaiting evaluatipn
I am having similar symptoms with high b12 test. Did you figure out cause?
Hi; I’m wondering if any doctor ever resolved or explained any correlation between elevated high B-12 levels and neurological symptoms. (tingling/pins and needles sensations). I’ve ready many comments to this video, including yours detailing these symptoms. I’m struggling with something similar.
I’ve had high b12 last few blood tests. Followed up with hematologist/oncologist who seemed to rule out blood cancers. B12 over 2000, and positive ana screen. I’ve been getting pains in arms, legs as well as burning in my mid back which I was told by gastro is gerd.Hematologist said he can’t figure it out but want too concerned. not sure who to see at this point, been very frustrating. Also my calcium was elevated but PTH normal
Check out my book Don’t B12 deficient there are specific things on high b12 in there
Are you taking a Statin or a PCSK9 inhibitor like Repatha? Maybe that is causing your pain.
@@rosepavlas6491 thanks for the reply, nope no meds. Nobody can seem to figure it out. Really frustrating. On one sense there’s relief the hemotolgist didn’t find anything serious but i feel like a dog chasing it’s tale. I think it may be gut related bc at one point I was taking omeprazole which made the pains worse
My B12 levels was 1,219 pg/mL.
did your problem solve?
How r u now plllllzzz pllllzzzzz reply facing same problem
If I drank an energy drink the night before my blood test could that elevate B 12. My level was 1400. Normally it’s between 400-500. I have been supplementing with (NO) nitric oxide as well. Could that elevate it?
Yes I would think so somewhat
@@swintegrative hope so!!!!
My 18 month old has high B12 and she had teardrop cells. With other symptoms like reoccurring fevers for 15 days now. Reduce energy. Reduce balance. She doesn't eat much. And takes no supplements. Had a normal WBC and RBC and normal platelets. My gut tell me something is wrong. That's why I asked the doctor for blood work. It's currently Friday so I can't talk to PCP till Monday. She was also a premature baby at 30 weeks. And has BPD so she is on an inhaler. She struggles to gain weight due to not eating as well. Has history of UTI that lead to blood infection requiring IV antibiotics. Everything I'm researching is worrying me. I hope my doctor looks into it more. If not I'm gonna call a pediatric hematologist. Any input would be great TIA.
How can decrease
Hi Ranjana, There are many ways but each person will be unique. Have you seen the video I did on how to approach this?
Hi Doc, I had 868 pg/ml ... I googled and read something with "you get cancer for sure". I am a bit scared now. I dont have any health issues, expect my ggt is high from time to time up to 220. but I was in several hospitals and they never found anything.
That is a very high GGT and likely the source of your high B12 (although 868 is not that high). Any ggt above 25 is high. common causes are alcohol and Tylenol.
@@swintegrative thanks. I do not consume any alcohol or tylenol, but I do take antidepressants. my ggt is not always that high, it depends on my diet. during my visits in hospitals, my liver was examined with everyhing possible, but they never found anything.
That's good that they did not find anything but if you are having consistently elevated liver enzymes (above 25), you should look deeper. It may be a separate issue from the B12, but they could be connected. Watch all 3 of the high b12 videos for some additional ideas.
@@swintegrative thank you doc!
How r u now plllllzzz pllllzzzzz reply facing same problem
Hey Doctor, my last 2 B12 tests have been high. (First 1080, second 1200). All of my hematology came back normal and my liver/kidney blood work was perfect as well. I do take a multivitamin every day that contains 6mcg. I don’t have any symptoms and wouldn’t have known if it wasn’t for the blood work. Is this a cause for concern or can the multivitamin be causing a high B12? I do take Plant protein but no b12 nutrition fact was on the label. I am 21 years old, weight lift and healthy.
Brother how are you facing same problem
@@sumeenahmed5099 Same
My B12 is 1500. I've been sick since around oct. At first they thought it was GI related because I throw up, stomach hurts when I do eat, burping, dizziness that will go down my arms in to my hands. Very fatigued. I have lost 35-40 pounds not trying and I don't take any supplements. It's been a long rode. I've done all the GI tests. Entriconologist found the high B12 but no plan yet. Any suggestions oh and I'm 43 yrs old female
Hi Jennifer, each person is unique so that makes it hard to know what to do for you. There are some GI situations (bacterial and fungal overgrowth syndromes) that can cause high B12, so I would focus more on this angle. I have a book coming out on everything related to B12 in a month or two. If you still need help at that time, it will go into all the details on this topic.
did your problem solve?
How are you now? Mine was 1927. Extremely tired, cold, fingers numb very blurry vision.
@@nikkisolis5304 and mine 1150. Years ago was 1000.wonder Why Dr didn't say anything about it
@@nikkisolis5304hey lovely did you ever get to the bottom of this? I'm the same.
If your b12 is high because of supplements, would it eventually decrease after stop taking them? Also does vitamin c helps make it hard to intake of b12?
Yes it would. Vitamin c does not affect b12 absorption as far as I know.
@@swintegrative thank you so much!
@@swintegrative so does this I also have to stop eating salmon?
Why is it everywhere on the net saying you pee out b12? It really doesn’t seem to be the case 🤔
Can green juicing cause your B12 to go high if you're taking vitamins and minerals
Not clear on your question… juicing would not but taking b vitamins would.
My b12 is 2000 and has been around this figure for some time. My GP keeps signing this off as satisfactory so I didn’t even know it was this raised, previously it was around 900 or so. I had low folate and supplemented for 4 months getting it up to 20 but within 2 months it is down to 8 again. My esr is also 115 and has been above 100 for a year now. Had testing for autoimmune diseases but nothing coming out. Seeing a rheumatologist privately as my GP thought it may have been autoimmune. Not sure where to go now, rheumy is ordering CT scan of chest, abdomen and pelvis… possibly looking for tumour. GP has made me feel like a mad woman wanting to get to the bottom of the b12 and esr, just keep brushing over it.
Hey how are you doing now ... What happened
@@Vivekdevopsall tests have been clear. Esr up again now at 122. Have been referred for a lip biopsy for sjogrens and a full body pet scan. I dont really have symptoms, esr was done last year for chronic constipation and I was diagnosed with IBS-C, referred onto rheum to get to the bottom of esr but she is grasping at serronegative sjogrens, im not so sure.
Can SIBO be a cause of high b12?
Yes I think it can.
can protein bars have high b12?
some do you have to look at the ingredients.
I just had a lot of blood test done. Everything was perfect except B12. My liver function and liver enzymes great, no sign of fatty liver. I don’t drink alcohol. I don’t take any B12 supplement or drink any powered shakes. Not on any meds. I take only Vit D3 drops and CBD oil. I do eat a lot of red meat and cheese. My B12 is 1251. Dr said it’s not from my liver because my test results show it’s perfect. Should be I worried about my level? I do have a couple fatty cyst. All my cancer markers on the blood test were all fine. Tcell, white and red blood cells are great. My kidney function showed perfect also. Inflammation levels all great but 1 was just slightly raised. I have fibro, RA, celiac disease and chronic fatigue but my inflammation has come WAY down to basically normal.
Hi Teresa, it does not sound like it is something you should worry too much about and just follow for now. If it continues to be high then you might want to investigate further.
I hope you’re doing well now! Just read your comment. Going thru the same thing now & just trying to learn from others. Thank you for sharing.
Teresa - any update?
Hello. I live in Victoria, Australia and received my 2nd blood test results yesterday. My doctor wanted to check my B12 levels, as my first results showed enlarged red blood cells. My B12 levels are 1300. I have never had low or elevated levels before, so have never taken supplements. I also do not drink. I have ADHD, so I have a lot of restless energy and difficulty focusing anyway. However, I have noticed that it’s getting worse, as is my insomnia. Could my elevated B12 be causing the increase in these symptoms? I am extremely anxious just thinking about this.
Hi Avi, I don't think the elevated B12 levels would cause restlessness and anxiety. These symptoms can happen with supplementation of B12 but it is rare. More likely is that the cause of elevated B12 is causing these symptoms or there is no association in the B12 and your symptoms.
did your problem solve?
what about aktive B12, MMA, is it elevated too?
Is it possible that the covid vaccinations can cause high b12 please I have had many issues since having these vaccines that I never had before including high b12 thank you Dr 💜
Because vaccinations in general cause an immune response, there is inflammation. Some inflammatory and immune responses can cause this type of thing. However it will be temporary
@@swintegrative thank you 💜
My b12 is 864 pg/ml but lab given normal value is upto 771pg/ml...864 is normal or high ?
That does not seem very high.
Brother how are you facing same problem
My vitamin B12 level is 960 pg. I live vegan and don't take any supplements. But it is added in small amounts in some of the foods I eat. In total, I must have consumed 40μg every day for at least a year. Is 960 pg actually too high and is it really just a result of the nutritional supplement or should I have further tests done? Maybe someone here has the same experience. Thanks for the Videos!
Seems normal
@@swintegrative thank you 😊
How does this elevation happen & what can we do? I have been healthy & what would be cause?
Hi Kristen, did you see this video? czcams.com/video/ly9_rDnwcJ8/video.html
Hello, accidentally I have discovered that my B12 is 1050 pg/ml. We checked full blood account twice and everything there is in order. I have also undergone physical examination and nothing wrong was found. I have not consumed any supplements. And I was asked to double check B12 again in a couple of months. Should I be concerned? I am reading a lot in Google and nearly drove myself to madness 😳
Hi Thea, There is nothing concerning about this level of vitamin B12. The reference ranges may vary slightly by region. The range here in AZ is 1245 pg/ml for instance.
@@swintegrative thanks a lot for your response. The lab reference range here was 200 - 866 pg/ml, I am from Georgia, the country. Currently I am waiting for homocysteine test result, holo TC being unavailable unfortunately. But as I guessed you still think 1050 is OK for
P.S. In March I finished getting multivitamin which I had consumed for two months containing B12.
I do think the 1050 is ok but it is also good to get the other tests done and re-check the b12 in another month.
@@swintegrative Many thanks for your responses and videos, they were informative and really helpful. I will let you know the outcome.
My last test over a month ago showed 1856 pg/ml. My doctor didn't mention this at all, but mentioned I have high ALP and GGT levels (ALP 175 UI/L: 16% liver fraction, 72% bone, 12% intestinal) and GGT 226 IU/L
I got diagnosed with Crohn's recently and my GI thinks I have primary sclerosis cholangitis I have to get tested for that. With some things that I've been told, it doesn't make sense to me. The high ALP if I understand correctly is coming from the bone? My vitamin D3 was lower, 20.8, but my b12 is high which I've been reading liver is one of the big concerns. What could be going on or what tests should I ask for?
I would every now and then take a multivitamin powder with 50mcg or 833% daily value. But like I said I wouldn't take it religiously, more like 1 or 2 a week, mainly cus I'd forget. It wasn't a consistent thing. That's the only source of b12 I could think I was getting. Im just getting overwhelmed, for the third time already I've had to switch doctors cus they leave to another location. Maybe for a higher position, more paying, can't blame them but it is a struglly having to start fresh with another doctor who already has their load and I don't feel like I'm being listened to. And now I'm here venting on your channel lol sorry. Anyways thanks for the video and Info, if definitely makes things easier on looking where to start to read up
Hi APM, This is a good question and I can see why you might be confused. Alkaline phosphatase is an enzyme found in many tissues including liver, bone, intestines, etc. When it is high and other liver enzymes (like GGT) are high, it suggests the problem is the liver. The high B12 is probably coming from lack of liver absorption and storage and / or release of the B12 from the liver's storage. The absolute answer on cause would really depend on how long it has been like this and some other lab tests. For now it seems like it is best to stick with the tests the GI doctors is recommending. Hope that helps, good luck!
I contacted a professor in Strasbourg Emannuel Andres, he suggested doing this:
You have to exclude several abnormalities, disorders or diseases:
- Renal failure (not the case in view of your results)
- Liver disease (not the case)
- Hematological disease
You have to realize several additional analysis
- Found monoclonal gammopathy (blood sample)
- Search antinuclear antibodies (blood sample)
- Dose holotranscobalamin and total homocysteine (blood sample)
- Abdominal liver and kidney TDM
did your problem solve?
Tudca is fantastic for lowering liver enzymes
Hi doctor i like 👍 your videos thank you! I have tested b12 2000 my liver is a little inflamed, I do have hypothyroidism! My colesterol a little high as well I was eating a lot of eggs , chicken , sometimes red meat , lots of pecans , salmon , do you think all of the above ☝️ has something to be the cause of high levels of b12 ?? No b12 supplementation !! About 8 months ago I had covid ! My first test was done on January and second test was made on July 2022 and both came at 2000b12
Liver maybe, diet not likely.
@@swintegrative thank you doctor! How long do I have to wait to check b12 again? Last test was on July 2022!
Hello. My vitamin D level is 8.71 and I saw on the internet that normal vitamin D level is 25-80. My vitamin B12 level is 1307 and the range from the lab is 211-946. Should I be concerned?
It sounds like you just need to supplement with vitamin D.
I used to supplement with biotin 2 months ago. Yesterday I got a blood test and my b12 was elevated. Is it possible that my b12 level is elevated because the biotin I used to take a few months ago?
No I don't think Biotin would cause a high B12 level but many hair and nail supplement with Biotin have B12 in them. Also Biotin can skew lab test results but if you have not taken it for a few weeks it would not interfere.
Hello hope you are well please i wanna share with you my blood test results if i can send it to you somewhere messenger Instagram anywhere giving you details as well, would like to hear your advice please doctor. thank you
Hi Nahla, I am happy to help. if you want me to analyze your blood results you can reach out via email DrT@swintegrativemedicine.com. There typically is a fee for this.
What if level goes down in year 2000 to 1500.
That is a good sign (if you have not been taking B12 for 3-4 yrs). If you have been taking B12 it does not mean much (other than you levels are coming down).
@@swintegrative what if platelets elevated, what causes metallic taste , had covid just got taste n smell back and within week now this.
did your problem solve?
Mine is 1047 is it high?What shall I do thank you
Hi, Did you see this video czcams.com/video/ly9_rDnwcJ8/video.html
Same problem how r u now plllllzzz pllllzzzzz reply
mine is 2000
That's pretty high Mollie. Do you take B12?
Mine just says ">2000" so I'm not really sure how high it is. I don't take b12 supplements.
Hello doctor
I m from india ,i m 32 years old new mother, i m experiencing hives all over my body, so i did full body tests , where my b12 is 949 , i have vitamin d deficiency also and my tsh levels are also high (5. 5 ) my s g o t liver is also raised .. do i need to worry ,. I m epileptic and having levipil 250 thrise a day .i am tensed since i read that elevated b12 is linked to to lukimiya or cancer.. plz help me out ... Where can i sent you my reports... reply soon 🙏 waiting.....
Hi Shivani, with elevated liver enzymes and hives, you should be looking at resolving these before worrying about blood cancers. While high b12 can be a signal that there is increased production of certain white blood cells it does not mean you have a blood cancer. So focus on hives and liver first then re-check levels.
Sister how r u now plllllzzz pllllzzzzz reply facing same problem
@@sumeenahmed5099 i m fine now brother ..
@@lovemomvlogs3547 thank you for your reply
Just to be clear; are we talking about high levels of what is referred to as 'active' B12..?
If so, can high levels of active B12 be caused by having a fatty liver..?
The first thing that comes up when I Google it is that B12 levels are LOWER in people with NAFLD.
No not active, serum B12. Fatty liver is not high on the list of causes but if your liver enzymes are elevated, it may be playing a role.
@@swintegrative OK, thanks.
Would high levels of active B12 be considered worse / more concerning than high serum levels..?
I've never taken B12 a supplement.
@@kye903 not sure what is meant by active b12. I you mean unbound to transcobalamin... I have never heard of such a test. IN any case it would not be more or less concerning. It would be more telling where the problem is... deficiency in transcobalamin.
6 months ago and last month, my blood tests showed >2,000. Prior to that my levels were normal. No supplementation.
Hi Pam if u want an in-depth approach to understanding what causes it or lowering it, check out my book Don’t B Deficient.
B12 is elevated when B1 is low.
Hi Karen Young what makes you say that?
@@swintegrative B1 uses up B12, if deficient the methylation process hampers and B12 pools. I have beriberi and pernicious anemia.
Thanks for sharing. It's true that B1 is needed for some post-methylation biochemical processes. Im not sure if slowing the B1 dependent enzymes will cause B12 to build up, however. If this is the case then it would be expected for many other enzymes as well. It sounds like this happened to you though, is that right?
@@swintegrative Folate and B12 are known to be elevated when B1 is deficient. Since the transketolase lab is unavailable I relied on the B12/folate panel before I ended up getting B12 pernicious anemia. I worked with a luminary biochemist that was one of the first doctors to treat
Methylation. Dr. Derrick Lonsdale had cited this explanation in his thiamine research and treatment.
Serum B12 testing is not an accurate way to measure B12 levels in the body. The better test is methylmalonic acid and homocystine.
Thanks Hikari 8, it's true these are good tests. High MMA may not show up until b12 deficiency has been present for some time. Other things can mask homocysteine. Bottom line... you need all the test.