Mirum PFIC Series: Cedar

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Progressive Familial Intrahepatic Cholestasis (PFIC) is a rare genetic condition that causes progressive liver disease, often leading to liver failure and requiring a liver transplant. In patients with PFIC, liver cells are less able to eliminate bile, leading to a buildup of bile which causes itching so severe and constant that it becomes a major life disruption for the patients and their families. Itching typically begins in infancy along with other symptoms including jaundice, failure to grow at the expected rate (failure to thrive), and increasingly severe liver disease.