The Genes We Lost Along the Way

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  • čas přidán 29. 05. 2024
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    Our DNA holds thousands of dead genes and we’ve only just begun to unravel their stories. But one thing is already clear: we’re not just defined by the genes that we’ve gained over the course of our evolution, but also by the genes that we’ve lost along the way.
    Thanks to these illustrators for their wonderful hominin illustrations featured throughout this episode!
    Julio Lacerda: / juliotheartist
    Fabrizio de Rossi: / artoffabricious
    Jack Byrley: / bedupolker
    This video features this Paleogeographic Map: Scotese, C.R., 2019. Plate Tectonics, Paleogeography, and Ice Ages, CZcams video: • Scotese Plate Tectonic... ​.
    Produced in collaboration with PBS Digital Studios: / pbsdigitalstudios
    Super special thanks to the following Patreon patrons for helping make Eons possible:
    Mark Talbott-Williams, Elizabeth Baker, Jake Myers, BuddyTheOtter, The Dec of Cards, Eddy, Andrii Makukha, Angel Alchin, Julie Cohen, salsablog.band, Michael Hof, simon read, Sean C. Kennedy, Eric Roberto Rodriguez, Hillary Ryde-Collins, Facts Dinosaurs, Frida, YaBoiSam36, Matthew Donnelly, Yu Mei, Colleen Troussel, Dan Ritter, faxo, Jayme Coyle, Gary Walker, Amanda Straw, Stephanie Tan, Laura Sanborn, Minyuan Li, Ben Cooper, Leonid, Robert Noah, Matt Parker, Heathe Kyle Yeakley, Jerrit Erickson, Anton Bryl, MissyElliottSmith, Zachary Spencer, Stefan Weber, Andrey, Ilya Murashov, Merri Snaidman, Gabriel Cortez, Marcus Lejon, Robert Arévalo, Todd Dittman, Betsy Radley, Anthony Callaghan, Philip Slingerland, John Vanek, Eric Vonk, Henrik Peteri, Jon Monteiro, James Bording, Miles Chaston, Michael McClellan, Jeff Graham, Maria Humphrey, Daisuke Goto, Gregory Kintz, Chandler Bass, Tsee Lee, Robert Hill
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    References: docs.google.com/document/d/1c...
  • Věda a technologie

Komentáře • 3,6K

  • @theoveranalist6381
    @theoveranalist6381 Před 3 lety +10108

    Lemurs watching us give up the ability to synthesize vitamin C and then catch the common cold: "Pathetic."

    • @matthewcahill4475
      @matthewcahill4475 Před 3 lety +352

      The cure to covid, get gulop back

    • @ColonelFredPuntridge
      @ColonelFredPuntridge Před 3 lety +313

      Actually, I recall reading that there is a biochemical benefit we get from NOT having the enzyme which would catalyze the final step in synthesis of vitamin C. I can't remember where I read this or what the benefit is, and in any case it's technical and wouldn't mean anything to most viewers, but the enzyme which used to catalyze the final reaction in the multi-step biosynthesis of vitamin-C, which lemurs still have, also catalyzes another reaction which is in some way a little bit harmful. So IF a species or population has lots of vitamin C in its diet, and doesn't need to make its own vitamin C, then it's BETTER for that species or popuation to have that final enzyme deactivated by a mutation. So nature selects FOR that mutation, so long as the species or population can get vitamin C from its food. And THAT is why our mutant gene which makes us unable to make our own vitamin C has survived and persisted, even though we have to drink orange juice now.
      So maybe we get the last laugh on the lemurs. They are paying a price for keeping their ability to make their own vitamin C.

    • @casteretpollux
      @casteretpollux Před 3 lety +29

      Chimpanzees used to have handsike ours but evolved to become better tree climbers.

    • @josephdahdouh2725
      @josephdahdouh2725 Před 3 lety +53

      @@ColonelFredPuntridge Well maybe for other animals keeping that gene is quite beneficial for them. Hence why it remained present for them. But for us the story is different i guess.

    • @arnowisp6244
      @arnowisp6244 Před 3 lety +13

      @@josephdahdouh2725 Cost and benefits.

  • @cancerino666
    @cancerino666 Před 3 lety +7539

    Gene dies in the Palocene: "I'm not required"
    Sailors in the 15th century with scurvy: "I'm sorry what?"

    • @truthinaction0000
      @truthinaction0000 Před 3 lety +305

      Old world ocean travel got no respect on this discovery.

    • @im70water93
      @im70water93 Před 3 lety +48

      Damnnn, that's true

    • @MissGlassButterfly
      @MissGlassButterfly Před 3 lety +161

      Yeah you’d think if it’s a Fossil in our genes it would be able to Slowly be reactivated over generations as the issue it fixes becomes more apparent again.

    • @laurahall5218
      @laurahall5218 Před 3 lety +238

      Likely there's a limit to how much can be current and active on a chromosome. Vitamin c got bumped so we could have something better, like standing upright or iTunes.

    • @theunslickbiscuit611
      @theunslickbiscuit611 Před 3 lety +98

      @@laurahall5218 iTunes 😭😭

  • @Denny_Boi
    @Denny_Boi Před 3 lety +1364

    RIP Gulop. You would've made the age of exploration a bit more manageable.

  • @saltymcsaltface
    @saltymcsaltface Před 2 lety +935

    Best narrator on the show. Her tone, speed and pitch is perfect which makes it easy to follow the information she is presenting .

    • @js5787
      @js5787 Před 2 lety +39

      Agree! She is one of the few that actually doesn't give me a headache, and also doesn't make dumb faces and doesn't talk fast.

    • @luotuoshangdui
      @luotuoshangdui Před 2 lety +9

      Her accent seems to have the PIN-PEN merger, which makes her English a little difficult to understand for non-natives like me.

    • @gorbachevspizzahut2809
      @gorbachevspizzahut2809 Před 2 lety +2

      I like the guy who did the virus video as well

    • @ducngominh7669
      @ducngominh7669 Před 2 lety

      Agree!

    • @danielalozovska2050
      @danielalozovska2050 Před 2 lety +5

      @@luotuoshangdui I am a non-native fluent English speaker, and I like her accent and voice, as well. She is an amazing host!

  • @CPrs3394
    @CPrs3394 Před 3 lety +3099

    “Maybe the real evolution was the genes we lost along the way”

  • @rajasimanta
    @rajasimanta Před 3 lety +1643

    Pirates were probably really confused seeing 'Gulop.exe missing' error all the time

    • @NeonRahkshi
      @NeonRahkshi Před 3 lety +55

      Gulop.dna

    • @ragnkja
      @ragnkja Před 3 lety +23

      Sailors in general, really, as well as some explorers.

    • @Anonymous-zd1ow
      @Anonymous-zd1ow Před 3 lety +2

      🤣

    • @singletona082
      @singletona082 Před 3 lety +8

      Wouldn't it be more of a dll than exe as it is an ancillistory library in the gene coding exe.

    • @drt4789
      @drt4789 Před 3 lety +8

      Wish we can find our Gulop.exe and run it.

  • @SurprisedPikacheesecake
    @SurprisedPikacheesecake Před rokem +119

    This coulda been a several hours long video essay listing and discussing every single one and i woulda watched the whole darn thing. Great stuff

    • @SurprisedPikacheesecake
      @SurprisedPikacheesecake Před 2 měsíci

      @@Noradory you're joking, right? get a freaking hobby, mate 🤣

    • @venkkai
      @venkkai Před 29 dny

      same, i was actually sad she only talked about 2 of them, its so interesting

    • @BeTheChange99
      @BeTheChange99 Před 26 dny

      Yess!! PBS eons, please do another one on this topic!!! Or a podcast episode!!!

  • @simonezampa9239
    @simonezampa9239 Před rokem +24

    i'm an archivist and i realized now that our genome is actually the archive of our evolution

  • @SayItAintTso
    @SayItAintTso Před 3 lety +5496

    I was gonna type “if we can resurrect uricase, can we use it as a medication to treat gout?” but then I googled and saw we’re already doing that! Yay science!

  • @vesawuoristo4162
    @vesawuoristo4162 Před 3 lety +5311

    I can see the Vitamin C gene being activated articially in the future, would be very useful for space travel .

    • @acedianihil8208
      @acedianihil8208 Před 3 lety +606

      gene therapy is a fascinating thing to think about, but sadly with people still being caught up about gender and abortion the only way something like that will see the light of day is if the masses dont know about it

    • @dafttool
      @dafttool Před 3 lety +294

      ...And maybe there are other Vitamins we can make for ourselves with a little tinkering. 🧐

    • @susiekbryan
      @susiekbryan Před 3 lety +13

      Good point! Totally

    • @hinkich1
      @hinkich1 Před 3 lety +154

      for now we're still trying convince people that cloning a black footed ferret is OK and nothing wrong with it

    • @Great_Olaf5
      @Great_Olaf5 Před 3 lety +274

      Honestly, it's not that difficult to get enough vitamin C, the other one though... Turning that uricase gene back on would be nice, being better at making fat isn't really an advantage anymore.

  • @liamleonard9120
    @liamleonard9120 Před 3 lety +265

    Pretty crazy how the game Ancestors nails this. When “leveling up” your early human you unlock genes that add benefits but you can only keep them past your generation if you spend points to “Lock” them in place. I didn’t realize how accurate that mechanic was until this video.

    • @mikuenjoyerXD
      @mikuenjoyerXD Před 2 lety +12

      Reminds me of the game Spore

    • @Sally6861
      @Sally6861 Před rokem +1

      @@mikuenjoyerXD Spore was a magnificent game

    • @hanaluong2672
      @hanaluong2672 Před rokem +4

      The key is that it takes a long time and many generations.

    • @Gallyan
      @Gallyan Před rokem +5

      Amazing game and teaching tool! It got my curiosity for human evolution quite satisfied!

    • @nightshade3115
      @nightshade3115 Před měsícem

      @@frenne_dilley i think its on xbox

  • @Clearlight201
    @Clearlight201 Před 2 lety +11

    Fun fact: since the Platypus produces both eggs and milk it's one of the few animals which can make it's own custard.

  • @Shadeem
    @Shadeem Před 3 lety +2308

    I want my functioning genes back!

    • @phonyk7212
      @phonyk7212 Před 3 lety +143

      You have to have a free trial on life to unlock your genes

    • @8AKI47
      @8AKI47 Před 3 lety +15

      Lol no ☕🥄

    • @NeonRahkshi
      @NeonRahkshi Před 3 lety +5

      some of*

    • @jv-lk7bc
      @jv-lk7bc Před 3 lety +1

      ...said BrundleFly

    • @triakbar1
      @triakbar1 Před 3 lety +29

      You want to call my genes manager, ma'am?

  • @Leto85
    @Leto85 Před 3 lety +2313

    I can imagine a science fiction story in where those and more dead genes can be reactivated to 'experience reality as how our ancestors did.'

    • @nimrodgrrrl
      @nimrodgrrrl Před 3 lety +83

      Write it!

    • @VoteOrDie99
      @VoteOrDie99 Před 3 lety +76

      @Rill that's the title

    • @SujalRajput10
      @SujalRajput10 Před 2 lety +18

      What about deep dive VR where you can actually go and live like your ancestors.
      Would be a lot easier than resurrecting the entire genome.

    • @17moonlily
      @17moonlily Před 2 lety +29

      @@SujalRajput10 Animus

    • @MiguelDLewis
      @MiguelDLewis Před 2 lety +40

      It’s called Assassins Creed.

  • @paullukens7154
    @paullukens7154 Před rokem +54

    Outstanding presenter. Enthusiastic and obviously highly knowledgeable as well. You have the perfect voice for this! Loved it. (retired Biology teacher)

  • @pocketrocket6604
    @pocketrocket6604 Před 2 lety +16

    I just found this channel recently.
    And this is one of the first videos I watched.
    Woah I'm overwhelmed by the clarity and precision of your content.
    Thanks so much for doing this!
    I'll probably watch all your videos in the near future.

  • @takashimasuda6724
    @takashimasuda6724 Před 3 lety +2963

    I think this is literally the coolest thing I learned
    This basically means that we have untapped potential in our genes
    It’s like having a superpower but it’s sealed away

    • @talalon4098
      @talalon4098 Před 3 lety +161

      I have the super power of making vitamin C by myself! *I am inevitable!*
      (I am being sarcastic, but it's actually really cool)

    • @rockstargerbilclan5631
      @rockstargerbilclan5631 Před 2 lety +130

      The genes are lost, so actually, no. But there are potentials for new mutations to pop up, yes. They just won’t be quite the same.

    • @gozzilla177
      @gozzilla177 Před 2 lety +88

      The problem is with these Gene's if we did bring them back, they could have functional uses of course. But we would have to stop eating things with vitamin C in it because once you have a gene that produces it you would have to much if you continued to eat it. Which would likely cause it to go dormant again because we have no use for it, it may also lead to underlying health issues if we had excess C in our bodies.

    • @theoneaboveall6768
      @theoneaboveall6768 Před 2 lety +50

      @@gozzilla177 same as taking testosterone we stop producing it to maintain a good level. You could be right. But also I always have a saying. Nature is ALWAYS perfect no flaws the only time it’s flawed is when human touch it. Meaning if we lost those gene it’s because nature intended to. BUT I’m sure we could and will revive those genes by force or luck. Example if human start living on Mars or other planets they will be different, might be way taller or shorter stronger or weaker etc .. since gravity and environment of the planet will be different and are greatest asset is we adapt so we would adapt to that end and be different from earth human thus maybe resurrect those genes or create new ones true reproduction. Lots of possibilities for future

    • @AlphineWolf
      @AlphineWolf Před 2 lety +10

      @@gozzilla177 more like our kidneys be working overtime flushing out the extra but we would have no canver

  • @chriskelvin248
    @chriskelvin248 Před 3 lety +2881

    I would like to thank mankind's top four most generous patrons: Adenine, Guanine, Cytosine and last but not least, Steve!

    • @zeusaurel6714
      @zeusaurel6714 Před 3 lety +26

      haha, you word-played and made a funny

    • @abigailjohnson4299
      @abigailjohnson4299 Před 3 lety +142

      Is anyone else lowkey worried about steve :/

    • @phillipsofthedriver
      @phillipsofthedriver Před 3 lety +24

      @@abigailjohnson4299 YUP.

    • @zddxddyddw
      @zddxddyddw Před 3 lety +180

      This is blatant Thymine-Uracil shaming and I won't stand it, smh.

    • @JR-gp2zk
      @JR-gp2zk Před 3 lety +18

      No Steve, and Kallie has no braids. I don't know what to think anymore.

  • @pjeverly
    @pjeverly Před 17 dny +1

    This episode is why I love this channel. It makes you think about things in a new way and ultimately become more curious. Keep up the great work.

  • @adw6894
    @adw6894 Před 5 měsíci +3

    I'am a non-native fluent English speaker, and I like her accent and voice, as well. She is an amazing host!

  • @KimberlyGreen
    @KimberlyGreen Před 3 lety +2532

    Remembering former Eontologist "Steve", who has become an Eons pseudo-gene. May you one day be resurrected and come back to us.

    • @ChombyChomp
      @ChombyChomp Před 3 lety +34

      Wait which one was Steve? What happened?

    • @nsalegit9482
      @nsalegit9482 Před 3 lety +31

      @@ChombyChomp I think he was one of the eontoligists that submitted a joke or two, but stopped subscribing on patreon.

    • @astaldogal
      @astaldogal Před 3 lety +106

      @@ChombyChomp i don't think anyone knows specifically, but i think he died. They stopped adding him to the end of the list of supporters.

    • @lewisirwin5363
      @lewisirwin5363 Před 3 lety +187

      @@astaldogal Word on the street is he's just a bit too poor to support at the mo.

    • @Unpainted_Huffhines
      @Unpainted_Huffhines Před 3 lety +84

      Pseudo-Steve

  • @bunstructors8591
    @bunstructors8591 Před 3 lety +568

    As a software engineer it's very painful to realize that I have a code coverage of less than 10%

    • @jeremybyington
      @jeremybyington Před 3 lety +44

      Why the hell is everything commented out? We need to remove it all and tag it *v1.10*

    • @Dragrath1
      @Dragrath1 Před 3 lety +64

      @@jeremybyington XD
      In a serious note evolution doesn't clean up because with the right typos a new gene might rise from the scrambled mess of pseudo genes and dead viruses. In other words evolution is an old inefficient legacy code that turns typos into new lines of code by losing the comment lines XDs

    • @justinhans
      @justinhans Před 3 lety +1

      That reminds me...

    • @89qwyg9yqa34t
      @89qwyg9yqa34t Před 3 lety +30

      90% of your code is commented-out and left there as placeholders because for some reason your program wouldn't originally compile without them.

    • @popcornproductions99
      @popcornproductions99 Před 3 lety +2

      With no unit tests!

  • @Wulfdane
    @Wulfdane Před 9 měsíci +14

    I want my gulop.

  • @karenarmijo22
    @karenarmijo22 Před 2 lety +18

    Outstanding distillation. I was turned-on to this channel by the dinosaurs and now that I am copyediting lesson plans for gene editing I'm happy to see that the platform has evolved with me. Great work PBS and my fave Kallie Moore.

  • @casonjones2801
    @casonjones2801 Před 3 lety +809

    The last time I was this early, I still had a functioning Gulop

  • @joshuasalem5022
    @joshuasalem5022 Před 3 lety +1360

    Can we all seriously take a moment to appreciate how fortunate we are to have things like PBS?
    We are so lucky to have a public broadcaster with a vast domain. It is universally accepted by our institutions to be something we need, and does stuff like have amazing people teach us new things and make learning easier than ever

    • @BJETNT
      @BJETNT Před 3 lety +26

      That's an awesome comment by the way!! We could live in a place like North Korea where they totally dominate any kind of knowledge that they give to the public. I mean don't get me wrong I know some of that goes on here but not when it comes to this kind of thing.I really enjoy learning everything there is to know about the human body.

    • @perfectlypurepinkpompompan3467
      @perfectlypurepinkpompompan3467 Před 3 lety +33

      @@volkskrieg8735 lol more like cheerleader: Public broadcasting systems in many places around the world, such as the UK and Canada - and yes even in the USA - provide TONS of high-quality programming that would never have been made if all communication organizations were run by private companies. The for-profit marketplace has many drawbacks when it comes to deciding what gets produced and sent out to everyone and what doesn't. The kind of science programming this video represents, is a prime example: look what happened to commercial channels such as the History Channel... started off all idealistic and gung-ho with wonderful content, but gradually pandered to the lowest common denominator and now is 90% crap: Hillbilly Hand-Fishing Hour and Monster Truck Obstacle Course level.

    • @ArchangelActual86
      @ArchangelActual86 Před 3 lety +1

      For this I am thankful.

    • @fastbuckwu
      @fastbuckwu Před 3 lety +19

      Donate to your local PBS station if you can. I grew up watching Nature, Nova, Mr. Rogers, Sesame Street, etc. I give them all credit for making me a empathetic and decent human.

    • @jamesmccarte1609
      @jamesmccarte1609 Před 3 lety +13

      PBS is so good, that even Canadians donate money to support it! When I lived in Montreal we had access to 2 PBS stations ota, and likewise now that I live in Windsor

  • @edo4867
    @edo4867 Před 3 lety +12

    This was a great perfect episode. Thanks PBS Eons.

  • @I-wishsomeday
    @I-wishsomeday Před 23 dny +2

    I loved the way she was talking i could understand every single world she said even though i m not a native , her voice is angelic 💞
    Thank u so much

  • @alexliger1893
    @alexliger1893 Před 3 lety +1224

    Kallie’s voice always carries a sense of wonder and excitement that keeps my attention... as if she can’t wait to tell you the next thing. Awesome work.

    • @qbasic16
      @qbasic16 Před 3 lety +10

      absolutely 🙏

    • @CrankyPantss
      @CrankyPantss Před 3 lety +35

      Agreed. I like that it always sounds like one friend sharing an interesting story with us, not like someone reading something to us.

    • @ricardubazinga
      @ricardubazinga Před 3 lety +34

      Exactly! Like that one teacher in high school that you wouldn't miss a class cause you liked her so much because she can pass on so much knowledge with such ease

    • @ShayanSaqiba
      @ShayanSaqiba Před 3 lety

      simp

    • @besticudcumupwith202
      @besticudcumupwith202 Před 3 lety +9

      ...agree...and this is the first time I've ever seen her let her hair down.
      Nice.

  • @jakobnev5973
    @jakobnev5973 Před 3 lety +2696

    It's not just genes, humanity drags a lot of dead memes along too.

    • @marzouk6270
      @marzouk6270 Před 3 lety +21

      😂😂😂

    • @dx-ek4vr
      @dx-ek4vr Před 3 lety +97

      Memes: The DNA of the soul

    • @pluspiping
      @pluspiping Před 3 lety +20

      Just think - there are some people who are still playing The Game

    • @Burn_Angel
      @Burn_Angel Před 3 lety +4

      Problem, evolution?

    • @nazojin7557
      @nazojin7557 Před 3 lety +9

      @@pluspiping frick you

  • @Vak_g
    @Vak_g Před rokem +5

    One of the most interesting videos in youtube! Your channel is an oasis! I can't get enough of it!

  • @trevorzane272
    @trevorzane272 Před 2 lety +10

    I LOVE these PBS nature and science videos!! They literally go over YEARS of research and data and summarize it in minutes!! These PBS videos are so underrated!!

  • @ruchiRocksta
    @ruchiRocksta Před 3 lety +1386

    We are not just defined by the genes we gained over the course of evolution, but also by the genes that we've lost on the way.
    I liked this line.

    • @jxu826
      @jxu826 Před 2 lety +11

      Rip those genes

    • @crazyshemshem7897
      @crazyshemshem7897 Před 2 lety +6

      Legit read it as she said it

    • @jooot_6850
      @jooot_6850 Před 2 lety +2

      The real evolution were the genes we lost along the way

    • @Sienisota
      @Sienisota Před 2 lety +3

      I wouldn't mind getting some of those genes working again. You never know what we might need in the future.

    • @cringe_shattles69
      @cringe_shattles69 Před 2 lety +2

      Maybe the real genes gained were the genes lost along our way lolol

  • @corrinlex1359
    @corrinlex1359 Před 3 lety +440

    this vid takes "you are what you eat" to a whole new level

  • @simonhanson5990
    @simonhanson5990 Před 2 lety +9

    Such a clear and informative presentation. Information packed and very easy to listen to. Thank you

  • @ashtynmm
    @ashtynmm Před 4 měsíci +2

    This is the coolest thing I’ve learned in a while - thankful for videos like these! ❤

  • @sanjanadesai5128
    @sanjanadesai5128 Před 3 lety +1647

    Just imagine what kind of awesome skin we could have had if gullop gene was still functioning and producing vitamin c

    • @AJ-te6tf
      @AJ-te6tf Před 3 lety +84

      We wouldn’t need to take vitamin c

    • @rampagesmackssons508
      @rampagesmackssons508 Před 3 lety +47

      Just make sure you get enough vitamin C

    • @drt4789
      @drt4789 Před 3 lety +198

      We’l have skin like the lemurs.

    • @angelrufo1780
      @angelrufo1780 Před 3 lety +26

      @@drt4789 HAHAHAHAHAHAHA

    • @hafizhan8654
      @hafizhan8654 Před 3 lety +10

      @@drt4789 hahahaaha i would love that

  • @TigirlakaLaserwolf6
    @TigirlakaLaserwolf6 Před 3 lety +482

    all I can think about is that Doctor Who episode where the guy turns into a giant skeletal scorpion and the doctor just goes 'that machine reactivated lost genes' implying that somehow humans... used to be giant scorpions with human faces

  • @thomassutherland2647
    @thomassutherland2647 Před 2 lety +2

    R.I.P. Susumu Ohno.
    Feb 1st, 1928 - Jan. 13th, 2000
    You Rocked! I Love a Great Mind!

  • @crypton_8l87
    @crypton_8l87 Před rokem +1

    You're a great teacher! So simple and clear on such a complex subject!

  • @impishDullahan
    @impishDullahan Před 3 lety +480

    Kallie without a braid really threw me for a loop at first.

    • @astaldogal
      @astaldogal Před 3 lety +35

      Do you mean you came unbraided?

    • @watsTHEtime52
      @watsTHEtime52 Před 3 lety +5

      RIGHT

    • @impishDullahan
      @impishDullahan Před 3 lety +17

      @@astaldogal That pun left me in stitches, just leave hair to catch my breath after that one.

    • @richardhaselwood9478
      @richardhaselwood9478 Před 3 lety +15

      I was wondering what was different... Thanks for point it out :)

    • @dereksmalls6238
      @dereksmalls6238 Před 3 lety +26

      I'm glad someone else pointed this out. Don't get me wrong, I'm here for the science but Kallie with her hair down is... kinda cute ;)

  • @rexlupusetxe8367
    @rexlupusetxe8367 Před 3 lety +246

    So I have a museum inside my genes, I'm really happy to know that.

    • @whoskamo8742
      @whoskamo8742 Před 3 lety +15

      More like a cemetery but eh

    • @Abominatrix650
      @Abominatrix650 Před 3 lety +8

      If you had an Animus, you could access and explore that museum anytime you want!

    • @insidethebox2470
      @insidethebox2470 Před 3 lety +2

      @@Abominatrix650 hehehe nice

    • @ojeda5577
      @ojeda5577 Před 2 lety

      @@whoskamo8742 a museum is where history (death of the past) is stored

  • @boxy3087
    @boxy3087 Před 2 lety +12

    Activate my gulop and uox again

  • @cyrilpanerio5542
    @cyrilpanerio5542 Před 3 lety +2

    This is extremely fascinating. I'm optimistic of the coming tech from this study! Thanks PBS👍

  • @MrCrazyeyes07
    @MrCrazyeyes07 Před 3 lety +422

    Imagine if every time your body started producing Vitamin C, you’d sense the faint taste of orange on the back of your tongue.

    • @rolfs2165
      @rolfs2165 Před 3 lety +40

      Toothpaste would stop tasting like mint. Sounds good.

    • @reob12
      @reob12 Před 3 lety +77

      i could be wrong, but that's not how I think vitamin C works

    • @BJETNT
      @BJETNT Před 3 lety +55

      That would be funny but vitamin C' does not taste like oranges. Taste more like citric acid unless you go a mineral ascorbate. It's more stable than regular ascorbic acid anyway.

    • @WillPhil290
      @WillPhil290 Před 3 lety +2

      @@reob12 lol I was about to say something similar

    • @davidanderson_surrey_bc
      @davidanderson_surrey_bc Před 3 lety +3

      Don't you just love it when every reply is from someone named Poindexter?

  • @Leitis_Fella
    @Leitis_Fella Před 3 lety +335

    Me: Return to Monke
    My genes: No

    • @ANTSEMUT1
      @ANTSEMUT1 Před 3 lety +40

      What about crab?
      Genes: maybe 🤷‍♂️ we will see hehehe.

    • @Burn_Angel
      @Burn_Angel Před 3 lety +2

      Quite literally, actually.

    • @willtancha7163
      @willtancha7163 Před 3 lety +1

      Turn me back to a fish

    • @wizzzer1337
      @wizzzer1337 Před 3 lety +3

      me: return to single cell?!
      my genes: you bet your sweet bippy!

    • @baguette4607
      @baguette4607 Před 3 lety

      I’m gonna to commit turn back into singular atom

  • @creuvette29
    @creuvette29 Před 2 lety +5

    Your explanations are easy to understand and make sense, even for a non english person like me. Thank you for this great and interesting video !

  • @divyanjalisharma319
    @divyanjalisharma319 Před 2 lety +3

    It's almost like magic. Beautiful ❤️
    To think we are here because of beings living for the last million years. And to think it's our responsibility for the future.
    The irony of how each individual is important, and yet means nothing in the larger scheme of things..
    Just beautiful.

  • @shawnmckernan2277
    @shawnmckernan2277 Před 3 lety +180

    As Homer Simpson said: I'm not fat, I'm drought and famine resistant. I so want to experience the two types of bitter our tongues are blind to.

    • @davidanderson_surrey_bc
      @davidanderson_surrey_bc Před 3 lety +17

      Also, the three types of smell our ears can't feel.

    • @samhainlegge9563
      @samhainlegge9563 Před 3 lety +8

      @@davidanderson_surrey_bc I’m sorry, what?

    • @gozzilla177
      @gozzilla177 Před 2 lety +5

      @@samhainlegge9563 Its true, and did you know your skin cant taste 90% of what it use to?

    • @samhainlegge9563
      @samhainlegge9563 Před 2 lety +1

      @@gozzilla177 …dang, that’s cool.

    • @briciolaa
      @briciolaa Před 2 lety +1

      @@gozzilla177 wait our ancestors could do all that and also were tripping balls?

  • @FaeQueenCory
    @FaeQueenCory Před 3 lety +389

    "How do genes die like this?"
    Literally typos.

    • @BJETNT
      @BJETNT Před 3 lety +1

      Pretty much yep!!! I'm stealing that That was pretty funny

    • @shersockholmes6261
      @shersockholmes6261 Před 3 lety +2

      Underrated

    • @SpazzyMcGee1337
      @SpazzyMcGee1337 Před 3 lety +1

      Part of my brain got more entertainment from this comment than another party of my brain feels was justified.

    • @ccvcharger
      @ccvcharger Před 3 lety +1

      @@volkskrieg8735 Is that when pirates breed?
      ...
      I'll leave.

  • @dharmagirl5889
    @dharmagirl5889 Před rokem

    This may be the coolest video I've come across in months! Love it!

  • @chefmarcos
    @chefmarcos Před rokem +5

    You are an excellent narrator. I enjoy listening. Bravo!! 👏🏽

  • @brandonwang4270
    @brandonwang4270 Před 3 lety +152

    Maybe these genes are all the friends we lost along the way

  • @bakakubi
    @bakakubi Před 3 lety +246

    I have gout. Thanks to this ep, I can officially blame my ancestors!

  • @kowalityjesus
    @kowalityjesus Před 2 lety +2

    bruh this is insanely amazing that we can know this. Thanks Eons!

  • @adw6894
    @adw6894 Před 5 měsíci +3

    The evolution is amazing, such a long journey of natural selection

  • @MatanteDodo
    @MatanteDodo Před 3 lety +74

    The UoX part intrigued me because as anyone who cared for reptiles, I know they're quite vulnerable to gout, more so than us. They also excrete a white goop made out of amorphous urates just like birds. So I looked it up and indeed, humans, birds and reptiles independently lost the ability to break down uric acid.

    • @bhartiparihar8151
      @bhartiparihar8151 Před 2 lety +2

      Wow, that's really interesting! Thanks for sharing. Not surprising birds and reptiles would have a shared method of eliminating it with their close genetic relationship. I'm glad us apes don't do this though lol.

    • @khajiitkitten5679
      @khajiitkitten5679 Před rokem +3

      @@bhartiparihar8151 I don't know...I have gout, and I'd love to be able to break down uric acid in my body. Gout is no fun.

  • @TunaFreeDolphinMeat
    @TunaFreeDolphinMeat Před 3 lety +90

    I lost my jeans at the laundrymat

  • @weyounion9112
    @weyounion9112 Před 2 lety +9

    Evolutionary genomics could become one of PBS Eons' focus. It's interesting, discoveries every year... And you're so good at explaining simply. Great channel, thanks

  • @greenbeanwater6686
    @greenbeanwater6686 Před rokem +4

    Maybe the real treasure was the genes we made along the way

    • @nymphobunny
      @nymphobunny Před měsícem

      This is a beautiful way of thinking

  • @starguardlux2874
    @starguardlux2874 Před 3 lety +128

    My stupid self saw the title and I thought to myself, "yes, but how many friends did we make?"

  • @johannesschutz780
    @johannesschutz780 Před 3 lety +48

    My background is historical linguistics so I kinda do things that are very similar to what you guys do: a deep dive into the past based on what remains of hundreds, thousands, and in this case millions of years of history. I really love everything involving reconstructing which is why I loved this video so much.

  • @kyjo72682
    @kyjo72682 Před 2 lety +14

    Great episode. Genetic "archaeology" is quite interesting.

  • @turquoisewitch.wild-owl
    @turquoisewitch.wild-owl Před rokem +2

    That was extremely interesting and very well communicated! Thank you.

  • @1ntwndrboy198
    @1ntwndrboy198 Před 3 lety +70

    When we lost the uric acid Gene we could have also lost the hair most of our hair so we could sweat and sweat out the uric acid.

    • @sammijanemorrison2284
      @sammijanemorrison2284 Před 3 lety +6

      Awsome point. It would be an excellent look ent study. Thanks for ur comment.

    • @BJETNT
      @BJETNT Před 3 lety +2

      I don't know if we sweat that out. I mean I know we do but it's very very insignificant but it seems like you should be right and we should get rid of more of it that way. As compared to what comes out of our urine it's not even statistically significant. But then again your average person in good health does not have a lot of it floating around. That means urine is usually enough to do what it needs to do while it's treating it. Being able to do it through our sweat glands would be problematic to say the least if it was in large amounts.

    • @shersockholmes6261
      @shersockholmes6261 Před 3 lety +1

      Actually uric acid is excreted through urine. And I don't think decreasing amount of hair makes u sweat more , it should be the other way around as more hair means more heat which results in our body's cooling action that is sweat.

    • @Burn_Angel
      @Burn_Angel Před 3 lety +10

      @@shersockholmes6261 What he meant was that having less hair helps sweat cool down the body because it flows easier, instead of it only wetting the hair.
      Eliminating uric acid via sweat would be easier since it flows out of the body easier than if we had more hair, so it's not about sweating more but rather sweating more effectively.
      And there's no other animal that sweats as much or as effectively as humans, that's actually one of our species' traits, so if the idea was to eliminate ANYTHING from our body via sweating, we'd be the best creatures to do so.

    • @Pippis78
      @Pippis78 Před 3 lety +2

      @@Burn_Angel Yup - like dogs. They can only pant. And that's why they can get heat stroke rather easily. Human is quite well adapted for heat and cooling down. We did use to hunt by running after (injured) prey and exhausting them. If I've understood correctly, the human body is actually better equipped for running than walking.
      (Randominator infobank in my brain: Pre sturdy shoes we used to both run and walk toe first, not heel first. Our modern style of walking is super recent. Like the last 200-300 years. Would be interesting to know the effect that has on our back or knee problems etc.)

  • @mst4309
    @mst4309 Před 3 lety +58

    Eons, Space Time, History of the Earth: 3 channels uploading on the same day. Oh my.

  • @kjron1548
    @kjron1548 Před 2 lety +18

    I love how paleontology is headed to genetics to better draw an image of what the past looked like

  • @AndyStarrrr
    @AndyStarrrr Před 3 lety

    I often get scared because I know it's impossible to know everything there is to know, but this channel makes me feel like I'm getting SOMEWHERE at least.

  • @omarqudah7848
    @omarqudah7848 Před 3 lety +67

    Our ancient ancestors: *Evolve for over 8 million years*
    Modern day humans: Evolution isn't real!!!
    Their DNA: *oh*

    • @generalwreck7662
      @generalwreck7662 Před 3 lety

      Literally everyone when Charles Dickens was alive

    • @LetYourMindPlay
      @LetYourMindPlay Před 2 lety +1

      I'm interested in what part of this video you think shows evolution. There was no creation of new material/information. Just the reordering of older information. In a pundit square there are the initial letters. Those letters may be rearranged over generations, however no new letters are ever introduced. Instead where an ancestor might have had Aa you now have AA. Meaning you have lost the ability of the "a". You did not evolve but devolved. Instead of new letters being added into the pundit square you might actually end up with letters missing on certain branches. Natural selection is the opposite of evolution.

  • @Kurtizss
    @Kurtizss Před 3 lety +76

    some gene: *dies*
    Monke: *Oh no!* anyways

  • @sabarinathan1287
    @sabarinathan1287 Před 2 lety +1

    The background music till 1:50, well done team, it just hooked me to the video.

  • @octopus8978
    @octopus8978 Před rokem +2

    I could watch this video 100 times and not get bored

  • @Quintinohthree
    @Quintinohthree Před 3 lety +72

    7:55 is not the structure of fructose. There shouldn't be a methyl on the left. This 1-O-methylfructose. Also unusual to show the open form but I'll leave that to you.

  • @FalconFire13
    @FalconFire13 Před 3 lety +33

    As a medical student, I'd abhorred reading Biochemistry. With such interesting context, I'm gonna love studying it now !
    PBS Eons is an absolute treasure !

  • @cuddlepaws4423
    @cuddlepaws4423 Před 6 měsíci +3

    Very very interesting . When I was doing my Human Biology ' A ' level back in 1995 we were taught that Vit. C synthesis is a 10 step process , but for some reason we had lost the 10th step conversion . Apparently animals who can still self generate have much better cardiovascular health and increase out to combat when they have an infection .
    Just think if this could be switched back on to help with the heart disease problem worldwide .

  • @vintagelady1
    @vintagelady1 Před rokem

    This is so dang cool & well explained. And the medical possibilities are enormous, as they are doing with the uricase gene. Love this channel--if I were still teaching, I'd be using it in my classroom

  • @Laserblade
    @Laserblade Před 3 lety +71

    For me, one of the most educational of the series I've seen. Thank you, PBS Rocks. Always has.

  • @haroonzia2214
    @haroonzia2214 Před 3 lety +119

    These videos are so well-made - the visuals, the writing, music, and of course the interesting content and studies themselves!
    Great work. It's a real privilege to have science presented in such a convenient and engaging way! Thank you for this.

  • @matthn64
    @matthn64 Před 2 lety +1

    What an amazingly executed video. Subscribed!!!

  • @roryfriththetraveller4982

    this is soooo interesting !! im super curious to find out what gets found out about these dead genes in the next few years

  • @domib.3924
    @domib.3924 Před 3 lety +21

    9:53 That guy looks stoked to have found some leaves.

  • @meetaverma8372
    @meetaverma8372 Před 3 lety +61

    Now I know why Lemurs are healthier than me

  • @TarunKumar-kb4ln
    @TarunKumar-kb4ln Před rokem +1

    oh god. This channel is hidden gold. underrated and addictive

  • @pokemonfanthings4444
    @pokemonfanthings4444 Před 2 lety +3

    This was awesome. I had no idea generic fossils even existed. Thank😊

  • @jonathanbibi799
    @jonathanbibi799 Před 3 lety +89

    I don't know why but these videos are so educating and are so interesting, already been taught more in an hour from your channel than recent years of school.

  • @mitchgunzler3737
    @mitchgunzler3737 Před 3 lety +13

    My favorite example of being shaped by the genes we lost comes from cats. The last common ancestor of all felines seems to have had a broken version of the gene for tasting sweetness. That must be part of a cycle that led cats to become such capable obligate carnivores-the less they enjoyed and sought out fruits, the more important finding enough alternative foods survived, which made failing to eat available fruits less of an issue and so on.

    • @freandwhickquest
      @freandwhickquest Před 3 lety +2

      there are also transposable elements called alu elements in the primate genomes. these elements sometimes jump into genes and render them non-functional. since the insertion locus is primarily random, if you find a pseudogene which seems to have been broken by the same insert element exactly at the same nucleotide position proves carriers of this pseudogene share a common ancestor. probability of two independent insertion events in different species occuring at the same nucleotide positions is virtually zero. event happened in the common ancestor and passed on to its descendents. a molecular fossil. presence/absence patterns of those insertion events can be used for phylogenetic tree construction and those trees perfectly match the morhological and molecular trees. this is what convinced me that evolution is real. there are also endogenous retroviral insertions which we share with chimps. nucleotide by nucleoitide same location: proves common ancestry.

  • @sarahmcmorn8475
    @sarahmcmorn8475 Před 6 měsíci +1

    10/10 This episode allowed me to sound smarter than I am at a family gathering.

  • @Rat-tea
    @Rat-tea Před 3 lety

    If there isn’t one already, y’all should make this into a podcast on spotify!

  • @CaptainComradeCool
    @CaptainComradeCool Před 3 lety +151

    Yeah, but the denim ones we have now are pretty ok too.

  • @sakurabender
    @sakurabender Před 3 lety +265

    So what you’re telling me is that if we still had uricase we would be loosing weight better? Hmmmm damn evolution lol

    • @griffinbird3000
      @griffinbird3000 Před 3 lety +24

      We'd probably need it considering the amount of obese people is increasing a lot

    • @everentropy
      @everentropy Před 3 lety +14

      Weight isn't automatically unhealthy and I suggest you look up the history of BMI. We were DESIGNED to be heavier!

    • @griffinbird3000
      @griffinbird3000 Před 3 lety +70

      @@everentropy yes in the past if we lost weight quickly we'd die because food wasnt as readily available but now that food is more readily available and more and more people are dying of obesity pls come back soon uricase :^((

    • @everentropy
      @everentropy Před 3 lety +8

      @@griffinbird3000 Studies have shown fat is still protective and BMI was not made by a medical doctor. It is not the measure we should use to measure healthy weight even! It is NOT based on actual science and was never meant to be used that way

    • @everentropy
      @everentropy Před 3 lety +7

      People are not "dying of obesity". Being fat doesn't kill people by itself and you can be completely healthy and be fat. For instance a study came out recently that people who are underweight fare WORSE when hospitalized with COVID. So why is being overweight not considered a health risk?

  • @RaynmanPlays
    @RaynmanPlays Před 2 lety +1

    "We used to be able to make our own vitamin C, but we lost the gene for it."
    Pirates: "This is outrageous! It's unfair!"

  • @Homo_sAPEien
    @Homo_sAPEien Před rokem +2

    Kind of like how I lose my genes when I get in the shower.

  • @spicywonton9428
    @spicywonton9428 Před 3 lety +23

    It’s like a video game equipping and discarding some items that give us buffs lmao

  • @michaelsoares8160
    @michaelsoares8160 Před 3 lety +251

    So what I’m hearing is we need to defragment our genomes because there’s a bunch of useless data on it 😝

    • @scienceface8884
      @scienceface8884 Před 3 lety +34

      Or start looking through broken code for medical breakthroughs.
      Also, the junk is a pretty good cushion in case you contract a retrovirus.

    • @tesconstamylo
      @tesconstamylo Před 3 lety +21

      Trust me junk DNA is much more important than the 1% encoding proteins!!!
      It's all about control and regulation

    • @cheesymac6732
      @cheesymac6732 Před 3 lety +9

      Even useless DNA is useful and “defragmenting” specific DNA would be incredibly risky

    • @Iainttrynadoxxmyself
      @Iainttrynadoxxmyself Před 3 lety +15

      I’m keeping it. You never know. I might find something I want reactivated.

    • @devlandiablo
      @devlandiablo Před 3 lety

      L. Warren Douglas wrote a book "Simply Human" that touches on this

  • @surajrshetty
    @surajrshetty Před rokem

    Beautiful narrative! Thanks 🙏🏽

  • @alexia3552
    @alexia3552 Před 2 lety +6

    I wonder if there's a gene for reabsorbing the uterine lining instead of having a period. Also, it would be cool if we could turn the "vitamin C" gene back on

  • @Leomoon101
    @Leomoon101 Před 3 lety +39

    Wow, genes are like computer files. I mean how many people can relate that they lost a file and have no backups to it.

    • @natchu96
      @natchu96 Před 3 lety +12

      Well it really is just a big pile of manufacturing programs.
      With the one flaw that the only way to write new code is to wait for the data to corrupt/erroneously duplicate while praying that what comes out of it actually runs.

    • @Leomoon101
      @Leomoon101 Před 3 lety

      @@natchu96 That’s one way of looking it.

    • @natchu96
      @natchu96 Před 3 lety

      @__-NeKceNoS-__ Run? Not really.
      ...write? corrupting your hard drive repeatedly until you get something useful is generally not an efficient idea.

  • @joaovitorreisdasilva9573
    @joaovitorreisdasilva9573 Před 3 lety +18

    Is this title a play with "on the friends we made along the way"? Because if it is, I love it.

  • @happyfairyjerry
    @happyfairyjerry Před 2 lety +1

    It's such an awesome thing to realize the DNA from animals is their story and how they evolved but further with genes they don't use❤️

  • @akhilram64
    @akhilram64 Před rokem

    Past comments are really knowledge provoked and feeling very happy to appreciate the researchers and re-researchers(video makers)👏👏👏🙂