WHAT ARE ANALGESICS? - Analgesic (Part 1) - ICU Drips
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- čas přidán 23. 07. 2024
- This video is the first part of our lesson on analgesics drip medications and pain relief in the ICU. We start this lesson off talking about what are analgesics? These group of medications, which compose many different medications, have many different ways in which they help control our patients pain in the critical care environment. The are distinguishable from anesthetics because instead of blocking all sensation, they work to only block the sensation of pain.
The rest of the lesson we take the time to go over our pain pathophysiology as we talk about the pain pathway. Starting with an example of an injury that would cause pain, our body’s first response is to release prostaglandins which ultimate activate our nociceptors, aka our 1st order neurons. These neurons carry the signal back to the dorsal horn of the spinal cord and synapse with our 2nd order neuron through the use of a chemical messenger called Substance “P”. From here the 2nd order neuron carry the signal to the Thalamus in our brain, synapsing with our 3rd order neuron, who’s job it is to carry the signal to the appropriate part of our somatosensory cortex. The primary job here is to provide us with the perception of pain as well as to provide the location of where the pain is. All of this is thanks to our ascending pathway.
We also have the descending pathway who’s job it is to control and inhibit the descending pathway. From the Midbrain a neuron carries the signal to the Medulla where it synapses with the Serotonergic Neuron. This neuron carries the signal to the dorsal horn of the spinal cord. Here through the release of Serotonin and Noradrenaline it can cause the inhibition of Substance “P” from our presynaptic 1st order neuron. These chemical messengers can also stimulate something we call an interneuron in the dorsal horn, which in turn then releases an endogenous opioid. This opioid, along with other opioids that we can administer does two things. First it also inhibits the release of Substance “P” and second it works to prevent the 2nd order neuron from depolarizing, essentially making it harder to pass a signal along to the brain, essentially raising the pain threshold. Finally we also talk about the NMDA/AMPA receptors which also help to regulate the depolarization of this 2nd order neuron.
Hopefully after watching this lesson you will have a good basis of understanding of what analgesics are and how we control pain through their use by understanding the pain pathway and the different areas in which we can intervene in order to try and prevent this signal from reaching our brain.
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Don't forget to check out the playlist for this series of lessons here: • ICU Drips
Also check out these other great lessons and series of lessons below!
Hemodynamics Principals: • Hemodynamic Principals
Shock: • Shock
ECG/EKG Rhythm Interpretation: • ECG/EKG Interpretation
Blood Tubes - Order of Draw: • Order of Draw and Addi...
Glasgow Coma Scale: • Glasgow Coma Scale (GC...
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Thank you guys so much for watching! 🙏 Please leave us a like 👍if you enjoyed the video. We truly do appreciate it! Also we love 💗hearing your comments so feel free to tell us what you think of the video. 😍
Check out the rest of the videos in this series here: czcams.com/play/PL2oVjKTYocdPLrS0odnyih8wf6zZ7WfVW.html
Don't forget to check out these other great series of lessons that we have available!
Hemodynamics: czcams.com/play/PL2oVjKTYocdMBZlcIcWlESbOFFaGugQS2.html
Shock: czcams.com/play/PL2oVjKTYocdPP0K8Fi49GfUgprICS-xMf.html
Arterial Blood Gases: czcams.com/play/PL2oVjKTYocdMz1qF-3iS6iUZ-R_fKbeJw.html
ECG/EKG Interpretation: czcams.com/play/PL2oVjKTYocdPMaNwn4xbg6xAIaAnyraMj.html
Heart Failure: czcams.com/play/PL2oVjKTYocdNdFoS31yGhylKwib9lRf73.html
Endocrine System: czcams.com/play/PL2oVjKTYocdO74cmXgmKjexoq59j93-Wv.html
OR these individual lessons!
Blood Tubes - Order of Draw: czcams.com/video/mAmwdDdbkUI/video.html
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Very useful and informative explanation 👍
Thank you 🙏🏻
Hi Eddie.... Thanks for another great video!!! I've been following your work since nursing school, using it to better my grades in CC courses and now caring for my patients in the MSD. I really appreciate the graphic depictions and use of multi-colors, as this helps me to envision the afferent/efferent pathways of the PNS/CNS activity. I noticed there is mention of neurochemicals (PG and Substance P) at the first and second order neurons, respectively. Is there a specific neurochemical required for the synapse to take place at the third order neuron as it travels from the thalamus to the somatosensory cortex? ACh perhaps or something else?
Thank you
Watching these videos for my crna interview!!
Nice!!! Best of luck on your interview. I've had several people mention about this series helping with a question or 2 during interview
@@ICUAdvantage yes! I’ve already been watching you for years but your channel has been specifically recommended to watch for CRNA interviews by several perspective and current SRNAs. Thank you!
@@msme9790 that’s so cool! You’ll have to update me after your interview!
Hai Eddie,I’m deshani a nurse from Srilanka.I used to follow your all vedios and they were very attractive and helpful for me to my professiona.✍
Hi Deshani! Nice to meet you and happy to hear you enjoy these videos. Thank you for taking the time to leave a comment!
@Keenan Jordy what is flixzone?
❤❤❤
Great!
Thank you!
Nice Video
Thank you!
Nice kne
Yes it gets blurry for me too
I think thats just a connection issue. CZcams drops the quality depending on how well the connection is so it can come and go if you connection has a hiccup.
Love all the works have been done, but the pain pathway is a bit difficult to understand. Wish it was explained more easier.
Sorry, I tried my best. What is it you don't understand.
Love the work you guys do, but it seems to go blurry at about 3 mins.
Might just be me 🤔
Hmm, I just went and checked and it seems ok on my end?? Maybe just a bad connection?
Thanks for the kind words and for point that out. I'll make sure and keep an eye on it.
Thank u Eddie I always watch your video on my rest day. This is a great tool in reviewing my previously learn knowledge in Nursing School.
Thats awesome Joe! So glad that you find that they are helping you out!
@@ICUAdvantage Yeah, it might happen for some people. Didn't happen for me thankfully!