The Final Steps of Making Pyrimethamine ("Daraprim")
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- čas přidán 8. 09. 2017
- In this video we finally make Pyrimethamine. Pyrimethamine is also known as Daraprim.
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I love the deep introspection after such a huge accomplishment. Congratulations!
Thanks! I appreciate it!
Oh man, Destin has been following along? Nice to see you man, I'd love to see a collaboration between you two!
Let's hope CZcams doesn't flag this one. And remember: If you've turned on notificaitions or subscriptions and don't see my video in there (at least after an hour or so), report the bug to youtube to fix it. They'll listen to you more than they'll listen to me.
Anyway, thanks for standing by me. This would never have gotten done without all of you supporting me.
Break out the champagne, we've succeeded.
NurdRage Keep up with the good work. We will always support you.
NurdRage Congratulations! I knew it will happen eventually. If i may ask, are you planning to do another long term project after your pyrimethamine synthesis? Anyways congrats, Dr N-butyllithium.
NurdRage Congrats! It's been a long 2 years, but it was worth all the failures. Thank you for your dedication to this project!
Cost breakdown is explained in the video
I see it 5 by 5. Oh my God this is a year in the making its like a season finale!
The acetone contamination more than likely is from the nmr tube. Acetone is commonly used to clean the tubes and to get rid of all traces usually requires vacuum and IR lamp.
7:16 Gorgeous.
Congratulations, NurdRage. It's been a long and bumpy road, but you made it.
+1
tehlaser "where will he go? What will he do"
7:16 separates the undergrads from the PhDs
Congrats, i can't find the words to describe this. You're right, this is like building a computer from sand. But the result is awesome.
YouCubed22 ok but all the process aren't done by the same industry.
The people who thumb down this video are not very intelligent. This whole process of synthesizing this drug has been such a great learning opportunity and has expanded my point of view of OTC viability. Bravo Dr. Butyl Lithium AKA (NerdRage)! Your an amazing chemist.
I have no idea what Pyrimethamine is or does, but, it's been a fascinating journey seeing all the different processes and reactions... :)
It's a drug used in the treatment of toxoplasmosis or acute malaria.
you know it. Remember all that hoopla about the pharma ceo who hiked up the price of his drugs 1000% fold?
same drug
It was Martin Shkreli, he jacked the prices up by 5000% and later down the line got arrested for fraud charges I believe.
he really needs to be deported, and any interests he has in pharma needs to be confiscated.
Jacob it has around, maybe a bit under an 80% success rate of treating toxo, but yeah that's about it
"I don't think reactions performed in a soup can would pass any form of medical certification" Come on! That's how you know it's the good stuff! Thanks for all the inspiration!! #NurdRageisKing
I believe that's called "free range" 😉
This is awesome. I'd say congratulations, but you worked your ass off for this. The world needs more people like you.
I call this ~dedication~. And no one, absolutely no one can contradict me.
Hats off to NurdRage!
Whenever y get tired of studing and working hard , you make me remember why i'm studying chemistry , thanks
Congrats +NurdRage. The work finally paid off. Are you planning to publish this in a journal? We all hope you continue to do innovative projects in the future like this one.
A journal would be really nice :) I would really like to show this to my professor
Thumbing this message all the way. The discoveries you've made along the way, as well as the final process, need to be made more widely available than this youtube channel, please publish, and congratulations. It's been a fascinating few years and we look forward to watching whatever you do next!
I guess he did, but he will not say it because of conspiracy.
Pikefish Yeah, having this material on CZcams for amateurs and laymen is great, but this guy could do some real groundbreaking work!
Like +Charles Augustus said I think you should publish this in a science journal. You have proven that synthesis method and that it can be acomplished in an relatively amateur lab. Moreso you actually have video evidence on how to synthesize it from the beggining to end. As always nice work, you have my congratulations as always on the brilliant videos and brilliant chemistry +NurdRage. Keep up this awesome work, I wish my Chem teachers in college we're as engaging as you.
Wow...just wow! I've been watching this channel for more than 5 years now and this is probably his best result. You're an inspiration for fellow researchers, like me. Thank you, Nurdrage!
I'm so happy for you nurd, i've been watching this since day one and i've loved it every step of the way. Congrats Nurd!!!
Totally awesome! Congratulations on your success. I knew there was a lot of work that went into this, but I had no idea it was THAT much! Thank you for gutting it out, I am sure I would have thrown in the towel a long time ago.
I have enjoyed watching you go through this entire process from day one! Congratulations! Thank you for being persistant through even the failures along the way.
This has been a very informative and entertaining series. Congratulations on your well deserved success.
Congratulations !years of work finally paid off !
After two years of watching these amazing videos, seeing the layer of pyrimethamine appear between the ether and aqueous layer was amazingly satisfying. Well done, and thanks for all the hard work.
This is amazing! I loved your work and the final product looks really clean.
Congratulations!!! What an accomplishment. It's been very fun to watch.
What an incredible accomplishment! You should be truly proud.
I'm glad i stuck around to really see this come to fruition. Good work man.
Congrats! I remember checking in on this a year back... It's been a long and difficult process that's for sure. It's very impressive that you kept going, precisely why yours is one of the best chemistry channels on youtube.
Congratulations on finally completing this project! I've been watching your channel since 2012 while I was going through my chemistry series, while working on my ME degree, and enjoyed each new video you came out with. I know this has been a very trying project for you and it almost had you to the point of giving up, but you finished it. I'm not a patron of you, but after all the enjoyment I've gotten from your videos, I think it's only right that I become one. Thanks for doing what you do and please don't stop. This project was fascinating and I'd love to see more.
Congratulations! I'd been following you on this experiment and your perseverance finally paid off!
Congratulations and well done. From one synthetic chemist to another, I truly do understand the epic effort, grit and determination it takes to achieve something like this. Once again, congrats!
I 'm so happy for you, and I'm so excited for your success. Fantastic work.
CONGRATS!!!!! Well done, and I look forward to more videos!!
This was an amazing journey! Thanks for sharing and listening to your subscribers! :)
This is one of the most phenomenal videos on CZcams. Awesome.
Your dedication inspires me. Thank you for your work!
I've waited so long for this, thank you so much for working so hard on it.
Amazing! Congratulations, it's been fun seeing this progress over the last 2 years!
Bloody bravo, Mr Rage! You've done an amazing job! All the work and effort has finally paid off.
Kick back, relax and enjoy the beverages, it's well deserved.
Congratulations I have been watching the whole way and I am very proud that you completed it. Thank you I have.learned a lot about home chemistry from you and love your content.
thank you for this. it was INCREDIBLE! you are gonna do so much amazing work.
I've followed and wached every step in your pyrimethamine synthesis with all the struggels and set backs. It is awesome you've finally synthesized pyrimethamine from household chemicals!! Thanks for not giving up and continuing this project great work!! I hope you've enjoyed the road to this succes!
That's why I love chemestry, You can make anything from anything else.
Your channel is amazing, congratulations.
You did it man. I remember the first video I saw on your channel, I didn't know what you were trying to do then and still don't but it was awsome seeing you come closer step by step to your goal.
Cheers to you!
Got a notification and it showed up in my feed. Love your videos!
Wow You're a real life superhero! So amazing, never thought I would find myself crying on a chemistry video.
That was the most epic series of science videos on CZcams! So glad to have followed the whole process.
Been a subscriber before you tried this. I am so happy you finally did! Congratulations!
It's been over a year. I reviewed all the steps and am still amazed. Again, Congrats.
Wonderful work, it must feel damn satisfying seeing that crystallization in the end after all the time and effort. It was an amazing ride only watching this, I can only imagine what it is like achieving it.
Most sincere congratulations to THE amateur chemist!
Congratulations! Was a great journey to watch.
Good job! I have been watching your vids for 4 years. Im glad you were able to make it this far!
Congrats man - that was a ton of work. Been following since the beginning, and this is a pretty amazing result. Great work seeing it through to the end!
Awesome final crystallization, almost an iridescent glow about them.
Congratulations on completing the journey. I enjoyed the ride.
Congratulations Nurdrage!!!!!!!! I am so happy that you have finally succeeded!!!! You will always be my favorite chemist!!!
Wow. I'm completely blown away. I hope you lead a completely fulfilling life and get compensated well for all your knowledge and skill.
Congratulations! Fantastic work. Very inspirational!
congratulations! one of the best journeys on youtube ever
congratulations, my guy. I really enjoyed this entire series.
What a wonderful chemist. Congratulations.
Absolutely amazing. Thanks for your effort. I hope you will take on another project like this.
Great video and fantastic series dude. great job! Keep up the fantastic work
Woo I've been waiting for this for a long time, it's been amazing to watch
You finally did it! Congratulations!
Really Epic! This has been a hell of a journey for all of us too, I'm not a chemist but I learn a lot from watching the procedures and a little from the theoretical part. Thank you!
So glad you stuck with it, great job on the outcome! Knew you could do it!
Holy crap, you did it man!
Two years, and you refused to give up; that is very admirable.
Huuuuge congrats!
Congratulations Nurdrage! I've been following your whole journey from the beginning as a chemistry enthusiast and although I haven't had funds to contribute, I've been rooting for you the whole way.
This has been an amazing science journey! Thank you NurdRage for your efforts in making chemistry education accessible to the hobbyist!
Thank you for the fantastic journey. Even though I am not a chemist, I find you work fascinating and extremely informative. I look forward to your future experiments.
AWESOME! You did it. I've been following this adventure for the whole time :)
Congrats at your significant accomplishment!
Congrats. This is incredible and you've made a wonderful contribution to science.
I highly recommend getting the sodium metal refining process published, if not the entire process for making Pyrimethamine. You've done great work and accomplished tons.
Thank you.
Easily one of my if not my favourite video! Thanks for this series. It showed various methods of chemistry that isn't easily or often found on youtube in such great quality (like free radical chlorination, etc.). All in all thank you very much for your commitement.
Congrats to you sir, half the time when I watch your vids I have no clue what your doing but I still find it very interesting an find it fascinating. I can't wait to see what you do next. thank you for the great content an learning opportunity
This is such a accomplishment, it really should be appreciated for all that went into it. I hope this knowledge bomb sets off a chain reaction of shared information to get people inspired to investigate, do, make, learn and invent.
So Badass!!!! Very good job Nurdrage for completing the synthesis and for showing the beauty of chemistry to so many people :)
Congrats! Was a great ride to watch you do this. I am but a ChemE, but it is amazing watching what professional chemists can do!
WOHOOO! Congrats! This right here is dedication people!!
Well done! In my opinion, it's been worth all the effort you've put in. I've watched each video from start to finish & have enjoyed it all. Even though I haven't any background in chemistry - outside of high school - I'm still fascinated by it. Keep up the great work!
This is such a cool series. Thank you Dr. NerdRage for putting your valuable time into this project and thank you to everyone that supported the project so nerds like me can enjoy it.
Congratulations! I'm very happy for you.
Bravo! Great job buddy. congrats! 👏🍾🥂
Congratulations! I enjoyed the series.
Nicely done, thank you for your very hard work.
Outstanding work NR!
Genuinely impressive, you've made me appreciate and enjoy learning (Attempt to understand ) chemistry in a way my teachers never did :)
Nicely done! Excellent series.
Hey man, Nice coverage on Vice. Huge fan of your work for the past couple years, and heard your name and instantly recognized it. Chemists like you and my pops are huge inspirations to me and inspire me to try and be awesome at everything I do. Stay awesome.
*Congratulations!* You are awesome. This was a massive undertaking. Even relatively simple procedures, with a couple of steps, are major undertakings when you must also synthesise many or almost all of the precursors, as you did by necessity. And this was not _that_ simple even _if_ you had the precursors. So, well done! What an excellent series. This will serve as inspiration for many a beginner chemist, I'm sure 😁
Congratulations what a journey. Very inspiring.
This is simply amazing.
Hard work, dedication, trial and error...
You, sir, deserve all the glory and applause.
Let's break the champagne!
Congratulations!!! It was an amazing journey.
Amazing work NurdRage!
I've been following your progress, and I can't help but crank the volume up on Post Malone - Congratulations in honor of your work.
I'm excited to see what's next, and again, from the bottom of my heart, thank you.
Yes! Finally! You're awesome!
I'm extremely impressed, give yourself a pat on the back.
Bravo!! You are one hell of a chemist.
Congratulations colleague, a nice chemistry lesson involving all real aspects of a synthesis, including safety and environment. Thank you vey much !
You are one impressive human being. Keep being awesome.
The video didn't appear in my feed, but it showed up in my Suggested Videos (released 18 hours ago).
I've now hit that Bell & will receive notifications from now on... 👍🏼
I absolutely loved this series. Semi-complex organic chemistry is fun to watch. Plus the added benefit of thinking about making medications in a dire scenario.
A huge congratulation on this accomplishment! Your determination, skill, and willpower has been shining through in every video of this series, it's been awesome to watch! Break out that champagne, doc! =D
been watching this process the entire 2 years youve been working on it. and im no chemist. to be honest i barely follow the names of the chems you use to do this, but its satisfying to see the reactions. congrats from a regular joe man. you blew my mind on this one.