THE MOST BEAUTIFUL EXPERIMENT IN BIOLOGY: Meselson & Stahl, The Semi-Conservative Replication of DNA
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- čas přidán 6. 05. 2014
- yourekascience.org/portfolio/t...
In 1958, Matthew Meselson and Frank Stahl published the "most beautiful experiment", where they demonstrated that DNA undergoes semi-conservative replication. In this video, we describe the experiments that lead to this discovery and why understanding how DNA replicates is so important. This video is a complement to Matthew Meselson's iBiology Discovery talk, where Meselson recalls the events that led him to meet Frank Stahl and to plan and execute these experiments.
This video was produced in collaboration with iBiology.
iBiology (www.ibiology.org) is a growing collection of free open-access online videos by scientists about research and discoveries in fields including cell biology, neuroscience, molecular biology, microbiology, ecology, development, and biophysics, and also features short talks on topics such as professional development, careers, policy, and education. iBiology is funded by NSF, NIGMS, and HHMI, and is supported by the ASCB and UCSF. - Věda a technologie
this was so satisfying to watch...your handwriting is GLORIOUS
Kind of like Vihart
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this must have taken ages, but I am so grateful for it! it's difficult for me to pay attention to stuff like this, but the drawings made it very entertaining
i've never ever written a comment on a youtube's video before. but this video totally helped me and it deserves all the recognition it can get. this video was so amazingly clear, fun to watch, understandable and just life saving. thank you so so much, love from Malaysia !
As a biology student I found this really helpful. Thank you for posting it!
Wow I'm German and hadn't unterstand the Meselson and Stahl experiment til yet. I watched 10 german videos about Meselson and Stahl, but only THIS video has show me how it works! I thank you so much!! :)
Indeed... :D
Salmmor haha Same 😂
How is being German related to better understanding of a molecular biology topic? Science is universal..nationality should hardly matter!
Omg ja einmal auf Englisch angeschaut und alles verstanden
The only Meselson and Stahl video on CZcams that actually helped me. Two thumbs up!
Actually, everyone gives Watson and Crick all the credit for discoverying DNA Structure buuuuuutttt, Rosalind Franklin was the one to discover this, for she spent so much time using X-Rays in order to figure out the DNA structure, which caused her Cancer. While she was sick battling cancer, two other students researching DNA Structure in the same University( WATSON AND CRICK) sneaked into her Dorm room and stole all her notes AND Published them taking all credit and A Nobel Prize for it But Rosalind Franklin died of cancer before she could take back all recognition of her Research.
+Adlin Hernandez I like how you talked about Rosalind Franklin! She was actually a huge part in the discovery of DNA because of the X-Ray diffraction she was able to obtain. It was critical in understanding that DNA spiraled in a double helix. Unfortunately, due to the reputation of women in science, her work wasn't really respected and neither was herself as a scientist in general. Unfortunate that her death occurred before the Nobel Prize because I believe she would have made a huge impact in the stigma that women scientists aren't as great as men -- which even exists today as women get paid less :) Hopefully that can change!
is it true ..? i mean i never heard of it before !
yea she basically told them everything they wrote about
This is not strictly true. Yes Rosalind Franklin was an X-Ray Crystallographer at Kings College London were work was undertaken to determine the crystal structure of DNA (along with the scientist Maurice Wilkins) , the data of which Watson and Crick used to describe the structure of DNA in their publication 'The Double Helix'. However, Watson and Crick were working at a laboratory at Cambridge, not Kings College London and neither of them were students, they were all research scientists working in different laboratory groups. In 1956, three years after Watson and Crick had published their model, Franklin was diagnosed with ovarian cancer, which exposure to x-rays has been suggested to be a possible factor in her illness although other members of her family had previously died of cancer.Nonetheless, Franklin's work was crucial to the development of Watson and Crick's model and she definitely should have received recognition.
TRUTH she died because of her research and work
This was amazing because you gave it so much context. My Biology teacher wasn‘t able to explain it in a logical way. 🙆🏻♀️
Now I‘m feeling well-prepared for my pre-exams. 👍🏼
This video was so so SO well done. Please continue on!!
I have never studied anything bio related before my first bio class in college. I was crazy nervous but these videos have helped me understand much better! Thank you so much !! :)
Brilliant! Was having a hard time understanding my Biology paper but this makes everything so clear! Thank you very much!
OMG I finally understand what my teachers were talking about! Thank U so much ☺
This is the best video on the internet for learning this.
Thank you guys for the amazing video :)
Fantastic!!! Your videos keep getting better and better... Thanks for this videos...
Thank you so much! It was hard to understand in class and in my textbook, but you explained it very well and now I understand it!
this video is super good! definitely helped me understand this experiment A LOT more than i had before.
Yours is one of the most beautiful videos on this topic .
This literally gonna help me on the bio test tomorrow. Thanks
Thanks for this amazing video!!
It makes it much more easy to understand
simple, well explained, easy and clear sound , may Allah bless you for that !
🕸🕷and may your good angel 👼 support you
Ibrahim Aldhoon inshallah
false god and idol. Jesus is the ONE true living God.
@@Get2KnowJesus1 this might be a shocker but there is more than one religion in the world!
@@Get2KnowJesus1 stop shoving your religious beliefs into others, let people believe what they want to believe geez.
Whoever disliked the video has a mental problem ...seriously who In the damn world would dislike this amazing creation, it's perfect from the colours to the voice to the explanation .. everything in this video is perfect.. thank you soooo much ❤❤
It's awesome how it describes the process in such a interesting way and also the drawings are Soo good
Beautifully done, really helped!
This is such a logical explanation. Easy to understand. Thanks a bunch ❤
Just the video I was looking for!!!! Awesome!
Super, wonderful, fantastic, amazing, mind-blowing, such a good creativity , explaining using diagrams makes students understand the concept easily and remembering quickly , tq so much, for this type of videos
This really helped clear my concepts. Thanks a lot
Your voice makes the video more understandable ❤️
This is truly an amazing video. Thank you so much!
Very educative, thank you very much. My semester just got saved!
+Anant Goswami I feel your pain. School is tough.
I'm in college bru!
Anant Goswami oh boy
The best video in CZcams
Hats off for you sir.
this was awesome plz don't stop making such type ved and thank you so much!
Great explanation!! LOVED IT
Thank you for this thorough and clear explanation of Meselson's and Stahl's experiment.
Thank you for posting it!
OMGG!!!! THANK YOU SO MUCH!!!
This was so helpful!!
Thank you so much! Very informative and understandable!
Thanks a lot for such informative content!
So useful😍 simple and clear thank you❤️
Thank you, it helped me so much!
This lesson is quite amazing, am glad that I finally understand DNA replication
I loved it even for the international student was so easy to understand
Beautifully explained!
Thank you So much. It is Simple,Intresting to understand the concept.
Thank u for d video.. It was so simple and clear.
thank you so much this was so easy to understand!! 😭😭👍👍
this video is sooo good thank you!!
This is the most beautiful way to explain,the most beautiful experiment in the history of biology.
Thank you! So glad you like it :)
Easy to understand and fun to watch too
wheenever i watch ur videos your writing is so satisyying
thank you! this video helped a lot
Thanks now the concept is crystal clear😊😊😊
This video is so so helpful, I'm definitely a visual learner
same!
English Rose me too
Thankssssss. The german yt videos were as complicated as my biology book, but this Video was easy to understand
You saved my life xD
AMAZING EXPLANATION!!! I finally understand this yayayaya :D
one question though: what if the bacteria were allowed to replicate a third time in N-14?
Afifa Amjed it would depend on which strand was getting replicated i think. So if it was the light strand it would just come out as 2 light strands. But if it was the hald half strand it would come up with 1 strand that is light and 1 strand that is half half
www.thestudentroom.co.uk/attachment.php?attachmentid=698336&stc=1&d=1508899096
This is the picture in my textbook. I don't get the results of the 3rd generation with N-14 (test tube 4).
Wow .....‼️‼️‼️‼️ excellent explanation
excellent presentation👍👍
Muchas gracias ♥
Nice clarification information 👍
Very nice explanation.
Tysm for this video 💜
Thank you... I understand!!
thank you so much! this saved me.
thank you for this really helped me
Amazing. Very very damn helpful.
Very helpful 😊
Very useful to me,thank you!
Amazing video.
woww wowww woowwww... this video is superb as u gave us the information from the beginning :D
Perfect video.
GATTACA reference 5:27
Death Metal?
This is basically rewriting we
No, battlestar gattaca
wow i have a bio final for college tommorrrow and you helped so muc
You're very welcome!
Very well explained
Beautiful video
so nicely explaned...thnks
You deserve more subs
You explaind it soo well that I can unterstand it even if I am german
This is really good
You should add time stamps it will be more convenient for us 😉 .
👏 Amazing video
Thanks for the tip!
It is indeed a very elegant experiment
Outstanding effort👌👌
Thanks a lot 😊
Even if english isn't my first languaje you managed to explain it better than other videos in spanish (first languaje) congrats
Beautiful .
Thank you very much doctor
Well done! ^.^
Really thanks a lot! It was explained so nicely that after watching many videos I finally understood because of this!!!!
Ceasium chloride density gradient was used to separate.
Very clear
really beautifull idea....
why does the 1st to 2nd replication support semi conservative? i know you said it doesn't support conservative but it does support semi and dispersive, but why?
Good work, here!
can u explain beadle and tautum experiment
thank you so much bless you
THANK YOU
thank you!
Thanks for this. I come from engineering background, so this might be a naive question, but why do we care about 3 'types' of replication? I mean, isn't next generation essentially the same in structure?
sahdeV The question was how does DNA replicate? The three replication "types" were
hypotheses about how replication can happen. Only one of them was true.
It's important to understand exactly how replication happens in order to
better understand how genetic information is spread and how disease
genes can be transmitted. It has also opened up many doors for
developing useful tools to manipulate DNA in the lab. I hope this makes
sense!
Cheers!
Florie
YourekaScience I see... So only one of the three models is true. But there was another youtube video I came across that said *most* of the replication is through semi-conservative mode of replication.... did NOT say it only *is* the true mechanism. Therefore the confusion...
I have kind of heard that the sequences made with A,G,C and T make up our physical attributes including characteristic facial features, dictate our immunity etc. What video is the good point to learn about that from your series? I am interested in learning these from CS/pattern recognition point of view, I do not have much of chemistry/biology background, but I wouldn't mind learning a bit about it if its absolutely necessary to.
sahdeV DNA replication is always done in a semi-conservative manner. There is no other way DNA can be replicated.
Regarding learning how genetics works, my videos apply these concepts to specific examples. You can see all of our genetics videos by clicking on "Genetics" here: yourekascience.org/videos/
I would say a few that you may be interested in are slightly older videos: "He’s Got His Father’s Eyes and His Mother’s Mutations" "Shedding Light on the DNA’s Dark Matter" or "Colon Cancer: Signed, Sealed, Resected"
YourekaScience there is another type of replication called binary fission but only works for bacteria yes/no?
Xin yuan Binary Fission is a type of cell division. During binary fission, the DNA is replicated and it's replicated in a semi-conservative manner, as in the video. I hope this makes sense!
superb!
That was absolutely helpful
Thank You guys great job :)
Ahhh thank God for CZcams!
Awesome n best n beautiful vedio ever watched
Thank you so much 😀