Omygoodness! In all honesty, thank you so much for your videos! I was completely lost in my biochem class but i thankfully found ur videos and i finally see the light! Thank u soooo much! ^.^
Nice that I stumbled upon your videos. I have no experience with biochem and got research with molecular dynamics so these videos really help me understand the underlying principles :D.
thanku so very much you are life saver . I'm a medical student and tomorrow is my biochem exam. I had some confusions related to protein structures which your tutorials cleared in short amount of time ! thanku! ☺☺☺
Thank you for this very clear presentation, we`re gonna be having an exam tomorrow on biochemistry and your video lesson is very much helpful! :D God bless.
Hello, thank you for taking the time to create and post these lectures for free. Many students, myself included, appreciate your work greatly. Just one question from this video -- if bond formation gives off energy and is exergonic, and the reverse is true for bond breaking, wouldn't the formation of a peptide bond be favorable since it is exergonic?
This is super late but just in case someone else has this question: Breaking bonds requires energy and forming bonds releases energy, but every chemical reaction has both (including the formation of a peptide bond). In every chemical reaction, the reactants’ bonds are broken (in this case C-O and 2 N-H bonds) and new bonds are formed to make the products (in this case the C-N peptide bond). Though energy was released in forming the peptide bond, energy is required to break the other three bonds. The energy required to break those bonds is greater than the energy released by the formation of the peptide bond so the reaction overall is endergonic and requires a net addition of energy and its thermodynamically unfavorable!
Where does the high activation energy needed to break down the peptide come from? What is the origin of it so to say? Is it in the interaction between the atoms of the two aminoacids?
Hey, do you think you could do a video on gene mapping sometime? How to efficiently find the distance between genes on a chromosome and go into mutations and why these distances actually matter? I've been having a lot of trouble with this in bio!
if the activation energy for the hydrolysis reaction is more, how can the condensation reaction take place since the activation energy for the peptide synthesis is greater than in the reverse process? (from the energy level diag), please do reply ASAP
Cognitive Philosophy Dehydration synthesis implies that we are synthesizing something and in the process releasing a water molecule. Dehydrolysis is the process by which we release water in the reaction. I'd say the two are the same.
Hlo sir, Sir there is a confusion regarding the graph. Sir would u just reply that how does the progression of the reaction depends upon thermodynamics and kinetics . Like the reversed rxn is not kinetically favorable....but sir if our body break the EA( barrier) for the forward rxn then why does is it able to break the EA(barrier) in the reversed dirn...
I believe ATP can take part in the reverse reaction but will require a lot, but the body can't produce that therefore enzymes and other factors will be needed.
Thank you Andrey for linking multiple concepts together to fully understand by exploring the larger picture of the peptide bond process.
Your videos are just awesome! Im currently going through the proteins playlist and so far so good! Thank you!
Really your are an amazing lecturer that i reviewed most of biochemistry in no time
Thank you very much
waiting much more lectures
Omygoodness! In all honesty, thank you so much for your videos! I was completely lost in my biochem class but i thankfully found ur videos and i finally see the light! Thank u soooo much! ^.^
Nice that I stumbled upon your videos. I have no experience with biochem and got research with molecular dynamics so these videos really help me understand the underlying principles :D.
I ACTUALLY find this very helpful. Thanks
WOW, clear and precise... youve saved me a ton amount of time and stress...Sir , you are amazing. Thank you...Im going pass this course.
Clear explanation of peptide bond formation
literally saving me in my Biochem class. Thank you so much!
thanku so very much you are life saver . I'm a medical student and tomorrow is my biochem exam. I had some confusions related to protein structures which your tutorials cleared in short amount of time ! thanku! ☺☺☺
You're the best! Thank you!
wonderful,amazing and very helpful thankyou sir may God bless you
Thank you for this very clear presentation, we`re gonna be having an exam tomorrow on biochemistry and your video lesson is very much helpful! :D God bless.
vince kaizer thats awesome! best of luck, let me know how it goes!
Great lecture!!!👏👏👏You really know what you teach!!!👏👏
Thank u very much, you’re a life saver
Your videos are amazing!thank you ! I wish you could do some problems too.
2024, and I still watch your awesome videos 🎉
Thank you so much, this is so helpful
U make it very simple,well done
Thank You very much! This is very very very helpful
Rio Kristine Latoreno You're welcome Rio :)
You are a great teacher...I wish to take a lecture in one of your classes
Excellent work Doctor 👍🏾
thanks sir, u r simply amazing
Your lectures are always awesome 👌
Thank you sir , nice explanations
you are brilliant!!!!!
Thanks Andrew!
Hello, thank you for taking the time to create and post these lectures for free. Many students, myself included, appreciate your work greatly. Just one question from this video -- if bond formation gives off energy and is exergonic, and the reverse is true for bond breaking, wouldn't the formation of a peptide bond be favorable since it is exergonic?
This is super late but just in case someone else has this question:
Breaking bonds requires energy and forming bonds releases energy, but every chemical reaction has both (including the formation of a peptide bond).
In every chemical reaction, the reactants’ bonds are broken (in this case C-O and 2 N-H bonds) and new bonds are formed to make the products (in this case the C-N peptide bond). Though energy was released in forming the peptide bond, energy is required to break the other three bonds. The energy required to break those bonds is greater than the energy released by the formation of the peptide bond so the reaction overall is endergonic and requires a net addition of energy and its thermodynamically unfavorable!
@@ernestorallon you r the best honestly thank you so much for explaining cause I was EXTREMELY confused
You are awesome, thank you so much
Where does the high activation energy needed to break down the peptide come from? What is the origin of it so to say? Is it in the interaction between the atoms of the two aminoacids?
can i ask one question please? what is the polarity of peptide chain?
thank you
Thank you very much this was really helpful,,,
I have a question regarding the bonding of glutamic acid why is it involving the y-side??
At which point would I find the N-Terminus and C-Terminus?
Thanks a lot
Thanks from Pakistan 👍👍👍
Thank you!!!!!!
good job bro
Thanks
THANK YOU like really thank you
-a medical student from palestine
Hey, do you think you could do a video on gene mapping sometime? How to efficiently find the distance between genes on a chromosome and go into mutations and why these distances actually matter? I've been having a lot of trouble with this in bio!
i have a lecture on gene mapping and determining gene order.
Uli wakulekafye iwe 👏👏👏
if the activation energy for the hydrolysis reaction is more, how can the condensation reaction take place since the activation energy for the peptide synthesis is greater than in the reverse process? (from the energy level diag), please do reply ASAP
ATP from the rnas that put aminoacids together in the cytoplasm
Also catalyst help decrease the energy, but atp is still needed
Is the term dehydrolysis reaction synonymous with dehydration synthesis?
Cognitive Philosophy Dehydration synthesis implies that we are synthesizing something and in the process releasing a water molecule. Dehydrolysis is the process by which we release water in the reaction. I'd say the two are the same.
thanks sir
Hlo sir,
Sir there is a confusion regarding the graph. Sir would u just reply that how does the progression of the reaction depends upon thermodynamics and kinetics . Like the reversed rxn is not kinetically favorable....but sir if our body break the EA( barrier) for the forward rxn then why does is it able to break the EA(barrier) in the reversed dirn...
Sweet
Superior lecture. I am a tutor and have watched many sources. Keep the white background. It makes for good screen captures and printing.
Can u please do lectures on immunology
Where to get pdf notes Sir Please guide me
💛💛💛
Why ATP molecules cant break peptide bond?? The same way that they form peptide bond?
I believe ATP can take part in the reverse reaction but will require a lot, but the body can't produce that therefore enzymes and other factors will be needed.
not being funny bruv im grateful for your videos but how many times did you have to repeat about the activation energy hump i nearly did a backflip