Epigenetics3: Histone Modification and ChIP-seq
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- čas přidán 31. 01. 2019
- This module discusses the ways that we study histone modifications in epigenomes, primarily through chromatin immunoprecipitation (ChIP) and ChIP-Seq analysis. At the beginning of this course module you will be introduced to the basics of ChIP and ChIP-Seq analysis followed by a more practical section on how to prepare for ChIP and how to analyze ChIP-Seq results. Finally, you’ll participate in a hands on ChIP-Seq analysis activity and have the opportunity to complete your own research project, if you choose. Learn about it with hands-on examples: edu.t-bio.info/course/epigene...
I like your presentation very much! Very clear understanding. Thanks for your hard work.
Thank you! Please visit our website to join these online courses: edu.t-bio.info
Great video! Thank you!
thank you for the feedback!
great vedio on epigenetic reguations
Really good one .very clear and constructive
Glad you liked it
Super clear explaination
Glad it helped
Thank you so much, it's pretty clear and good video, and your channel is great.
I appreciate that! learn.omicslogic.com
thks
Hello, I remember reading about how epigenetic changes can be prevented from being reversed if they have a lot of chemical markers on them. However, I cannot find the video that talked about this. Could you elaborate on this idea? Thank you
thanks a lot for this video, I have one question, what is the difference between chip seq and MeDIP seq. thx in advance
Thank a lot for this video! I really appreciate it, where can I find part 1 and 2?
these courses are available on edu.t-bio.info
@@omicslogic I think I will take the courses as soon as my semester ends, thanks a lot!
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@Raylan Camden instablaster :)
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can ChIP seq identify all histone modification? because from what i know the efficient technique to identify histone modification is by using sequencing. so can this method also be used to identify all the histone modification?
ChIP seq stands for Chromatin (Ch) Immunoprecipitation (IP) - sequencing (seq). The process starts with specifically designed antibodies that will bind to the histones. After they are bound, these DNA regions are clipped, then the portion of DNA where histones were bound are sequenced. Analyzing the sequences of those portions can help us understand where specific types of histones were attached to the DNA. Learn more: edu.t-bio.info/course/epigenetics-1/
Do histone active or repressive marks present in normal cells, or only in diseases? Thank you
Also cell differentiation is affected by such histone modification. www.nature.com/articles/pr2006122.pdf?origin=ppub
For as long as eukaryotic cells have existed, it is likely that CpG methylation, histones, acetylation and deacetylation, and phosphorylation have been selected for, and active in development and differentiation.
While any complex system is subject to errors disrupting what we might cell healthy activity, expect that the processes, however complex, arose through selection for optimal utility.