Kipoi Seminar - David Kelley (Calico)

Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
Abstract:
I will describe a neural network model, Borzoi, trained to predict cell- and tissue-specific RNA-seq coverage from DNA sequence. Statistics derived from Borzoi’s predicted coverage isolate and accurately score variant effects across multiple layers of regulation, including transcription, splicing, and polyadenylation. The wide availability of RNA-seq data across species, conditions, and assays profiling specific aspects of regulation emphasizes the potential of this approach to decipher the mapping from DNA sequence to regulatory function.