Epstein-Barr Virus Causes Multiple Sclerosis! [US Military Longitudinal Study]
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- čas přidán 7. 06. 2024
- An incredible case-control study from Harvard provides strong evidence that Epstein-Barr Virus, the cause of mononucleosis ("The Kissing Disease") causes multiple sclerosis. I also review 3 potential treatments of EBV which could benefit people living with MS in the future.
The study I am discussing:
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis: www.science.org/doi/10.1126/s...
Other Sources:
Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis: jamanetwork.com/journals/jama...
Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase: www.pnas.org/content/117/22/1...
Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple Sclerosis: clinicaltrials.gov/ct2/show/N...
Moderna’s vaccine trial: trials.modernatx.com/study/?i...
Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis (EMBOLD): clinicaltrials.gov/ct2/show/N...
Comment or ask questions below! I would be happy to answer!
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My book "Resilience in the Face of Multiple Sclerosis" on Amazon: www.amazon.com/dp/B07WP7H5LK
Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.
Follow me on twitter: / brandon_beaber
Music: INNER GRACE - Copyright 2018 Wilton Vought Source: Really Really Free Music Link: • Video T
he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information. - Věda a technologie
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I shed tears watching this. I always thought the idea that the immune system would just randomly go after the cns as an absurd idea. Thank u for sharing dr. Baeber
I'm glad you liked it.
My thoughts exactly! My theory (no scientific support whatsoever) is combination of brocken blood brain barrier (trauma or oth causes) and viruses/toxins/ anything going into CNS tissues. Immune system is NOT stupid! It's trying to kill the cells containing those infectious/ or toxic substances.
@@DrBrandonBeaber Do you know if low CD57 test results (17) would possibly indicate EBV/possible MS? When having this test, I had other Lyme like symptoms and was later determined (without MRI) that I was infected with Burgdorferi Borrelia. My symptoms were primarily central nervous system brain related symptoms. I was told that I tested positive for previously having EBV but that everyone would. I don't recall having mono.
@@amygignac2668 CD57 is a marker of natural killer cell differentiation and has been associated with various infections, but I don't think it is specific to EBV or MS.
@@DrBrandonBeaber Okay thank you, I just wasn't sure.
Had EBV and Mono for months back when I was 16. Diagnosed with MS at the age of 33, but first symptoms started 10 years prior to that...
I also have read the research, and i was informed that moderna is trying to develop an EBV " vacine " based on MRNA tecnology to eradicate the virus. My question is how is this gonna help people who already have been diagnosed with the disease and have symptoms? What could they expect ? ( I have been diagnosed with ms 3 years ago ).
I hope you didn't take it. EBV has been discussed by the best of the best with NO ANSWERS in sight.. I first heard about it in the early 80s
@@IsabellaHale Take what? There is no vacine for the moment. And even in the case it existed, i already have MS.
I had severe mono at 23 and was diagnosed with MS at age 37…this discovery is fascinating and I hope the vaccine for EPV changes MS for the future!
I also had MONO at the age of 20 and have been checked for possible MS since 2019, have had funny symptoms since 2016.
I grew up in a tick area (had two ticks/nymphs at two points as a child). I had EBV and a severe case of Mono which had me bedridden and ”half dead” for months when I was 15. Then I had a noticeable case of CMV in my early 20’s.
And after that it went completely downhill for me. I developed Severe M.E. and have been trying to battle this illness now for 15+ years.
I have days and weeks that are slightly better (when physical and mental torture is less and I can actually write and think and participate for a few hours).
I just had Covid for three weeks and now all my M.E. symptoms are way out of control again with feelings of sinusitis (but in my brain), severe POTS, abnormal heart rate and uneven heartbeatings, personality changes - besides all my other M.E. symptoms that are always there.
I have not MS, but ME.
And yes, I have gotten slightly better and lessen some symptoms with extremely strict diet which among other things exclude sugar, gluten and milk products (I’ve gotten so much worse those times I’ve tried them again).
Also doing antiviral herbs and raw food vitamins has helped me be able to get my thoughts together, my speech and ability to write back.
I need to do Pacing (do as little mental and physical activities as possible - or I get much worse again and turn into a person who only lays in a silent dark room for weeks).
Now, when I feel I can, I do gentle Qigong and deep breathing techniques.
Coconut water (magnesium and potassium are good for POTS. Keltic Seasalt, water.
I’m crashing as I write. I have a lot of advices on what can help somewhat for at least M.E. But I must rest now.
Even if it might sound corny: Wishing everyone better/good health, love and peace. 💜👋☺️
CMV is also a herpesvirales organism. CMV also came in through the Po' Leo shot. CMV and TB have an affinity for adrenals which can explain some of the profound fatigue.
👋 Hello Dr. Beaber what are your thoughts on bovine lactoferrin consumption? 📣
- Immunomodulatory
- Anti-viral
- Regulates intestinal permeability
EBV Study: LF prevented EBV infection of primary B cells mediated by its direct binding to the EBV receptor (CD21) on the B-cell surface.
**See next comment. (character limit, forces me to break these up)
Pdem1c Study: A study in Italy found the time to test negative was 46% lower in patients taking Lactoferrin in pat1ents with a Forbidden word virus. (A follow-up study is currently underway)
MS Study: The histological analysis of the spinal cord revealed reduction in the number and size of inflammatory foci in LTF-treated rats. In addition, a small clinical trial on subjects suffering from multiple sclerosis (137) demonstrated that oral treatment of the patients with LTF resulted in a profound decrease of IFN γ and increase of IL-10 secretion by whole blood cell cultures stimulated with cytokine inducers. These changes were accompanied with an improvement of their clinical status.
Lactoferrin has demonstrated positive results across a number of d1seases including Rheumat0id arthr1tis, Chrons D1sease, Alzhe1mers, etc. ( In vivo and vitro. In mice and humans)
Unlikely to see further clin1cal stud1es or progress unless a "comapny" can develop strong IP around LF. 🤷♂️
My subjective experience: 2 family member have taken LF. 1 with MS had daily headaches and blurry vision haIt within 2 weeks of use. No other clin1cal symptoms present. The other has stage 4 melanoma and became anemic. Between blood tests he added in LF. Iron and RBC increased to n0rmal range. (Has since started immunotherapy)
It took me over an hour to get this posted. YT kept removing my comment. Apologies for having to encode the message.
@Dr. Brandon Beaber
MS has some strong link with stress. Because i had no symptoms until last years when i suffered severe stress January last year in december i was diagnosed with optic neurtis . MRI shows a lesion in periventricular region 5mm size and in lesion juxtacortical region. OCB test says tha band are present in both blood serum and spinal fluid.
Good morning doctor Brandon, thank you for doing this video. It was excellent. At the age of 55 I honestly don't know if I ever had EBV but I do recall somewhere in my late teens and early 20s I experienced major fatigue and sleepiness and often wondered if that was related. Could this be a question I could pose to my neurologist? It's so ironic that doing doing a video on this because there's also been some articles on it lately. Also I just lost the love of my life of 31 years last week and not long before she passed away she had asked me do you think you ever had the EBV virus. Again I want to thank you for this one and yes if there ever was a possibility I would love to take a treatment to shut this disease down or at least quiet it. Thank you for reading my long-winded message and I always enjoy listening to you because to me you're not just a doctor but a friend also. Until next time take care and have a great day.
Sorry to hear about you losing your partner Robert. The episode of fatigue certainly could have been mononucleosis. I had a similar episode in my 20s and wonder if I could have had mono myself.
@@DrBrandonBeaber thank you for getting back to me as quick you did because I know you're a very busy man to say the least and it means a lot. I'm blessed to have my 24 year old son with me and a number of family and friends in our corner and I really need that right now. Thanks again for answering me so quickly, it's much appreciated. See you next time kind sir.
I had mono as a teen and now have MS. I wonder if they should be monitoring titers of EBV now to get those with higher levels preventative treatment
Thank you for these videos! I was infected with mono when I was 15 and at 30 I was diagnosed with MS. I am happy to hear there are studies underway and I’m looking forward to more effective treatments!
Me too ❤️
Hi Dr. B! I had many episodes of strep throat and Mono as a child. I was actually diagnosed with RRMS at age 19. Can't recall if I was diagnosed with EBV, would have to look through old medical records, am now 48 and just now experiencing SPMS. This study is so very interesting!! Thank you for your video! 👌
Mono is a symptomatic form of EBV so if you were diagnosed with that then you were diagnosed with EBV
Will an EBV vaccine help an already affected MS person ?
Thank you so much for doing this video! I had mono when I was in the US Navy back in 2011. Developed symptoms of MS in 2015 and was diagnosed with MS last summer after a significant flare. I hope that this study provides enough proof that the medical community will see the importance of creating a safe and effective vaccine against EBV. My children are 2 and 4 years old and while a vaccine can't help me it could help my children. There is hope for the future 🧡
There is definitely hope, though the vaccine is probably many years away. I imagine people would be reluctant to take it as well. Perhaps some of the early studies will be in the children of people with MS who are most likely to benefit from it.
@@DrBrandonBeaber totally agree! In our current culture some people will definitely be against it, but that's their choice.
Dr. Beaber - THANK YOU for making this video. FYI - I have MS and my viral panel lit up like a Xmas tree and I also have CMV. Tests can also be so faulty. No one ever mentioned EBV to me until 4 or 5 years into my diagnosis and a functional med doctor told me it showed up in some tests as a "past infection" and it was nothing to worry about. WRONG!!!
Glad the video was helpful. EBV is long-known to be a major risk factor for MS.
Thank you for the very detailed explanation, Dr Beaber.
I'll start Mavenclad on Monday, and I hope that new medicine targeting EBV will become available for the time I'll finish my second year cycle.
How long do you imagine it will take for these new medicines targeting EBV to be released?
Thank you!
For the vaccine, it will take many years. For repurposing of antivirals or ATA188, it could be faster. For ATA188, is theoretically possible it could get approved after the phase II trial if it is a spectacular success, but this is unlikely.
I'm on Mavenclad as well. Just finished year one. Mavenclad targets B and T cells. Hopefully it'll help me... I got mono at 14 and MS at 21.
Science, and I mean proper science that actually follows the scientific method is non-ex!stent in virology. So no one can say that there is or ever was a "v-!-r us". Unfortunately, most people don't understand the methods used in virology, so they don't realize these fictional "v-!-r us" objects have never been seen or found in a person's clinical specimen. They're the modern equivalent of "evil spirits" for today's society. Beliefs. Really. All with mass regulations, ritualistic like injections, masks, etc. based on these beliefs. I think it's time people learned the truth. Those are the facts.
@@prestige8161 you sound really sick, I hope you get help.
@@Elem70 If you think I "sound sick", then you should be concerned. Because what I stated is the fact of the matter. You should be disturbed by that.
Hi Dr. B my son has MOG and presented with TM. He also tested positive for EBV I am wondering if we will find a link to MOG and EBV. I know MOG and MS are different but similar.
Thank you for all of your videos. Any info on Evusheld, especially for people on B cell depleters?
could you measure sNFL to see if you got activity or is it not the way to go and too expensive?
Thanks Dr. Bieber !
I never had mono but my sister law with MS had mono in her teens. I’m hopeful something will happen sooner than later with all this research.
Hey, Dr. Beaber -- my wife has 24/7/365 vertigo with her MS. She's tried motion sickness medications with no effect. It's so bad, the dizziness often takes her breath away and the associated nausea impacts her ability to eat. Any suggestions to help impact this? We're pretty desperate and open to anything. We appreciate all you do for the MS community!
Excellent video, as is always expected and delivered by you! Thank you. I had a severe case of mono at 14, with a swollen spleen/liver and all the rest of the typical symptoms. I was out of school for 2 months! I hope some kind of anti viral will be able to come to market in the next few years. A girl can dream...
I have never been diagnosed with mono, but I was definitely exposed many times in my high school years. Annnd I don’t know the statistics but quite a few women I’ve met in support groups had their MS start up after giving birth, can pregnancy reactivate the virus?
Thank you for delving into this - in English and breaking it down… it is SO hard to get people to understand this- who are not familiar with the medical field.
#Sharingiscaring ❤️
:)
Thank you again for your work!
Will the vaccine be also effective for those who already have ms? This one is another one than the other vaccine which was discussed, right?
Suggestions:
There was a little study about the effect of frankincense extract a few years ago, maybe it’s worth to take a look
Also I watched the series unnatural selection which discuss genome editing. I know it’s a very sensitive topic, anyway I am wondering if this could be a chance in the future
i have the same question with you, what could be expected for us which are already diagnosed with symptoms?
I think you have to tag Dr. Beaber with the @ symbol or by hitting the reply under his name for him to see your question.
Back in 1982, a friend and I ate at a certain restaurant, after which he got mono and I got hepatitis. I'm sure I was also exposed to mono, though the symptoms would have been masked by the hepatitis. I had my first attack of optic neuritis in 1985. The EBV link to MS makes sense to me!
Do you know (for certain) which type in hepatitis you had?
There IS such a thing as "EBV Hepatitis".
Also, roughly 5% of cases of mononucleosis are caused by CMV and not by EBV.
Have you been "officially" diagnosed with MS?
@@MissAstorDancer Great question! I was diagnosed with Hep A and treated at the University of Virginia med center, so I'm pretty sure they were right. And yes, unfortunately, I really do have MS. My MRI scans tell the tale even more than my symptoms do.
Hi- I don’t remember having mono- my EBV results was greater than 600k- any DMT that will beneficial for us now? Do you do any telehealth consults? - hello from Florida - glad to have found you!
Does the higher the IGG titer is level correlate with a higher chance of causation of MS?
Fast and very good to follow a rare combination 👌 I love to see an in depth video about BTK inhibitors. Hoping to be in the Perseus Trial (Tolebrutinib) here in Holland, maybe this will buy some time . Some sort of EBV specific CTL trial done here in Europe in yhr near future would really be fantastic!
I do have a video on masitinib which could be useful: czcams.com/video/AG0gYGdk_gU/video.html I am interested in the results of the PERSEUS trial, so best of luck if you enter the study.
Wow, this is epic news! It will be interesting to see the development of the EBV vaccine. Kudos to all the scientists involved in this process. I had mono in college in 1981 and was diagnosed with MS in 1993 although I had symptoms since 1989.
How can one know if u have it, i k ow many people measured negative and still have ms
Thanks Dr. B! As always I learn so much from your videos. Could you do a video on low level inflammation, how it affects the course of our MS, and what we can do to help mitigate it? Is there anything we can do tamp it down to slow down or stop symptoms or progression?
This is a good idea. Professor Gavin Giovannoni had a nice article about smouldering inflammation in MS which I want to do a review on. It may be that a treatment geared toward the innate immune system (i.e. microglia in the brain parenchyma which have been implicated in progressive MS) may be a better target.
@@DrBrandonBeaber awesome! I look forward to hearing your thoughts on it.
As a biomedical engineer that's been studying this type of material for nearly 20 years and recognizes the blatant flaws in virology; One of the questions I get asked a lot is "what proof or process would you regard as being valid in confirming (or otherwise) the existence of v ! r uses" (a.k.a. mythical creatures)? Basically scientists would just need to adhere to the Scientific Method, but that's apparently too much to ask.
To hold any validity, scientists would need to actually Isolate & Purify out whatever particles they hypothesize could be v! r uses from a sick person, and then perform proper scientific experiments with them in order to prove that hypothesis true (or not). Ironically, the isolation method I'm about to describe is even written in microbiology text books and universally recognized as the Gold Standard of isolation. Yet virologists never do it:
ISOLATION & PURIFICATION
They should be taking fluid samples from a diseased person and then filtering through "viral sized" particles to bulk remove larger things from the sample. Then follow that up with density gradient centrifugation; which allows objects in a centrifuge tube to be separated by their density. That process would create separated "bands” (objects of different density) around the centrifuge tube. The suspected v! r us particles (if they existed) could then be extracted from one of those bands - thereby Isolated & Purified from everything else. Just Step-1.
CONFIRMATION AND CHARACTERIZATION
The suspected particles should be visualized under a microscope to see what they look like and Ensure everything under the scope are the same type of particles. Those objects should be mapped and characterized for their physical structure, size, and genetic makeup. Once scientists have ensured they've captured those unique particles only, they would then need to determine if they are in fact real life v ! r uses.
EXPERIMENTAL STUDIES
They'd need to use those particles in properly conducted experiments to see if they cause the original disease; using animal/plant/human hosts as test subjects, depending on the hypothesis. They would also need to run at least one equivalent negative control experiment (i.e. a control group) in parallel for comparison. If the hosts that were exposed to the particles become ill with the original disease and the otherwise equally treated control group does not, that would be suggestive of the particles being the cause. However, the basic idea of a v ! r us is that it invades a host, replicates itself via hijacking cells, and then comes out with bodily fluid (sneezes, coughs, etc.) and then goes on to repeat that process in different hosts, which is how it "spreads". So scientists would need to try and confirm that by again isolating & purify out those same particles from the hosts fluid samples. If the particles are discovered again in the exposed sick hosts, but not in the otherwise equally treated control group, then those particles could be said to be something like real life v ! r uses. They'd still need to do further studies to confirm the "hijack cells" theory, but hopefully you get the idea.
OBVIOUS FLAWS OF VIROLOGY
Virologists can’t just take pictures of something or sequence genetic material or claim symptoms/effects equals proof of a “v ! r us”. They need to FIRST demonstrate that through proper experimentation that follows the scientific method - That approach has never occurred in validating what they claim. It's simply a circular reasoning kind of belief system.
Their claims of “we have pictures” is ridiculous because microscopic particles don’t have little name tags on them that say “I’m a v ! rus”.
Their claims of genetic sequencing and pcr detection is equally ridiculous because they never separated out a “v ! r us" in the first place to prove that’s the origin of the genetic material.
They assume they found a virus by comparing it to genetic “virus templates” that were ALSO “found” the same way. It’s like claiming to have found a unicorn based on genetic material that you believe has a genetic similarity to that of a previous unicorn, yet no one ever found an ACTUAL Unicorn to get any genetic material in the first place!
Their claims of Effects/Symptoms equals an obvious sign of a “v ! r us” is probably the worst one yet. “The burned bodies MUST have been caused by a fire breathing dragon!".
Their claims of “cytophathic effects” (i.e. cell destruction) observed in cell cultures equals a “v ! r us” must be the cause of it is really just silly, for reasons that should be obvious.
So on and so forth… Just an endless loop of circular reasoning.
Thanks for reading. Feel free to let me know if you have any questions.
@@prestige8161 hello, thanks for this, I’ve read before about the flaws on isolating viruses …
What would be your view on ms being triggered by a virus? Thank you
@@prestige8161 so you think they have found nothing?
Very informative video as always dr , i had a question dr brandon is there a protocol or some sort of way to get people off DMT's that got rebound syndrome (Tysabri and Gilenya) . I recently started gilenya and I'm scared to death about that
Would you please doctor make a video about it
Supper intresting reaserch. I've never had mono and I don't recall if I had an EBV antibody test. It has been a causal consideration for many years for me though. Perhaps having a very low amount of such virus or antibodies lends to less sivear MS. Maybe the virus just likes to hang out in B cells or on myelin.
Very interesting, thank you for going trough the paper. Is my understanding correct that EBV is more in involved in onset of MS and thus treatments against EBV would ve rather preventive for developing MS than be able to treat already active MS?
If you look at the older study I showed on anti-EBV antibody levels, it suggests that ongoing EBV activity is involved in MS pathogenesis. Also EBV-infected b-lymphocytes have been discovered in the central nervous system of people with MS. You may be right that prevention would be more effective than treatment.
@@DrBrandonBeaber thank you very much for your response. Will definitly be interesting to see further results from upcoming clinical trials!
You ask if I found this talk useful - Off the Chart useful! Others could give the same talk, and no way could I follow to the end. BRAVO for presenting 19 minutes of fascinating and incredibly easy to understand EBV information. Fingers crossed for an MS path in prevention, management, and much more. Thank you, Dr. Beaber and yes, a shout-out to Professor Alberto Ascherio.
Thanks Jeff!
Mono at 19, my MS is said to have kicked into gear when I was 24 (according to my diagnosing neuro). This makes 100% sense to me.
I feel like you do I good job of letting the facts speak for themselves. I am wondering if your next video will be about the Stanford University paper that was published in Nature? I am very excited to hear you take on that paper!
so will there might be a drug study on about that virus?
My mom has Alzheimer's and my dad is deceased. There is no one that can recall if I ever had mono. I do recall always having chronic ear infections and sore throats/strep as a child. (I even suffered from horrific fever blisters.) As an adult, I have chronic sinus infections. Think there could be any relation?
I had mono at 13 or 14 years old. I was diagnosed with MS at 21. I began showing increasing heat intolerance and a few other symptoms at 17
In those who are not iron deficient iron supplements can wreak havoc in the body.
Does a negative EBV test eliminate a MS diagnosis?
Excellent video! Thank you for making this one!
Thanks!
What is the best blood test for chronic infection? EBV IgG and/or EBV nuclear antigen (EBNA)?
Hey doc,
Thank you for this great video. It was very informative for me.
I have some questions about ata188, because it's the most promising option for PwMS as I understand.
1. Firstly, why don't they measure or announce how much disease progression is slowed or maybe for how many people disease progression stopped in ata188?
2. By the way, is disability progression something that is targeted in this type of drugs? I think, I didn't see someone targeted this before.
3. Finally, is there any explanation for why only 9 out of 24 patients showed improvement?
Thanks for your effort.
This video on ATA-188 may be helpful to you: czcams.com/video/1ufzMFl8ykw/video.html They do look at the specific outcomes in terms of disability. I show some of this data in the video. Disability progression is a common outcome in clinical trials. I am not sure why only 9/24 improved.
This is so exciting news! I strongly hope that finding out more about what causes MS is the way to a better treatment. Thanks so much for your great videos Dr. Beaber! I finally understand my disease better because of your channel.
I'm curious about whether I still have traces of EBV after recieving aHSCT in Mexico which includes cyclophosphimide and also ends with rituxan? Is there any point in knowing my post HSCT EBV status?
I don't think there is a point other than curiosity. You could lose anti-EBV immunoglobins without necessarily clearing the virus.
@@DrBrandonBeaber I guess it'd always be wise to be well rested and stress free to avoid unwanted re-activations - at least in theory :)
Excellent job in driving home the causal nature of EBV that has been identified here. This has been missing from many of the current discussions. Looking forward, let’s hope that Gavin‘s predictions of approx. 5 yrs for ATA 188 and 6-8 yrs for the Moderna Vaccine prove to be correct!
We shall see. 5 years is not far away.
Thank you Brandon your videos are significantly interesting. My son got glandular fever in 2010 in 2011 exactly after a year of his glandular fever he was diagnosed as an MS patient. This a clear evidence that EBV is the cause of his MS. Now he is a wheel chair user and bed ridden with all the symptoms of a very severe and active MS. Is there a way to eliminate this EBV from his blood. Now he is 36 yrs old. Can you please advise us how to make him better is there a new drug, now he takes Ocrevus every 6 months. It has only stopped the frequent relapses, but he is deteriorating slowly. Thank you so much.
I can't give personal advice here. Unfortunately, there is no currently proven anti-EBV therapy, but I think ATA-188 and repurposed antivirals are promising. If you are interested, you could look into local sites for the Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis (EMBOLD): clinicaltrials.gov/ct2/show/NCT03283826
@@DrBrandonBeaber people ask you how to heal
you're still saying the same immune drugs work
Please look up the Coimbre Protocol and also Dr Terry Wahls. The analysis on this channel is incomplete.
Hello Dr Beaber. Thank you so much for this very valuable information. I wanted to ask you if you could do a review on the article that just came out entitled " Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM". Greetings from France.
So in the meantime, should we not be suppressing our immune systems? Should we take antivirals at the same time as a DMT?
What studies have been done on the c19 vaccine and those that have had mono/burkitts/ MS? My son had mono that turned into burkitts. Should he have gotten a vaccine in trial? is there anything to show what effects it may have on EBV/MS/Burkitts
There are observational studies showing covid-19 vaccines are safe in MS. ~95% of adults have EBV, so it doesn't make sense to do a specific study on this. I am not sure about specific research in Burkitt's lymphoma.
I must have been exposed to mono st some point but i don't get sick. For example ehen i tested positive for COVID i was asymptomatic BUT instead o will get a cold sore. Do you think there's a correlation?
Dr Apatoff asked me that question 12 years ago. Did I have severe mono as a teenager. And I had! Major swollen lymph glands, spleen enlargement and out of school for over a month.
Now my son just had mono last year right before catching COViD. I will he watching him like a hawk.
Never had mono, I did have tonsillitis as a child so not sure if that is when I was exposed to EBV?🤔
Hi. I don't think I ever had mono, but I tested positive for ms when I was 54. I'm now 64, I don't have ms symptoms but my mri's shows ms lesions. Very odd..
May I ask why you were tested with an MRI without MS symptoms? Do you not show any health issues at all? I know from having been infected with Lyme many of those symptoms overlap with MS but I showed symptoms. The two along with Covid seem to have many similarities.
@@amygignac2668 , I had a really bad cold and a clogged ear. I went to my ENT who said I needed to get an mri. It came back saying that I had a sinus infection, ms and thyroid cancer. CRAZY.
thankyou for this detailed information.
one thing if i am not wrong, 1/801 is 0.1% not 1% in case of the samples taken in your study.
Thank you. Excellent detailed information. Yes, I had mono and now have MS.
TOPIC/QUESTION: wondering 1. If pediatric MS is always preceded with EBV infection; and 2. Should a sNFL test or EBV titer be standard by PCP to time the vaccine delivery?
For pediatric MS, the rate of EBV positivity has been reported to be lower, but I am not sure about the accuracy of this result. Currently, I don't think there is much clinical utility to sNFL testing in an individual person (too much individual variation). I suppose in the future if there is an EBV vaccine, there might not be much point to give it if someone is already EBV positive.
@@DrBrandonBeaber Thx. Understood about timing in future of EBV and getting vaccine. But certainly any type of routine test might open the conversation prior to EBV exposure. A girl can dream, right? 😁
Hi Dr. Beaber. I had clinical Mono when I was 16 and got diagnosed with MS at 32, two years ago. I've always wondered when the onset of MS happened because I came down with Optic Neuritis only to discover 10-15 lesions including a black hole in my brain. No spinal cord lesions though. I also follow Matthew Embry and go off of his directed diet with no DMT's.
I have MS, diagnosed 2014, am currently undergoing HSCT as copaxone, tecfidera, tysabri, lemtrada and ocrevus have all failed. I have repeatedly tested negative for EBV, I've never had glandular fever. It might cause some MS, it hasn't caused mine.
Hi, again. Yes, I had EBV, I really don’t know that I had mono, because I grow up without mother, and dad didn’t take much care about my health. I’m very interested to take part in any kind of study. I think that my MS is interesting, because I don’t have any significant symptoms, actually I don’t have it at all.
Thanks for this breakdown Dr. - Fingers crossed for treatment and prevention pathways.
Indeed Justin
I ad mononucleosis when I was 15... and developed ms (diagnosed with RRMS when was around 34) but I had symptoms earlier then that (heat intolerance and fatigue)... also I had a cousin (passed away now) who also had mononucleosis and later developed a progressive ms.. and another cousin on opposite side of the family with progressive ms.. interesting information thank you for demystifying the study.
Could also pwms profit from vaccine against EBV?
But if EBV affect B cells, shouldn't that mean that CD20 drugs like rituximab and ocrevus will stop the disease completely?
The DISEASE is spirochetes. The SYMPTOMS are the body trying to seek & destroy cell wall deficient organisms but targeting host cells. Drugs will ONLY shut off the SYMPTOMS if they even work.
@@vaccinefraud5570 no it's not, and the drugs do work.
Try to read something from now and then
Very interesting stuff here! I had a severe case of mono at 16. Months after the birth of my second child at age 21, I began having symptoms I later recognized as MS (diagnosed at 25).
Just curious, but are these different strains of ebv, like certain ones connected with these various other conditions like the nasopharyngal(sp?) cancer, etc and is there increased prevalence in certain geographical locations like there is with MS?
Thank you for the video!
“Causes” is probably too strong of a word. “Increases susceptibility to,” sure. “Contributes to the pathogenesis of,” perhaps. But the bar to prove causation is quite high and isn’t going to be met with a single large study, right?
Omgeee!!! I was diagnosed with mono my freshman year in college 1997/98. Within a couple years I had weird neurological issues with no explanation. Actually I was told it’s all in my head. 😒😒
I wonder if the Epstein-Barr Virus can cause other auto-immune diseases in addition to MS. Great video and I look forward to more studies!
EBV is thought to be implicated in a wide range if diseases
Txs! I never had EBV, which was confirmed by labs. What negative EBV MS-ers should hope for?
Can EBV be linked to lyme age as a comorbidity? Could Lyme be a trigger?
EBV may also be responsible for Hodgkin.🤔
170 comments to get to the ONLY ONE that GETS IT!
EBV as well as CMV, Herpes, HPV and all of the viruses of Herpesvirales order of organisms COME from the Lyme spirochetes that are shuttled to the central nervous system by filarial worms (See: Alan MacDonald: MS is parasitosis). The 'viruses' came from the Po' Leo shot which is why it can be passed down through families via germ cells and all lyme is 100% communicable by ALL body fluids. I'm not allowed to post links but you've got enough keywords to get started. Lida Mattman wrote a book on Cell Wall Deficient Organisms.
I've been dx with reactive mono 2x (last time included an enlarged spleen, first time at 17 later at 23) but negative for EBV. It's been retested at least 3x that I know of. But I am jc positive. With 26 yrs of ms symptoms and secondary progressive. 45 now but also awaiting testing for oMG. But I am on the antiviral Amantadine for energy and my leg tremors are gone.
Regarding autoimmune illnesses:
Wouldn’t it be strange to believe people’s immune system’s would just randomly start attacking themselves if there wasn’t something the body actually is trying to fight off?
38 year old woman trying to get control over severe M.E. for 15 + years.
Lida Mattman: Cell Wall Deficient Organisms. The body is trying to rid itself of stealth infections that evade immune surveillance due to lack of surface antigens so it attacks self.
Does it mean that eliminating EBV has the potential of (at least partially) eliminating the effects of MS?
Potentially. yes.
Thank you for this information. I’ve seen a couple of your videos a few years ago pre my diagnosis. The information helped me deal with my nerves
My antibodies are quite strong for EBV still, but I have no idea when I was exposed (first MS attack in 2007, diagnosed in 2009) I remember I had a period of being constantly tired and constantly getting tonsillitis in my late teens / early twenties - around the turn of the century so I suppose all of this tracks!
I hate to be one of the doubtful ones, so I will call myself the one that's hard to sway my opinion. Why the reason for my doubt, you ask? My 1st MS symptom (woke up with leg paralysis) was not for almost 20yrs AFTER having severe case of mono and then it took another 15yrs of Dr to Dr, test to test, surgery to surgery to find out "what is wrong with me". Now here we are 2022 & my teen daughter has been having nerve related symptoms throughout much of early and late teen yrs (no diagnosis found of anything yet) & she had never gotten mono/ebv until recently- 3 months ago. In spite of all this & my doubts, I am still looking forward to the research ensuing though, as I believe EBV continues to stay hidden in my darkest place & comes out now and again to play & reak havoc on MANY of my body systems. I would love for a vaccine to put EBV back in it's corner for good whether or not it is the cause of MS or not.
This is how Lyme can work as well if not treated immediately. My doctor described it to think of it like Shingles...with stress/trauma and poor diet it can become active.
@@amygignac2668 we both have been tested for Lyme & are negative. I am progressive MS. My daughter also has undiagnosed stomach disorder as well where all of a sudden she will vomit constantly for months at a time. Then all of a sudden it's gone and dormant for a few yrs. We have an array of other autoimmune disorders in my family. I have 2. I hate this for my daughter! And now she's had EBV/Mono so more stuff to possibly look forward to. 😭
I tested positive for aquaporin4 antibody in my blood draw. I’m trying to learn about this aquaporin4 📝
Thank u Brandon. Do u think this will make any difference in the next decade (in terms of cure) or not?
It is difficult to predict, but I think there is a good chance for some kind of approved anti-EBV product in the next decade. Aside from vaccination, I don't think these products would necessarily "cure" MS, but they could be beneficial.
Instead of EBV "causing" MS maybe there is a different interpretation of the data.
Everyone responds to pathogens differently. Some have a weak response and others have a strong response or even a waaay too strong a response (they overshoot the necessary response).
Maybe the EBV response titers highlighted in the paper are merely an indicator of the individual's response to an exposure. Some people may have a hyperactive immune system. It may overcompensate to an exposure to EBV. Then later in life their immune system also overresponds to the true root cause of MS--as outlined in Dr. Swank's book (weakened epithelial linings in the brain).
Neuroborelliosis.
Brilliant! I'm very impressed with you, Dr. Beaber. I had severe tonsillitis when I was a child and they removed my tonsils when I was 4 years old. I recently learned that the EB virus targets the tonsils first. I'm pretty sure this is the reason I developed MS...stemming from that infection when I was a child. What do you think?
I was between 14 and 16 years old when I had mono. I had my first official symptoms of MS and diagnosis when I was 36. Looking back over the many years between, there are many little things that could have been MS, but never were significant enough to go to a doctor and get evaluated. I'm 56 now. Crazy stuff.
@@amyweinstein3428 It was the exact same for me...many inexplicable things over the years leading up to dx. The earliest one was at age 13.
@@ldjt6184 I also had a period of time when I was 12 or 13 I had several tonsillitis like sore throats. I got over it and still have my tonsils. Who knows.
Oh thank you for this. I’ll definitely be here languishing away even on Gilenya, hoping that this leads to a different path somewhere in the future. Dreaming about maybe even getting some of my myelin back.
The drug suppresses white blood cells that are chasing stealth infections. Addressing filarial worms carrying spirochetes into the cerebrospinal space is the first step. Because even if you were to try to remyelinate with adenosylcobalamin and lecithin the buggers would eat it as fast as you can make it.
@@vaccinefraud5570 Thanks for the info. Fortunately(?) I’m not expecting anything much of anything so spectacular to come along in what’s left of my time. It is nice to see that this promising path may be available in the future for younger ms sufferers.
Excellent video. Thanks for doing this!
This research is such an instrument of hope! Thank you for sharing!
I have a diagnosis of 10,240 times higher EBV titers than the infection disease doctor has ever seen. I have also been diagnosed with multiple sclerosis. Very debilitating.
Is there possibly a written text of what he is saying?
The link to the source article is in the description.
@@DrBrandonBeaber thank you very much
My partner caught covid and had ebv reactivation. A week later i had gladular fever and three months later my feet went numb and i had my first ms relapse so i can well believe this.
EBV can live dormant in the body without actually become detectable via testing.
Dr Paul Thibault has published studies on another critical and necessary infection involved in the development of MS (the respiratory pathogen c.pneumoniae). Perhaps they are acting in concert?
They actually didn't look at c.pneumoniae in this particular study (they examined several other pathogens with no clear association with MS).
@@DrBrandonBeaber strange they didn’t look at c.pneumoniae. Maybe including this in the result would muddy the waters?
I have MS they took an LP to make sure and gave me lemtrada wich is for leukemia but they just told me I have new lesions in the brain
And I got omicron COVID19
Alan MacDonald: MS is parasitosis. Filaria carry spirochetes to the brain. The lesions are from Lyme eating away at the central and peripheral nerves.
Thank you Dr. Beaber.. Wife dx with ms back in 2010. She had a severe bout with mono when she was 17, and always suspected EBV might play a role in her ms. Since there currently is no therapy to treat EBV, what about Resveratrol..?? Wife has been taking this supplement since her dx with no side effects, and I think she has actually benefited from it..
Despite the potential benefits of reservatrol as an anti-aging supplement, I'm not aware of specific high-quality evidence in MS.
Thank you Dr. Brandon Beaber.
What do you think about this?
Multiple Sclerosis (MS) is a chronic, autoimmune disease that affects the central nervous system. It is characterized by the destruction of the myelin sheath, which is the protective covering surrounding nerve fibers, leading to communication problems between the brain and the rest of the body. The disease can cause a range of symptoms, including muscle weakness, fatigue, and difficulty with coordination and balance. There is no cure for MS, but various treatment options are available to manage the symptoms and slow the progression of the disease. One promising area of research focuses on the potential benefits of resveratrol, a natural compound found in red wine and some plants.
Resveratrol has been studied for its potential neuroprotective effects in MS. One study conducted on animal models found that resveratrol treatment reduced the severity of symptoms and slowed the progression of the disease. The researchers attributed these effects to the compound's ability to reduce inflammation and oxidative stress in the nervous system. Inflammation and oxidative stress are two key factors that contribute to the damage done to the myelin sheath in MS patients.
Another study conducted on human subjects found that resveratrol supplementation improved cognitive function in MS patients. The study participants were given resveratrol supplements for six months, and their cognitive function was assessed before and after the treatment period. The researchers found that the resveratrol group had a significant improvement in cognitive function compared to the placebo group. The researchers suggested that the neuroprotective effects of resveratrol may have contributed to the improvement in cognitive function.
Despite these promising findings, more research is needed to fully understand the potential benefits of resveratrol in MS patients. It is important to note that while resveratrol is a natural compound, it can still have side effects and interactions with other medications. Therefore, it is important to consult with a healthcare professional before starting any new supplement regimen.
In conclusion, MS is a debilitating disease that affects millions of people worldwide. While there is no cure for the disease, various treatment options are available to manage symptoms and slow the disease's progression. Resveratrol is a natural compound that has shown promise in reducing inflammation and oxidative stress in the nervous system, potentially slowing the progression of the disease. More research is needed to fully understand the benefits of resveratrol in MS patients, but it is an exciting area of research that could lead to new and effective treatment options for those living with the disease.
I almost died as a "tweener" of Reye's Syndrome in the 70s. Any relation?
To my knowledge, there is no known association between Reye's syndrome (which is currently rare) and MS.
@@DrBrandonBeaber I was not specific, many apologies. Any relationship to Epstein Barr virus? which I also have...
Having primary progressive multiple sclerosis at age 42 it was when I was diagnosed You kind of feel abandoned in the MS world
Something so simple. Nature is terrifyingly amazing. How far away are we from this evolving into anything useful to ms sufferers?
Didn’t medical medium said this 7 years ago at the first medical medium book that ebv causes ms and Harvard copy paste it 7 years later ???
The link between EBV an MS has been known for about 50 years. For instance, here is an article from 1972 on the topic: www.ncbi.nlm.nih.gov/pmc/articles/PMC1786242/
The Doctors aren't listening looking or feeling. Try getting treated with low socioeconomic scores. GOOD LUCK
??
when will the cure come, that's the important thing
Interesting. I had mono at 16. First MS episode at 36.
yeah I had glandular fever now sp MS
Dr bante you are indeed the best herbalist I have ever met thank you for your work, am okay now
I can't comment with details. I must be saying a forbidden word.
What are your thoughts on bovine lactoferrin?
I don't have any opinion on bovine lactoferrin. Do you have a citation on it with respects to MS?
@@DrBrandonBeaber I have a separate comment posted above with more details. It finally posted after breaking it up and encoding it. Tried adding it here and YT is giving an error.
Most profound news I've heard since my diagnosis. I had Mono when I was 19 and it was very bad....lost 40 lbs and basically laid on a couch for a month. I'd read some speculation of a possible link and this is the most evidence of a link...not an association, but causality than anyone has discovered. The trail is hot for sure.