The Truth About the Gut to Brain Connection

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  • čas přidán 22. 07. 2024
  • There aren't many bodily connections as powerful as the gut to brain connection. Why? Watch this new episode of SciShow hosted by Olivia Gordon to learn about the immense power of the microbiome!
    Meet your Microbiome: • What Your Microbiome D...
    Hosted by: Olivia Gordon
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    Sources:
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ncbi.nlm.nih.gov/pmc/arti...
    link.springer.com/chapter/10....
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.nature.com/news/the-tantal...
    www.nature.com/news/gut-brain-...
    www.gastrojournal.org/article/...
    www.ncbi.nlm.nih.gov/pmc/arti...
    www.ncbi.nlm.nih.gov/pmc/arti...
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Komentáře • 1K

  • @weeliano
    @weeliano Před 4 lety +74

    I suffer from anxiety related stress and I find taking Bulgarian yoghurt helped tremendously in stabilizing my mood and anxiety. I believe there is a strong correlation between the mind and the gut biome.

    • @iloveplasticbottles
      @iloveplasticbottles Před 2 lety +4

      That or you're experiencing the placebo effect. I'd try regular, non-bulgarian yogurt without knowing thats what you're eating.

    • @evatsaneva8202
      @evatsaneva8202 Před 2 lety +5

      From what I know, there are good studies documenting the effect of Lactobacilli on the physical health. I don't know anything about mental health in relation to the bacteria, however, Japan has tried to 'copy' and be able to implement the bacteria in dairy products who lack it. As a Bulgarian myself, I am happy there is someone who is aware of its benefits, and I suggest that more research is definitely needed.

    • @helenamcginty4920
      @helenamcginty4920 Před 2 lety

      @@iloveplasticbottles Maybe Bulgarian yoghurt is the same as Greek yoghurt? Maybe it is live rather than pasturised to death? I dont know but it would make a difference.

    • @Qliphirot
      @Qliphirot Před 2 lety +2

      @@iloveplasticbottles gaba is produced in the gut so if he has a low gaba deficiency his body won't be able to tolerate stress and it'll lead to anxiety symptoms

    • @savesoil3133
      @savesoil3133 Před rokem

      Hi there!
      Since you are interested in food:
      It is said that by 2045 we would be producing 40% less food than what we are producing right now and our population would be over 9.3billion people. #nosoilnofood
      We can take action now and turn this situation around, and create a significant change. #SaveSoil #ConsciousPlanet #Mentsükatalajt #Tudatosbolygó
      I thought it's important to share🌿
      Love from Hungary 🌏🌎🌍

  • @WoodChoppa911
    @WoodChoppa911 Před 6 lety +99

    When someone say "my gut is telling me ....", that means that their gut were actually telling them

  • @mahenonz
    @mahenonz Před 7 lety +20

    I was completely cynical about this "your gut can affect your brain " theory until a recent bout of food poisoning. I felt perfectly fine after 12 hours or so - except I had zero interest in food which lasted several days. My doctor said my stomach needed a "reset" and probiotics did the trick. I was amazed how much an illness could completely change my thoughts.

  • @Master_Therion
    @Master_Therion Před 7 lety +745

    1:47 The Vagus Nerve connects the ENS to the brain? So, what happens in Vagus doesn't stay in Vagus.

    • @SeaMower
      @SeaMower Před 7 lety +60

      I haven't got the vagus idea what would happen.

    • @sacr3
      @sacr3 Před 7 lety +38

      Not enough information, its too vagus

    • @CAPSLOCKPUNDIT
      @CAPSLOCKPUNDIT Před 7 lety +9

      Only if your "second brain" is the one in charge .

    • @umm_rit_
      @umm_rit_ Před 7 lety +3

      you win

    • @Joxman2k
      @Joxman2k Před 7 lety +4

      What happens in Vagus stays in vagus :)

  • @ItsMe-ox8lm
    @ItsMe-ox8lm Před 7 lety +89

    This is one of the best videos! It is very interesting, when she talked about how a shy mouse can change its behavior, just by changing the bacteria in its gut, that groundbreaking to me. Thank you Olivia!

    • @wiameena39
      @wiameena39 Před 7 lety +4

      :) In real life that's so logical. When a person is hungry even if they are shy, they might go ask other people for food or just find them self surprisingly more out going to a point where they might "find them self" stealing food sometimes (it's not an excuse tho). Scientifically it's all gut bacteria!
      What i wonder about now : does any kind of bacteria interfere when people are scared, hopeless, traumatized, happy, ... even when they are not hungry?! in other words can the emotional state or even the personality of a person be related to it's bacteria?

  • @shreddermcscumbag9755
    @shreddermcscumbag9755 Před 7 lety +23

    I think Naturopathic doctors can have some very misguided views at times, but in this situation I've seen that they definitely have a point. Many have been pointing out this connection for decades and "prescribing" remedies for stress through this medium.

  • @em0860
    @em0860 Před 7 lety +47

    I am so glad you presented a video on this topic - As a microbiologist suffering with Ulcerative Colitis, I find this to be a highly important subject and the explanations you give are more than relevant to my dissertation. I cannot wait to see how what I learnt about stress and the microbiome affects later studies :)

    • @michaelroy6046
      @michaelroy6046 Před 5 lety +3

      glad to not be a fecal transplant recipient mouse

  • @PfEMP
    @PfEMP Před 7 lety +112

    Research on microbiomes is really hot right now, they seem to have an impact on basically everything

    • @johndough23
      @johndough23 Před 4 lety +1

      @N K Her early diet failed to turn-on the usual sexuality genes. This is very common these days of GMOs and pesticide food consumption. It is WHY the entire gender confusion expression we see in the news. This is new and not something which was hidden by a tyrannical system run by Charlton Heston and Ronald Reagan. We do have millions more severely screwed up people with gender issues now because of a crappy food supply. The bugs who benefit don't want us changing this in fact the opposite.

    • @OswaldDigestiveClinic
      @OswaldDigestiveClinic Před 3 lety +3

      It really is. Did you know that changing what you eat can change your gut microbiome in just 2 days?

  • @bengarcia2074
    @bengarcia2074 Před 4 lety +38

    Remember that old saying....
    "You are what you you eat"
    Healthy food, good excercise, good friends, and love self. Keep it simple!

  • @64standardtrickyness
    @64standardtrickyness Před 6 lety +30

    so I CAN fill that hole in my heart with food I just haven't found the right food.

    • @moremerry57
      @moremerry57 Před 4 lety +4

      64standardtrickyness, I know you mean to be funny, but people will agree w/you out of loneliness. You can’t fill the hole w/food; you have to switch your focus away from the hole. Focus on a fuller life - that will start to close the hole.

  • @lisaoldwithsomanywhys5487

    My grandmother worked for a "resort" in Genova, Italy back in the 1950's where the "rich & famous " would go for a few months to completely cleanse their gut & mind✌🏻👏😱

  • @naarad_muni9440
    @naarad_muni9440 Před 2 lety +10

    I’m so glad I took Ayurveda as my way. The Ayurvedic concept of food affecting mental state (Satvik, Rajsik and Tamsik food) is just one among many things which are now making complete sense to me.

  • @cosimodirondo6214
    @cosimodirondo6214 Před 7 lety +4

    I'm an italian medical student and I'd like to compliment this channel, your contents and divulgation efficacy are really amazing! Go on like this

  • @BRUXXUS
    @BRUXXUS Před 7 lety +12

    This is really interesting to me, especially as a guy who's had ulcerative colitis for about 10 years now and has struggled with depression for about the same time frame. UC sucks, but UC AND depression make a pretty brutal combination.

  • @julia393n
    @julia393n Před 7 lety +34

    Didn't Hippocrates advise us "Let food be thy medicine and medicine be thy food"

    • @SunnyDeeTee
      @SunnyDeeTee Před 4 lety +6

      And he also said, "all disease begins in the gut."

    • @allisond.46
      @allisond.46 Před 4 lety +4

      And he also said, "What's for dinner?"

  • @OswaldDigestiveClinic
    @OswaldDigestiveClinic Před 3 lety +9

    Great video! To add to this, nutrition issues can result in anxiety. For example, magnesium deficiency can be a problem. This deficiency may result from our soils being depleted of magnesium, the increased amount of magnesium used by the body during stress, medications like birth control, and not eating enough magnesium. One good food source of magnesium (and delicious) is pumpkin seeds!

  • @ejlerthomsen
    @ejlerthomsen Před 7 lety +23

    For the last two years I have had a dysbiosis, Small intestinal bacterial overgrowth. During that time I have been treated with antibiotics twice which has let me perceive at least 4 drastically different gut microbiomes. I have a first hand perspective of drastic mental changes that accompany changes in human gut flora. In the last two years I have felt some of the worst forms of mental illnesses from being suicidally depressed, to crippling anxiety that caused me to become agoraphobic. I have been able to treat all of my symptoms of SIBO, including the mental, with a short dose of antibiotic and long term probiotics. To me it is no question that the human microbiome is at the central cause of everything from IBS, to many mental illnesses. It is my belief that dysbiosis are getting more prevalent due to the increase in consumption of highly ferment-able foods and the widespread use of antibiotics.

    • @ejlerthomsen
      @ejlerthomsen Před 7 lety +3

      Margaret Thatcher I used what's called a low fodmap diet to find what foods I can eat. The diet was at first very restrictive of fruits and vegetables. As I progressed I found that pretty much only wheat and corn are the main irritants to my gut.

    • @Alexandriafrancescakiel
      @Alexandriafrancescakiel Před 4 lety +1

      Iron Manatee I’m sorry you had to go through that. I hope you are doing better now. I too had to go through two rounds of strong antibiotics and I literally could feel myself becoming more and more depressed everyday. Hopefully doctors start to listen to us.

    • @Qliphirot
      @Qliphirot Před 2 lety +1

      Very interesting.

  • @XxFreako64xX
    @XxFreako64xX Před 6 lety +55

    Literally 3 1/2 years ago I had to go to a doctor because I was severely ill. He doesn't go through insurance because he really tries to get to the root of the problem. He found out my whole GI tract was inflamed and I had horrible IBS (while my other dr just said pretty much that's the way it is). When he told me that 80-85% of serotonin was made in my gut and could explain why I was so severely depressed and having over 10 panic attacks a day. Once he worked on helping heal my gut- I honestly had hope again. I thought I was dying and there was no way out of the mental hell I was in. By the grace of God. I am doing so much better. And honestly, could be doing even better. I just need to be more intentional. But he knew all of this stuff for years!! If you are not doing well. How is your gut?? I now don't eat gluten (inflamitory or milk) to keep the inflammation a bay. I know some people don't get this whole gluten then but trust me. If you have ibs, anxiety, depression, getting sick all the time-, there's a reason. Don't just let a doctor give you some pills to manage it. Dive in and find what's the problem. There's hope! I will share this with who ever because I know the mental hell and physical pain and how hard that was.

    • @romeoromeo9651
      @romeoromeo9651 Před 5 lety

      Thanks for writing this.
      It helps me. M suffering from anxiety nd don't know how to deal with it. Doctor advised for yoga nd meditation. I will be thankful if you can suggest me some thing to cure it. (Sry for poor english)

    • @MapMonkeyTube
      @MapMonkeyTube Před 4 lety +6

      Could you elaborate on the "helping heal my gut" part beyond removing gluten? Diet changes? Probiotics? It is not something you covered in your post and I'd like to know more.

    • @moremerry57
      @moremerry57 Před 4 lety +3

      Romeo Romeo, are you saying the doctor prescribed NO meds to help with the attacks?!? That is incomplete response to your problem. Yes, yoga and meditation are good ways to fulfill the exercise part, and diet IS important. But unless these have eliminated your problem, you should have meds to carry you through attacks.
      I should mention that I used mine as a last resort, and was able to calm myself when an attack began in part by knowing tat the meds were on the cabinet if I needed them. Consider asking your doctor for fallback prescription.

    • @freeyourselfmorowa9243
      @freeyourselfmorowa9243 Před 4 lety

      TMI but was one of your symptoms a very loose stool 👀 (asking for myself)

    • @mohammeduddin7082
      @mohammeduddin7082 Před 4 měsíci

      Xxfreak054xx what is the name of the doctor you went through

  • @kiwiboy1999
    @kiwiboy1999 Před 7 lety +238

    This really does give some alarming concerns for how various antibiotics can severely damage your mental health.

    • @MacCoalieCoalson
      @MacCoalieCoalson Před 7 lety +9

      kiwiboy1999 ...not really.

    • @rincewind304
      @rincewind304 Před 7 lety +15

      Not really, at all. The antibiotics we take have minimal effect on our microbiome for many reasons. A major one being that the microbes we don't want usually have a different make-up than the ones we do. We also have so many of the good microbes that any damage to their numbers is quickly repaired.

    • @kiwiboy1999
      @kiwiboy1999 Před 7 lety +31

      I have one response to that; we apparently had no idea that the intestines, and the microbes within, had a large impact on mental health and general mood. it'd be foolish to rule out us simply not knowing the potentially damaging effect you'd expect from killing microbes.

    • @amicableenmity9820
      @amicableenmity9820 Před 7 lety +21

      Eh, it depends. There's a lot of antibiotics that can give you a C. Diff infection because the good bacteria were killed too.

    • @rincewind304
      @rincewind304 Před 7 lety +6

      But if we have never measured a noticeable mental effect from antibiotics. Why would it suddenly start being an issue?

  • @calebcross3894
    @calebcross3894 Před 4 lety +6

    I’m on Antibiotics and Antidepressants, your video is scaring me

  • @LaceNWhisky
    @LaceNWhisky Před 7 lety +4

    It made me really damn happy when Olivia started the episode so chipper and excited! She's my favorite host SciShow has ever had.

  • @MakeMeThinkAgain
    @MakeMeThinkAgain Před 7 lety +9

    In medicine (and psychology) I predict this is going to be the century of the human microbiome.

  • @rgrateful
    @rgrateful Před 4 lety +3

    Stress causes illness, resistance in life causes the body to go into fight or flight. When discernment kicks in. Use it! It's a message from the brain to protect you..... If you live in truth, you'll do what is right, and your gut will flow...and your immunity will be most healthy....live in truth for a healthy life.

  • @hermanman8235
    @hermanman8235 Před 2 lety +5

    Gut instinct/gut feeling really do have a basis in reality after all.VERY INFORMATIVE VIDEO.

  • @TodayIFoundOut
    @TodayIFoundOut Před 7 lety +272

    Super interesting :-)

    • @willynebula6193
      @willynebula6193 Před 7 lety +12

      one channel watching another channel.
      mind blown!

    • @stardreamer8996
      @stardreamer8996 Před 7 lety +5

      Rare, don't steal.

    • @tehgendo
      @tehgendo Před 7 lety +1

      original character doughnut steel.

    • @bunbundabunni3843
      @bunbundabunni3843 Před 7 lety +9

      You should make a video on Toxoplasma gondii and all the weird research into it!

    • @thecrazyisreal
      @thecrazyisreal Před 7 lety +1

      I always thought it was the Vegas nerve. Today I found out that I'm a moron.

  • @EmoPurpleTurtle17
    @EmoPurpleTurtle17 Před 7 lety +214

    Does this mean people with the lactose mutation could have different brain chemistry to people without the mutation?

    •  Před 7 lety +18

      Nice thought!

    • @liquidminds
      @liquidminds Před 7 lety +62

      Even worse. Proof that Vegans actually have a different brain than regular humans!

    • @Notlordstark
      @Notlordstark Před 7 lety +53

      Yes actually, that's possible. I've been working in a feeding behavior-based neuroscience lab for some time now, and the gut-microbiome-brain axis is one topic we are currently exploring. The lactose mutation would cause there to be an increase in sugar availability for those microbes that can metabolize lactose, giving them an advantage. Larger colonies of those microbes could affect the chemistry of the enteric nervous system. (By-products of lactose metabolism could also play a role; gas production in response to lactose availability for example could give a separate species a carbon source). It's an extremely complex system and literally any changes can have an effect on the entire system as a whole.

    • @seanpeery7780
      @seanpeery7780 Před 7 lety

      Sarcastic dog whistle. Props.

    • @DocESARobsidianbruk
      @DocESARobsidianbruk Před 7 lety +9

      Wouldn't the pressence of lactase in the gut deprive the microbes that metabolize lactose of their sustenance, putting them in a Disadvantage?

  • @jayatherton8673
    @jayatherton8673 Před 7 lety +1

    Thanks for doing an episode on this; I've been wanting one for a while.

  • @mindyabizniss
    @mindyabizniss Před 7 lety +2

    what we ACTUALLY understand about nutrition and everything that's involved with it, bacteria, microbiome etc doesn't even scratch the surface of what's going on... this is exciting, proper understanding of this kind of information changes EVERYTHING

  • @sbrodie99
    @sbrodie99 Před 4 lety +4

    I’m here trying to build a case for a natural approach to treating my MS - by strengthening my blood brain barrier/improving my gut-brain microbiome. At the moment, I don’t believe I actually have MS. I believe that the antibiotic I was on for an infected finger crossed my blood brain barrier because it was weak, poisoning me and causing damage to some of the myelin and altering my body’s functions. Lots of natural approaches to treatment use blood brain barrier/gut-brain microbiome science. I’ve decided that this is the best approach for me because it means that I’m completely in control of my own “treatment” and won’t be opening myself up to unwanted side effects or risks. I *think* that MS, Alzheimer’s and other neurodegenerative diseases are actually results of weakened blood brain barriers/gut-brain microbiomes and that by finding ways to strengthen the barriers between the body and the brain, we can reduce or even eliminate the risks of neurodegeneration. I REALLY hope I’m right. Next month I’ll be telling my neurologist all this and hope that he will support my logic and my choice 😅

  • @butterflyfx57
    @butterflyfx57 Před 7 lety +97

    What if kissing evolved as a means to colonize each other with microbiomes?

    • @followyourideas
      @followyourideas Před 5 lety +8

      Mind-blowing

    • @chrisvaccaro229
      @chrisvaccaro229 Před 4 lety +4

      it definitely transfers sex hormones

    • @allisond.46
      @allisond.46 Před 4 lety

      Are you serious?

    • @BMN_Prime
      @BMN_Prime Před 4 lety +1

      If it was we'd all have ulcers

    • @johndough23
      @johndough23 Před 4 lety +6

      Good point. I think it is rather naive to think any behavior we do is NOT being driven by microbial need. I think it is rather obvious the oldest parts of the brain are the ones responsible for the most basic of human functions. They house the original microbes. The pecky order flows from there.

  • @AllenLeland
    @AllenLeland Před 7 lety +2

    This is a topic that means a lot to me since when I take a probiotic it really helps my mental state & I have tried to go some time without them & I just don't feel as well.

  • @pompey333
    @pompey333 Před 7 lety +2

    A possible use for this research could be future space travel in which some humans are almost germ free but that sounds like something we would need way down the line

  • @ProfessorPolitics
    @ProfessorPolitics Před 7 lety +4

    For those who are interested in this topic, I'd recommend the book "I contain multitudes." I'm going through it right now and it hits on all of the topics in this video and then some (like, for instance, how cows and other rumanids need their microbiome in order to actually digest their food). It's also pretty fair about what evidence on the impacts of the microbiome are more "certain" or more speculative.

  • @ashi_no_ko
    @ashi_no_ko Před 7 lety +12

    I already knew that microbes in my guts have some impact on my brain, but didn`t exactly knew what and how they cause. Thank you for explaining this to me. And especially thanks for the host, whose voice I can listen whole day.

  • @LeMikerophone
    @LeMikerophone Před 6 lety +2

    Of course SciShow would be super beneficial to my dissertation work. Thank you.

  • @LucMMailloux
    @LucMMailloux Před 7 lety +1

    Thanks Olivia! This is some crazy stuff I want to hear more about in SciShow Psych

  • @workman88
    @workman88 Před 7 lety +20

    What if we aren't controlling us but the little city in us is.. lifeception

  • @plantpotshoes2644
    @plantpotshoes2644 Před 7 lety +103

    Does this mean by kissing someone you become more like them?

    • @59acres
      @59acres Před 7 lety +106

      If you're kissing their ass,yes.

    • @TheFronkinator
      @TheFronkinator Před 7 lety +24

      59acres specifically the anus

    • @adygombos4469
      @adygombos4469 Před 7 lety +20

      59acres Because someone eats your booty like groceries.

    • @Schradermusic
      @Schradermusic Před 7 lety +11

      It means that if someone vomits in your mouth and you swallow it, you become more like them.
      So Rick & Morty got it right.

    • @duchessedeberne3909
      @duchessedeberne3909 Před 6 lety

      Bum

  • @rebecca3647
    @rebecca3647 Před 7 lety +2

    Putting a literal meaning to the term 'gut feeling'.

  • @arjunratnadev
    @arjunratnadev Před 5 lety

    I was really stressed to watch this video, during that day this video was uploaded. This is really amazing!

  • @amberkat8147
    @amberkat8147 Před 2 lety +4

    Given that everyone in my family from my Dad on down- I don't know about his siblings or parents except that his mother had many of the same health issues I do- has IBS/food sensitivities/fodmap issues, this is a VERY important topic to me. If there's a way to tweak our systems so we react less to foods that would help all of us. Especially me, since I have the worst of it- the inflammation and blood sugar issues from our normal diets contributes to pretty much every health problem I have aside from the inability to sweat normally that my sister and I were born with. Anything that would let me lose weight, somehow fix the hypothyroidism, help me to get my blood sugar under control, make my mental illnesses less serious, and cause my stupid asthma to tone it down to what it was when I was a kid and I could still go hiking and ride my bike as far as I wanted to would be an absolute Godsend.

    • @V.Hansen.
      @V.Hansen. Před rokem

      Have your doctors ever considered a decade transplant?

    • @dualbrainr
      @dualbrainr Před 2 měsíci

      @amberkat8147 This is going to sound way out there but aside from all the info about chemicals, bacteria and such there is one thing no one is talking about. It’s the mysterious interactions that happen inside the tiny spaces between the neurons. Called the synapse, this space could be infused with a calming power that can cause dramatic positive changes in how you experience your life. For example, if you could optimize both your head and gut brain together you would find huge improvement in your mental health. Let me know if you’d like to know more.❤

  • @angelikahemker712
    @angelikahemker712 Před 6 lety +3

    This is a super-interesting and extremely well-done presentation. I have just gone through an entire course on the microbiome on the edX platform which I think is rather boring in comparison. Thank you very much and keep up the fantastic work!

  • @AngelJabreel
    @AngelJabreel Před 7 lety +1

    This is the most interesting i have ever seen by you guys. This might have confirmed a lot of my own thoughts and observations.

  • @djinnisequoia
    @djinnisequoia Před 7 lety +1

    This is deeply fascinating. It kind of makes me wonder if an individual's microbiome is involved in the cluster of information and conditions we refer to as wisdom.

  • @superjukud
    @superjukud Před 7 lety +22

    Have to study for something completely diffrent, yet here i am.

  • @rickspalding3047
    @rickspalding3047 Před 7 lety +4

    If they want to learn more, they should study me. I've always felt blah. I've drank heavier over the years to the point my gut was getting really screwed up, to the point where eating soluble fiber was a major problem while heavy drinking. When this happened, and I ate something with simple sugars, I had the greatest highs and wish I always felt like this. It wasn't a sugar high, I never had a crash and was wondering how I could always feel like this. Hapiper and more confident. Anyways, I would have to go to a clear liquid diet to let my gut heal.

  • @DoorSCARF
    @DoorSCARF Před 7 lety

    Wowowowow your speech has improved so much this was a joy to listen to! Well done

  • @TheKd8lvt
    @TheKd8lvt Před 6 lety +2

    Great video!
    I don't know if anyone has tested this, but could the reason the mice were getting more stressed be because their gut wasn't creating as much seratonin, due to the reduced variety of gut microbes? I didn't read the paper, but it seems plausible to me.

  • @robertopran1587
    @robertopran1587 Před 7 lety +12

    Does anyone know how to get into this type of research? What do you need for that? What kind of studies you need?

    • @kiren3168
      @kiren3168 Před 7 lety +9

      Robert Opran Biochemistry. Biology.

    • @robertopran1587
      @robertopran1587 Před 7 lety

      thank you.

    • @pramitbanerjee
      @pramitbanerjee Před 7 lety +2

      study a subject called microbiology. Or just biology. Actually, you can study pretty much any of the basic sciences and still get into this research because its all interdisciplinary nowadays

    • @1onearth
      @1onearth Před 7 lety +3

      Strains of Bifidobacterium, which is common in the gut flora of many mammals, including humans, have generated the best results so far. Cryan recently published a study in which two varieties of Bifidobacterium produced by his lab were more effective than escitalopram (Lexapro) at treating anxious and depressive behavior in a lab mouse strain known for pathological anxiety. Although Cryan is optimistic that such findings may point the way to the development of psychobiotics, he is wary of hype. “We still need a lot more research into the mechanisms by which gut bacteria interact with the brain,” he says.
      www.scientificamerican.com/article/mental-health-may-depend-on-creatures-in-the-gut/
      A decade ago a research team led by Nobuyuki Sudo, now a professor of internal medicine at Kyushu University in Japan, restrained germ-free mice in a narrow tube for up to an hour and then measured their stress hormone output. The amounts detected in the germ-free animals were far higher than those measured in normal control mice exposed to the same restraint. These hormones are released by the hypothalamic-pituitary-adrenal axis, which in the germ-free mice was clearly dysfunctional. But more important, the scientists also found they could induce more normal hormonal responses simply by pretreating the animals with a single microbe: a bacterium called Bifidobacterium infantis. This finding showed for the first time that intestinal microbes could influence stress responses in the brain and hinted at the possibility of using probiotic treatments to affect brain function in beneficial ways. “It really got the field off the ground,” says Emeran Mayer, a gastroenterologist and director of the Center for Neurobiology of Stress at the University of California, Los Angeles.
      Searching the internet for Emeram Mayer is a good place to start.

  • @SayAnything8
    @SayAnything8 Před 7 lety +16

    I can see a new field in psychology being formed during the next few years. It'll be called microbe-psychology.

  • @tawnyatorgl8731
    @tawnyatorgl8731 Před 7 lety +1

    great great information! thank you

  • @adriancoleman2876
    @adriancoleman2876 Před 7 lety

    this was an awesome video. great job.

  • @CorpusOrganic
    @CorpusOrganic Před 7 lety +3

    does that mean if microbiomes are passed from generation to generation that mental illness in families might not be purely genetic? would be interesting to know. do to my family history.

  • @Snailz5
    @Snailz5 Před 7 lety +3

    That had to be a fun grant proposal to review..."Hey Marty, these guys wanna take poop from people and put it up some mouse butts and see if it makes them act funny. They got some freaky scientists over at (whatever university did this study)!!!"

    • @joshshe3941
      @joshshe3941 Před 7 lety

      Alexander Cooper they shoved poop 💩 up there butt and then cut the brain up to study it.

    • @Snailz5
      @Snailz5 Před 7 lety

      ......it's a joke

  • @rhiannon14982
    @rhiannon14982 Před 6 lety +1

    I'm really anticipating more findings because, as a migraineur, my personal experience is one of both brain and gut suffering.

  • @urielalbertosanchezm
    @urielalbertosanchezm Před rokem +1

    Fascinating, now I want to know more!

  • @renze7133
    @renze7133 Před 6 lety +5

    In a video about the microbiome the channel What I’ve Learned made, he talks about how certain bacteria might cause autism. He tells the story of a kid who was developing normally, but after several antibiotics courses started acting weird and was later diagnosed with severe autism. Noticing a link between the antibiotics and the sudden autism, the mother dove into the studies and found that antibiotics could cause autism-like behaviour in mice. Antibiotics targeted a lot of bacteria, but not a certain bacterium which was also overly present in autistic children’s guts. So she found a doctor willing to experiment and gave her son a antibiotic targeted specifically at this bacterium and the autism in the kid slowly became less.
    I find it very interesting how much your microbiome affects your brain and how it could be the cause of a lot of mental issues. Another example: a transplantation of gut microbiome between two sisters led the receiving sister to become overweight like the other sister, even though she didn’t change her diet or workout schedule.
    Future research about this topic really could result in a lot of problems disappearing, it’s amazing

    • @EliteprosoldierMW3
      @EliteprosoldierMW3 Před 3 lety

      Beautifully stated but the sci show will not look at or address this ground breaking discovery

  • @Kibaoftheleaves
    @Kibaoftheleaves Před 7 lety +4

    Uh maybe those mice were stressed out more because they'd been separated from their mothers at birth. In fact I'm willing to bet they didn't even patch up those c-section mice mommas up after their babies were pulled through their abdomens.

  • @bethsusaynedelim2300
    @bethsusaynedelim2300 Před 4 lety

    yes I have hope now, these studies might help to people that suffers from depression, thank you SciShow, and I am learning everyday

  • @LuisDiegoMontero21
    @LuisDiegoMontero21 Před 7 lety +1

    That is super interesting. in Costa Rica, the Bribri people (an indigenous people) believe that you actually do a lot of your thinking with your gut. They believe the stomach and the liver do the same or more thinking than the brain. They have based their ancient medical treatments (based on herbs and different ways to prepare them) on that belief. It turns out they seem to have, at least, a solid ground for that.

  • @MusiCaninesTheMusicalDogs

    I have no brain, though. CheckMate, microbiome! 😁

  • @valeriobertoncello1809
    @valeriobertoncello1809 Před 7 lety +16

    Memes are like the microbiome of the internet. They are little, they reproduce and they spread inside the guts of the net... and I'll tell ya, they surely affect our brains!

    • @johndough23
      @johndough23 Před 4 lety +1

      This has been known since the late 90s. memetics Richard Brodie...he also developed the original Microsoft Word...duh en.wikipedia.org/wiki/Richard_Brodie_(programmer)

  • @patrickhodson8715
    @patrickhodson8715 Před 7 lety +1

    There's a thing that can happen where yeast becomes a part of your microbiome, and it causes you to get dangerously drunk when you eat too much sugar and simple carbs like bread. It can be hard to diagnose because it's pretty rare, and because doctors tend not to believe the patients when they come to the hospital drunk and say they haven't been drinking.

  • @AnneAndersonFoxiepaws
    @AnneAndersonFoxiepaws Před 2 lety +1

    I have been logging my symptoms with the King's College, London, Zoe app which are front runners in researching the gut microbiome. It's fascinating! I have been logging since it started at the beginning of the pandemic and recently its branched out to other areas of health as it has the largest group of test subjects ever, logging whatever they need. It's a new and amazing way of testing things and of keeping tabs on whatever symptoms each survey needs. It's truly ground breaking and if you can join in the US it's a great way to help scientists and you feel like you've actually contributed.

  • @moremerry57
    @moremerry57 Před 4 lety +9

    SciShoe, please do a presentation on the Vagus system. I have just been introduced to it, told it probably figures largely in my mental heatflt struggles.

  • @jitendrasingoriya515
    @jitendrasingoriya515 Před 4 lety +5

    She looks like amy from big bang theory 😂

  • @jamescarson3826
    @jamescarson3826 Před 7 lety +2

    I'm glad to see some news about this subject, since I was assuming nothing much was being done about it and would be another 20-30 years before the science and medical community as a whole was clued on to the idea that gut health plays a surprising role in both metal health and physical health.
    Right now I have a doctor directed nutrition and diet plan (yes, with probiotics) to help with chronic depression, and I'm making slow but encouraging progress after dealing with it for most of my life. But one thing that seems to keep coming up when trying to get things fixed right has been gut health. Honestly, I've ran into more stuff about the connection between mental disorders and nutrition and gut health than I'd ever care to know.
    Shame though, since I know that the big pharmaceuticals (mostly here in the US) aren't going to like the idea that proper food and microbes might actually be the best medicine, and not the drugs they have spent so much money on researching and looking for a use for.

  • @chrisboucher1987
    @chrisboucher1987 Před 4 lety +2

    Explains why my depression isn't as bad now that I'm paying attention to my gut health... maybe?

    • @1878Devils
      @1878Devils Před 3 lety +1

      What did you do to change it? And how significant was the change

  • @joshuaolorocisimo7611
    @joshuaolorocisimo7611 Před 7 lety +5

    I'm currently working on this for my thesis and it's really interesting!!

  • @boy638
    @boy638 Před 7 lety +91

    Uploaded just a minute ago and there's already anus jokes

  • @code4chaosmobile
    @code4chaosmobile Před 7 lety

    great video, thank you.

  • @jaredrojo2201
    @jaredrojo2201 Před 7 lety

    amazing video as always

    • @OswaldDigestiveClinic
      @OswaldDigestiveClinic Před 3 lety

      If you're interested in this video, you may also be interested to know that when the gut microbiome is out of balance, it typically has 2 characteristics: low production of butyrate-producing bacteria, and overgrowth of bad bacteria! The more you know!

  • @invinciblenoodle
    @invinciblenoodle Před 7 lety +417

    I have nothing of value to say.

    • @UnderEuropa
      @UnderEuropa Před 7 lety +2

      invinciblenoodle don't we all?

    • @mrtannzr
      @mrtannzr Před 7 lety +18

      You don't need to because you're a valuable person and I love you.

    • @YourOwnange
      @YourOwnange Před 7 lety +5

      Are you really completely invincible?

    • @RialuCaos
      @RialuCaos Před 7 lety +26

      If only everyone had your capacity for self-awareness.

    • @stevebluh
      @stevebluh Před 7 lety +6

      Best comment I've ever seen. I'll say that instead of letting people I don't know, know what I think.

  • @bjrnhjortshjandersen1286
    @bjrnhjortshjandersen1286 Před 3 lety +3

    Interesting..but I really would like it if they would pitch down a bit and talk more quietly.

  • @Neoaxelot
    @Neoaxelot Před 7 lety

    Excellent video. Loved it!

  • @coreymerrill3257
    @coreymerrill3257 Před 4 lety +2

    This makes for two fecal transplant conversations in a row during lunch today...
    I feel that i can relate to multiple parts of this video from being a cesarean birth, and have major issues be bound or restrained. I also can easily adjust to basically any environmental situation or living situation without it becoming to big of a problem. I in fact have a harder time going to a public place than facing complete power grid failure in the u.s. rational? Nope ? Id help it if I can just figure out how. I can relate by feeling mentally terrible when I eat a poor diet. Depressed and lethargic and dim. I had internal chemical burns in the early two thousands and my digestive track no longer works right. When I have a steady intake of live culture yogurt and/ or Keefer, I have a much easier time of life internally and externally.

  • @papinkelman7695
    @papinkelman7695 Před 7 lety +6

    there she is...
    and what about midi-chlorians?

  • @ridjf
    @ridjf Před 7 lety +31

    Can we then make a microbiome promoting baby formula to make super children who learn and handle stress easier?

    • @ooooneeee
      @ooooneeee Před 7 lety +17

      ridjf breast milk actually contains many different oligosaccharides which the baby cannot digest to promote helpful bacteria colonization of the gut by feeding them. Baby formula needs to incorporate those to get close to breast milk.

    • @clarelusher
      @clarelusher Před 7 lety +14

      Dark Rainbow I'm glad someone pointed that out! I wonder if anyone is studying possible correlations between dramatic decline in breastfeeding rates and dramatic increases in mental health issues in the 'developed' world? Probably not as there is no profit in it! Yet it could be one answer to a conundrum of mental health issues in the developed nations.

    • @cellocovers3982
      @cellocovers3982 Před 7 lety +29

      it's called breast feeding

    • @jamesburleson1916
      @jamesburleson1916 Před 7 lety +3

      +Clare Lusher I was thinking something similar. How much does one's diet affect one's mental health or even how one reacts to daily challenges? This entire field of study will likely lead scientists to the conclusion that maintaining a healthy diet is imperative to healthy brain development and maintenance. All these kids who were raised on McDonalds and taught to use these soaps and hand sanitizers that kill 99.99% of bacteria might be so disadvantaged by the negative impact on their microbiome. If you really stop and think about how much you could be effected by poor diet, it kind of puts a lot of things in perspective.

    • @dreadfairy6963
      @dreadfairy6963 Před 5 lety +2

      There already IS a "formula" for that! It's called BREAST MILK from each of our mothers! XD
      We need to stop trying to create fixes for things, most of our "fixes" lead to more problems. Nature, living by the natural order of our own biology, already has all the fixes! It's because we have moved so far from the natural order of the world that we have so many problems/disorders/illnesses to begin with.

  • @b_z5571
    @b_z5571 Před 7 lety

    I was a part of a study relating to this research cuz I had IBS...That sounded a lot cooler in my head😬

  • @cacodaemonia
    @cacodaemonia Před 7 lety

    Speaking of the vagus nerve, you all should do an episode about the vasovagal response. It's interesting how many different things can trigger it.

  • @NPEvM
    @NPEvM Před 7 lety +6

    Great video topic, very intresting, however I'd like to say that:
    AS a person WITH DYSLEXIA i FIND it pretty HARD TO read some OF YOUR TEXT in the VIDEO. ESPECIALLY HAVING A smaller font LETTERTYPE which IS still TYPED IN caps.
    Easy to read: 7:04
    Realy hard to read: 4:28
    I can imagen that you do this to make it more clear, but for me it actually worsens the readability.

  • @Meandmymirror
    @Meandmymirror Před 4 lety +6

    She is speaking to fast! Neither of my brains can operate with that stress!

  • @889bball
    @889bball Před 5 lety +2

    These people sound so sure and yet so doubtful at the same time.

  • @KotobukiGirl
    @KotobukiGirl Před 3 lety

    Well done!

  • @drenidautaj
    @drenidautaj Před 7 lety +5

    Always had a gut feeling about this.

  • @josiahbaumgartner7643
    @josiahbaumgartner7643 Před 7 lety +4

    I read an article about this from a magazine that just came out this month, coincidence?! Yeah, probably.

    • @josiahbaumgartner7643
      @josiahbaumgartner7643 Před 7 lety +4

      I'm going to post the entire article here for anyone interested in it.
      "The Enteric Nervous System-Your Body’s “Second Brain”?
      HOW many brains do you have? If you answer “one,” you are correct. Yet, there are other nervous systems in your body. One network of neurons is so extensive that some scientists have referred to it as a “second brain.” It is the enteric nervous system (ENS) and is located, not in your head, but mostly in your belly.
      It takes an enormous amount of coordination and effort for the body to transform food into fuel. Hence, it is fitting that the brain is designed to delegate, as it were, most digestive control to the ENS.
      While much simpler than the brain, the ENS is immensely complex. In humans, it is made up of an estimated 200 to 600 million neurons. This complex network of neurons is built into the digestive system. Scientists believe that if the function of the ENS were to take place in the brain, the needed nerves would be too thick. According to the book The Second Brain, “it is thus both safer and more convenient to let the [digestive system] look after itself.”
      “A CHEMICAL WORKSHOP”
      Food digestion requires a variety of very precise chemical mixtures produced at the right times and delivered to the right locations. Professor Gary Mawe aptly describes the digestive system as “a chemical workshop.” The sophistication of this chemical operation is mind-boggling. For instance, the intestinal wall is lined with specialized cells that act as chemical detectors, or taste receptors, identifying chemicals present in the food you eat. This data helps the ENS enlist the right digestive enzymes to break the food down into particles that the body can absorb. Also, the ENS plays a vital role in monitoring the acidity and other chemical properties of food particles and in adjusting the digestive enzymes accordingly.
      Think of the digestive tract as a factory line managed mostly by the ENS. Your “second brain” moves food through the digestive system by directing the muscles along the wall of the digestive tract to contract. The ENS varies the strength and frequency of these muscle contractions as needed to make the system function like a line of conveyor belts.
      The ENS also supervises safety functions. The food you swallow is likely to contain potentially harmful bacteria. It is no wonder that about 70 to 80 percent of your body’s lymphocyte cells-a vital component of your immune defense system-are housed inside your belly! If you ingest high levels of harmful organisms, the ENS protects the body by triggering powerful contractions that expel most of the toxic matter through vomiting or diarrhea.
      GOOD COMMUNICATION
      While the ENS seems to function independently of the brain, these two nerve centers engage in constant communication. For example, the ENS plays a role in the regulation of hormones that tell the brain when you should eat and how much you should eat. ENS nerve cells signal the brain when you are full and may possibly trigger nausea if you eat too much.
      Even before reading this article, you may have suspected that there is a communication link between your digestive tract and your brain. Have you noticed, for instance, that eating some fatty foods seems to improve your mood? Research suggests that this happens when your ENS sends ‘happy signals’ to your brain, starting a chain reaction that makes you feel better. This may explain why people tend to eat so-called comfort food when feeling stressed. Scientists are exploring the possibility of artificially stimulating the ENS as a treatment for depression.
      Another example of communication between the brain and the digestive system is what has been described as having butterflies in one’s stomach. This feeling may be the result of the ENS diverting blood away from the stomach when the brain experiences tension or stress. Nausea can be another result, as during stress the brain triggers the ENS to change the gut’s normal contractions. According to experts, this brain-gut connection might also be the basis for so-called gut instincts.
      While the ENS may generate such gut feelings, it cannot think for you or direct your decisions. In other words, the ENS is not really a brain. It cannot help you to compose a song, balance your bank account, or do your homework. Still, this marvelous system continues to amaze scientists for its complexity-much of it perhaps still undiscovered. So the next time you are about to eat a meal, pause and think about all the monitoring, data processing, coordination, and communication that is about to take place in your digestive system!"

  • @evelisisdavis7242
    @evelisisdavis7242 Před 2 lety +1

    Thank you

  • @bestplayerever816
    @bestplayerever816 Před 7 lety

    Great job Olivia

  • @seanross7611
    @seanross7611 Před 7 lety +13

    Can't think of any jokes, might ask my gut

    • @mr_sowong9464
      @mr_sowong9464 Před 7 lety +1

      Sean Ross pulled out the biggest fart ever

  • @KamiltheCamel
    @KamiltheCamel Před 7 lety +72

    Too bad my brain didn't send enough signals to certain parts of me because they are now forever stuck being micro.

  • @willowleaf17
    @willowleaf17 Před 7 lety

    This is so cooool!

  • @anhtopoftheworld
    @anhtopoftheworld Před 7 lety

    Love this topic!

  • @chinookvalley
    @chinookvalley Před 6 lety +3

    I went to my neurologist a few years ago and asked if my Vagus Nerve could be affecting my Fibromyalgia, Mitochondrial Myopathy, and Traumatic Brain Injury thru my gut. He got really nervous, called his nurse and they took me into his office and closed the door. They asked how I knew about the Vagus Nerve, they were angry, they said I didn't know what I was talking about, and that I should forget what I was talking about. They took me into another office and wanted me to discuss this with another one of the PA's there. I left and never went back. How many physicians KNOW that the cures are easily found - cutting their practices out of the profits to be made. Do I seem paranoid? Not really, just waking up to what the medical "industry" is doing, and how cures are not welcome. I eat my yoghurt, and have increased my probiotics, see my Naturopathic Doctor, and guess what? I'm getting better!

    • @ZeMarkKrazee
      @ZeMarkKrazee Před 3 lety

      Your story doesn’t make sense at all. You sound like a paranoid conspiracy theorist.

  • @con.k
    @con.k Před 7 lety +6

    6:19 serotonin produced in the gut doesn't get to the brain I believe. it acts differently in each organ

    • @pramitbanerjee
      @pramitbanerjee Před 7 lety

      that is true. The function of a neurotransmitter seems to vary depending on where they are localized to.

    • @andrewneff5458
      @andrewneff5458 Před 6 lety

      Sure doesn't, so unless gut and platelet serotonin is what emotion & behavior is all about.... Also, tryptophan does get to the brain (serotonin precursor), but little/no evidence microbes influence ppl's tryptophan levels.

  • @cameronstrommen1714
    @cameronstrommen1714 Před 7 lety

    1:17 mouse mouth lol i love it

  • @SC86Canuck
    @SC86Canuck Před 4 lety +1

    Well hopefully we can figure out how to make sure we are getting beneficial things from this microbiome

  • @ZennExile
    @ZennExile Před 7 lety +242

    Nothing about this is weird.
    We have always known, "You are what you eat"

    • @danielmonteiro2161
      @danielmonteiro2161 Před 7 lety +3

      those mice must have eaten fecal matter as heavenly possible

    • @catgodswim
      @catgodswim Před 7 lety +29

      I dont remember eating a human

    • @MacCoalieCoalson
      @MacCoalieCoalson Před 7 lety +1

      Redstone Pro duhhhh your memory was wiped

    • @ozcr6179
      @ozcr6179 Před 7 lety +1

      Zenn Exile so if I eat pssy then does that turn me into a pssy.

    • @ZennExile
      @ZennExile Před 7 lety +8

      Every single day you consume a measurable amount of human, in the form of hair and skin cells.
      So it is not that you don't remember, Redstone Newb, it is that you did not even notice. Because you are a disgusting waste of cognitive ability, and have developed no concept of what it means to have a single perspective, among many.
      You kinda disgust me tbh.

  • @insertnamehere001
    @insertnamehere001 Před 7 lety +3

    As the old saying goes: 'the way to a man's heart is through his stomach'.

  • @mrs.kaetlynwest4878
    @mrs.kaetlynwest4878 Před 4 lety

    Idt it pays homage to pin it down to one detail or another.. IDK all I can tell you is that this is something about you that totally gives me the Amy Farrah Fowler vibe!! And I fking love it!!!! So, thank you for doing this job!!!! I hope you're having a blast as much as I enjoy spectating!!!!!

  • @unixbash
    @unixbash Před 7 lety

    Great video, glad to be early!