The Role of p53 in Cancer

p53 is a sentinel protein recruited rapidly in response to DNA damage. p53 slides along the DNA until it finds a critical site, to which it binds. p53 then sends the message, to halt cell division until DNA is repaired, or If damage is too severe, the cell is destroyed. p53 is therefore known as the ‘guardian of the genome.’ A tiny change in p53 results in a structure that is unable to securely bind to the critical site. This means no decisions can be made about whether to repair DNA or destroy the cell. Without functional p53, cells can accumulate more and more DNA damage, possibly leading to cancer.

[@kanetao]

That rattle! I will never imagine DNA without that sound again.

[@marlondavid1108]

I’m from Germany and I’m 16 years old and no teacher in my school and no German video could help me more than you! Thank you now i understand :)

[@PatientsPortal]

I just visited my friend in hospital day 36 at UCLA, who has the P53 mutation and Diffuse Large B-Cell Lymphoma (DLBCL). Seeing her strength firsthand, despite her white blood cell count being at 0.9, has been incredibly inspiring. It's true what they say: the best teacher is learning from a patient. My friend is the most resilient person I know, and their journey is a powerful reminder of the strength and courage in the face of adversity.

[@yunxizha2276]

I have my finals today. I never understood 053 throughout the semister. You helped me so much. THANKYOU!!!

[@pierpaolocasamassima8652]

Amazing animation and explanation, thanks

[@peters972]

What a great video! It’s not that often I find out something new these days there is quite a lot of recycling. But this was new to me! Thank you.

[@nightmaregamer3711]

Just what I was looking for. Great video; informative narration and superb visuals 🧬

[@EzioAuditore]

Wow such an amazingly well done presentation , great work!

[@josefvymazal7091]

A very good explanation. Thanks!! Josef

[@kamendinand7]

This is so well made and easy to understand. Thank you soo much for helping my study 🙏🙏

[@lisa-rouletlawfirm9307]

Excellent explanation, thank you!!!

[@randjietsingh]

Extremely well explained. I did my minor on this subject. Also your vid sound like the inside of Starcraft Zerg hive, which makes it extra cool!

[@hishamaly9090]

Excellent animation

[@katerinaslama312]

super video thank you

[@fijianhustler6879]

This was helpful. Thanks!!! Bula from Fiji.

[@farahdeebakhan5322]

Wow what an amazing animation

[@islemabdelmalek1115]

Very well made

[@piamuller6744]

I could only focus on these sounds

[@mukarambhat]

wow amazing

[@cosmicsailor7329]

amazing