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Hi arpan. Great video. Loved the explanation. Just a suggestion usually I like to navigate through the playlist to understand a subject, I bet others too do the same. So the more you annotate and organise the playlist the more would people find relevant content easily. Division on the basis of subjects is nice but if you could also make playlist based on content that'd be great. For example everything related to gene expression (including genetics to mil bio to metabolism) e.t.c That enriches the context.
hi, i appreciate all your work! i just wanted to pass on the importance of cholecalciferol as a substrate that all other metabolites of vitamin d (umbrella term use) are dependent on its availability in physiologic levels, (apprx 24hr halflife, so one can be cholecalciferol deficient and be calcidiol sufficient which is a great misunderstanding in medical education, to only look at 25OHD as a 'nutrient' repletion lab assay, that would be false, as 25OHD calcidiol has a halflife of about 3 weeks or longer, and is tightly regulated by the renal feedback loops, and, circulating calcitriol 1,25OH2D plays very little in the body's need and use for immune modulation as well as all other autocrine/paracrine fnxs. Preferentially those cells will want cholecalciferol and in innate fnx there will be use of 25OHD. Keep in mind all further metabolites of cholecalciferol vitamin d the nutrient, (proper use of the term vitamin d), are all dependent on cholecalciferol. As such, the better way to use 25OHD as a nutrient status lab assay is only if one builds and maintains that level into physiologic range best above 50ng/ml by mostly daily intake of vitamin d cholecaliferol. Though vitamin d (umbrella term use) is considered steroidal family, it is different than all other steroidal hormones in its origin, and indeed calcitriol is an active hormone, all cells have the cellular apparatus to convert from either cholecalciferol, and or calcidiol for their own use, not dependent on megalin and cubilin as found in tissues of kidney for example in endocrine use. In fact most of the activity that vitamin d (umbrella term use) is found in autocrine/paracrine, with much less so in endocrine, though that canonical paradigm lays stuck there sadly. if you want to read research a great place to start is with The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes: Hollis and Wagner: www.ncbi.nlm.nih.gov/pmc/articles/PMC3849670/ and please read on to their updated New insights into the vitamin D requirements during pregnancy: www.ncbi.nlm.nih.gov/pmc/articles/PMC5573964/ both these articles explain nicely the different metabolites, please note the addition of endothelial cells in the updated graph/map.
Thanks for putting this video... was looking of yours only . Really helped me
czcams.com/channels/4IpyopsGWSjaPACNTZLuqg.html please subscribe to my other channel
❤Thank you so much! Your content helps me as a network marketer...Im a Forever Business Owner (FBO).
Please support our channel by using super thanks. Your 2$ donation would give us motivation to do more. Super thanks option is present below any of my videos, a heart sign with $ in it.
Hi arpan. Great video. Loved the explanation. Just a suggestion usually I like to navigate through the playlist to understand a subject, I bet others too do the same. So the more you annotate and organise the playlist the more would people find relevant content easily. Division on the basis of subjects is nice but if you could also make playlist based on content that'd be great. For example everything related to gene expression (including genetics to mil bio to metabolism) e.t.c
That enriches the context.
Ayush thanks for the suggestion.....I would arrange them in order.
@@animatedbiologywitharpan best of luck ^~^
hi, i appreciate all your work! i just wanted to pass on the importance of cholecalciferol as a substrate that all other metabolites of vitamin d (umbrella term use) are dependent on its availability in physiologic levels, (apprx 24hr halflife, so one can be cholecalciferol deficient and be calcidiol sufficient which is a great misunderstanding in medical education, to only look at 25OHD as a 'nutrient' repletion lab assay, that would be false, as 25OHD calcidiol has a halflife of about 3 weeks or longer, and is tightly regulated by the renal feedback loops, and, circulating calcitriol 1,25OH2D plays very little in the body's need and use for immune modulation as well as all other autocrine/paracrine fnxs. Preferentially those cells will want cholecalciferol and in innate fnx there will be use of 25OHD.
Keep in mind all further metabolites of cholecalciferol vitamin d the nutrient, (proper use of the term vitamin d), are all dependent on cholecalciferol. As such, the better way to use 25OHD as a nutrient status lab assay is only if one builds and maintains that level into physiologic range best above 50ng/ml by mostly daily intake of vitamin d cholecaliferol.
Though vitamin d (umbrella term use) is considered steroidal family, it is different than all other steroidal hormones in its origin, and indeed calcitriol is an active hormone, all cells have the cellular apparatus to convert from either cholecalciferol, and or calcidiol for their own use, not dependent on megalin and cubilin as found in tissues of kidney for example in endocrine use.
In fact most of the activity that vitamin d (umbrella term use) is found in autocrine/paracrine, with much less so in endocrine, though that canonical paradigm lays stuck there sadly.
if you want to read research a great place to start is with The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes: Hollis and Wagner: www.ncbi.nlm.nih.gov/pmc/articles/PMC3849670/
and please read on to their updated New insights into the vitamin D requirements during pregnancy:
www.ncbi.nlm.nih.gov/pmc/articles/PMC5573964/
both these articles explain nicely the different metabolites, please note the addition of endothelial cells in the updated graph/map.
Wow thanks a lot for this detailed suggestion
Explain about pathogenesis of rickets and osteomalacia also
Thanks for the suggestion
Ill share with you 15+ simple things you can do to overcome Osteomalacia, Fibromialgia, Chronic Fatigue Syndrome and arthritis. Completely free.
Very nice Arpan. Please upload some metabolic pathways in molecular form. 👍
czcams.com/play/PLKtiwIJ8Q7rrfU2Y0NDy8S4rjJPd__qrf.html
This is the biochem playlist
@@animatedbiologywitharpan thank you dear.
👍
Really liked the animation. 😃
Super
Is serve vitamin d deficiency stop height in 14 yrs old boy
It might be one reason but not the soul reason for stunned height.