Nick Norwitz - Ketogenic diets for Alzheimer's Prevention: Don't Push the ApoE4 Boulder'
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- čas přidán 12. 09. 2024
- Dr. Nicholas Norwitz obtained his PhD in ketogenics and neurodegenerative diseases at Oxford University in just two years and is now pursing his MD at Harvard Medical School. His research expertise is ketosis and brain aging; however, he has published scientific papers on topics ranging from neuroscience to heart disease to gastrointestinal health to genetics to bone health to diabetes.
Nick’s passion for Food as Medicine is founded a personal history. At eighteen years old, he developed severe osteoporosis, a bone disease that crippled his promising running career. Next, Nick developed ulcerative colitis, an inflammatory bowel disease so severe as to cause him to lose twenty percent of his body weight in weeks and end up in the palliative care ward of a hospital with a heart rate in the twenties.
Through scientific self-study, Nick discovered his salvation in a ketogenic diet. He reversed his osteoporosis and colitis and is thriving! But Nick is grateful for his apparent misfortunes. In his words, “The most remarkable part of my story is that it’s not unique. The healthcare system isn’t built to address metabolic diseases. For that, we need metabolic medicine rooted in nutrition. My lifelong goal is to help reform the system and educate people. Plus, I’d like to think being a patient has made me a more compassionate person.”
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There are not many people like Nick. He is a soon to be medical doctor with a doctorate degree in bioscience. Incredibly smart yet humble and open-minded. Thank you, Nick, for the good work you and your friends are doing.
I am ApoE3/4. 24 year history with keto low carb. I am counting on my ketones to keep my brain intact. So far so good. 64 yo still 100%. Still working developing software for the scace station. I will ckeck back in 20 years.
Congratulations🌸
are you sure about those ketones working? scace station?
😁@@cybermillers 😁
Wow, brilliant presentation. I need to watch it 2 or 3 more times to digest it so I can readily communicate it to others. You could stop apologizing, you are obviously more than fit to be in the room with the finest of today.
Nursing home food… it must be making things worse…
Certainly is. We were preparing keto meals for my mom daily and yet the staff at her memory care would sabotage (ignorantly I presume) with hot chocolate and doughnuts and snacks. Was so frustrating… they all thought we were crazy. She passed in 2020.
I knew a lady who worked at a facility. She said the cooks would give the elderly people baked goods and empty calories (rice, bread, iceberg lettuce) and say to each other, "you know the family can hardly wait to get the inheritance".
Very detailed and thorough researcher. Someone like Nick should be working for FDA. He has an excellent insight to how the brain is affected by nutrition. We need more like him to help get the message across that prevention is the key.
I am ab n =1 I am no longer pre diabetic. I have reduced inflammation so joint pains disappeared.
I dont take medication as my mood is much improved . And I have lost 60 pounds.
It is nice to hear the science behind the story.
Excellent video, keep up the good work.
TheFdAisNotForUsAndSoeCallItTheFraudDeathAdministration.
Keep him Independent in service of the public world wide, the FDA works for a few legally toxic food and drug lords
@@chalintje history goes in cycles, people will get to see the FDA straighten itself out at least somewhat ... if they dont die from a toxic dose of prescription meds before then
@@ActivateMission2ThisTimeline its not for dogs either if you've been down the vet meds rabbit hole
I need to watch this a few times .
Me too
That's all of Low Carb Down under!
The "Boulder rolling down hill" I believe is 100% correct as that is exactly what I've seen clinically, over & over again...
Hey Nicholas, really enjoying your data and presentation. I’m also a PhD and Apoe4/4 and have found this out recently, I’m looking to learn more to better dictate my lifestyle and I’m so glad I found you on here. Keep up the incredible work
Im E4/4 also. Hard to find really good valid info on this topic. Do you know how high the ketone count should be? I won‘t het over 0.5-0.8mmol. Also do you know if it‘s true that saturated fats oxidize even more in e4/e4 phenotypes and therefor should be avoided?
cheers
The cause of AD etc. Is living a life without ketones; living a life NOT as a fat adapted fat burner producing ketones, but rather as a sugar burner. We block ketosis by eating way too much carbs.
And damage from fructose czcams.com/video/NolUugkz0VI/video.html
Naturally, babies will be in ketosis very shortly after eating. Healthy humans go into low level ketosis between meals and at night. My healthiest elders eat lower carb meals and usually twice a day. More protein, lower carbs, more physical activity.
Dr Norwitz new stuff is also amazing. I really enjoy his videos and look forward to new posts.
respect for all the details and thank you for the vid, but a shorter video on the hard medical details and a longer video on what to do to help with alz might be more beneficial for those who are afflicted (and caregivers)
I gave up on the ApoE4 diet.
Avoiding carbohydrates was not enough and people with ApoE4 have to avoid saturated fat too.
This makes everything unpalatable.
We cannot put butter on vegetables or eat meat with its fat but have to replace them all with olive oil and lean meat.
Great Info Nick! am wanting to embed the info in my brain ! I am APOe4 3 🥴 with moderate symptoms. Thank you so much! for sharing your work. Deo gratias +
My wife began to experience medical issues in 2019.Her back was constantly hurting her - and after paying the doctors a visit, they advised her to take it easy and to come in for an MRI.Two days post-MRI, she was called back into the emergency room because her sixth vertebra was severely affected by cancer.They then diagnosed her with plasmacytoma,this turned my world upside down.I was so desperate that all I could think was, ‘How can I fix this situation?’ I did a lot of reading on keto diet, including how some science suggests eating this way could potentially help to treat cancer.And before long, I thought my wife should give it a try.One year later, in a miraculous turn of events, my wife’s cancer is under control - and we all feel so much better eating this way.Edit: For people asking me about the article you can find it on google *keto inject*
Amazing story.Such an inspiration!
You inspired me.
Can you share some of the articles you’ve read?
This is wonderful. Miraculous or proper human diet?
Read Dr Annette Bosworth, she has couple of books. She dramatically changed her mothers cancer in Any Way You Can thru fasting and ketogenisis
Amazingly detailed data! I knew ApoE4 could make things worse but I finally understand why, now, and how to deal with it.
Please do the 4 hour presentation on this topic. So appreciate your knowledge and enthusiasm for prevention. My mom was APOE3/3 but passed from alz. I’m 3/4 so hyper focused on prevention.
Not in spotlight yet, but cut out seed oils - inflammatory omega 6. Probably worse than carbs. (many can eat big carb macros and not get diabetes and brain issues)
@@BR-hi6yt Very true... this is likely to have been the case in the Kithava population (Lindeberg) also - their staple food having been sweet potatoes :-)) - yet practically no PUFA's !!!!!!
@@BR-hi6yt Yep, I’m all over that. Eat only single ingredient food and nothing from a box or bag. This year will begin raising/growing my own food supply too.
@@adrianlaussermayer3557I think with more exercise, and less overall calorie intake, the body is healthy enough to handle some carbs. Sugar being lower is also notable as fructose causes liver damage similar to alcohol. Gluten seems to be a common leaky gut factor..
Would enjoy seeing you and a conversation with Dale Bredesen who has seen reversal of Alzheimer’s ie pushing the stone back up. Keep up your work!!
I'm recovering from Covid v*x brain injuries (& body injuries) and this information is very pertinent and valuable.
Thank you.
I'm following the FLCCC i-recover treatment protocol to reduce inflammation with good effect.
I have regularly fasted and prayed as an adult, and find it interesting that it has these keto benefits too.
How are you today? Greetings from Berlin🤗
Can u drop a link to your cookbook, several people have written a book with similar titles but not you as author
Thank you so much for breaking this down! My grandmother had Alzheimer’s, dad has memory issues and have increased in me over the last year. We both drink exogenous Ketones, but I think we need to be more diligent! I love the studies breaking down the differences about where we are living!
This is one of the most valuable lectures I've seen in a long time. Thank you so very much! I haven't been tested for the APOE genotype yet, but my father's brother and sister suffered from AD and I'm terrified I might be the carrier of APOE4. I have too many memory issues for my age (47) and my brain is "the tool of my trade" (medical translator and interpreter), so once I start losing words I'm done.
I can understand your position from personal experience. The more I research however the less anxiety I feel.
ApoE4 needs parasites to thrive!
Apolipoprotein E4 is associated with improved cognitive function with a high parasite burden
www.ncbi.nlm.nih.gov/pmc/articles/PMC5349792/
Great presentation, need to watch it again.
Great to see you on this channel Nick! ...although Boston is far from "down under" 😉
80 years old Carnivore elderly athlete.
Incredibly valuable information. I wish I had a transcript. But I’ll definitely continue keto and exogenous ketones!
You can get the transcript by clicking the three dots on the right hand side under the video, and a new list will appear, one of them being transcript. You can copy and paste from there.
Thank you so much for all this vital information! I am so grateful to those of you who do all this research and share it with those of us who need it ♥️
Great video! Curious Nick what your daily diet looks like as a researcher and advocate of the keto lifestyle. We rarely hear what the website founders actually eat. TIA
He has a cookbook mentioned at 1:00 that I'd assume would be close to his ideal diet at least.
If you are on twitter he regularly posts examples of his meals.
Great one. I hope to see more of Nick. Did he study under Dr Richard Veech?
Are you able to connect any of this hypothesis to the apparent benefit for the blood brain barrier of ingesting DHA phospholipids. Thanks, Im encouraged by this presentation as much as I was able to follow it.
Very interesting! I just wished that he was more articulated when he mentions all of these scientific words. He talks a bit too fast for me to fully hear what he is saying at times.🌞
Go back to your beloved Ray Peat, and don’t bother with the scientific process then. It’s challenging, for most of us. Which makes it even more interesting.
How big a role, if any, does sea food play in the diets of the Nigerians in Nigeria, who were studied? Does DHA deficiency play a role in this hypothesis, or is it an alternate factor or is it incidental?
13:31 his paper "Precision Nutrition for Alzheimer's Prevention in ApoE4 Carriers" is free to read online if you Google it.
Are there early lifestyle (& neonatal) factors that can affect neurodevelopmental disorders like ADHD (brain areas controlling executive functions don’t develop fully and development is delayed compared to peers) in the way that lifestyle factors affect cognitive decline in old age?
Cool info but the audio is awful man
Real information is sometimes the hardest to access.
I has no issues with audio.
Good talk - thx.
Cheers, mate! 👍
Book name?
Our thoughts can affect the way proteins fold just like the nutrients we ingest. Read that in The Wisdom of our Cells by Dr Bruce Lipton. Fascinating stuff!
Does this advice extend to other dementias beside alzheimers? My father died of vascular dementia last year which makes up about 20% of dementias.
yes, but fasting will work better. This is pretty hard on people when they are elderly though so be careful.
Absolutely. And it could never hurt to:
-become metabolically healthy
-perform high intensity exercise and long walks
-get sunlight, both early morning in the eyes and midday on exposed skin
-eat ancestrally
-expose one’s self to heat and cold
-walk barefooted on the earth (lots of proof that grounding works)
-enhance and entrain your circadian rhythm
Essentially, fortifying your basic, human bodily systems. Fixing the derangement that our society has induced.
In other presentations-- please refer to them first-- that low carb, keto improve cardiovascular health. This could help.
@@blahizake These suggestions are basic to prolong healthful lifespan. We should try to incorporarte as many of them as possible in our lifestyle.
@@blahizakeI am skeptical of grounding, however walking in the way your feet are meant to operate would help fix a looot of posture, feet and other issues people have
Hello Mr.Norwitz
Have you heared of the new spanish study that basically shows, that all E4 / E4 carriers will get Alzheimers sooner or later?
I am, like you homozygous and pretty freaked out by this - thought perhaps you have a view on this that doesn‘t see it as dramatic?
He said that fructose decreases NO. But doesn't Ray Peat talk about increased NO from orange juice for example?
You cite Ray Peat in a forum related to Nick’s well researched presentation - and brung up high carb o.j.?
Awesome!
👍👊😎
If you have one APOE4 gene, does it matter if ge other one is 2 or 3?
2/4 is better than 3/4
I wonder if the antiflammatory effects of Keto extend to fibromyalgia ?
Of course.
One or more of the boulder pushers will be correct imo.
I'll be back with data and bullet points but these two in particular, and Dr Norwitz are doing a great dis-service to APOE4 homozygous (2 copies) carriers (including himself and myself) by not pulling this video and others that need to be updated, NOW. 2020 and 2021 are not new and as Dr Nick says, a lot changes in a couple years. If you''re APOE2/3, and 3/3, Keto to your heart's content (pun intended). But if you're APOE 3/4 or especially 4/4, you need to look at the data much more closely. Yes, better than a shrug but that "informed mechanism" can cut both ways. Even 3/4s may be okay on Keto IF they have no familial cholesterol history, and a number of other genetic predispositions but if you're not getting lipid testing done on a regular basis every 3-6 mos, you could be making things worse, if not your potential risk of Dementias then heart disease and stroke risk. Diet and nutrition (as Nick and many others have said) is the most difficult factor to research well because of all of the many interacting factors plus you can't do any double-blinds and all of the long-term studies are based on self-reporting. It's possible to mitigate some but not all skewing and you may end up with statistically significant results but NOT clinically significant on top of putting one or more segments of the population under a greater, not a lesser risk due to self-interest. Too many people blindly follow this and other diets because they "sound" plausible, and they work for some (which is great) but they've not gene-tested for APOE4 and other genetic risk factors, nor do "many" even have a handle on their cholesterol and especially their triglyceride levels. Nor do enough people understand the difference between body cholesterol and brain cholesterol, which is why the blood-brain integrity is so very, very important. And above all remember that (currently) the best we can do is build models and models of anything are not the real thing, they are ALWAYS simplified to a large degree no matter what the field let alone such a new and (finally) fast changing field. Do your due diligence on this as much as you can. Today's great thing can be tomorrow's Hindenberg (weird analogy but I'm rushed). I don't have the time that Dr. Nick has or many of you. I have 3-5 years before the average age of symptoms beginning in my family. Maybe the dice roll will go my way but since the last 25 years of Alz research yielded little due to ego, ignoring and/or beating down alt theories to beta and tau as THE key which ended up sucking up 90% or more of the research $ (money goes with the leading contender and potential money makers) until finally a few years back more and more broke away and are now following many more potentially fruitful paths and what do we have on the market for all that effort and $ and an unmeasurable at this time, increase in false/corrupt data and studies being changed or retracted but like in many professions, there's a lot more that hasn't been discovered or being protected by self-interested institutions and companies. All this crap and more is casting at least some doubt on the process itself. Then of course, here in the Capitalist States of Merica, BigPharma was able to fast-track 3 (or 4?) related meds and the best MAYBE slows progress by up to "27%" (what's the range, demographics and more), at a monthly cost of $26K a month(!). So much more but I've gone on too long but I'm so angry at the waste and corruption and greed. I really wanted to go on the Keto diet but what I've read lately for my situation (more than just the relatively rare 2xAPOE4), it would definitely add to the damage that has likely been going on already for X years. Alz is definitely a multi-source killer that we're just beginning to really understand small pieces of it and diet, etc is definitely a huge part but if you go with this, do yourself a favor and start learning (if you don't already know) how to find and read journal articles and not just the overview and conclusions at least if you're APOE4. There are least two problems with (almost?) every article cited here if you're 2xAPOE4, one is that the effects are watered down by combining (if the homozygous group is even "represented" ) the two groups. Total APOE4 population is estimated (and everything is an estimate) in the neighborhood of 27% but the 25% works just as well but the 2XAPOE4 pop is only about 2-3% but has a 3x (or higher) estimated risk factor on its own. So, risks for "my" group for everything from diet to drugs in reality fit for the most part in "unknown" especially to be considered "statistically significant". For APOE3s and 3/4s, it could very well the reverse, in at least some studies that have or have a larger representation of 4/4s, that 3/3 or 3/4 risk is lower than reported for a particular test of a particular whatever. As best as I can tell and I do not have the credentials, nor do I have access to any of the journals behind $$$walls, but it seems very likely that 2xAPOE4s, if they're represented at all depending on the mouse models being used, are mostly under-reported-represented and it's very, very difficult or impossible to tell in data sections (but I'm getting better) due to a lack of data transparency, a lack of "interest", due to the small population (only one smaller is the 2/2 group). After all this I doubt if I'll be back. Just be careful and if you can't get an Alz type test due to cost, and it is a big barrier, get regular cholesterol panels done. Look at family dementia history, and family member cholesterol issues to help inform your decision. And lastly, the field will be greatly changed in 5 years, let alone what will occur in the next 50, as long as publicly funded basic, evidence-based research continues, because it is in danger from political, public, religious, and MedIndustry groups who couldn't care less
Does emitting protons mean it’s emitting light? So it glows.
I always thought Indy should have ducked the boulder.
Proof we have too many chemicals and additives in our food. Where does GMO food come in play? European don't do GMO food.
Oh, we really do.
Problem with keto for people with APOE4 is the rise in apob and ldl; of which the former has a strong correlation to cardiovascular disease. I know not all low carbers believe this, but.
Is low carb instead of keto, with few saturated fats and maybe a bit more protein and carbs a better approach?
The person in this video has experimented and found that even vegan keto with low saturated fat did not significantly lower LDL. Eating a sleeve of Oreos a day basically quartered LDL. I think LDL is needed as part of the disease process, but without the preliminary risk factors, it doesn't really happen. High blood pressure, nicotine, high blood sugar, fatty liver/failure, etc.
Sounds like Dr. Ford Brewer an Dr Erick Westman challenge the AOPB marker as well as other Doctors in that it's not as a big player as it's made out to be neither is LDL. More importantly having low triglycerides and higher HDL indicating metabolic health is far more predictive of heart health. High triglycerides is indicating inflammation and possibly heart disease is what the new research is showing.
Even top Professor Ben Bikman who has a PHD in cell health metabolic health has said not to fear saturated fats and in fact to eat them and some other animal fats instead of plant/seed oils/fats.
Nigerians don’t eat ketogenic diets
I believe this is a good presentation for sure but I was not able to follow his thoughts througtout the end of video. Too much technical and difficult terms. This is not for commum people but for specialists.
Sounds like USA food has too much chemical and addictive. GMO food where does that fit in? Oversea don't do GMO.
How do you know if you are apo e4?
Genetic testing specifically hunting for it
Simple test, you can ask your doctor or most genetic testing services include it in their tests.
I feel mental clarity on keto but weak af exercises
Electrolytes
When it boosts the economy, anything goes 😂, pretty sad, but that's what they think.
👍👍🙏
“I’m going to be jumping around a lot” indeed, it’s a jumbled presentation.
Provided quite a bit that was useful for me, I must say.
There’s no need for that comment. Check your personality.
Not exactly presented in an accessible way. Translation???
essentially don't eat sugar
You should try reading books.
ShowWentOverMyHeadButItSoundedImpressive,
Ok, Nigerians have Apoe4 too and don't have Alzheimer's. But Nigerians do not eat keto diet. They eat more plant based, corn, tubers, beans, vegetables, less meat
What is the typical consumption of processed foods, esp. sugar?
They are probably less likely to be consuming sweeteners containing high fructose corn syrup, seed oils, processed carbohydrates, snacks and food six times a day etc etc.,
The 'Civilised' world needs to re-evaluate everything that we do, to try to avoid the Diseases of Civilisation..!!
An excellent talk, and thank you for putting it all together in the way that you did.
I am trying to help to ameliorate my wife's Altzheimer's. (And I am a retired GP in England)
Many aspects of her health (And mine !!), are considerably improved and I am pleased that she now appears not to be 'declining', and even improving in some aspects.
Keep up your good work....
If everyone with the condition was enrolled in a study, it might turn probability into Reality, purely by force of numbers...
The merits of keto seem to come from eliminating processed foods, especially sugar, refined flour, and refined oils. All of those bad things are plant based.
Do Nigerians eat a whole food diet or processed food diet … where is their diet on that spectrum?
Refer to Paul Saladino on Blue Zones
can say it in english ??
Eat steak and wild caught fish and your chances of getting Alzheimer's is very low even if you have the ApoE4 gene.
The problem is with your education, not his.
La diabetes no se cura, ni el VIH, la herbolaria no tiene nada que ver con las enfermedades mentales. Investiga con un verdadero profesional .
Your credentials list something that you might do 3 years from now???
You can list being a student as part of his credential. But he is already a phd.
Great video, although I doubt you will send all your royalities to research from your book. There's no proof you are doing that.
There probably isn't much
He does research on this stuff. If he should only fund his own continued research we’d all benefit.
And why do you mistrust? Do you think Nick plunged through his indepth studies in search of dollar bills?
Pathetic comment. Check your personality.