Cystic Fibrosis - Pathophysiology, Genetics, Causes, Signs and Symptoms
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- čas přidán 24. 11. 2017
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This video presents Cystic Fibrosis, a type of obstructive lung disease.
Following topics are discussed:
Definition
Causes
CFTR gene mutation and the sweat glands
CFTR gene mutation and the pulmonary issues ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
this is by far the best explanation in whole youtube on CF...
Great lecture sir. One correction, cystic fibrosis is a monogenic disorder. involving a single gene which codes for the protein CFTR. What you are talking about is deletion of three nucleotides which codes for phenylalanine, the most common of all mutations- F508 del. there are in fact more than 1500 mutations causing cystic fibrosis.
Medicine and reading textbooks are truly difficult unless someone like you start to teach it with all of his efforts
Thank you your video. I am a Respiratory Therapist who been out of the field for a few years and now have my first grandbaby diagnosed with CF from the baby screening that was done after she was born.
Your video is a great refresher and I am wanting to learn as much as I can. When it is your own it is a little different with your own. Your brain does not remember everything that I learned in college or on the job.
It's you only sir, who is able to make me understand the pathophysiology of CF in my medical carrier of 17 years.
Thank you sir.
Best lecture ! Cleared out my confusions regarding different mechanisms in sweat gland and digestive secretions! Great explanation Sir!
They thought my niece was going to be sick from this because both parents are CF carriers but my niece is healthy, she is turning 10 soon and hardly ever gets sick from anything.🙏🏼
Good for her. Praying that she always stays healthy, prosperous, and happy.
Such a detailed explanation with easy understanding... Best lecture I have heard ever about CF. Thank you Sir.
THANK YOU ! THIS IS THE BEST VIDEO FOR CF
Really good lectures
extremely thankful for a very important lecture.
First time, I got the answer of my question of salty sweat basis.
Hats Off to the lecturer
Ammmaaazzziiinnng! Thanks a lot!
Well explained
excellent. Thank you so much Sir..
thank you sir good lecture.........
really and simply superb sir
wonderful Dr. Mubeen, Thanks :)
Please make more videos Sir
We need more teachers like you!!
Easiest and concept based understanding , thank you sir 🙏♥️
absolutely brilliant and logical. thank you dr!
No word for your lacture sir.. thanks and make more video for us ...
Great explanation Sir...
It is great explanation on the pathophysiology aspect. ON the treatments part, there is also a new approach of CFTR correctors/modulators that you didn't mention. These drugs improve/modulate the CFTR chloride channel performances. Few products approved by FDA and being used by health care community are Symdeko (FDA approved February 2018), Ivacaftor ...
Great explanation
thank you , amaaaaazing
Very good explain sir
excellent
Great lecture, thank you!
Pleasure. Check drbeen.com for more lectures.
amazing! thannkss
Thank you sooo much
excellent presentatiomDr.been.thanks
Thank you dear.
amazing video sir...i wish i had came across this video before.
Thank you
a great brother of dr najeeb both are just gem of med school Met you at seminar imperial college bahria town Seminar or stroke rehab great description given there by Dr been still refreshing my concepts about there
No mention of ivacaftor agent which reverses abnormality in chloride channels used in G551D defect cystic fibrosis .
One of the best explanation of cystic fibrosis .
Thank u. Its my first lecture.It is awesome..first time i got the real story behind cystic fibrosis ✌
You are most welcome. Glad the lecture is valuable.
thank you from algeria
As usual your the best sir it's great lecture.
Thank you dear. Check drbeen.com for more lectures. #Drbeen
good efforts sir
Simple, short and brilliant
Thank you sir :)
However could you please detail about the channels which are working differently in sweat glands and respiratory system.? Detail as in more precisely the mechanism and effects.
Would be grateful !
Don't you mean three bases are deleted instead of 3 genes? There is only a single CFTR gene. The phenylalanine is the 508th amino acid that is deleted, but not 3 whole genes...
Great...👍
Thank you very much , god bless you 💕💕
You are very welcome
Thank you dr been the best of all cystic fibrosis you are special
Thanks sir plz give us some lectures on biochemistry or biophysics
Awesome sir. Love your lecture
Thank you dear 😍
Great lecture. Question though, isn’t it most often that males are infertile due to congenital agenesis of the vas deferens in CF and not due to thick secretions?
Thanks a lot... sir...your explanation skill is too much good...sir..🙏
You are very welcome!
Thank.you.so.much.sir.
Its very helpfull thank you❤️❤️❤️
Glad to know that. You are welcome!
thanks sir
cool one👍
thanks ALOOOOOT
At the end of lecture plz repeat all points again 🙏🙏tnx
Wholesome video
Thank you!
Sir I have a question, if CFTR Cl- is not present at all. How come Chlorid Ions get inside the cell?
One doubt Sir, chloride ions in respiratory tract where do they ultimately go? Reabsorped or secreted?
Sir there is a problem with cftr channel (chlorine channel) so chlorine won't be absorbed but why sodium channel won't work to absorb again
Sir....i had a doubt...the expired air is considered to be more warm than the air inspired.The reason stated is with the physiological heat of our RT and water vapours. Can u explain from where did water vapours originate???
Water vapors come from the moist airways. Water is part of the airway secretions.
They are water molecules originated from the surface of the respiratory epithelium, when a dry air is passing across the respiratory passage
Great lecture sir
Thank you!
Good explanation, just wanted to clarify at @1:30 that 3 genes are not deleted bur rather within the cftr gene a single nucleotide codon that sequences the amino acid phenylalanine is deleted thus leading to some conformational changes in the translated protein
Hi anyone plz help me out from this Iam having a symptoms for past 1yrs that include wheezing (only when black or brownish sputum comes out),middle of chest pain,sputum with black or brownish color (@that time alone cough) and iam an NON SMOKER 20yrs old . I have consulted 2 pulmonologist and ENT but nothing works ...kindly help me 😔😔🙏
can u explain the genetic cause of cistic fibrosis
Will do.
I love you
my child is "salty" when i kiss him hahahha. great lecture btw! thankyou!
me indiya me rheti hu mere bete ko cystic fibrosis hai me kya kru??? kucch ilaj btaye koi docter btaye plz plz
I am also from india and my daughter also has CF. She also has bronchiectasis....
"Please pay attention". Lol. That can be your phrase. All my professors have their own phrase.
That was awesome sir, thanks alot.