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The Physiological Society
Registrace 18. 03. 2010
Physiology is the study of how our cells, organs and muscles interact. It is an essential discipline which seeks to understand how the human body works. The Physiological Society brings together over 3000 scientists from over 60 countries and since its foundation in 1876, its members have made significant contributions to our knowledge of biological systems and the treatment of disease.
The main aim of the Society is to promote the advancement of physiology for the benefit of the public, and these videos are one way for us communicate what we do and engage with new audiences.
For more information please visit www.physoc.org
The main aim of the Society is to promote the advancement of physiology for the benefit of the public, and these videos are one way for us communicate what we do and engage with new audiences.
For more information please visit www.physoc.org
PHYSIOLOGY SHORTS: Cardiac responses to a daily dose of exercise
In this Physiology Shorts, Dr. Robert Lakin of York University in Toronto, Canada discusses their recent paper: The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation
Read more in The Journal of Physiology: The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation. Renée A Gorman, Simona Yakobov, Nazari Polidovitch, Ryan Debi, Victoria C Sanfrancesco, David A Hood, Robert Lakin, Peter H Backx. 602(4), pp 569-596.
Transcript:
Hi. My name is Dr. Robert Lakin and I am a Research Associate at York University in Toronto, Canada. On behalf of myself, Renee Gorman, Peter Backx, and the other coauthors, I will be highlighting our most recent publication in The Journal of Physiology.
What your group works on?
Our group is focused on unravelling the mechanistic basis of atrial fibrillation (or AF), which is the most frequent sustained supraventricular arrhythmia in humans. While cardiovascular disease and aging are linked to an increased risk of AF, it is now clear that endurance athletes paradoxically have an AF risk similar to CVD, despite profoundly better ventricular function and cardiovascular health.
The relationship between exercise and AF is complex, with studies demonstrating that intensity, duration, frequency and total dose can increase AF risk by as much as 10-fold. Indeed, previous studies have suggested that a J-shaped dose-response relationship exists between physical activity and cardiovascular health outcomes, wherein the benefits of low-to-moderate exercise to reduce AF prevalence yield to increased AF incidence in cohorts performing very high volumes of intense endurance exercise. Unfortunately, establishing an absolute risk of AF with exercise is difficult given the differences in study methodologies, with most conclusions relying on self-reporting to characterize exercise intensities and volumes.
What your study investigated and found?
Therefore, our current study was designed to assess quantitatively the impact of daily exercise dose on atrial remodeling and AF vulnerability using our mouse swim model (Figure 1 - 1:18-1:34). To achieve this, we quantified the exercise effort (work) of mice swimming for either 120, 180 or 240 minutes per day (split into two sessions) by measuring oxygen consumption rates and compared cardiac and skeletal muscle responses after all mice had achieved the same cumulative work during training.
Despite physiological autonomic, ventricular and skeletal muscle adaptations characteristic of the athlete’s heart phenotype, (Figure 6 - 1:42-1:54) our findings demonstrated a novel interplay between electrical and structural changes in atria that appear to progressively predispose to AF inducibility as daily exercise dose is increased above 180 minutes per day, which was remarkedly consistent with thresholds linked to AF in humans.
Mechanistically, our findings showed that beneficial elevations in vagal tone enhanced AF inducibility by reducing atrial refractoriness. Structurally (Figure 8 - 2:03-2:09), we found that collagen content and atrial size were increased in exercised mice, with a strong dependence on daily exercise amount. Importantly (Figure 11 - 2:10-2:22), tissue fibrosis and hypertrophy were invariably associated with increased atrial inflammation, with macrophage numbers significantly elevated in the atria (but not ventricles) of those mice with the greatest daily exercise dose.
Significance of findings and its implications for future work (including any translational or clinical relevance)
We believe our study is the first to quantitatively link daily exercise dose and AF risk in mice. Our findings support directly the previous human studies suggesting that CV health outcomes and AF vulnerability shows a J-shaped dependence on physical activity. The common atrial features of our exercised mice and persistent AF patients, including atrial fibrosis and inflammation, raise the possibility that the atria of endurance athletes may also undergo adverse changes, which might explain why endurance athletes, especially veteran athletes, have AF risks rivalling that seen in disease conditions despite the well-established benefits of moderate physical activity.
Closing statement
Thank you for taking the time to learn more about our study published in The Journal of Physiology. The full paper was published in Volume 602, issue 4.
Read more in The Journal of Physiology: The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation. Renée A Gorman, Simona Yakobov, Nazari Polidovitch, Ryan Debi, Victoria C Sanfrancesco, David A Hood, Robert Lakin, Peter H Backx. 602(4), pp 569-596.
Transcript:
Hi. My name is Dr. Robert Lakin and I am a Research Associate at York University in Toronto, Canada. On behalf of myself, Renee Gorman, Peter Backx, and the other coauthors, I will be highlighting our most recent publication in The Journal of Physiology.
What your group works on?
Our group is focused on unravelling the mechanistic basis of atrial fibrillation (or AF), which is the most frequent sustained supraventricular arrhythmia in humans. While cardiovascular disease and aging are linked to an increased risk of AF, it is now clear that endurance athletes paradoxically have an AF risk similar to CVD, despite profoundly better ventricular function and cardiovascular health.
The relationship between exercise and AF is complex, with studies demonstrating that intensity, duration, frequency and total dose can increase AF risk by as much as 10-fold. Indeed, previous studies have suggested that a J-shaped dose-response relationship exists between physical activity and cardiovascular health outcomes, wherein the benefits of low-to-moderate exercise to reduce AF prevalence yield to increased AF incidence in cohorts performing very high volumes of intense endurance exercise. Unfortunately, establishing an absolute risk of AF with exercise is difficult given the differences in study methodologies, with most conclusions relying on self-reporting to characterize exercise intensities and volumes.
What your study investigated and found?
Therefore, our current study was designed to assess quantitatively the impact of daily exercise dose on atrial remodeling and AF vulnerability using our mouse swim model (Figure 1 - 1:18-1:34). To achieve this, we quantified the exercise effort (work) of mice swimming for either 120, 180 or 240 minutes per day (split into two sessions) by measuring oxygen consumption rates and compared cardiac and skeletal muscle responses after all mice had achieved the same cumulative work during training.
Despite physiological autonomic, ventricular and skeletal muscle adaptations characteristic of the athlete’s heart phenotype, (Figure 6 - 1:42-1:54) our findings demonstrated a novel interplay between electrical and structural changes in atria that appear to progressively predispose to AF inducibility as daily exercise dose is increased above 180 minutes per day, which was remarkedly consistent with thresholds linked to AF in humans.
Mechanistically, our findings showed that beneficial elevations in vagal tone enhanced AF inducibility by reducing atrial refractoriness. Structurally (Figure 8 - 2:03-2:09), we found that collagen content and atrial size were increased in exercised mice, with a strong dependence on daily exercise amount. Importantly (Figure 11 - 2:10-2:22), tissue fibrosis and hypertrophy were invariably associated with increased atrial inflammation, with macrophage numbers significantly elevated in the atria (but not ventricles) of those mice with the greatest daily exercise dose.
Significance of findings and its implications for future work (including any translational or clinical relevance)
We believe our study is the first to quantitatively link daily exercise dose and AF risk in mice. Our findings support directly the previous human studies suggesting that CV health outcomes and AF vulnerability shows a J-shaped dependence on physical activity. The common atrial features of our exercised mice and persistent AF patients, including atrial fibrosis and inflammation, raise the possibility that the atria of endurance athletes may also undergo adverse changes, which might explain why endurance athletes, especially veteran athletes, have AF risks rivalling that seen in disease conditions despite the well-established benefits of moderate physical activity.
Closing statement
Thank you for taking the time to learn more about our study published in The Journal of Physiology. The full paper was published in Volume 602, issue 4.
zhlédnutí: 133
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Our community around the world share their research and experience of the effects of heat on human health and make the case for why we need urgent, coordinated action to combat rising temperatures. For more information and to read our consensus statement 'A Roadmap for Global Heat Resilience' see our website: www.physoc.org/policy/climate-change-and-health/
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zhlédnutí 58Před 14 dny
On Wednesday 12 June we brought together 150 people from across research, policy and climate science to launch a consensus statement in Parliament 'A Roadmap for Global Heat Resilience' to protect health and save lives in the face of rising temperatures. Three takeaways from the event: Collaboration will be key. Only by working in an interdisciplinary way and by bringing people from across dive...
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zhlédnutí 44Před 21 dnem
Working with organisations from the UK and across the world, The Society has developed a Roadmap for Heat Resilience consensus statement to support initiatives that establish ‘virtuous cycles’ of well-being and productivity, urgently addressing the climate change crisis and enhancing heat resilience, thereby promoting healthier, more prosperous communities. Our Roadmap for Global Heat Resilienc...
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Why do we urgently need A Roadmap for Global Heat Resilience?
How do we protect the most vulnerable against rising temperatures?
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zhlédnutí 34Před 21 dnem
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EPicks: Cardiorespiratory adaptations in small cetaceans and marine mammals
zhlédnutí 90Před měsícem
In this EPicks videos, Andreas Fahlman of Global Diving Research SL, Valencia, Spain, talks about his research paper on 'Cardiorespiratory adaptations in small cetaceans and marine mammals'. Find out more in Experimental Physiology: 'Cardiorespiratory adaptations in small cetaceans and marine mammals'. Andreas Fahlman. 109 (3) pp. 324-334 physoc.onlinelibrary.wiley.com/doi/10.1113/EP091095 Tran...
The Physiological Society's Member Stories with Professor George Havenith
zhlédnutí 60Před měsícem
Hear from Professor George Havenith, Professor of Environmental Physiology and Ergonomics and Director of the Environmental Ergonomics Research Centre at Loughborough University, UK. George has been a member of The Physiological Society since January 2002. In this video Professor George Havenith shares his experience being a member of The Society. In our interview he shared - "By joining The So...
The Physiological Society's Member Stories with Dr Samantha Rowland
zhlédnutí 79Před měsícem
Hear from Dr Samantha Rowland, Post Doctoral Research Associate at Loughborough University, UK. Dr Samantha Rowland has been a member of The Physiological Society since September 2019. In this video Dr Rowland shares her experience being a member of The Society and how her membership has helped shape her career. In our interview she shared - "The Physiological Society has supported me throughou...
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zhlédnutí 198Před 2 měsíci
In this Physiology Shorts, Dr Zoltán Somogyvári of HUN-REN WIGNER Research Centre for Physics, Hungary discusses their recent paper: Seeing beyond the spikes: reconstructing the complete spatiotemporal membrane potential distribution from paired intra- and extracellular recordings. Read more in The Journal of Physiology: Seeing beyond the spikes: reconstructing the complete spatiotemporal membr...
EPicks: Attenuated pulsatile transition to the cerebral vasculature during high-intensity exercise
zhlédnutí 221Před 3 měsíci
In this EPicks videos, Jun Sugawara talks about their research paper on 'Attenuated pulsatile transition to the cerebral vasculature during high-intensity interval exercise in young healthy men'. Find out more in Experimental Physiology: 'Attenuated pulsatile transition to the cerebral vasculature during high-intensity interval exercise in young healthy men'. Jun Sugawara, Takeshi Hashimoto, Ha...
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In this Physiology Shorts, Thomas A. Lea of School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia, discusses their recent paper: Hypochlorous acid exposure impairs skeletal muscle function and Ca2 signalling: implications for Duchenne muscular dystrophy pathology. Read more in The Journal of Physiology: Hypochlorous acid exposure impairs skeletal muscle ...
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zhlédnutí 202Před 4 měsíci
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zhlédnutí 287Před 5 měsíci
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Drowning Prevention Research Online Meeting - Friday, 13 October 2023
zhlédnutí 155Před 5 měsíci
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Drowning Prevention Research Online Meeting - Thursday, 12 October 2023
zhlédnutí 94Před 5 měsíci
Drowning Prevention Research Online Meeting - Thursday, 12 October 2023
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zhlédnutí 47Před 7 měsíci
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zhlédnutí 32Před 7 měsíci
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zhlédnutí 103Před 7 měsíci
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zhlédnutí 56Před 7 měsíci
Why do we need a heat resilience strategy?
Are there individual differences in the body’s ability to regulate heat?
zhlédnutí 87Před 7 měsíci
Are there individual differences in the body’s ability to regulate heat?
What is the impact of heat on vulnerable populations?
zhlédnutí 111Před 7 měsíci
What is the impact of heat on vulnerable populations?
Listen Sidhu moosewala
I just. Messed up my science exam my favourite subject because i was panicked i worked so hard and yet i wrote the exam with shaking hands messing up everything
czcams.com/video/d1Ekwh9bvh8/video.htmlsi=0rufoxpNsN-0yPLQ for your interest
Me watching this on 2024
It's my exam and idk why I'm so scared 😢😢😢😢 pls god help me
Help my heart is gonna break the riv cage and get out anytime soon
If you are unable to sleep try listening to music ,it would definitely help reducing your mental agony. I hope this one would help atleast one person who is in need ❤ czcams.com/video/H_pCwspIWhQ/video.htmlsi=4C-1VU93zzxU6891
I'm shaking
Physiology the Human body anatomy.
Fiserv M034646/form.us treasury.partnership.and.one.intellemgent.stude t
My math exam is tomorrow 😭😭😭
So everyone is here the night before our big exam huh 😂
Morocco Bac 2024
I am currently training to join the police force. But the anxiety of the exam made me fail my blood pressure test every time. It can reach as high as 170! While my blood pressure is somewhere between 110-125 most of the time. 🙃
Man I did so bad with paper 1 and now I'm having exam stress and anxiety for paper 2
I really trying to study, but Ive had no breaks and I am doing IB... im literally going to fail this chemistry exam as ive been burnt out. Im at a 90% unrounded and this is going to knock it down big time... i haye IB, dont ever donit
What about a perfectly circular orifice that is best entered or dwelled in with centrifugal types of forces or movement.
Just found this piece of GOLD. Thank you!!
9 days before the start of my exams, I locked myself for the the past two months, I don't remember the last time I got outside, I it's okay until now, the anxiety is slowly killing me, literally. I can only study for like 4 hours and then I get tension headache, no matter what I do it won't go away and when I try to force myself to study it only get worse, I can only pray that what I've accomplished for the past two months won't be a waste.
Try to go out for à walk , or you can try to study in your balacony at the early morning and when the sunshine disturb u go inside
Same. I don't go out before exam
VISIT NEPAL in the background 😮😊❤
Edit: after actually watching this presentation and seeing the design style they’ve used, I am now convinced this area of study is jeopardised. I’d love to get involved, but the emphasis on “tackling global issues” really deters me - like most sciences I fear it will be ideologically driven, and only focussed on suppressing truth rather than making advancements that could actually help everyone. Is there anyone who studies /studied it that can tell me if it has been compromised? It seems the education system has been taken over by insane people, from pre-schools to universities.
Szkoda, że nie ma tłumaczenia na język polski😢
I had a heat stroke now when I go out in heat for 3 to 4 hours I get real irritated and it's like someone else is controlling me
My anxiety was so bad that I started throwing up
It's One month before my final exams I'm stressed now what would happen to me the night before the exam... Only GOD knows..
I have 3 days only,and a huge syllabus to cover. I can't focus,I feel like hell.. Panic seize me thinking what will happen if I fail.. I feel like to die...
Hi samira wachrari cv kriti maaya fel cem ahmed bey raki mliha
Twahachnak❤❤❤❤❤
This is a great documentation showcasing the ingenuity of nureobilologiical scientists. I have the original film. Does anyone want it?
What if i marry ..... will it reduce stress in my life
On 23 may its going to be my exam and I am in so much stress including that I have OCD that makes me to think more stressful but still I do alot of hardwork in last exam I got 90% and before that got 92%
The average person today weights 30 pounds more despite the same calori intake and height compared to the average person who lived in the 80's, persevatives, chemicals and change in gut bacteria is the blame.
Hey guys, if you ever see this please pray for my final exams..
Watching this video is so ironic because the exam I am anxious about is neuroanatomy. It only worsens my state lol bye🥲
exam in 3h HELP
Im gonna die.
Having my finals in one week and haven't started learning
Im literally going insane
Neet 2 days later I'm going nuts
Hahahaha losers I don’t get stressed
Night before the exam and I’m feeling overwhelmingly stressed and nervous, praying to God helps me be more confident at the time of taking the test.
The same for me right now. Hope it went well for you, i just feel that you aced it💪
@@Mina_c I did actually but I got very sick with the flu afterwards because my immune system went down for the stress I felt and my defenses weren’t able to contain the virus and that’s why got sick but I’m getting better now 👍🏼stress is not good for the immune system
@@robertolopez9483 you're right.. sorry that you had to went through it, happy that you're better now:)
@@Mina_c thanks, I hope you do well on your exam too.
😢 Luv sxscdcdxscfvccc. C ccdcdc
Wonderful video with beautiful animations, soothing voice 🌺,and helpful tips ◕‿◕｡
I am on the verge of getting admitted into a psychiatric ward
There's nothing genetic about obesity. Stop eating processed food and you will cure obesity. Stop the government subsidies for sugar, soy, wheat and corn. Genetic factors are just an excuse not to look in the right direction. Fasting, eating real food and lowering stress will reverse/avoid all major modern deseases. That's a fact!
Is there any way for me to reduce exam stress because I'm always dealing with this kind of problem?
Very nice video.
Can you ahare the cheat sheet please and notes for digital and circuit please
exams will make me kill my self
deep breathing, socializing, good sleep, exercise, MAKE STRESS UR ENERGY AND OVERCOME EXTRA STRESS.
The problem isn't genetics or even the people alone, it's the fact that we let huge corporations get away with giving us highly palatable ultra processed foods and they lobby so that you don't usually hear about it, you virtually think nothing of it, if anything, you hear about how bad the people themselves are... for eating food that frankly should be illegal. There's literally no need for a 1,200 calorie lunch with zero nutritional value.