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Total Synthesis
United States
Registrace 8. 06. 2018
Total synthesis is the complete chemical synthesis of complex molecules - leveraging the power of organic chemistry.
This interdisciplinary science channel focuses on interesting molecules: historical aspects, biology and biochemistry, (retro)synthetic strategy and in-depth analysis of organic chemistry (e.g., reaction mechanisms).
The topics span traditional total synthesis, pharmaceuticals, psychedelics, supramolecular chemistry, materials and much more!
Your support is greatly appreciated:
www.patreon.com/totalsynthesis
totalsynthesis_official
total-synthesis.com/
Look forward to having you join the ride!
DISCLAIMER: THIS CHANNEL DOES NOT PROVIDE MEDICAL ADVICE
This interdisciplinary science channel focuses on interesting molecules: historical aspects, biology and biochemistry, (retro)synthetic strategy and in-depth analysis of organic chemistry (e.g., reaction mechanisms).
The topics span traditional total synthesis, pharmaceuticals, psychedelics, supramolecular chemistry, materials and much more!
Your support is greatly appreciated:
www.patreon.com/totalsynthesis
totalsynthesis_official
total-synthesis.com/
Look forward to having you join the ride!
DISCLAIMER: THIS CHANNEL DOES NOT PROVIDE MEDICAL ADVICE
This Drug Synthesis is Literally Breathtaking | Medicinal Chemistry & Organic Synthesis
This molecule might look like any other 'flat drug' - but there's a mystery hidden behind its synthesis! Coupled with the fact that it showed promise in asthma due to its novel mechanism, you could say that it's breath-taking (actually more like breath-giving, but I figured no one will understand this).
Watch this video to learn more about organic synthesis, drug development and more!
00:00 A breath-taking synthesis
00:23 Structure of our target molecule
01:37 Intro to PI3K enzymes and inhibitor drugs
03:41 Levels of chemistry sophistication
05:09 Retrosynthesis of AZD8154 and overview
05:57 Forward synthesis # 1
07:26 What was the problem?
08:19 Forward synthesis # 2
11:10 How legit is the solution?
12:03 FDA stance on PI3K inhibitors, and conclusion
www.patreon.com/totalsynthesis
🚀 Thanks to all channel supporters!!!
totalsynthesis_official
👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news!
www.total-synthesis.com
Disclaimer - This channel does not provide medical advice!
No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on CZcams.
Key references:
- Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma | J. Med. Chem. 2021, 64, 8053
- Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer | Int. J. Mol. Sci. 2018, 19, 3931
- The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review | Cancers 2021, 13, 3949
- Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors | J. Med. Chem. 2018, 61, 5435
- An Intramolecular Diels-Alder Approach to the Isoindolinone Core of AZD8154 | doi.org/10.1021/acs.oprd.3c00507
- Selection and Development of the Manufacturing Route for EP1 Antagonist GSK269984B | Org. Process Res. Dev. 2010, 14, 820
- Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease | Br J Clin Pharmacol. 2022, 88, 260
- Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib | Drug Des Devel Ther 2018, 12, 2577
Watch this video to learn more about organic synthesis, drug development and more!
00:00 A breath-taking synthesis
00:23 Structure of our target molecule
01:37 Intro to PI3K enzymes and inhibitor drugs
03:41 Levels of chemistry sophistication
05:09 Retrosynthesis of AZD8154 and overview
05:57 Forward synthesis # 1
07:26 What was the problem?
08:19 Forward synthesis # 2
11:10 How legit is the solution?
12:03 FDA stance on PI3K inhibitors, and conclusion
www.patreon.com/totalsynthesis
🚀 Thanks to all channel supporters!!!
totalsynthesis_official
👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news!
www.total-synthesis.com
Disclaimer - This channel does not provide medical advice!
No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on CZcams.
Key references:
- Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma | J. Med. Chem. 2021, 64, 8053
- Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer | Int. J. Mol. Sci. 2018, 19, 3931
- The Pathogenic Role of PI3K/AKT Pathway in Cancer Onset and Drug Resistance: An Updated Review | Cancers 2021, 13, 3949
- Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors | J. Med. Chem. 2018, 61, 5435
- An Intramolecular Diels-Alder Approach to the Isoindolinone Core of AZD8154 | doi.org/10.1021/acs.oprd.3c00507
- Selection and Development of the Manufacturing Route for EP1 Antagonist GSK269984B | Org. Process Res. Dev. 2010, 14, 820
- Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease | Br J Clin Pharmacol. 2022, 88, 260
- Copanlisib for treatment of B-cell malignancies: the development of a PI3K inhibitor with considerable differences to idelalisib | Drug Des Devel Ther 2018, 12, 2577
zhlédnutí: 28 592
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Epic First Cocaine Synthesis in 25 Steps (Educational)
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Cocaine is intertwined with the fabric of society and science in more profound ways than most realize. Join us to hear about 1) current data on cocaine use, 2) history and discovery of cocaine, 3) the first landmark total synthesis of cocaine by Richard Wilstätter, and 4) other evolutions of (bio)chemical synthesis (Robinson, Noyori). Note that we do not cover biological origins, isolation or o...
How E2 Elimination Reactions Work (Animation) | Mechanism & Orbitals | Organic Chemistry
zhlédnutí 3,2KPřed 2 měsíci
👀 This video explains E2 eliminations: basics of geometries, orbitals, selectivities... www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! totalsynthesis_official 👉 Follow me on Instagram for updates on random research, chemistry problems and interesting news! total-synthesis.com 00:00 E2 elimination basics and orbitals 01:14 Ask yourself these questions 01:31 L...
How Chemists Make Carbon 2+ (Octet Rule: Violated) | Organic Chemistry & Synthesis
zhlédnutí 7KPřed 3 měsíci
Yep, you're looking at a carbon with four valence electrons. How can such an unfavorable species be synthesized, how is it stabilized, and how does it behave? Watch this video to learn exotic chemical reactions and unique properties and geometries - which you likely have never seen before! www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! totalsynthesis_official...
How SN2 Reactions Look Like (Animation) | Organic Chemistry Substitution Mechanism
zhlédnutí 4,1KPřed 4 měsíci
👀 Let's take a "more visual look" (is that a pleonasm?) at SN2 reactions, geometries and molecular structures. www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! totalsynthesis_official 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! total-synthesis.com 00:00 Classic SN2 reaction (Williamson ether synthesis) 02:14...
Why "Horror Drugs" Sold for Billions After the Tragedy (Science of Thalidomide)
zhlédnutí 9KPřed 5 měsíci
👶 You are wrong if you think that the thalidomide tragedy put an end to this molecule. Scientifically - with all due respect to harmed individuals - this molecule proved to be incredibly innovative, unlocking a completely new mechanism of action of "therapeutic glues". ❓ What is thalidomide? Why is one enantiomer safe and the other is not? In this video, we uncover the history, chemistry, biolo...
Obesity Drug "Tricks" Your Body Into Burning Fat? Exercise Mimetics Science
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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect....
Extreme Diels-Alder Reactions Your Chemistry Teacher Warned You About
zhlédnutí 9KPřed 7 měsíci
🧠 Remember your chemistry introduction to Diels-Alder reactions? At that time, these extreme reactions would have been beyond your wildest imagination. If you want to learn some unique aspects to one of the most versatile and robust reactions known to chemists, check out this video! We will focus on two natural product total syntheses, covering basic organic chemistry and advanced synthesis. ww...
Ibogaine Synthesis & How It Might Solve the Opioid Crisis / Treat Addiction | Psychedelic Science
zhlédnutí 24KPřed 8 měsíci
To try everything Brilliant has to offer-free-for a full 30 days, visit brilliant.org/TotalSynthesis/. The first 200 of you will get 20% off Brilliant’s annual premium subscription. If you this is you 🤓 and you like the video, consider commenting, sharing it with a fellow nerd, and subscribing to the channel so you do not miss future videos! www.patreon.com/totalsynthesis 🚀 Thanks to all channe...
The Disturbing Truth About New Medicines: Are They Really Better? (Pharmaceutical Chemistry)
zhlédnutí 5KPřed 9 měsíci
🤑 Are newly approved drugs indeed therapeutically superior to already existing medicines? Does their pricing reflect their benefit? Are drugs with breakthrough designations and accelerated approvals actually more impactful than normal therapeutics? Watch this video to learn about these elements and more! Please drop a like and comment to support the video's visibility, activate notifications an...
World’s Most EXPENSIVE Medicines: Greedy or Fair? What Makes them Special? (Gene Therapy, Chemistry)
zhlédnutí 14KPřed 10 měsíci
To try everything Brilliant has to offer-free-for a full 30 days, visit brilliant.org/TotalSynthesis/. The first 200 of you will get 20% off Brilliant’s annual premium subscription. 🤑 Imagine a single dose of medicine priced at $3.5 MILLION. Since the approval of the gene therapy Hemgenix , this is a reality. How can this be fair? Stay tuned to better understand the costs and risks of drug deve...
Psilocybin Synthesis in 4 Steps & How Magic Mushrooms Rewire Brain Networks (Psychedelic Science)
zhlédnutí 377KPřed rokem
🍄 Psilocybin is emerging as a promising "therapeutic psychedelic" across various different conditions and diseases. What is the buzz about, and how does psilocybin work? In this video, we dive into psilocybin's rich history, chemical structure and biochemical mechanism of action. This includes striking effects like dendritogenesis and synaptic rewiring in mice. We will review a large scale synt...
Genius CUBANE Synthesis by Nobel Laureate & Overpriced Drugs | Organic Chemistry (MacMillan)
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🤔 Cubane is a frequently discussed - and highly coveted - top chemistry meme molecule. This interdisciplinary video showcases the synthesis and application of cubanes in medicinal chemistry by presenting research work from MacMillan and co-workers. Given their proof-of-concept on the cystic fibrosis drug Lumacaftor, we also walk through a high-level primer on cystic fibrosis disease landscape a...
Organic Chemistry Masterclass: Insanely complex neuroprotective Illisimonin A (+reaction mechanisms)
zhlédnutí 10KPřed rokem
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MDMA synthesis in 3 steps & how it could help PTSD therapy (educational) | Chemistry & Science
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This Cursed Molecule Will Teach You About Aromaticity | Pagodane & dodecahedrane synthesis chemistry
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Explosive & Strained Molecular Cubes: Azahomocubane: Organic Chemistry Cubane Synthesis & Mechanisms
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LSD Synthesis in 7 Steps (Educational) | Lysergic acid, organic chemistry, reaction mechanisms
zhlédnutí 541KPřed rokem
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How chemists create SUPER-FULLERENE / GRAPHULLERENE | Organic Chemistry Physical Chemistry Materials
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Advanced Organic Chemistry: Total Synthesis of Gibberelins, Retrosynthesis, Mechanisms
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How chemists create "SUPERBENZENE" (Kekulene) | Organic chemistry, synthesis & reaction mechanisms
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How "Heavy Hydrogen" makes Drugs work: Deuterium in Pharmaceuticals, Organic Chemistry & Synthesis
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How scientists discover new drugs against viruses: Medicinal Chemistry & Drug Design (Hepatitis C)
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Exotic Sources of Cancer Medicines: Total Synthesis of Glionitrin Natural Products (Organic Chem)
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How one of Nature's Most Complex Molecules Is Made: Synthesis of Taxol's "Complicated Cousin"
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Organic Chemistry Explained: Total Synthesis of Anti-Cancer Ginkgo Tree Molecule Bilobalide (Corey)
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This is what peak Organic Chemistry looks like | Retrosynthesis & Modern Total Synthesis
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Legal High from Moss better than Medical Cannabis? THC & CBD Biology, Chemistry & Synthesis
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Organic Chemistry Walkthrough Steroid Total Synthesis: Equilenin, Retrosynthesis, Reaction Mechanism
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Total Synthesis of Lysergic Acid (LSD Precursor): Retrosynthesis & Mechanisms (Hofmann, Woodward)
zhlédnutí 280KPřed 5 lety
Total Synthesis of Lysergic Acid (LSD Precursor): Retrosynthesis & Mechanisms (Hofmann, Woodward)
In The Rych-guy's synthesis, the enol ether D-A reaction is actually very interesting! DBU first deprotonates the unsaturated ketone at the delta-position, then the silyl group captures the oxygens. Then a very facile [1,5]-H migration happens before the cycloaddition, so if you deuterates the ketone alpha-H, you will find it in the single bridge in the product. Came across this in a quiz, and missed it
2:22 - So, OT Genasis is responsible for more use. Catchy song, but I have doubts.
Some PTSD is just well-earned guilt for crimes committed.
*Promo sm*
9:30 shouldn’t the arrow go c=o bond instead of o-p bond?
You could oxidize the methyl side-chain instead of making the bromide, then reductive amination. I cant understand why a benzyl bromide would give any problem, just treat the final produkt with ammoniak in a solvent and convert and trace to the benzyl amine then remove tris with a simple acid wash
video
great
Thanks!
are you german by any chance?
Nope 😎
I would like to share my experience on SLU-PP-332 : I took 2 tablets in the morning on an empty stomach for 15 days. I have not changed my diet or habits. Unfortunately so far I have not lost even 100 grams. So I am very disappointed.
Hello feds
Liquid HCN as a solvent... 😳💀💀💀 Also no way arpund it. Definitely would need a good means of fume extractoon. These reactions would require very strict anhydrous conditions and an argon or nitrogen atmosphere for most of it. Also would need dim red light as well. Excellent adventure in organic chemistry. Would make a great final exam practical for Master's level synthetic chemistry, while MDMA would ve an excellent Bachelors level findl practical. ❤
not only tabernamontana iboga produces it but also other members of apocyanceae produces it. most common species is star jasmin which a common ornamental shrub
The background music is irritating...
Sorry was my first attempt at making a cool reel 🥲
hi, thanks for pirceless content you create i appreciate it. could ou please send me chemical pictures so i can put in my word to write essay
Cocke was good 50 years ago. We have XXI century. This record should be in museums 😆😆😆😆😆
It’s a huge problem? For who?
Wonder if you could functionalise the solvent exposed region of this to attach a dual action component
what technique was used to determine the structure of cocaine? I think NMR didn't exist back then
Combination of various methods, but notably Hofmann degradation if you want to look that up
But for sure NMR and most other analytical methods did not exist
Random bloke part made smile. Thanks for the shout out
I knew you would watch this after 6 years!
seeing more plates more dates in this channel of all places is wild
😂😂😂
Oh my god what is this. hexagons pentagons, TRIANGLES EVEN?! sulphur in +6 STATE WTF
Yup the molecule is pretty cursed.
the one question i have is will you pass a thc drug test
So there is a niche pharma market for only the most wealthy of people. Shocking huh, the rest of us a expendable while Billionaire can buy life.