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Onkoview
Germany
Registrace 10. 02. 2010
The videos accompany the text book ‘Molekulare Onkolologie’, 3rd ed., published in the Georg Thieme Verlag, Stuttgart, Germany. In malignant tumours, pathways that control cell growth and cell death are disturbed. In addition, the communication between tumour cells and their environment is altered. In order to interfere with pathways governing malignant growth, the molecular basis of the pathways should be understood in detail. The videos intend to serve this goal. Once the pathways can be targeted, new therapeutic options for cancer patients may ensue.
Update 2017: New videos are available accompany the textbook ‘Cancer Signaling: From Molecular Biology to Targeted Therapy’, published by Wiley-VCH in 2017. The link is posted under the "links" section.
THE AUTHORS:
Prof. Dr. med. Christoph Wagener
Prof. Dr. med. Dr. rer nat. Oliver Müller
VIDEO PRODUCTION:
artindustries.de
VOICEOVER ARTIST:
Ellen Wagner
Update 2017: New videos are available accompany the textbook ‘Cancer Signaling: From Molecular Biology to Targeted Therapy’, published by Wiley-VCH in 2017. The link is posted under the "links" section.
THE AUTHORS:
Prof. Dr. med. Christoph Wagener
Prof. Dr. med. Dr. rer nat. Oliver Müller
VIDEO PRODUCTION:
artindustries.de
VOICEOVER ARTIST:
Ellen Wagner
The Wnt pathway in a normal and in a tumour cell HD
In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein beta-catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of beta-catenin in the cytosol and also in the nucleus is increased. Nuclear beta-catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of beta-catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.
#onkoview, #myc, #wnt, #tumor, #cell, #beta-catenin, #oncogenes, #genes
#onkoview, #myc, #wnt, #tumor, #cell, #beta-catenin, #oncogenes, #genes
zhlédnutí: 2 105
Video
The metastatic thrombus HD
zhlédnutí 332Před 2 lety
This video shows the formation of a metastatic thrombus. Tissue Factor (TF) in the cell membrane of the tumor cells activates factor VII, which in turn activates factor X in association with factor V, calcium-ions and phospholipids (e.g. from platelets). Active factor X catalyzes the conversion of factor II (prothrombin) into factor IIa (thrombin). Thrombin catalyzes the formation of fibrin fro...
Vicious cycle in the generation of osteoclastic bone metastases in mammary cancer HD
zhlédnutí 533Před 2 lety
This video describes the bone loss through metastases of breast cancer. The CXCL12 chemokine formed by stromal cells of the bone marrow binds to the CXCR4 receptor of the tumor cells, which migrate into the bone marrow along the chemokine gradient. IL-11 stimulates the synthesis of RANKL (RANK ligand) in osteoblasts. RANKL binds to RANK (Receptor Activator of NF-Kappa B) of osteoclast precursor...
Apoptosis HD
zhlédnutí 1,7KPřed 2 lety
The term apoptosis describes the regulated and gradual death of a cell. In contrast to uncontrolled necrosis, apoptosis is limited to one or a few cells and is not accompanied by inflammation. Through apoptosis, the organism can get rid of cells, which are non-functional or which are harmful, such as virus infected or tumor cells. The apoptotic process goes through the three different phases of...
Molecular actions of the PML-RARα fusion protein in promyelocytic leukaemia HD
zhlédnutí 1,1KPřed 2 lety
The naturally occurring retinoic acid isomers 13-cis-retinoic acid and all-trans-retinoic acid (ATRA) influence processes of morphogenesis and differentiation. The effect of retinoic acid is mediated via the retinoic acid receptors α, β and γ (RARα, RARβ, RARγ). In the absence of ligands, retinoic acid receptors repress transcription by binding to retinoic acid response elements on the DNA. The...
Communication of tumour cells with the microenvironment HD
zhlédnutí 984Před 2 lety
Epithelial cells are in contact with the extracellular matrix. This video shows the acinus of a mammary gland surrounded by connective tissue. Fibroblasts, macrophages and endothelial cells are embedded in the connective tissue. After the malignant transformation of a mammary gland cell, the tumor cells spread in the glandular duct and penetrate into the surrounding connective tissue. Cells and...
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumour progression HD
zhlédnutí 780Před 2 lety
By degradation of cell adhesion molecules, metalloproteases increase the motility of epithelial cells. Growth factors, which are bound to the plasma membrane, are released. In this way, the growth factors can reach their receptors on target cells. Growth factors, for example TGF-beta, may bind to components of the extracellular matrix. By degradation of such components, growth factors are relea...
The PI3K/AKT signalling pathway HD
zhlédnutí 2,2KPřed 2 lety
The phoshatidylinositol-3 kinase (PI3K) can be activated by binding directly or via the protein IRS-1 to the activated receptor tyrosine kinase. Alternatively, PI3K can be activated by binding to the GTP-bound form of the membrane bound protein Ras. Active PI3K catalyzes the formation of membrane bound PIP3. The second messenger PIP3 activates the serine-threonine kinase AKT. Active AKT phospho...
Molecular action of p53 in carcinogenesis HD
zhlédnutí 1,1KPřed 2 lety
The tumor suppressor protein p53 is a transcription factor. p53 monomers assemble into tetramers that bind to consensus sequences in the DNA and activate the transcription of p53 response genes. P53 target genes are involved in the regulation of proliferation, apoptosis and genomic stability. The loss of p53 functions can promote the development and progression of malignant tumors. This can be ...
The MAP-Kinase (MAPK) signalling pathway HD
zhlédnutí 2,8KPřed 2 lety
The MAPK pathway is dysregulated in more than 50 % of all human tumors. The pathway starts with the activation of a receptor tyrosine kinase, which transmits the signal to a protein that catalyzes the exchange of the guanine nucleotide GDP for GTP associated with the membrane bound protein Ras. The activated GTP-bound form of Ras activates the kinase B-Raf, which itself phosphorylates several c...
Protein kinase C HD
zhlédnutí 2,4KPřed 2 lety
The second messenger PIP3 formed by PI3K can be hydrolyzed to PIP2 by the phosphatase PTEN. PIP2 can be hydrolyzed to diacyl glycerol (DAG) and inositol trisphosphate (IP3) by phospholipase C (PLC). IP3 dissociates from the membrane into the cell, where it opens channels of intracellular vesicles, which store calcium. As a result, the intracellular intracellular calcium level rises. Calcium bin...
The tumour suppressor protein PTEN HD
zhlédnutí 1,2KPřed 2 lety
The phosphatase PTEN dephosphorylates PIP3 to PIP2, which can then be hydrolyzed to DAG and IP3. In addition, PTEN performs many other functions by binding to and activating or inactivating several nuclear proteins. Through these effects PTEN activates DNA repair and inhibits proliferation and thus acts as an important tumor suppressor protein. #pten, #pip3, #pip2, #dag, #ip3, #protein, #dna, #...
Oncogenic activation receptor tyrosine kinases HD
zhlédnutí 699Před 2 lety
Receptor tyrosine kinases transmit signals from outside the cell via the membrane into the cytosol. After activation by an external factor, the receptor monomers dimerize and phosphorylate each other’s intracellular domains. Cytosolic proteins bind to the phosphorylated domains and transmit the signal to other cytosolic proteins. In tumor cells, receptor tyrosine kinases can be dysregulated by ...
Clonal evolution of tumours HD
zhlédnutí 1,4KPřed 2 lety
Tumors are usually of clonal origin, that is, they arise from a single cell. The monoclonality of tumors can be seen, for example, in multiple myeloma, a tumor of the plasma cells. In serum protein electrophoresis, antibodies migrate mainly in the gamma globulin fraction. Antibodies are produced by a large number of different plasma cell clones. The antibodies produced by the various clones dif...
Antibody therapy
zhlédnutí 698Před 2 lety
In the context of cancer therapy, antibodies produced outside the patient are used which are directed against secreted factors, membrane receptors or surface antigens of tumor cells. In order to avoid an immune reaction against the foreign protein in the patient, the domains outside the antigen binding region are replaced by the domains of human antibodies. One speaks of a humanization of the a...
Hypoxia Inducible Factors (HIFs), Part 3: Effects of Hypoxia Inducible Factors (HIFs)
zhlédnutí 7KPřed 2 lety
Hypoxia Inducible Factors (HIFs), Part 3: Effects of Hypoxia Inducible Factors (HIFs)
Hypoxia Inducible Factors (HIFs), Part 2: Regulation of HIF under normoxic and hypoxic conditions
zhlédnutí 18KPřed 2 lety
Hypoxia Inducible Factors (HIFs), Part 2: Regulation of HIF under normoxic and hypoxic conditions
Hypoxia Inducible Factors (HIFs), Part 1: Tumor hypoxia
zhlédnutí 12KPřed 2 lety
Hypoxia Inducible Factors (HIFs), Part 1: Tumor hypoxia
NF-κB pathways, Part 3: Activation of the NF-κB pathway in malignant disease
zhlédnutí 5KPřed 2 lety
NF-κB pathways, Part 3: Activation of the NF-κB pathway in malignant disease
NF-κB pathways, Part 2: Alternative NF-κB pathway
zhlédnutí 9KPřed 2 lety
NF-κB pathways, Part 2: Alternative NF-κB pathway
NF-κB pathways, Part 1: The canonical pathway of NF-κB activation
zhlédnutí 25KPřed 2 lety
NF-κB pathways, Part 1: The canonical pathway of NF-κB activation
The hedgehog signaling pathway - Part 3
zhlédnutí 1,8KPřed 2 lety
The hedgehog signaling pathway - Part 3
The hedgehog signaling pathway - Part 2
zhlédnutí 4,3KPřed 2 lety
The hedgehog signaling pathway - Part 2
The hedgehog signaling pathway - Part 1: Normal situation
zhlédnutí 11KPřed 2 lety
The hedgehog signaling pathway - Part 1: Normal situation
Activation of mTORC1 in hamartoma syndromes and spontaneous tumors
zhlédnutí 1,1KPřed 2 lety
Activation of mTORC1 in hamartoma syndromes and spontaneous tumors
BCR-ABL1 and the Philadelphia chromosome - Part 4: Therapy of tumors with BCR-ABL1 fusion proteins
zhlédnutí 3,8KPřed 2 lety
BCR-ABL1 and the Philadelphia chromosome - Part 4: Therapy of tumors with BCR-ABL1 fusion proteins
BCR-ABL1 and the Philadelphia chromosome - Part 3: The BCR-ABL fusion protein
zhlédnutí 10KPřed 2 lety
BCR-ABL1 and the Philadelphia chromosome - Part 3: The BCR-ABL fusion protein
Pls share link part 1 of this session.
Thank you. Your videos are golden ❤
Thank you
Thanks
thanks
Excellent video! Thank you very much
Awesome
very informative, thank you
What's the "y" supposed to mean?
Y stands for tyrosine (Tyr) amino acid.
2024 anyone
Thank you so much
This explanation is unmatched Thanks alot for your hard work
Thaaank u
Thanks a lot🥹🥹
Have a good day. Productions. 😊
Thank you beautiful lady. You made my life so much easier
❤ so good
This brings to mind the words of the Psalmist……..”I will praise you for I am fearfully, and wonderfully made. Marvelous are your works and that my soul knows RIGHT well”! PWG
Que sea en español latino
This is just too much at once...
Excellent channel 😊👍
the video is wrong. about ligand numbers. not one, two
LOL @ "homogolous" rather than "homologous." Feels like when Bush says "nucular" instead of "nuclear." ....Otherwise a very helpful video xD Thank you!
2:20
6:15
Thank you!!! We are waiting for more videos from you! 😸
The way you guys illustrate the beauty of chemical structures dictating the faith a human life (such as the case of threnonine 315 to isoleucin mutation) and that we can overcome such destiny thorugh the deep and detailed scientific knowledge behind pathophysiology, biochemstry and pharmacology is so awesome. it's hard to find content like this
Thank you ❤️
this video is a very high quality one. I love all the molecular details and the illustrations to express such information
I absolutely adore this channel
Viral etiology. Herpes infection.
Great work, genius in did
Such a good explanation thank you so much
Fantastic!
Great detail! This must have been really time consuming to write the text and create the video. Thanks!
Amazing video, explained really well. Thank you so much <3
Thanks!
nicely explained. thank you
Could you please explain a mutation in this particular pathway? I assume activation of the PKC pathway induces Raf kinase, thus induces the kinase cascade and induces cell growth. So I would assume that a mutation in PKC would lead to no cell growth? Am I correct?
Isn't that asparagine? Not arginine?
It is asparigine
yes
Great Explanation! Thanks
thank you. I don't know what this video is but thank you
Thank you!! Was easy to understand!!! THX!!!
Great explanation. understood so easily, thanks a lot
⚠️JESUS CHRIST IS COMING SOON. BELIEVE IN HIM. JESUS CHRIST IS THE ONLY WAY TO HEAVEN⚠️
Amen! He is! 🙏🏼
No
Encore une masterclass
I mean true, but what does it have to do with the JAK related video?
Thanks for the clear demonstration!
💯
Is this called survival pathway?
Η
Tnq mam