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GenScript USA Inc.
Registrace 27. 06. 2014
GenScript Biotech is a leading life sciences research and application service and product provider that applies its proprietary technology to various fields from basic life sciences research to translational biomedical development, industrial synthetic products, and cell therapeutic solutions.
Leveraging in the Group’s proprietary gene synthesis and other technology and know-hows, the Group has established four major platforms including (i) a leading contracted research organization (“CRO”) platform to provide one-stop solutions to global research communities; (ii) a contract development and manufacturing organization (“CDMO”) platform; (iii) an industrial synthetic products platform; and (iv) an integrated global cell therapy platform.
Leveraging in the Group’s proprietary gene synthesis and other technology and know-hows, the Group has established four major platforms including (i) a leading contracted research organization (“CRO”) platform to provide one-stop solutions to global research communities; (ii) a contract development and manufacturing organization (“CDMO”) platform; (iii) an industrial synthetic products platform; and (iv) an integrated global cell therapy platform.
AI based Antibody Therapeutics Developability Assessment and Its Engineering
Learn from an informative webinar about how AI-based platforms can facilitate the development process for antibody therapeutics and ensure candidates are not only therapeutically effective but also viable for large-scale production and clinical use.
Monoclonal antibodies (mAbs) have become essential in treating a wide spectrum of diseases, with over 100 therapeutic antibody products now approved and commercially available. Although mAbs represent the fastest-growing sector in therapeutics, their development is complex, with developability being a crucial consideration. Developability evaluates the potential of an antibody candidate to be produced as a safe and effective drug.
In the context of Contract Research and Manufacturing Organizations (CRMOs), the developability assessment focuses on ensuring that an antibody candidate can progress through the chemistry, manufacturing and control (CMC) processes efficiently, affordably and within an acceptable timeframe.
It is important to examine and refine the properties related to developability early on, ideally during the discovery phase, to reduce the chances of advancing an antibody with limited developability to the CMC stage. Artificial intelligence (AI) is transforming bioinformatics research and its applications, particularly in protein and antibody analysis. AI methods are now being employed to improve the developability screening and optimization of antibody candidates.
In this webinar, the expert speaker will present the Immunoinformatics Comprehensive Service Platform, which leverages AI for the developability assessment of antibody therapeutics. This covers assessments of immunogenicity, viscosity, aggregation, degradation and post-translational modifications (PTMs). They will also cover antibody engineering services, including humanization, caninization, felinization and optimizing expression.
Case studies will be presented to demonstrate the capabilities in assessing developability and performing antibody engineering. The webinar will end with a Q&A session, allowing participants to delve into any specific areas of interest regarding AI in antibody development.
Monoclonal antibodies (mAbs) have become essential in treating a wide spectrum of diseases, with over 100 therapeutic antibody products now approved and commercially available. Although mAbs represent the fastest-growing sector in therapeutics, their development is complex, with developability being a crucial consideration. Developability evaluates the potential of an antibody candidate to be produced as a safe and effective drug.
In the context of Contract Research and Manufacturing Organizations (CRMOs), the developability assessment focuses on ensuring that an antibody candidate can progress through the chemistry, manufacturing and control (CMC) processes efficiently, affordably and within an acceptable timeframe.
It is important to examine and refine the properties related to developability early on, ideally during the discovery phase, to reduce the chances of advancing an antibody with limited developability to the CMC stage. Artificial intelligence (AI) is transforming bioinformatics research and its applications, particularly in protein and antibody analysis. AI methods are now being employed to improve the developability screening and optimization of antibody candidates.
In this webinar, the expert speaker will present the Immunoinformatics Comprehensive Service Platform, which leverages AI for the developability assessment of antibody therapeutics. This covers assessments of immunogenicity, viscosity, aggregation, degradation and post-translational modifications (PTMs). They will also cover antibody engineering services, including humanization, caninization, felinization and optimizing expression.
Case studies will be presented to demonstrate the capabilities in assessing developability and performing antibody engineering. The webinar will end with a Q&A session, allowing participants to delve into any specific areas of interest regarding AI in antibody development.
zhlédnutí: 77
Video
AET London 2024: Bispecific Antibody Therapeutics: Challenges, Opportunities and Future Directions
zhlédnutí 57Před 14 dny
This talk, “Bispecific Antibody Therapeutics: Challenges, Opportunities and Future Directions” was given during the 2024 Antibodies Engineering & Therapeutics Europe meeting in London, UK, by Robert Ford, PhD, Field Application Specialist at GenScript. In this presentation, you will learn about bi-specific antibodies (bsAbs) demonstrating novel functionalities that yield remarkable promise in i...
Streamlining Cell and Ex Vivo Gene Therapy Manufacturing Innovative Solutions from GenScript
zhlédnutí 101Před 2 měsíci
Cell and gene therapies are on the brink of transforming the pharmaceutical industry, presenting unique challenges such as ensuring the quality and consistent supply of reagents. Reagents play a crucial role in various stages of cell therapy development, from cell isolation and expansion to gene editing and characterization. Any inconsistency or variation in the quality of reagents can affect t...
Complete Toolbox for Gene Therapy Development with Live Q&A
zhlédnutí 72Před 2 měsíci
Gene therapy has revolutionized the field of medicine, and it has the potential to cure a wide variety of genetic disorders. Gene therapy involves the introduction of a functional gene into the patient's cells to replace the missing or defective one. The two main technologies used for gene therapy are viral-based and non-viral gene editing. The primary advantage of viral-based gene editing is t...
Advanced Solutions for mRNA Vaccine Development with Live Q&A
zhlédnutí 85Před 2 měsíci
mRNA vaccines represent a pivotal innovation in prophylactic healthcare, offering a rapid response to emerging infectious diseases. Leveraging the cellular machinery to produce antigenic proteins, these vaccines induce robust immune responses without introducing live pathogens. Recent developments have focused on optimizing mRNA stability, delivery systems, and targeted immune activation. This ...
Bispecific Antibody Overview & Production with CrossMab Technology
zhlédnutí 448Před 2 měsíci
In this webinar, Dr. Sai Wang, protein senior scientist at GenScript Biotech Singapore, will discuss the advantages of bispecific antibodies (bsAbs), their mechanism of action (MOA), and the development history of bsAb platform. She will also help attendees to gain an understanding of the CrossMab production method and its significance in the field of antibody engineering. Additionally, Dr. Wan...
Advancing Brain Shuttle-Enabled Therapeutics for Efficient Delivery to CNS
zhlédnutí 152Před 3 měsíci
This talk, “Advancing Brain Shuttle-Enabled Therapeutics for Efficient Delivery to CNS - Translation to Primates” was given during the 2024 Biologics conference in London, UK by Dr. Pawel Stocki - Vice President of Research at Ossianix. In this presentation, you will learn about how Ossianix has developed the TXP1 brain shuttle based on anti-TfR1 antibody that can be fused to any therapeutic pa...
Enhancing Treatments using Targeted Protein Degradation
zhlédnutí 202Před 5 měsíci
Enhancing Treatments using Targeted Protein Degradation
The Future of Plasmid Maxi-prep is Here: AmMag™ Quatro Automated Solution
zhlédnutí 141Před 5 měsíci
The Future of Plasmid Maxi-prep is Here: AmMag™ Quatro Automated Solution
Robust production of antibody fragments and their therapeutic applications
zhlédnutí 182Před 5 měsíci
Robust production of antibody fragments and their therapeutic applications
PEGS Europe 2023: Empowering Therapeutic Antibody Development
zhlédnutí 76Před 6 měsíci
This talk, “Empowering Therapeutic Antibody Development” was given during the 2023 PEGS Europe conference in Lisbon, Portugal by Roumen Bogoev from GenScript Biotech Inc. Roumen Bogoev is the Head of Segment Marketing at GenScript. Antibody-based therapeutics have transformed drug development, offering precise treatments for diseases. GenScript empowers antibody development from discovery to ma...
Bispecific Antibodies Structural Design, Production and Purification Strategies
zhlédnutí 1KPřed 6 měsíci
Bispecific antibodies have become increasingly of interest by enabling new therapeutic applications for a variety of indications. While natural antibodies are monospecific, bispecific antibodies recognize two different epitopes or antigens. This makes BsAbs hold great therapeutic promise for many diseases by linking an effector to a target cell, acting as ligands to two receptors or other mecha...
Best in class antiviral antibodies from cognate recombinant antibody repertoires of human donors
zhlédnutí 47Před 6 měsíci
This talk, “Best in class antiviral antibodies from cognate recombinant antibody repertoires of human donors” was given during the 2023 PEGS Europe conference in Lisbon, Portugal by Matthias Hillenbrand from Memo Therapeutics AG. Matthias Hillenbrand is the Head of Infectious Diseases at Memo Therapeutics, an ETH spin-off, overseeing antibody discovery campaigns that yielded potent nAbs against...
GenScript x XTalks Webinar: Adaptive Immune Response in Narcolepsy Type 1
zhlédnutí 93Před 8 měsíci
In this webinar, the featured speaker will discuss determining peptide binding affinity to human leukocyte antigen (HLA). The speaker will also share insights into isolating antigen-HLA-restricted CD4 T cells using tetramer HLA. Attendees will also learn about single-cell RNA sequencing of CD4 T cells and cerebrospinal fluid (CSF).
What to Expect from a CRO: What can you expect from GenScript once a project starts?
zhlédnutí 47Před 8 měsíci
What to Expect from a CRO: What can you expect from GenScript once a project starts?
What to Expect from a CRO: How to establish a Contract for Services
zhlédnutí 27Před 8 měsíci
What to Expect from a CRO: How to establish a Contract for Services
What to Expect from a CRO: How to start your Partnership with GenScript
zhlédnutí 23Před 8 měsíci
What to Expect from a CRO: How to start your Partnership with GenScript
What to Expect from a CRO: Why start your partnership with GenScript?
zhlédnutí 20Před 8 měsíci
What to Expect from a CRO: Why start your partnership with GenScript?
What to Expect from a CRO: The GenScript Experience
zhlédnutí 45Před 8 měsíci
What to Expect from a CRO: The GenScript Experience
Enzyme Manufacturing and Optimization via an E coli One Stop Solution
zhlédnutí 274Před 9 měsíci
Enzyme Manufacturing and Optimization via an E coli One Stop Solution
Introducing the latest solution for automated large-scale & transfection-grade plasmid purification
zhlédnutí 96Před 10 měsíci
Introducing the latest solution for automated large-scale & transfection-grade plasmid purification
A robust expression and purification platform for bsAb modalities
zhlédnutí 80Před 10 měsíci
A robust expression and purification platform for bsAb modalities
CD3ζ as a novel integration site for reprogramming immune cells with Chimeric Antigen Receptors
zhlédnutí 422Před 10 měsíci
CD3ζ as a novel integration site for reprogramming immune cells with Chimeric Antigen Receptors
Characterization and biodistribution of REGENXBIO NAV® platform capsids
zhlédnutí 240Před 10 měsíci
Characterization and biodistribution of REGENXBIO NAV® platform capsids
Advancing Protein Stabilization Therapeutic Development and DUBTAC Drug Discovery
zhlédnutí 292Před 10 měsíci
Advancing Protein Stabilization Therapeutic Development and DUBTAC Drug Discovery
This is a very nice introduction. Thank you!
It's a great privilege coming across your CZcams channel Dr Odija. You have always been there for me health wise. I can vividly remember how you turned up for me when I was down with HIV virus. Your contribution and care was highly appreciated. You are the best doctor I have ever come across. Thank you so much for the difference you make in the lives of your patients! Your kindness, sincere caring, and concern make everything better and are a great encouragement ,,.
How to M13 vector construct using laptop
am definitely happy to have met Dr Odija on CZcams channel. You have done a great improvement in my life. Thanks for curing my HIV completely. May God continue to bless Dr Odija
Blah, blah, blah, blah. Now translate into English.
Immune response does not imply immunity! If someone is poisoned with heavy metals or other toxin any bacterial infection etc enters their body they get an immune response!
This video is giving "Turbo Encabulator"
Doing the devils work
Thank you
dulce
I found hope and my complete treatment for my Infection through Dr Ogoh Herbal Medication. ...
Only God can make such complexity such as cells, organs and organisms. We are this far into technology yet can barely make cells or living things with deoxyribonucleic acid.
All my respect for Dr. Liu Pel but it was really hard to follow the ideas she was presenting
Where can the rest of this presentation be found?
😊 All thanks to Dr abiola for curing me permanently from HIV #drabiola
Very nice information
Can I get certificate
I’m so happy for DR OGOH on CZcams for his good HIV MEDICATION that defeated my virus.
I’m so happy for DR OGOH on CZcams for his good HIV MEDICATION that defeated my virus. 0:03 😊
wtf is she saying bruh 💀
Except DNA is far more than Guanine Adenine cytosine & thyamine maybe learn how DNA actually works and the information it stored and stop oversimplifying the human body and Gods work you don’t understand properly and you’ll realise your causing problems not solving them at all this is just idiotic foolery playing with peoples lives and causing disease! Not curing it!
what is a fusion tag?
Can we use the baculovirus system for vaccine for poultry or it only go with the mammalian cells
This is critically important science I too have long been working on, more recently with Mr. Elon Musk in direct live teleconferencing through the modality of XAI. From my view, one of the more important applications of this science will be to proceed with our creation of physical, industrial, etc., droid workers with synthesized DNA; This allows them to compete and be eliminated, thus becoming fitter, more adapted workers and also thinking machines; but most importantly, it gives them the Darwinian and Lamarckian motivation that makes humans so resourceful and adaptive. I have always known that despite some fireworks, AI would be limited, really only semi-'intelligent' until it had the genetic drive to survive, excel, thrive, and reproduce potentially in plethora of progeny. The potential is enough as long as it's real. These droid workers will be alert, linguistic, and self-maintaining like human workers almost; and will have certain applications. It is not my intention to replace the human work force. I greatly admire and often cite as a model Phetchaburi Rajabhat University where I taught and employs so many, all of 100 street-sweeping specialists with a couple rakes and a bag; this is one part of university maintenance and it employs many and makes for a great community. And for those who do not work, perhaps they create art or go to church or temple as laity; They should eat, too. I am a socialist; do not misunderstand nor abuse my system please. We create and share abundance in civilized manner.
The great Dr Kanayo Peterson saved my life when I discovered his CZcams page and contacted him through WhatsApp about how badly I was struggling with my hiv aids infection. He sent me his wonder tonic which saved my life.
How is possible the government don't provide this kids with everything they need ?
'PromoSM'
“Come On” by Doc Hartley is truly one of the greatest musical masterpieces of our era
❤
This woman knows nothing about immunology and is spouting rubbish in poor English.
❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤❤
Please share the link for registration.
I would like to know a bit more about how the gene therapies for baby skin blistering disease are being studied and produced. Are they ethically researched? Are they studied and/or propagated using aborted human cell lines? I found out way more than I ever wanted to know concerning many other pharmaceutical interventions.
Dr Ejemhen on has the cure for hiv…
Nice work, Jane!
When monsters become GOD
thanks
All the love to you for helping so many children ❤❤❤❤❤❤
How is lily now?
Could you just clarify me in 27:36. When you say n-terminus and c-terminus in the MCS, how could that be possible? Don't they only exist in protein chains? How can the tags be put in n-terminus or c-terminus? Do you put them before translation? But then how do they bind to the resultant protein? So these proteases are a post-translational treatment, how do you insert them into the host? Plasmids?
great
Thank you so much!!
omg how about targeted delivery of things that enhance asymmetrical segregation of stem cell division so they don't deplete with age?
Ok can we use this to deliver intelligence genes into the brain b/c it's impt for AI alignment
Permit me introduce you the herbal mixture that cured my herpes in a period of 21days. I am a living witness of this wonderful work of DR ALUED . For information on how I was cured, contact Doctor Alued now for more details on herbal medications and get cured completely Herbs are also effective in curing HIV cancer, hepatitis, fibroids, Hpv and other disease and virus. Search him on CZcams Doctor Aued
Once again thanks to Dr Ejemhen for using his herbal medicine to cure my HIV
Greetings to the general public, I want to inform the public how I was cured of my HERPES Simplex Virus by a doctor called Dr Ejemhen on CZcams
i looking for a vector for my gene . that vector should contain histag in n-terminal , 2 restriction enzymes and there is no extra sequences to be present immediately after the reverse primer .and that vector suitable for ecoli expression system . could you suggest any vector for cloning my gene of interest
Jurassic Park-Life Finds a Way
Often this step that we dread is exactly the right one. Thank you so.... much @doctorogie, for your encouragement and for not failing me throughout the revolution. Your herbs for HIV works like magic 👍👍👍👍