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VALIDATE Network
Registrace 19. 10. 2018
VALIDATE is an international network of researchers working together to accelerate the development of vaccines against tuberculosis (TB), leishmaniasis, melioidosis & leprosy. It is led by the University of Oxford and funded by the UK's Medical Research Council and the Bill & Melinda Gates Foundation. We also aim to facilitate the career progression of our members. Find out more at www.validate-network.org.
VALIDATE Seminar: Immunopathogenesis in cutaneous leishmaniasis
Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical manifestations. Although parasites influence disease severity, cytolytic CD8 T cell responses mediate disease. While these responses originate in the lymph node, we find that expression of the cytolytic effector molecule granzyme B is restricted to lesional CD8 T cells in Leishmania-infected mice, suggesting that local cues within inflamed skin induce cytolytic function. We recently found that Leishmania-infected lesions are hypoxic, and that the recruitment of neutrophils causes hypoxia. Notably, the hypoxic state of the infected skin results in the expression of granzyme B in CD8 T cells, resulting in more severe disease. Thus, targeting hypoxia-driven signals that support local differentiation of cytolytic CD8 T cells may improve the prognosis for patients with cutaneous leishmaniasis, as well as other inflammatory skin diseases where cytolytic CD8 T cells contribute to pathogenesis.
About the Speaker
Dr Fernanda Novais was born in Brazil, a country where cutaneous leishmaniasis is endemic, and she has studied immunity to cutaneous leishmaniasis in mice and humans for over 20 years. Dr. Novais’ discoveries have led to (i) an understanding of how neutrophil-macrophage crosstalk promotes Leishmania killing, (ii) the identification of monocyte subsets responsible for parasite control, and (iii) a new paradigm in which CD8 T cells are pathogenic rather than protective in cutaneous leishmaniasis. Her lab is currently focused on understanding how the environmental signals from the Leishmania-inflamed skin dictate the function of immune cells.
About the Speaker
Dr Fernanda Novais was born in Brazil, a country where cutaneous leishmaniasis is endemic, and she has studied immunity to cutaneous leishmaniasis in mice and humans for over 20 years. Dr. Novais’ discoveries have led to (i) an understanding of how neutrophil-macrophage crosstalk promotes Leishmania killing, (ii) the identification of monocyte subsets responsible for parasite control, and (iii) a new paradigm in which CD8 T cells are pathogenic rather than protective in cutaneous leishmaniasis. Her lab is currently focused on understanding how the environmental signals from the Leishmania-inflamed skin dictate the function of immune cells.
zhlédnutí: 150
Video
VALIDATE Seminar: BCG & COVID - A century-old vaccine in a novel proposal for heterologous recall d
zhlédnutí 82Před 3 měsíci
Recently, there have been strong indications that it is possible to increase the immune response by a second dose of BCG vaccine. Thus, the BCG vaccine re-emerged to be considered based on a significant protective effect of BCG revaccination against TB and supporting its beneficial non-specific, agnostic, or heterologous effects. The latter has also been reported to reduce neonatal sepsis, resp...
VALIDATE ECDN Explained
zhlédnutí 39Před 3 měsíci
The Early Career Development Network (ECDN) provides tailored support and resources for post-doctoral and early PI researchers who identify as female or non-binary, fostering professional growth and addressing career challenges within the VALIDATE community. A call for cohort 2 is currently open, so on 1 May, VALIDATE Network Executive Manager, Samantha Vermaak, will host an online session wher...
VALIDATE Seminar Developing vaccines in a developing country
zhlédnutí 55Před 5 měsíci
The recent COVID-19 pandemic made it clear that a lot could be gained from decentralised vaccine development. Also, many diseases are localized to Low and Middle Income Countries, especially in tropical regions. However, research in immunobiologicals is costly and requires infrastructure and collaborations that are scarce in poorer countries. In this seminar Breno Beirão exploree two important ...
Developing novel 'point of need' molecular tools for monitoring treatment efficacy in Skin NTDs
zhlédnutí 61Před 6 měsíci
In 2022, VALIDATE initiated the project: “Develop novel test for PKDL/Leprosy diagnosis”. This project, led by Prof Chatterjee, aims to address the challenge of post-kala-azar dermal leishmaniasis (PKDL) in South-East Asia. PKDL cases can harbor parasites, perpetuating the transmission cycle of the disease. The team plans to develop a field-applicable diagnostic tool, building on a validated is...
VALIDATE Fellowship - Q&A with Sam Vermaak
zhlédnutí 129Před 6 měsíci
Please note that the fellowship call closes on 8 April 2024 This seminar took place on 17 January 2024 and provided VALIDATE members with a chance to hear more information about the VALIDATE Fellowship grant call, hear some tips and advice, and hear from current VALIDATE Fellows about their experiences. VALIDATE members to ask any questions you may have to VALIDATE Executive Manager Samantha Ve...
VALIDATE One Health Seminar Three: Cross-species Disease Transmission and Mitigation Strategies
zhlédnutí 44Před 8 měsíci
In September 2023, members of the VALIDATE network and subject matter experts from around the world convened in Paarl, South Africa, to explore the application of the One Health model in the development of vaccines for Tuberculosis (TB) and Leishmaniasis. The One Health model is an interdisciplinary approach that acknowledges the interrelationships between human health, animal health, and envir...
VALIDATE One Health Seminar Two: Health System and Infrastructure Challenges in One Health
zhlédnutí 26Před 8 měsíci
In September 2023, members of the VALIDATE network and subject matter experts from around the world convened in Paarl, South Africa, to explore the application of the One Health model in the development of vaccines for Tuberculosis (TB) and Leishmaniasis. The One Health model is an interdisciplinary approach that acknowledges the interrelationships between human health, animal health, and envir...
One Health Seminar: Inequitable Access to Medicines and Health Technologies in a One Health Context
zhlédnutí 152Před 9 měsíci
In September 2023, members of the VALIDATE network and subject matter experts from around the world convened in Paarl, South Africa, to explore the application of the One Health model in the development of vaccines for Tuberculosis (TB) and Leishmaniasis. The One Health model is an interdisciplinary approach that acknowledges the interrelationships between human health, animal health, and envir...
How have you found the ECR Workshop?
zhlédnutí 24Před rokem
Following the very successful "Storytelling for Scientists" workshop, VALIDATE once again asked First Create The Media to provide their members with an in-person, full-day interactive workshop that helped build skills and confidence to talk about their research to the audiences that mattered. The workshop covered: - How to construct a compelling story and create a toolkit to communicate researc...
The VALIDATE 5th Annual Meeting 2023
zhlédnutí 48Před rokem
The 5th VALIDATE Annual Meeting was held on 7-8 March 2023 at the historic BMA House in London, UK. As always, our Annual Meeting gave our members talks from world-leading scientists in our research field, updates from our funded projects on their cutting-edge research, and the chance to meet members from across the globe. 2023 was the first in-person VALIDATE event since 2019, and it was a ple...
How is VALIDATE supporting Early Career Researchers and their career development?
zhlédnutí 27Před rokem
VALIDATE members discuss the support we offer to Early Career Researchers.
What is VALIDATE and what are some of its successes?
zhlédnutí 28Před rokem
VALIDATE members discuss the network and its impact on vaccine development for tuberculosis, melioidosis, leishmaniasis, and leprosy
How have you found the VALIDATE Annual Meeting 2023 and would you recommend it?
zhlédnutí 12Před rokem
VALIDATE members discuss the Annual Meeting 2023, which took place at BMA House, London 7 - 8 March 2023. www.validate-network.org/annual-meeting-2023
What are the benefits to members of being part of VALIDATE?
zhlédnutí 69Před rokem
VALIDATE members talk about the benefits of VALIDATE membership. www.validate-network.org/membership-benefits
How is VALIDATE working to accelerate vaccine development?
zhlédnutí 20Před rokem
How is VALIDATE working to accelerate vaccine development?
VALIDATE Seminar Spore FP1 mucosal vaccine candidate for TB
zhlédnutí 138Před rokem
VALIDATE Seminar Spore FP1 mucosal vaccine candidate for TB
VALIDATE Seminar Development of recombinant BCG Vaccine for tuberculosis utilizing Major Membrane
zhlédnutí 91Před rokem
VALIDATE Seminar Development of recombinant BCG Vaccine for tuberculosis utilizing Major Membrane
Vaccine against Human Leishmaniasis: Institut Pasteur de Tunis Contribution with Prof Dhafer Laouini
zhlédnutí 71Před rokem
Vaccine against Human Leishmaniasis: Institut Pasteur de Tunis Contribution with Prof Dhafer Laouini
Targeting FOXO3 transcription factor as a Host-Directed approach to enhance the efficacy of BCG
zhlédnutí 66Před rokem
Targeting FOXO3 transcription factor as a Host-Directed approach to enhance the efficacy of BCG
Targeting Immunometabolism in Host Defense Against Mycobacterium Tuberculosis
zhlédnutí 181Před rokem
Targeting Immunometabolism in Host Defense Against Mycobacterium Tuberculosis
A Vaccine for Leprosy? A VALIDATE Seminar
zhlédnutí 330Před 2 lety
A Vaccine for Leprosy? A VALIDATE Seminar
VALIDATE Seminar - A Vaccine for Leishmaniasis
zhlédnutí 281Před 2 lety
VALIDATE Seminar - A Vaccine for Leishmaniasis
A few things you might not know about Leishmaniasis
zhlédnutí 521Před 2 lety
A few things you might not know about Leishmaniasis
BCG Adventures - Three educational games for kids...all about vaccines!
zhlédnutí 14Před 2 lety
BCG Adventures - Three educational games for kids...all about vaccines!
Tuberculosis infection and T cell mediated immunity
zhlédnutí 586Před 3 lety
Tuberculosis infection and T cell mediated immunity
TB and the use of BCG in Animals Does it matter to people
zhlédnutí 226Před 3 lety
TB and the use of BCG in Animals Does it matter to people
BCG100 for Schools: Pathways to becoming wildlife researchers
zhlédnutí 82Před 3 lety
BCG100 for Schools: Pathways to becoming wildlife researchers
Thenk you 👍
B
cannot hear you!!
Kaha milega ye injection
Saan po ba nakakabili ng gamut n ito
Saan po ba nakakabili ng gamut n ito
Meron po bang gamut n habibi at Saan ito
Deo4
Sir ye veksin kha milti hai
Thank you very much sir . Good Luck !!!👍😊😀😀😀😀
oh wait look ....another vaccine.. o joy