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Center for Physical Genomics and Engineering
United States
Registrace 18. 05. 2021
The mission of the Center for Physical Genomics and Engineering at Northwestern University's McCormick School of Engineering is to create new strategies for the treatment of disease and the reversible manipulation of physical systems through the emerging field of physical genomics. It uses an evidence-based approach to train the next generation of engineering leaders engaged in research that bridges super-resolution imaging, molecular biology, bioengineering, physics, and chemistry.
The Center for Physical Genomics and Engineering at Northwestern University
Engineering living systems at the interface of biological, physical and computational sciences since 2019. CPGE conducts transdisciplinary research incorporating tools and techniques from diverse fields including super-resolution imaging, modeling, computational genomics and genome mapping, biology, chemistry and machine learning, and trains the next generation of scientific leaders.
CPGE focuses on studying and manipulating chromatin structure, which regulates gene expression, in order to treat disease, regenerate tissues, and engineer living systems to overcome environmental challenges. To learn more, visit our website at physicalgenomics.northwestern.edu/
CPGE focuses on studying and manipulating chromatin structure, which regulates gene expression, in order to treat disease, regenerate tissues, and engineer living systems to overcome environmental challenges. To learn more, visit our website at physicalgenomics.northwestern.edu/
zhlédnutí: 73
Video
Many-to-Many Networks: Multifunctional Modules for Multicellularity - Michael Elowitz
zhlédnutí 459Před dnem
In multicellular organisms, many biological pathways exhibit a curious structure, involving sets of protein variants that bind or interact with one another in a many-to-many fashion. What functions do these seemingly complicated architectures provide? And can similar architectures be useful in synthetic biology? Here, Dr. Elowitz discusses recent work in his lab that shows how many-to-many circ...
Mechanisms and Applications of DNA Methylation and Gene Silencing in Plants - Steve Jacobsen
zhlédnutí 125Před měsícem
Prof. Steve Jacobsen, Professor of Molecular Cell & Development Biology, HHMI Investigator, University of California, Los Angeles DNA methylation is associated with transcriptional repression of eukaryotic genes and transposons. Plants have evolved elaborate systems for the establishment and maintenance of DNA methylation, involving a number of self-reinforcing loop systems that allow for the h...
Q&A: Afternoon Session, 2024 Symposium on Physical Genomics
zhlédnutí 113Před měsícem
Profs. Haynes and Squires and PhD candidate Joseph Wakim answer audience questions at the 2024 Symposium on Physical Genomics at Northwestern University. Sponsored by the Center for Physical Genomics and Engineering at Northwestern University, the Cancer and Physical Sciences Program at the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084 physicalgenomics....
Q&A: Morning Session, 2024 Symposium on Physical Genomics
zhlédnutí 7Před měsícem
Profs. Narita, Lakadamyali, and Huang answer audience questions at the 2024 Symposium on Physical Genomics at Northwestern University. Sponsored by the Center for Physical Genomics and Engineering at Northwestern University, the Cancer and Physical Sciences Program at the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants T32GM142604 and U54CA268084 physicalgenomics.northwestern.edu
Capturing Biomolecular Interactions at Single-Molecule Level via ABEL Trap Fluorescence Spectroscopy
zhlédnutí 76Před měsícem
Dr. Allison Squires of the University of Chicago presents an invited talk at the 2024 Symposium on Physical Genomics at Northwestern University. Prof. Allison Squires is the Neubauer Family Assistant Professor of Molecular Engineering in the Pritzker School of Molecular Engineering. The Squires Group’s interdisciplinary research centers on sensing, imaging, and manipulating nanoscale processes ...
Investigating Gene Activation Dynamics in Human Polycomb Chromatin with Synthetic Reader-Effectors
zhlédnutí 77Před měsícem
Dr. Karmella Haynes presents an invited talk at the 2024 Symposium on Physical Genomics at Northwestern University. Karmella Haynes is an Assistant Professor of Biomedical Engineering at Emory University. She earned her Ph.D. studying epigenetics and chromatin in Drosophila at Washington University, St. Louis. Postdoctoral fellowships at Davidson College and Harvard Medical School introduced he...
Modeling of Nucleosome Clustering in Euchromatin Resulting from Interactions Between Reader Proteins
zhlédnutí 24Před měsícem
Joseph Wakim, PhD Candidate, Spakowitz Group, Stanford University The Spakowitz lab is engaged in projects that address fundamental chemical and physical phenomena underlying a range of biological processes and soft-material applications. Current research in the lab focuses on four main research themes: chromosomal organization and dynamics, protein self-assembly, polymer membranes, and charge ...
Ultraresolution Imaging Through Deep Tissue and a New Information-Based Theoretical Resolution Limit
zhlédnutí 84Před měsícem
Dr. Fang Huang presents an invited talk at the 2024 Symposium on Physical Genomics at Northwestern University. Prof. Huang is the Reilly Associate Professor of Biomedical Engineering at Purdue University. His research focuses on developing novel optical imaging technologies to make significant advances in defining the structure and function of cellular constituents in live cells and tissues wit...
Super-Resolution Imaging of Chromatin Structure and Dynamics in Health & Disease: Melike Lakadamyali
zhlédnutí 97Před měsícem
Dr. Melike Lakadamyali gives an invited lecture at the 2024 Symposium on Physical Genomics at Northwestern University. Dr. Lakadamyali obtained her BS in Physics in 2001 from the University of Texas, Austin and her PhD in Physics in 2006 from Harvard University. Dr. Lakadamyali started her independent group at ICFO-Institute of Photonic Sciences in Barcelona in 2010 and was awarded tenure in 20...
Gene Regulation in Cellular Senescence - Masashi Narita
zhlédnutí 115Před měsícem
Masashi Narita gives the keynote lecture at the 2024 Symposium on Physical Genomics at Northwestern University. Dr. Narita is a group leader at Cancer Research UK, Cambridge Institute (CRUK-CI) and Professor of Senobiology in the Department of Oncology at the University of Cambridge. Originally trained as a surgeon in Osaka, Japan, Masashi pursued a basic research PhD focusing on apoptosis befo...
3D Chromatin Rewiring During Melanoma Phenotypic Transition - Pietro Berico
zhlédnutí 51Před 3 měsíci
Melanoma intra-tumor heterogeneity is thought to be the root cause of cancer progression and therapy resistance. Melanoma cells can transiently “switch” between different transcriptional states or phenotypes as an adaptive response to microenvironmental cues. Genetic studies in patient cohorts, cell lines and melanoma mouse models have failed to identify drivers of phenotype transition, suggest...
Fossils of Ancient Chromosomes - Erez Lieberman Aiden
zhlédnutí 168Před 4 měsíci
Erez Lieberman Aiden is an applied mathematician and a molecular biologist. He received his PhD from Harvard and MIT in 2010, and spent several years at Harvard's Society of Fellows and at Google as Visiting Faculty before moving to the Baylor College of Medicine, where he is now an Associate Professor. His laboratory’s primary emphasis is on exploring the three dimensional structure of the hum...
The X Factor: Unveiling the Secrets of the X-Chromosome with Data-Driven 3D Modeling - Anna Lappala
zhlédnutí 386Před 5 měsíci
Anna Lappala, PhD - Harvard University To advance our understanding of the genetic underpinnings of sex-specific diseases, a deeper exploration of the X-chromosome structure and function is essential. In this talk, Dr. Lappala delves into how data-driven 3D modeling techniques have provided novel insights into the X-chromosome organization and its role in health and disease. The presentation co...
Towards an Understanding of Chromatin Remodeler Function in Development at Single-Cell Resolution
zhlédnutí 171Před 8 měsíci
David Gorkin, PhD - Assistant Professor of Biology, Emory University Many chromatin regulators are essential for mammalian development, and mutations in chromatin regulators cause a variety of human developmental disorders. However, the developmental cell types and gene regulatory networks that rely on each chromatin regulator for their proper function are not well characterized. Together with ...
Genomics and Transcriptomics of Heart Disease
zhlédnutí 111Před 9 měsíci
Genomics and Transcriptomics of Heart Disease
WWT/CPGE Seminar: A Day in the Life of a Data Scientist
zhlédnutí 15Před 9 měsíci
WWT/CPGE Seminar: A Day in the Life of a Data Scientist
Gene Structure Heterogeneity and Loop Extrusion Drive Transcriptional Noise in Human Cells
zhlédnutí 1,3KPřed 10 měsíci
Gene Structure Heterogeneity and Loop Extrusion Drive Transcriptional Noise in Human Cells
Physical Genomics Training Program Research Showcase
zhlédnutí 2,1KPřed 11 měsíci
Physical Genomics Training Program Research Showcase
Probing Principles of Genome Organization and Function - Bas van Steensel
zhlédnutí 259Před rokem
Probing Principles of Genome Organization and Function - Bas van Steensel
2023 Symposium on Physical Genomics - Question and Answer Session II
zhlédnutí 37Před rokem
2023 Symposium on Physical Genomics - Question and Answer Session II
2023 Symposium on Physical Genomics - Question and Answer Session I
zhlédnutí 11Před rokem
2023 Symposium on Physical Genomics - Question and Answer Session I
Chuan He - RNA Methylation in Chromatin Regulation
zhlédnutí 255Před rokem
Chuan He - RNA Methylation in Chromatin Regulation
Song Li - Mechano-Epigenetics for Cell Engineering
zhlédnutí 131Před rokem
Song Li - Mechano-Epigenetics for Cell Engineering
Carolyn Larabell - Quantitative Imaging of Nuclear Organization
zhlédnutí 31Před rokem
Carolyn Larabell - Quantitative Imaging of Nuclear Organization
Gary Karpen - New Insights into Formation, Organization and Function of Heterochromatin Condensates
zhlédnutí 81Před rokem
Gary Karpen - New Insights into Formation, Organization and Function of Heterochromatin Condensates
Clodagh O'Shea - Cracking the Nuclear Codes: Finding Order in Chaos
zhlédnutí 110Před rokem
Clodagh O'Shea - Cracking the Nuclear Codes: Finding Order in Chaos
Alterations in Spatial Genome Compartmentalization Associated with Constriction and Expansion
zhlédnutí 413Před rokem
Alterations in Spatial Genome Compartmentalization Associated with Constriction and Expansion
Abnormal Mechanics in Brain Tumors: Implications for Immunotherapy - Dr. Meenal Datta
zhlédnutí 110Před rokem
Abnormal Mechanics in Brain Tumors: Implications for Immunotherapy - Dr. Meenal Datta
Susan Gasser - Chromatin and Nucleosome Density: How DNA Damage Response Alters Chromatin Dynamics
zhlédnutí 282Před rokem
Susan Gasser - Chromatin and Nucleosome Density: How DNA Damage Response Alters Chromatin Dynamics
Thanks!!!
3:40
14:20 spatial compartment 17:00 compartmental,cell types 20:30 migration,expression GENE 25:00 contact loss in b compartment 29:00 💹expansion INHIBITOR 32:39 TOPOLOGY [✓]
4:00 7:00 structure 12:00 models
thank you, very very interesting .