Ocrevus, Rituxan & Kesimpta: How They Work and When to Use Them
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- čas přidán 1. 01. 2023
- Welcome to "Ocrevus, Kesimpta and Rituxan: How They Work and When to Use Them"! In this video, we will be exploring the mechanisms of action of three commonly used anti-CD20 B cell depleting medications: Ocrevus, Kisempta, and Rituxan.
Anti-CD20 B cell depleting medications are a type of immunotherapy that work by targeting and depleting specific types of immune cells called B cells. These medications are used to treat a variety of autoimmune and immune-mediated conditions, including multiple sclerosis (MS).
In this video, we will discuss how Ocrevus, Kesimpta, and Rituxan work in treating Multiple Sclerosis. Whether you are a person with MS, a care partner or a healthcare professional or a patient seeking information on anti-CD20 B cell depleting medications, this video is for you. Thanks for watching!
The Boster Center for Multiple Sclerosis accepts all major insurance carriers and accepts consults from around the globe, both in office and via telemedicine. www.BosterMS.com or call 614-304-3444 to schedule!
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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS to help educate others. These videos do not provide medical advice and are for informational/educational purposes only. This video for example is about Ocrevus, Rituxan & Kesimpta and How they work in Multiple Sclerosis. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!
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My hope in 2023, all people impacted by MS have a Dr. Boster in their life. Thank you for all you do. Who is going to clone you?
#StrongerTogether Fork U MS, #StrongerTogether!
Im starting kesimpta soon. My lovely UK neurologist gave me the option of Ocrevus or Kesimpta, but said his preference is kesimpta because i can inject at home, and its slightly more preservative of the immune system. I feel very blessed to have such amazing experts to support me, here in london - and all for free - on the NHS. Also Dr.Boster you are so positive, clear and proactive that you lift my spirits, as well as educate me, thanks from the bottom of my ❤
That's brilliant, doctor! ✌️✌️✌️
I am a career patient of MS, I've seen everything, done everything, spoke to many doctors. Nobody ever can get a point across like you did!
Thank you for taking time in your life and explaining MS complexation to all of us!
Recently diagnosed with PPMS (just over a month ago) and overwhelmed with acceptance and learning about the disease. Very thankful for finding your channel. I find myself listing to several videos daily and taking notes😂. Thank you so much for your time and effort.
This video is great! I've been on Ocrevus for just over a year and I have never been explained by anyone in my medical team how it works in this much detail! I have been watching your channel since before I was diagnosed (my dad also had MS) and I have always found it a source of comfort having this info, thank you!
translation from English to Croatian
Thank you for explaining this so well. I have tried to explain how Ocrevus works to my spouse, and he tries to understand my treatment. I’m planning on sharing this with him.
awesome sauce
I have all the symptoms of MS, but so far the results of the MRI I had say I have good arteries.
By the way, I really love the science-behind-the-disease videos! Lifelong learning!! Thanks.
More to come!
Thank you Dr Boster. You are invaluable to us in the MS community.
What are the side effects of long term use of Kisempta? Does it cause damage of other organs?
Hi ho Dr B from Kingman Az. I just started Kisimpta last month and so far I like it. The first shot was a bit rough , flu like symptoms, but no adverse effects since then. Thanks for the info.
I don’t know what I’d do without you. You’re so very helpful. I’m on Kesimpta and now I know I made the right decision. Thank you!😅
Glad I could help!
@@AaronBosterMD I heard what you said about vaccines prior to starting B-cell depletion therapy, but what about ongoing vaccinations like flu shots, pneumonia shots and ongoing COVID’s? I’m on KESIMPTA, but I’m due for my shots.
I've had chronic progressive MS 39 years. At this stage a quadriplegic from the neck down. I started taking Ocrevus about 2 years ago. It has definitely slowed the progression. Switching to Kesimpta it has a few less side effects I'm hoping to stop the progression at 64 years old age is not my friend either. It's not the end of your life, some people are amazed that I live alone at this stage with only a worker come in the morning and the evening to help with food and bathroom and cleaning. It just going to have to learn to do things a different way if you can't walk use a chair if you can't use your hands put a piece of tubing in your mouth and type with it, change your thermostat settings with it. Get smart devices and make your house smart. My lights are controlled by voice, my computer everything that I'm typing by voice I'm here alone in my house right now. The coolest thing lately Autoslide door to open my sliding door by my vocal command or my iPhone. I've had 39 years to learn to live with minimal assistance. Most people don't get this sick from MS some have even lived their life and never knew they had it until an autopsy was performed that discovered it!
You are a super hero !
THANK YOU
Thank you!!!
Very helpful, thank you!!
I’ve been on Ocrevus since early 2018. This is the best explanation.
Thank you for this.
Fab explanation 👏💙
Best explanation ever! Thank you, Dr. Boster!
Thank you for explaining this Dr.
After Avonex, Copaxone, Tecfidera, Tysabri, I have managed to convince my MS-doctor to switch to Ocrevus almost 3 years ago. I am so happy with this treatment, OMG! Besides good comfort of receiving the medicine (of course, Tecfidera was the most comfortable one), I had zero worsening and some improvement at the same time as well.
Happy new year everybody
Thanks for the informative vid. I love your analogies. And I love your humour too. 😁😆 I also loved that your doggy made a cameo appearance too. Lovely!! 😂
Oh Doc … this is such an informative ( and easy to understand) video on these meds! So glad you made this. “Go ahead man…. I’ll hold your bookbag “… that was me🤣🤷🏻♀️🤦♀️
Much love & respect
#Sharingiscaring
One of your best videos to date, thank you Dr. Boster
Wow, thank you!
Finally a great explanation as to how they work.
Now i understand. Thank you. 🙌
Thank you for all these videos.
Nice platen press!
thank you
I watched this just before I did my Rebif shot. Interesting stuff, thank you
WHAT A DOG! 😍🐶
Great video Aaron - thanks!
Glad you liked it!
Thanks!!!
You bet!
Thank you again for the explanation of how these meds work 😊 I always learn from each video! Thank you ❤
Easy simple explanation to such complex disease. Thank you
You’re such a good teacher! I’m constantly learning new things from watching your videos. Facing a possible/probable MS diagnosis and arming myself with as much info as I can 💪
Thanks for this great video; you made it so easy to understand what these drugs do.
This is GREAT! I completely understand about the T & B Cells now!! I've been on Ocrevus & Kesimpta and didn't understand what they were supposed to do. Now I do. I'm on Mavenclad now & I understand it, too!
Thanks SOOO much for realizing that not everyone is a neurologist or in the medical field!
Thank you so much! It was very educational and I understood everything!!!
FANTASTICALLY Thorough, yet Concise, explanation of our disease and treatments! Thank You
Liked, subscribed and the bell activated so I never miss a video
Thanks for the info 👍
Awesome, thank you!
Spectacular explanation, better than any doctor has explained👍🏼👍🏼
Thank you for explaining this most succinctly! Very helpful as I consider new treatment options :)
Great information!
Glad you think so!
Your high-school analogy was great 😆 It's so helpful to break it down like this so thank you for taking the time here!
You're so welcome!
Thank you
🔥🔥🌄🔥🔥
You're welcome 😊
I've been on Kesimpta since November. Fingers crossed, it's working.
Ocrevus and I didn't get along. Kesimpta, being in the same family of medications, had me worried.
Thank you for your videos and your layman's term explanations. 🙂
Thank you I've been on rituximab, and I'm about to start kisempta very soon.
thank you Doc for being bad ass doctor for the MS patients community.
I am currently on Ocrevus for the past year and a half and seem to be okay with it. Thank you for all of these informative videos, im grateful to have found you and your dog is gorgeous!!!
Thank You, your videos are very helpful and teach me a lot. I wish I could have a provider like you. You really are doing a great service.
Thank you for this wonderful explanation. Ive been on Rituximab (Norway) for a while, and for me its just so good.
Thank you Dr Boster - awesome video - very informative 😁. Have already shared multiple times! 🔥🔥🔥🔥🔥
Awesome, thank you!
I have been taking Ocrevus for about three years, but your explanation of the B cells and their function was so helpful and understanding what OCREVUS does. Thank you!❤
I'm starting Ocrevus Feb 21st, can u give any pointers as what I should expect? Dr. Aaron boster is very knowledgeable when it comes to this drug. What have u done different when it comes to your immune system, are you very cautious of being on Ocrevus, than if u weren't?
Appreciate ur response 🙏
Hey hello. How are you on Ocrevus. Would you recommend? I have ppms. Iv been offered it.
Thank you for the very important information.
Glad it was helpful!
Thanks Dr. Boster for the explanation. Part of the reason I'm living my best life is because of Kesimpta.
Wonderful!
I am on Tysabri and will be switching to Kesimpta this month because I became JCV+. I wanted to thank you for the thorough explanation of what I’m getting myself into! Happy New Year!
I thought if I tested negative for JCV then I never would get it’s? Am I wrong? Ty
Brilliant video 👏 Although I’m on Ocrevus & understand the why’s, it was hard to describe it to family, friends. This is an excellent way of describing how it works. Thanks, as always Dr B. Happy New Year 🥳 and keep up the hard work of informing, championing and being here for the MS community. If you stay well, it helps us to stay well 🤩🤗
Thank you very much for the fantastic explanation. Cheers from sunny England!
Glad it was helpful!
Thank you so much for your video! You explained the information so well by breaking it down and now I truly understand how depleting the B cells work. Your analogies were perfect!🤗
I've been offered Ocrevus today from University Hospital Coventry and Warwickshire, this video was really helpful, thanks
Thank you for this amazing explanation! Knowledge is power.
Hello to River❤
Thanks for watching!
Thank you so much for explaining this so well! I kind of knew a little about how the meds worked but no one could really answer any of my more focused questions.
You're so welcome!
Unfortunately, I had multiple infections while taking Kesimpta. I have not been on any MS meds since August; this is tbe longest since I was diagnosed. Thank you for your informative videos. My neurologist retired and I'm trying to get to know my new neurologist as he is me. Praying I can find something that I can trust and he agrees with also.
Thank you so much for this video and the explanation. Love your videos keep them coming
Glad you like them!
Wow😮😮, I understand everythingg now! 🎉 Thx alot Dr. Boster, I love your channel and your attitude ❤😎!
Happy to hear that!
This is a great video! Excellent topic. I really like the format of this video and the pacing. Very easy to watch and follow along. I really liked the purple words on screen for specific topics. Thank you so much for this great content!!🔥🔥🔥
Glad you enjoyed it!
Thank you doctor B! You rock, this video was bad to the bone, just like you!
#StrongerTogether
Thank you very much for explaining how these work!! Have been diagnosed recently at 19 and am currently in the rabbit hole for learning about MS as much as possible
Horrible rabbit hole i wish you are fine
Seems like information I need. I'll have to watch it a few times to understand better. Hope I remember. Wish me luck.👍
You got this.
Thanks alot for explaining the MS treatments in so details. I am MS patient as well n 'm on OCREVUS where i had no idea what difference does OCREVUS bring. Now i know. Thanks alot for explaining😊
What a great explanation
Very easy to understand. Thank you so much.
You are welcome!
Thank you, for the clear explanation. Since I’m an old man from the Netherlands, you’re languish is a bit difficult for me. After repeating the vid a few times, I now understand what you were telling us
Thank you for a great Monday morning video on B cell depletors. Being an Ocrevus recipient it was as eye opening as my morning black coffee in hand ..from Lyndhurst.
hey you're near by! i live in southampton
Thank you sending to family to help them understand
You are so kind
Thank you SO much for explaining how these therapy's work! I 've always wondered how they work & you explain things beautifully! I take Tecfidera & it's worked great for 3 years but have little understanding of how. I'd love to see a future video on this class of med, it's effects on lymphocytes, etc. Thank you again for these weekly videos & the livestreams. You are such a kind human!
You are so welcome!
A great video Dr. Boster. Thank you for the "Layman's" explanation of b-cell depleter. Ocrevus has been my only DMT since diagnosis in 2017. On another note, is that a Heidelberg printing press in the back ground??? I recall there being on in the Will Smith movie "Seven Pounds". Thanks again.
Thank you. This video is very helpful in my study. You made it so simple to understand all science behind B cell depleters.
Glad it was helpful!
Thank you so much for these videos, I just found them this morning and will begin my dive through them. I am newly diagnosed and these are so informative. In case I don’t find a video about it, I’m curious how vitamins/supplements (specifically immune boosting vitamins like vitamin c) impact if we are on a DMT. Does it make a difference? Are we undoing the medication? Thank you so much!!!
Thanks for the video, very well explained. Please how do you switch from Gilenya to Kesimpta?
Thank you dr boster you are doing great job by educating people on base levels of understanding complex things ...may god bless you always...please continue to do so you are helping a lot of people in pain...may you be rewarded immensely ..
Great information and so we'll explained. I'm 66 and was diagnosed with ppms 2 years ago. My last MRI showed no new lesions. My Neurologist has not put me on Ocrevus as the draw backs for my age is to great. Your explanation that the b cell depleters only attack b cells that affect my MS was interesting. Is this something I should inquire about with him. Other than my ppms my health is excellent. Thanks for all your videos. They have been great help for me. Greg
From a person that will be starting treatment soon, I can’t thank you enough.
This video answered every important question I had about treatment and beyond. I literally sighed a breath of relief.
Thank you.
I hope your treatment will be a benefit for you, as it is for me. I get Ocrevus every 6 month since 2018 and since then i had no progession. Got Ocrevus before and Had a lots of symptoms.
@@cassidykaiser5817 Thanks for your comment; much appreciated. I hope your journey with treatment continue with great success always. Though I’m a little nervous about treatment, I’m hopeful and feel fortunate.
@niltonmedeiros287 I was wondering how your treatment is going? I hope that your doing good.
I'm coming up on year 1 of being on Kesimpta. I've had very few MS symptoms in that time and recovered easily from COVID back in August. I have no regrets about starting an aggressive treatment immediately upon my diagnosis.
Me too Jerry! So far so good on recent MRI! 1 year this March for me! Praying my insurance will cover in the future.
i'm on Kesimpta for 2 months now AND i dare to say I feel great. Just a small question, do you take any supplements to keep the rest of your immune system healthy ?
@@colleensmith3374if it doesn’t, just remember many drug companies have Patient Assistance Programs (KESIMPTA does!)
Why Kesimpta instead of Ocrevus? How do they decide?
@@colleensmith3374 Ich lese gerade die Kommentare und freue mich, dass das Medikament bei euch so gut wirkt. Ich habe auch erst meine erste Injektion gehabt. Ich bin nur bisschen erschrocken, dass du dir Gedanken machst ob deine Versicherung das abdeckt. Ich danke Gott, dass ich in Deutschland geboren und aufgewachsen bin, dass ich mir über solche Sachen null Gedanken machen muss. Ich hoffe deine Behandlung wurde abgedeckt. Wünsch dir weiterhin alles Gute.
Happy New years Dr. Aaron, wishing you all the best and success :) I was wondering if B cell depletes also increase long term cancer risk? I have seen that this type of therapy might increase risk. Would also be nice to know how "safe" they are in terms of serious infection risk etc. I am on Vumerity at the moment but would like to go on Ocrevus. Because I am in the netherlands they will not allow this until I worsen sadly. My neuro said "someone died from Ocrevus" when I asked about it... not great bedside manner :/ If the risks are low long term I would love to swap over to something more effective!
I'm about to start Rituximab and I am so glad I found this video. Thank you for all that you do. I'll be sharing this with my friends and family so I don't completely confuse them when they ask about my medication 😅
How is Rituximab treating you?
Hello I have to make a decision to shift my drug i am advised Rituximab can you please tell me your experience did you had any hairloss with it ? Your advice would be greatly appreciated lots of blessings to you for your good health thank you
Thank you so much for this! Very informative. Now I understand the difference between the cells and how it works. You are so smart!! I have been on Copaxone since diagnosis in 2011. My MS Specialist doesn’t want to “fix what isn’t broken”. If anything should change I would definitely consider Ocrevus. I am on disability so I’m not sure how that would work financially with Medicare.
Thankyou for posting this. Just been offered either Ocrevus and Kesimpta as my last mri showed no new lesions on my brain or spine but I still have relapses. I'm going towards Kesimpta for my next treatment. Currently on Aubagio. This video has made my mind up 👍👍
#StrongerTogether
Can someone explain how you can have a relapse without active lesions on MRI?
@@dermlover1 some lesions are too small to be seen on MRI. There is also something called a pseudo relapse - where you have symptoms of a relapse but it is caused by an infection and once this is treated the symptoms resolve.
How has Kesimpta been working for you?
Truly fascinating Doc! The B-Cell T-Cell explanation and analogy are amazing. Thank you! I did wonder about their 'naming'!
So, if my take on attacking B-cells (via DMD) if correct, it is kind-of adding efficiency to the workings!
I'm 153 infusions in with Tysabri, next may be Ocrevus. Do you have a video linking Ocrevus with family cancer?
Many thanks 🙂
Thank you! I switched from Tysabri to Rituximab and this helps me understand what I’m taking and why it is every 6 months. Thank you for your channel!
Hello!
I'm going to have my first Rituximab infusion in two weeks, after finding out I'm jcv positive and can't maintain tysabri.
How did ritux. treat you? Are you keeping it to this day? Hope you are well
Hello I am advised to switch to Rituximab how was your experience did you had any hairloss your any advise would be much appreciated and lots of blessings to you for good health thank you .
Hello can you please let me know if Rituximab caused any hairless to you ...I am In a same posted your advice would be greatly appreciated and lots of blessings for good health. Thank you
I love Rituxan but had to stop it after a few years on it because i ended up getting bacterial vaginitis that me and the gynecologist can’t figure out hot to get rid of. They are pretty sure it’s the fault of my lack of B cells and my inability to fight the infection
Rituximab is *awesome* and extremely effective. I’ve been on it for 6.5 years and it allowed my brain to heal itself to the point my 20+ lesions aren’t visible on MRI (not the same as them disappearing) and I’ve had no relapses since starting Rituximab. Highly recommend.
I was diagnosed with multiple sclerosis 2 months ago and i have been given steroid. Now im on my first infusion of rituximab. Hoping that this will work for my brain lesion and that it will not relapse like you do.
What a wonderful thing to read!
I'm about to have my first rituximab infusion, and I also have 20+ lesions on my brain.
How are you now? Do you continue with the same treatment?
Have you tested for the JCV? (this is my only concern now)
@@fathinmahirah Hello! I was diagnosed 2 months ago and I had one natalizumab infusion, but I had to stop it because I am JCV positive.
Have you tested for the JCV? This is my only concern now I'm about to start with Rituximab.
How is your treatement going so far?
Hope you're doing well!
Hello ...I am in same position have to shift to Rituximab did you experience any hairloss or other upsetting issues or side effects with it ..your advise would be much appreciated lots of blessings for your good health. Thank you
@@fathinmahirahhello can you please tell me how was your experience with Rituximab? Did you had any hair loss ? I am in a same position need to shift the medicine I have to make a decision soon your advise about it would be much appreciated lots of blessings for you good health..thank you
just got my first Ocrevus transfusion today. I'm 32. Just happy my insurance is covering it and the only discomfort I felt today was the needle itself.
Thanks Dr. B and Happy New Year! I recently switched to Ocrevus from Tysabri and feeling great. I was curious about what happens if one was to stop Ocrevus and allow the b-cells to fully re-populate. I read a study exploring the possibility of b-cell depleaters acting like an induction therapy where the returning cells may behave like normal healthy cells. I would love if this were the case. Do you have an opinion on that study? Thanks again for keeping us all well informed!
Can you share the link of the study? I would like to know more.
starting Ocrevus very soon
Just had my first dose of rituximab for lupus, this was very helpful information. Thankyou 🙂
Does Rituximab helps with your lupus? I asked because I have lupus and osteoarthritis/rheumatoid arthritis. My doctor suggested me to take Rituximab.
Has it helped?
Thank u for great info as always! I'd like to ask, in your opinion, is there any possible explanation of abnormal CD19 count (below ref range) in absence of previous DMD/steroids and should it be taken into account when considering DMD choice (esp is there any theoretical problem with taking anti CD20 in this situation, either bc of safety or efficacy)? Thanks a lot!
Thank you!That was great! Question…what is the job of the B cells we are killing off? Bacterial? Is that why we are more prone to bacterial infections?
Waiting for my first 3 dose month shots of kesimpta to arrive!
Thank you so much for this easy to understand explanation of how Ocrevus works. I started Ocrevus in September of last year. You said in your video ‘that’s why it’s really important to have our vaccines up to date before we start on B cell depleting therapy.’ So,,,what about after we start the therapy? Are the vaccines going to work for us? I just had a pneumonia vaccine and it knocked me out for about 2 weeks. Pain in my arm, my joints were swollen and painful and both my neuro and my pc doc said I should go ahead with this vaccine. So I did..but wondering how effective it will be and other vaccines as they are recommended?
I’ve been on ocrelizumab since 2008 as part of the Phase II study. After about 7 years, I did have more frequent infections to deal with. Sinus and ear primarily but also one bout of cellulitis.
In 2018, I hame down with shingles. Not a terrible case and since I have a good deal of neuropathy, not terribly painful. (small MS benefit)
Was sent to an immunologist who did a bunch of testing and discovered by Immunoglobulin G level was very low. Makes sense since we were killing the B Cells that produce the antibodies.
So I was put on Privigen, which is Immunoglobulin G infusions. (IGG or IVIG therapy)
Works great and I have not had infections since then.
So, Dr. Boster, do you think this is a decent method of dealing with these side effects? Or does it make sense to be looking at another MS therapy and allow the B Cells to resume making normal antibodies? What factors should I consider when making this decision?