Nervous System Tumors
Vložit
- čas přidán 1. 05. 2016
- This is a summary of the major tumors of the nervous system.
I created this presentation with Google Slides.
Image were created or taken from Wikimedia Commons
I created this video with the CZcams Video Editor.
ADDITIONAL TAGS:
Medulloblastoma
Pilocytic astrocytoma
Diffuse astrocytoma
Anaplastic astrocytoma
Glioblastoma
Oligodendrogliomas
Ependymomas
Meningiomas
Neurofibromas
Schwannomas
By James Heilman, MD - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
Embryonal tumor
Meningeal tumor
Peripheral tumor
Astrocytoma
Gliomas
Medulloblastoma
Grade IV malignant tumor
Arises from external granular layer in cerebellum
Histo: small round blue cells; Homer-Wright rosettes; mitotically active
Located in the cerebellum
Can drop metastases to seed the CSF
Well-circumscribed (non diffuse, solid)
By Jensflorian - Own work, CC BY-SA 3.0, commons.wikimedia.org/wiki/Fi...
Pilocytic astrocytoma
Grade I
Imaging: Solid nodule with cystic component
Common in cerebellum, hypothalamus, and optic nerve
Well-circumscribed (non diffuse)
Histo: Rosenthal fibers, eosinophilic granular bodies
BRAF mutation
Tumor in hypthalmic region - By The Armed Forces Institute of Pathology - peir2.path.uab.edu/scripts/acd..., Public Domain, commons.wikimedia.org/w/index...
ROSENTHAL FIBERS - By Marvin 101 - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
Diffuse and anaplastic astrocytoma
Diffuse astrocytoma
Grade II malignant tumor
Diffuse
Most common in cerebral hemispheres
Histo: hypercellular
Molecular: no 1p/19p codeletion
Anaplastic astrocytoma
Grade III malignant tumor
Diffuse
Common location is cerebral hemispheres
Histo: hypercellular, increased mitotic activity
Molecular: no 1p/19p codeletion
Glioblastoma
Grade IV malignant tumor
Diffuse, infiltrative mass
Common location is cerebral hemispheres
Ring enhancement on imaging; internal necrosis
Histo: hypercellular, increased mitotic activity, microvascular proliferation, necrotizing, pseudopalisading
Molecular: EGFR, PTEN
Ring enhancing- By Christaras A - Created myself from anonymized patient MR, CC BY 2.5, commons.wikimedia.org/w/index...
Hypercellularity - By No machine-readable author provided. KGH assumed (based on copyright claims). - No machine-readable source provided. Own work assumed (based on copyright claims)., CC BY-SA 3.0, commons.wikimedia.org/w/index...
Oligodendrogliomas
Grade II-III malignant tumor
Common location is cerebral hemispheres
Histo: hypercellular, perinuclear halo (fried-egg appearance), negative for astrocyte marker
Molecular: 1p/19q co-deletions
Perinuclear halo - By Nephron - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
Ependymomas
Grade II-III malignant tumor
Common in cerebellum and spinal cord
Well-circumscribed (non diffuse)
Can drop metastases to seed the CSF
Histo: perivascular rosettes, ependymal rosettes
Rosettes - By Nephron - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
meningiomas
Grade I benign tumor
Tumor of adults, not children
More common in females
Might respond to hormone growth (progesterone/estrogen receptors)
Dural tails; extra-axial location
Can invade bone and less-commonly brain
Histo: cellular whorls, psammoma bodies (calcium deposits)
Whorls - By Nephron - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
Dural tails
By Glitzy queen00 - en.wikipedia.org/wiki/Image:Co..., Public Domain, commons.wikimedia.org/w/index...
Neurofibromas
Associated with neurofibromatosis type I
Cafe-au-lait spots, lisch nodules in eye
Histo: “shredded carrot appearance†of collagen strands
Lisch nodules - By Dimitrios Malamos - Own work, CC BY 4.0, commons.wikimedia.org/w/index...
Histo - By No machine-readable author provided. KGH assumed (based on copyright claims). - No machine-readable source provided. Own work assumed (based on copyright claims)., CC BY-SA 3.0, commons.wikimedia.org/w/index...
Schwannomas
Can be associated with NF2
Histo:
verocay bodies (palisading cells surrounding acellular zone)
biphasic neoplasm with Antoni A (hypercellular) and Antoni B (hypocellular) regions
Common: Vestibular schwannoma (aka acoustic neuroma) from CN VIII
Hearing problems and disequilibrium
Medulloblastoma
Pilocytic astrocytoma
Diffuse astrocytoma
Anaplastic astrocytoma
Glioblastoma
Oligodendrogliomas
Ependymomas
Meningiomas
Neurofibromas
Schwannomas
Biphasic histo - By Nephron - Own work, CC BY-SA 3.0, commons.wikimedia.org/w/index...
Excellent video. It was a great help. Thank you for uploading
WAO one of the best videos i have seen,keep doing it broth thanks a lot for your support
This is an easy-to-remember CNS tumor classification. Lovely
It was a great review of major tumors of the nervous system! Thanks!
It was helpful! Thank you for making it. Kudos!
Thank you for the video! It's very informative and extremely helpful!
Short precise and covering all brain tumours this presentation is very helpful
It provided an excellent overview of the ns tumors
Great review. Thank you so much!
This is the best classification video out there ever. I have been searching for so many months !!
Try dr devesh
Thank you very much
Thank You Sir.!
very helpful thanku so much best video on you tube for brain tumors must watch
so helpfull! also the way you say "cafe au lait" melts my heart
Excellent video thank u so much
Thanks !
Great! Thank u!
Amazing, Doctor! I finished 11min. lecture in an hour, because I rewrote all those things in my copybook and drew as well!
Thanks a lot!
Do you remember it now?
Well explained boss
Awesome
One of the best videos for cns tumours .
very helpful 😍
blessings!
Just wanted to point out that there was a tiny error. in diffuse and anaplastic astrocytoma, you mentioned that there is no 1p/19p codeletion. its supposed to be 1p/19q instead of 1p/19p. but you mentioned it right in the oligodendrocytoma :) its just a small error, your video is fantastic and so helpful. Thank you :))
Can u recommend places where I can get second opinions on a MRI. Had an brain tumor removed years ago and want to hear secons opnions but it is diffucult to fins a secure online source
Very good lecture. Thank you for your efforts
Thanks... the text book ones were becoming a pain in the ass.
Very helpful!! You missed craniopharyngioma though..
شنو قصدك قحفي عبالك
IS THERE ANY EXTERNAL GRANULAR LAYER IN CEREBELLUM MENTIONED AROUND 1:25. I believe you meant cerebrum. Please clarify if possible. Thanks.
yes. the granule cell layer is the external layer of the cerebellum.
Its 1p & 19q...not "19p"
7:16: Meningiomas "These are Grade 1. Also pretty benign. No big deal". Actually, any brain tumour is a *very big* deal.
Awesome