The Adrenergic Agonists
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- čas přidán 7. 09. 2024
- This is a quick intro lecture to review the concept of the adrenergic agonists. In this lecture we introduce the Direct, Indirect, and Mixed-action adrenergic agonists.
If you find errors, have comments or questions, please, let us know!
This is a very short introduction lecture
to the Adrenergic Agonists. Basically, I want
starting point or a definition of terms or
next after this lecture. The Adrenergic Agonists
use those terms interchangeably through the
real quick explain what these three things
Adrenergic Agonists and then from there, you
does it mean to be a direct sympthathomimetic
comes down to the mechanism of how the signal
The picture on the right is a pre synaptic
in the middle. If you zoom in on the synapse,
receptors. The normal physiology here at the
or the nerve impulse is propagated down to
is a series of cellular changes which causes
fuse to the membrane and then spill their
to stimulate their receptors. Alright, so
are stimulated by the neurotransmitter. Alright,
drug. It works the same way. It directly acts
called a direct adrenergic receptor agonist.
of drugs. These are examples of direct acting
So, we've explained what the direct-acting
what the indirect and mixed-action adrenergic
is released from the vessicles and goes off
direct-acting adrenergic agonists also directly
adrenergic agonists work? Well, one way that
of neurotransmitter. So take this purple star,
drug that does just that. Through a series
different drugs) it binds to the membrane
out, so the receptor you can see is stimulated,
What's another way? Well, notice that neurotransmitter
a couple of things happen usually. We know
is release from the presynaptic side is used
taken back up into the presynaptic nerve,
by this orange star. This drug acts to block
more, but the drug didn't directly stimulate
stimulation that these receptors get. So,
out in the synaptic gap. Some of that neurotransmitter
of it being metabolized right here in the
neurotransmitter from that gap. Well, what
red star. What if it is a drug that blocks
receptors are stimulated, but not directly
They do pretty much what they sound like they
kind of similar to the mechanism of the purple
receptors. Okay, let's go on. Okay, now on
Now, you may or may not know these drugs,
you don't, just try and pick up concepts or
you on the mechanism of action of each one
Which receptors does Epinephrine work on?
It's almost the same as epinephrine, except
1, Dopamine 1 and 2. How about Dobutamine?
it's a non-selective Beta. Albuterol: Beta 2
it favors Alpha 1 over Alpha 2. Clonidine:
the indirect-acting adrenergic agonists, starting
an increase in the release of neurotransmitter,
It also inhibits monoamine oxidase which is
works by blocking the re-uptake of neurotransmitter
the mixed-action Adrenergic Agonists, starting
these are similar in their mechanism of action,
but also cause an increase in release of neurotransmitter
from the presynaptic nerve.
Brilliantly explained. Used to find this topic so confusing but I totally understand it now!
your videos are absolutely amazing! So well organised and coherent. It makes so much sense because you explain them in a logical order! THANK YOU
you are the best. please dont stop uploading videos
+Ijeoma Emezzue ---You are very welcome! I'm working as fast as I can... I'm a resident by day and MedImmersion by night so I'm burning the candle on both ends!! Hang in there Ijeoma, and thanks for the comment!!!
+Med Immersion
you're lecture not only help medical student, I am a nurse, and I find the material on you channel extremely helpful, very empowering, please continue to upload
The perfect video after struggling with this topic. Thanks.
I shared this video to my professor, he gonna learn this better then. ;)
PLS MAKE A VIDEO ON ADRENERGIC ANTAGONISTS ALSO, PLS
This video was AWESOME!
I am so happy that I came across your videos, thank you so much, they are very helpful !!
good luck with your residency :)
thank you for being so wonderful and uploading these videos!
Really really helpful, I can't repeat that often enough. And useful no matter where you are. I study Medicine at the Medical University of Vienna - so your videos are helpful across the globe!
Thanks, that's very nice to hear! Good luck in school!
Great job.
These was really great materials please do more.....
Thank you so much. You have a catchy voice. Keep up!
You ROCK man!!
Hi , your videos are amazing and really helpful !!!! the graphics and your pace and the content (what you say and what you decide to leave for another video) is just well studied and keep the videos interesting!!! Thank You sooooooo much
Laila Alkassabi You are soooooo welcome! Good luck in school!
Very nice reviews. Much appreciated.
good :)
Thank You simple explanation do help in revision the material :)
What a life saver, thanks dude
wow cool videos!! all the love and support from the philippines :)
Made seriously easy.
Great session!! Thanks
good 👏🏼
Your videos are thd best 👍👍👍 thx 🙏
?
thank you very much Doc . it was really useful . Can you put a video of adrenergic antagonist
Awesome!! ur lectures are very much interesting :) love watching them :)
This is really good! Thanks =D
Thank you 😊
thank you very much,it's very helpful,merci beaucoup
Excellent!
Thank you!
good video easy to understand...
Sir some books write dopamine as mixed acting sympathomimetic drug so what's your take on this?
Hi, you're videos are awesome, so helpful. Thank you. Do you have a GPCR and any cardiac meds i.e. digoxin available? All the best, Jo
thank you so much. you saved me.
Glad I could help!
i love your channel..
U help me! Thank u so much.
beta 2 receptor agonists are vasodilators and hence decrease Total peripheral resistance.
so when wo give beta blocker propanolol it decreases cardiac output and blood pressure which causes a reflex peripheral vasoconstriction.
so on which basis we say that it is helpful in patients with hypertension.?
+sweet girl - True, that would be a component normal physiology!.. However the normal reflex vasoconstriction doesn't work as well in the presence of a beta-blocker! Thus the net effect is still a decrease in BP.
ok.
Thanku
thank you
your videos helped me a a lot thanks ,
do u have a video for adrenegic antagonist ?
omar abugassa Hey Omar! Unfortunately, I don't have an Adrenergic Antagonist video yet. But, that is a great idea. - I will start working on it very soon.
thanks doctor ^_^,, good luck
and keep up the good work ,your videos are amazing and very helpful (Y)
Where is the Serotonin receptor lectures? That's where all the info is. Can anybody point me in the right direction please? Cheers
You're awesome.Thx
You're welcome bro!
thank you ... 😍😍😍
Wow. I love you.
Please make more videos!!! :)
Haha! I'm trying, but I'm also busy with my residency!
Med Immersion Good luck with your residency.
your video is amazing. it is easy to understand. thank you. Can you please teach us adrenergic antagonist. please.
Tim Trinh Tim, Hey Man, Thanks for the comment! I will be making you an adrenergic antagonist video soon!
Plz post sm more
Great job :)
Soundos Al Thanks a lot!
Is it adrenergic agonists the same that sympathomimetic?
I'm confused
Yepp
yes it is..
Speed and coke lol
thank you