TWiN 42: Therapeutic effects of psychedelic drugs
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- čas přidán 16. 07. 2023
- TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.
Show notes at www.microbe.tv/twin/twin-42/
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Psilocybin has helped incredibly with many of my Long Covid symptoms. I started using them for PTSD and treatment resistant depression, for which they worked very well, and I noticed dramatic improvements in fatigue, headaches, muscle spasms/pain and most notably breathing problems.
Psilocybin and lsd absolutely saved my life. I had severe depression and don't believe in ssri pharmacology. They aren't very effective, the brain adapts, side effects are pronounced, withdrawal is severe.
I self medicated with Psilocybin and lsd and it always got me out of the mental hole and dusted me off with a new view on life. Obviously, i dont recommend folks self medicate when they are in distress, but there is something profoundly healing there.
I dont use them anymore, its probably been 5 years or so. But they were pivotal to my current success in life.
The careful approach to the subject is highly appreciated. It also fosters interesting philosophical questions which, of course, is a reason why psychedelics themselves are so interesting.
@_mycorabbi_'
On -IG
For the best psych edelics products''
This was not careful in the slightest. This program was about designer methamphetamine and battlefield dissociative anesthetics, not about psychedelics. Psychedelics were barely mentioned and the couple of times they were, they were mentioned in the same breath with designer methamphetamine which was mislabeled as a psychedelic. I have watched hundreds of shows on Microbe TV and this one was profoundly disappointing because it was so completely lacking understanding while trying to redefine the very field of psychedelic research to center around meth. This is easily the worst show I have watched out of hundreds here.
@@Peter_S_ I think you have confused MDMA with meth/amphetamine.
Thanksgiving break at college in 1968 I experienced 12 hours on Orange Sunshine. Best thing I ever did.
Psilocybin gave be panic attacks each time i used(2 time ) but glad it helped others
Well. golly. Vincent, we never got around to discussing certain element of this at ASV 2022...it's the -- social reward period for critical tlearning -- phraseology that's caught my attention.
thank you.
That sounds like a good experiment, see if language learning abilities differ in groups taking differing doses of psychedelics. Too bad drug scheduling is completely disjointed from reality, doing any experiments with these substances is very difficult.
I'm halfway through, and this is a program mostly about designer methamphetamine and dissociative anesthetics. It has barely mentioned actual psychedelics but mislabeled the designer speed and Special-K as such instead. This is very unfortunately great example of academia gone wrong. I'm fairly sure none of the participants has any first hand experience whatsoever with this topic. Aside from scheduling, there are decades of actual experience with these compounds in the music scene and there is already a huge base of knowledge, but academia dismisses it largely. I've done psychedelics over 100 times and I will never, ever get remotely close to MDMA. Never.
@@Peter_S_ What's wrong with MDMA? 100mg one time is worth trying, to know what it's all about. It'd be helpful in therapy and similar things.
@@jludo It's soul poison. I've got over 30 years of experience being around people who are on or have done MDMA. It leaves scars. I used to work rave parties in the 1990s where it was everywhere. It's soul poison. Mushrooms are excellent with 10,000 years of positive human history and they don't cause permanent brain damage like MDMA does. Acid is an amazing tool, but it's like a chef's knife and must be used very responsibly with complete understanding or you may make a bit of mess, but no brain damage there either. I'm extremely pro psychedelic, (I used to work for the Grateful Dead) but brain damaging designer speed is not a psychedelic and there has been a move to use it to replace real psychedelics in research and medical use. Say no to designer speed and yes to mushrooms every 6 months. I might try MDA once if I had a tested pure source but never MDMA.
@@jludo MDMA is soul poison. Would you stab yourself in the brain just to try it out?
@@Peter_S_ MDMA is not "designer speed". That is an ignorant comment. It is also rather strange that you admit having no experience with the substance yet think you know it's effects. Also, the paper is open access and linked in the show notes. They tested the various substances separately and compared their effect. Clearly you did not understand the research. It seems you were triggered because you have a narrow understanding of the word psychedelic, instead of listening and learning. Also, you have no idea whether any of the panel has experience or not, instead you just assume and project.
Lsd helps with alcohol addiction.. not that I ever had an alcohol problem to test that..
and psilocybin is reported to help cure nicotine addiction..
Think of true psychedelics like lsd and psilocybin as tools rather than something with a particular end action. They can help people "see" that habituation is just as powerful as physical addictions, but habituation can be broken easily with the right tool.
Podcast # 42 :D
Internal Receptors new knowledge
Happy to be a Naturalist
Created a new science three months ago
Sound
What is there a take away from this research? It sounds like they’re just starting out to me but, I am no neurologist!
They’re just starting out. I think the takeaway right now is that there are promising applications which probably ought to be further explored.
I've studied this topic for over 30 years and this 'research' strikes me as dishonest and without merritt. This research was NOT about psychedelics, instead it was about brain destroying hallucinogenic methamphetamine and dissociative anesthetics. That's dishonesty.
@@Peter_S_ hallucogenic meth amphetamine? You mean MDMA? It’s not hallucinogenic, MDA can be. They also mention ibogane, lsd and psilocybin. I’m not sure you gleaned from this what I did. Can you elaborate please.
@@skipscramble5915 I worked lots of raves in the 1990s. Yes, people on MDMA hallucinate so you seem lost to try to say otherwise. I've actually been at the same party with Sasha Shulgin. Do you have any idea who that is?, if not, look him up and then read both PiHKAL and TiHKAL from cover to cover. I read a pre-publication copy of TiKHAL which came directly from Sasha. This video was about designer methamphetamines and battlefield anesthetics, not psychedelics. Psychedelics are tryptamines, not phenethylamines. Designer meth destroys the fabric of who people are. Acid and mushrooms don't do that.
Why do I hear some Australian flavour in one of the gents' accent?
Vegimite - its does that to it's victims
@@Costa_Conn "Vegemite"
and it is Life
especially on hot toast with melting margarine
My youngest eats it with a spoon straight out of the jar
He sounds South Afrikaans
Cubes two shot glasses every three days for two weeks Dendrites Blossoming
ai lip reading plugin required stat!
The sound is working fine. Try reloading.
thanks!
sound?
No sound
Go to a wheat field look for a brown fungus ergot on the seed
Interesting to note, how the ECM operates in a Wifi and Cellular frequency proliferated environment, especially considering the exponential rise in these technologies, there should be ample extensive data out there already !?? ..is ECM electrical by nature?? as you are suggesting it is at least a conduit.
The ostrich can see
Psychiatry is filled with failed treatments.
@_mycorabbi_
On -IG
For the best psych edelics products
Psychiatry as a profession is perhaps the worst possible venue to attempt to extract value from psychedelics.
MDMA is designer speed which causes permanent brain damage, not a psychedelic. Ketamine is a dissociative anesthetic which causes permanent brain damage and not a psychedelic. The true definition of psychedelic revolves around tryptamines, not phenethylamines. The word was created by English psychiatrist Humphry Fortescue Osmond to describe LSD specifically. The synthesis of MDMA most used today was written by chemist Alexander Sasha Shulgin and published in the book PiHKAL.
The neurotoxicity of MDMA is contentious for a number of reasons - the neurotoxicity is due to a metabolite, not MDMA, and the metabolism of MDMA in both monkeys and humans, unlike rats and mice, exhibits non-linear pharmacokinetics. Thus increasing doses, leads to an increasing half-life, potentially exacerbating toxicity. Probably more significant is the fact that the studies reporting neurotoxicity were based on depletion of serotonin in the CSF of rats, but this is not necessarily indicative of damage to neurons. PET studies on MDMA users who were abstinent for 20 weeks did not show less serotonin transporter binding levels. On top of these complications, in mice, MDMA neurotoxicity tends to produce dopaminergic, but not serotonergic neurotoxicity, while in rats the opposite seems to be true, and adding to the contentiousness neurotoxicity was observed at 10 times the equivalent dose for humans. Then you have the studies on regular MDMA users, which supported neurotoxicity via brain imaging, however MDMA users tend to be polydrug users making it impossible to implicate MDMA alone, and that is just one of the confounding factors of in the study.
Clearly these issues significantly complicate any conclusion that MDMA is neurotoxic. Incidentally a few weeks ago, somewhat controversially, Australia became the first country to allow the use of MDMA and psilocybin for the treatment of PTSD and depression. Their is use will be regulated, and restricted to use by approved psychiatrists during therapy sessions.
Apologies for the essay, but as you can see the question of MDMA's neurotoxicity is a tad contentious at the moment.
'@_mycorabbi_'
"on -IG"
For the best psych edelics products "
@@Costa_Conn There has been a move for over 30 years to displace psychedelics and replace them with hallucinogenic methamphetamines while renaming the meth as a psychedelic which is is absolutely NOT. TWiN has fallen victim to this. Meth causes permanent damage and MDMA is just meth with a hat made from two oxygens and a methyl group so that it can jack 5-HT receptors. Actual Psychedelics are like a key to the 5-HT lock, opening it without damage. MDMA is like smashing lock with a hammer until it opens.
Vincent, please, please, please do not call hallucinogenic methamphetamine a psychedelic. Please.
Why is that?
@@silviopina_111 Psychedelics are tryptamines and they don't cause brain damage. MDMA is designer methamphetamine and a phenethylamine, it's not a psychedelic. MDMA causes brain damage and will never give a psychedelic experience. Never. There has been a sick trend to replace psychedelics in medicine and research with methamphetamines like MDMA. It's very sad to see TWiN fall victim to this and to fail to this extent.
@@silviopina_111 hallucinogenic methamphetamines are NOT psychedelics.
@@silviopina_111 _Clinical, academic, bioethical, and commercial entities largely disagree on the formal definition of “psychedelic.”_ ...no reason
@@nescius2 Humphry Osmond created the word psychedelic to describe tryptamines; indoles with a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the first one being the heterocyclic nitrogen). Anybody who disagrees is simply taking an existing word with an existing meaning and redefinit it nefariously and dishonestly.
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