Hydroxychloroquine and COVID-19: What We Know Right Now | SciShow News
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- čas přidán 2. 06. 2024
- You might have heard that we found a cure for the COVID-19, and that it comes from a drug we've used for centuries. But let's take a breath and look at the facts.
COVID-19 News & Updates: czcams.com/users/playlist?list...
#coronavirus #COVID19
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UPDATES: Please Note: This comment is no longer being updated. For the latest news, please see our COVID-19 playlist: czcams.com/play/PLsNB4peY6C6IQediwz2GzMTNvm_dMzr47.html
6/15/20: The US FDA has officially revoked its Emergency Use Authorization which allowed US doctors to prescribe hydroxychloroquine and chloroquine to treat COVID-19, stating that the drugs are "unlikely" to be effective and, given the potential for serious side effects, the potential benefits no longer outweigh the risks. More information about the revocation can be found here: www.fda.gov/media/138945/download; www.fda.gov/media/138946/download
6/5/20: 1) The large study which prompted the WHO to remove hydroxychloroquine from its Solidarity trial has been retracted after the authors could not verify the data they obtained and analyzed for the study. The authors' explanation for retracting the paper can be found here: www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31324-6/fulltext
6/5/20: 2) A trial testing the use of hydroxychloroquine as a preventative treatment has concluded the drug is not effective at preventing COVID-19. Read the paper here: www.nejm.org/doi/full/10.1056/NEJMoa2016638
5/26/20: Due to rising safety concerns, the World Health Organization has stopped administering hydroxycholoroquine in its global Solidarity trial for the time being. The decision was announced at a press briefing on Monday: czcams.com/video/g3biL-YDyAk/video.html
5/22/20: A global trial with over 96,000 participants has found no clinical benefit from hydroxychloroquine or chloroquine, either alone or with antibiotics. Instead, the drugs appeared to increase a person’s likelihood of dying and cause heart problems. The full study is available here: www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31180-6/fulltext
4/24/20: The US FDA has put out a drug safety communication cautioning against the use of hydroxychloroquine and/or chloroquine for COVID-19 except in hospitals and registered clinical trials: www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or
4/21/20: Additional trials have begun reporting results, and so far, they’re not looking promising. For example, a US trial reporting results in a preprint found that hydroxychloroquine didn’t speed recovery, and may have even made things worse: www.medrxiv.org/content/10.1101/2020.04.16.20065920v1.full.pdf
4/8/20: On April 8th, the American Heart Association put out a statement of concern regarding the heart-related side effects of using antimalarials for treating COVID-19 patients. In it, they note that the drugs can cause potentially-fatal changes to heart rhythms, and that these may not be detected in time. You can read their full statement here: www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.120.047521
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Get it up there!
SciShow Well,I won’t be trying it. My heart’s already wonky.😏😷
And the french doc doing the research in marseille, which he said that today is 90% effective, didn't even had a Control group when testing
We just need a true study with a control group
"Hospital-based Intravenous Vitamin C Treatment for Coronavirus and Related Illnesses" -
orthomolecular.org/resources/omns/v16n07.shtml
"VITAMIN C AND ITS APPLICATION TO THE TREATMENT OF nCoV CORONAVIRUS" -
orthomolecular.org/resources/omns/v16n09.shtml
my mom cant even get this medicine that she needs for arthritis thanks to all this hype...
This is a fun quote in the research community. "Science has cured every disease known to mice."
and provided treatments (not cure) to every disease of man cured in mice ;)
It is a scientifically proven fact that researchers cause cancer in lab rats. Lol
@@wunamon Funny what happens when healthcare is a for-profit enterprise.
The human race would be long gone without them
@@MinecraftianFlutterguy Who, the research community or the mice? Haha!
Whenever you see that something kills pathogens in a petri dish, just remember, so does a flamethrower. Just because it works in a lab doesn't mean it works in a person. Still, here's to hoping.
Cpt_Kodai technically, a flamethrower would work on a person to get rid of the pathogens.
The medicine has already helped
Indeed. I haven't read any papers on COVID treatment, but quite often in vitro and animal studies use a much larger dose than you could use in a human (I've seen one unrelated study in mice that showed a drug as effective, but used the equivalent of 50,000x the safe human dose).
Cpt_Kodai Well it does “work” on a person. It’s just that it could work against them. If a drug kills little critters, it can harm humans in large enough doses.
I'm not saying you should use a flamethrower but just try it, ask your doctor about it!
This was done 2months ago. Since then it’s found Hydroxychloroquine and zinc give great recovery rate. Also, patients can show improvements in 4-8 hours and recovery 2days to week.
Also 50 cents each vs a high priced drug.
Did they censor your post for a extended time period ?
Did they assasinate you yet?
I hate that people are using the term “cure.” It is not a cure! It is a treatment!
Yes and it does also seem it would work best as a,prophylactic for people at high risk, as it would slow the virus down and allow the immune system more time to prepare an attack.
If it works for people it is a treatment and a cure.
@@mungfam they mean two different things a cure would outright stop or kill the virus. a treatment is something that helps alleviate symptoms or slow the spread, etc....
@@klardfarkus3891 "A treatment improves a condition and improves the patient's quality of life, while a cure would completely remove the disease from the patient." Purportedly it will do both.
mungfam Not even doctors are claiming that. In fact doctors are saying there is inconclusive evidence that this will help anyone with covid-19.
This is the first time most people realize that medical science is a relatively slow process
Vaccines and drugs take a very long time to be approved and developed
Hydrochloriquine is 10c/pill, vaccines are worth billions. Watch whoever is promoting "the newest vax", they've got $take in it.
Wrong! CSI can stick a vial in a centrifuge and out pops a cure within minutes!
Why doesn't western civilization evolve to stop this virus as well as China has? China #1!!!!
@@Stunningandbrave because unfortunately, Western civilization values the individual over the collective. Good for democracy and equality, bad for nation wide quarantines
@@managersejinstan1523 Really?
Also, panic-buying loads of these medicines makes it really hard for people, who have already been prescribed, to get them.
Diego Parga God everyone’s been repeating this but the reality is this drug is one of the simplest to develop so ramping up production would not be difficult at all. There’s been no shortages so far.
Good thing no one is doing without.
@@SevereFamine The White House has already arranged for at least 39 MILLION doses to already be produced. More are on their way.
That's why the White House arranged for at least 39 MILLION doses to already be produced.
Jacob Sanderson You are incorrect, grossly incorrect. Please don’t repeat that. Just days afterTrump talked about plaquenil there was an international shortage. My partner takes plaquenil for Lupus, an autoimmune disease, to prevent life threatening complications. She could only get a 14-day supply at a time because of the shortage and was instructed to ration her medication to half a dose. Pharmacists and rheumatologists were saying that shady doctors were prescribing it to rich people as well as their family and friends. There were several cases of dentists doing this too. Rheumatologists had to inform pharmacists not to take any new Rx and report suspicious Rx.
Please do not encourage hoarding of plaquenil, people at risk of health complications due to Lupus need to stay out of the hospitals right now. We don’t need more people with chronic illnesses that affect their respiratory system contracting COVID because they have to go to the hospital for another reason other than COVID. Hospitals are already overwhelmed right now.
Btw, current data suggests it doesn’t do anything for COVID. One study recently found that 11 patients died. People have poisoned themselves with it when getting plaquenil from shady doctors or other means. Plaquinil is not candy, it is a serious drug that has a lot of contraindications. And the doctor in France that started this whole thing falsified his data.
I’ve learned of (literally) hundreds of cases - all of which happen to be in the United States - in which hydroxychloroquine was administered to treat a SARS-CoV-2 infection and the patient recovered within 3 days (and usually within 12 hours).
I haven’t learned of a single case in which hydroxychloroquine was administered to treat a SARS-CoV-2 infection and the patient didn’t recover.
In my humble opinion, those are strong anecdotal arguments for the administration of hydroxychloroquine to treat a SARS-CoV-2 infection.
And it’s been brought to light by alternative news media that the Center for Disease Control and the World Health Organization are less concerned with public health and much more political than the general public believes them to be. I’ll pass.
Last week I learned of a study group of approximately 1000 residents of France who were treated with a “common” hydroxychloroquine/azithromycin/zinc regimen. If I remember the figures correctly:
• approximately 99.4% experienced dramatic reduction of symptoms within 3 hours, and were cured within 4 days
• 1 person didn’t respond to treatment and expired because of an existing condition
• the remaining approximate 0.6% weren’t yet cured but responding favorably to treatment and were expected to be cured within another week
(But don’t take my word for it, go find out yourself from independent news media.)
If more people were this clear and informative, the world would be a totally different place. Amazing work, SciShow folks!!
I also recommend the latest video from Chubbyemu. He is also very straightforward about the drug in particular
This video shows me that we’re wasting time with clinical trials. If high doses causes side effects (like with all drugs) we should let the doctors prescribe this. They can better moderate the doses and people won’t have to drink fish tank cleaner in desperation
including the potus?
@Bigfoot: Uloric sounds like the name of some ancient Nordic or Saxon king.
harder thing is to get people to listen.. some people believe what they wanna believe
I'm really glad that you guys are a calm knowledgeable port in the storm of panic and fear.
Not really. Just another source for us to interpret and question.
@@joops110 So it's not knowledge? I think SciShow has decent experience in researching science. Prob better then you or I. 🤷♂️
It has to be taken with a zinc supplement and also an antibiotic. Otherwise it does not work. It is a blend of drugs.
Doctors in America are reporting back no deaths that have tried it.
@@joops110 I mean you should always question your sources, but this comment is correct. They gave a very calm, direct explanation of the situation and the drug. I didn't find an issue with what they were saying.
This was done 2months ago. Since then it’s found Hydroxychloroquine and zinc give great recovery rate. Also, patients can show improvements in 4-8 hours and recovery 2days to week.
Also Hydroxychloroquine is about 50 cents each vs a high priced drug.
You forgot about the other fact that Chloroquine Is a Zinc Ionophore (allows zinc into the cell) and Zinc blocks RdRp (the virus protein that is used for replication)
Conveniently
RyuDarragh HCQ has been tested on SARS coronaviruses since at least 2005.
@RyuDarragh you don't have internet access?
@RyuDarragh Sadly, the Trump administration cut funding to this research in 2018, otherwise the clinical trails would be finished about know (according to the testimony of the head researcher of this project before congress)
@@anrefg Why conveniently?
8:06 The core challenge of medicine: Find the thing that is invasive enough to solve the issue, *without* causing a worse issue down the line.
It is never a problem to kill the disease, but keeping the patient alive when doing it.
Yea, atomizeing myself will get rid of all the covid-19 real good.
@@dooterscoots2901 Interstingly most disesaes are self-defeating:
Either you get Immunity, wich is bad for the disease.
Or your die, wich is also bad for the disease.
That's why I tell people that if all we cared about was killing the pathogen, we'd have a perfect cure in a gram of cyanide.
DONT DRINK FISH TANK CLEANER
Word, common sense is not so common.
OR TIDE PODS!
Or do, i'm not a cop
#Thintheherd
don't worry, more people will do that and die..
To late buddy
And just too remind everyone. Don’t eat fish tank cleaner.
Kevin Hernandez except the women that drank it was a registered Democrat Hillary donor trying to smear Trump (and probably intending to murder her husband). But to know that you would have to be paying attention.
Clairification: you will almost always die.
Haha jokes on you! I already did.
@@kjh4112 how hard are you going to REEEEEEEEE when he is reelected for another 4 years?
@Kevin Hernandez A Hillary Donor registered Democrat saying “We trusted Trump so much... and now my husband is dead.” Is such an obvious smear I’m surprised you’re calling me the moron
"Trying to kill a fly with a hand grenade"
This made me exhale and spread the virus.
Already took your advice, sorry.
Dont worry we're all self isolating and wearing N95 to reduce a cytokine storm
Our local version is "firing a cannon to kill a mosquito", which is oddly more apt, considering the circumstances.
@@TathD Reminds me of a Monty Python Flying Circus Sketch.
Thanks for doing a deep dive on this.
anothaview then do your own deep dive and make your own video. I’ll be waiting
@anothaview Yes, I agree. The researcher did not do enough research. Just to let you know I am a research engineer.
Obligatory "It's never Lupus."
HOUSE M.D.
It's probably sarcoidocis
Yeah unless you have Lupus then its definitely Lupus.
"Cancer is boring."
"Is it Lupus? Tell me it's not Lupus."
Liking and commenting in the hopes that this gets shared. We need level headed thinking right now, and a clear, inteligent voice that can explain both why this drug may be the answer we're looking for but also why just giving it out to everyone could be a (literally) grave mistake. Thank you.
what the WHO did to Gaslight the world into thinking that it doesn't work. They gave deadly doses The Solidarity Trial is a WHO-led conglomeration of many national trials of treatments for Covid-19. Per the WHO: I was alerted to the fact that India's ICMR, its official medical research agency, had written to the WHO, telling WHO that the hydroxychloroquine doses being used in the Solidarity trial were 4 times higher than the doses being used in India. Then I learned that Singapore had been hesitant to participate in the WHO trial due to the hydroxychloroquine dose. read the whole article www.ageofautism.com/2020/06/who-solidarity-and-uk-recovery-clinical-trials-of-hydroxychloroquine-using-potentially-fatal-doses.html
@@nadineblack8102 thank you for sharing... clear that the WHO are sabotaging hydrochloriquine
This was EXCELLENT! I have been looking for an explanation of Hydroxychloroquine! Finally I understand how it works! Thanks Hank!
Kinda nuts how trump isnt explaining that it only works st low infection volume :/ Like hes the free world leader that will prob cause a lot of harm smh..
@@malikialgeriankabyleswag4200 free world leader my arse!.
You still dot have one. Read the medical Journals. Read the tests. People are getting cured.
You folks never cease to amaze me on a daily basis, with the breadth, depth, and balance of information that you provide in an understandable format. That's why I joined this channel!
I think you hit on the most important word there, "balance".
The flow and order of information is also an art in itself! Hats off!
I know someone who takes hydroxychloroquine for an autoimmune disorder, and they're not to impressed about the possibility of a drug shortage caused by mass hysteria.
Only if the doctors start prescribing if of course... Some doctors may be hoarding the stuff too
There won’t be a shortage. First of its generic and defense production act is in place. More then is needed will be made. Second it is only given in severe cases. Finally people dying now are more important than people in pain or someone that will die in 15 years from a condition. Talks of shortages are overblown it’s given only to icu patients in rapid decline.
u13erfitz Hope you have an autoimmune disease and that your doctor is as dismissive of you as you are being of others who need this drug to have a quality of life. Ass.
CVS has stock. I got another 90 day supply this week.
It's not about the patients that are prescribed those causing a shortage, it's about people that don't even show simptons going out and hoarding the medicine. I'm not from USA, but that has happened here and people that have to take those medicines were struggling to find them, even though here you can't just buy that kind of drug without prescription, not all drug stores care to check for it/ are more concerned on selling anything.
In short, ill informed and pannicking people would be the ones to cause shortage by hoarding medicine (or the ones trying to take advantage by selling stuff for higher prices during shortage), just like the toilet paper incident.
Q: What did the hydroxychloroquine molecule say?
A: Ya basic!
"I ain't nothin' without you, Zinc!"
As a new lupus patient and immuno comprised person I am at high risk for COVID-19. This was very helpful in understanding how Hydroxychroloquine works. Thank you very much for taking time out to do this video amidst this chaos. You're awesome. Keep rocking!
"Not much data to support their use..." How about the 2005 CDC study on Chloroquine which has been ignored by almost everyone?
Proof the CDC lied about Hydroxychloroquine:
Based on the following article from the CDC's own website, the CDC knew Chloroquine was an effective anti-viral against COVID viruses during 2005. Hydroxychloroquine has almost the same properties as its cousin Chloroquine. Why did the CDC mount a smear campaign against HCQ during the COVID-19 pandemic?
If a safe treatment alternative was available, the Emergency Use Authorization of the experimental gene therapies would not have been allowed under current law in the United States. Therefore, the CDC had to discredit all known drugs which could inhibit COVID-19. How many thousands of people would be alive today if they had been treated with HCQ or Chloroquine within the first week of COVID-19 infection?
Page 24 of Robert Kennedy's new book "The Real Anthony Fauci" reveals an organized group of buyers in Zambia emptying drugstores of HCQ and then burning the medication in bonfires outside the towns. Why was this done?
Why did North Carolina's governor Roy Cooper order pharmacies not to fill prescriptions for Hydroxychloroquine?
If you do not think there is an effective anti-viral medication for COVID-19, read the article in the link below from 2005. Then ask yourself… Why was this drug ignored?
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (cdc.gov)
stacks.cdc.gov/view/cdc/3620?fbclid=IwAR2KybtnansjXybP0tqfopnA1IyeWdiTMQwvA_dVPSSavXPhh_K8KcCQy1o
Several of the doctors involved in this study worked for the CDC. See the concentrations and conclusion of page 9. The concentrations used were the same as those currently used to treat Malaria. Were there African nations which had lower COVID-19 death rates because they were taking Hydroxychloroquine to prevent malaria?
Has a similar war been waged on Ivermectin, which was used in some parts of India to greatly reduce COVID-19 deaths? Why were the discoverers of this drug awarded the Nobel Prize during 2015?
As someone else pointed out, the high rate of recovery will make it extremely hard to get statistically significant results and a lot of the trials atm are basically anecdotal with small sample sizes, few controls and probably can't be compared with other hospitals.
I've said since it was brought up that this drug will probably help some people but we probably won't know until after this pandemic.
@Jonathan Williams Do you really want to give sick people a medication that will likely make them worse? Also remember that these are medications that are genuinely needed by other people and there is already a shortage of it so decisions have to be made do you give it to the lupus patient who definitely needs it or do you give it to the corona patient that it might help, kill, or do nothing for?
The speed of recovery also matters, among other things.
@hawkturkey Production increases are slow, there are already people with autoimmune diseases that are being told that they have to go with out their medication. When there is a surplus fine give dying people what ever, let them drink bleach if they want to but we shouldn't be taking critical medication away from people that need it just so that other people can take a medicine that will do them more harm than good.
That's because the deadliness of this virus is vastly overreaction. It has less fatality than a normal flu. Old people die from common cold because they are old and their immune response is bad.
@@dangus6934 That's a myth that is months out of date.
Since tonic water contains quinine, my dad and I had a whole conversation about how we should all start drinking gin and tonics to keep ourselves safe (he was joking, just FYI)
Awesome ! Alcohol and quinine...gotta help!🥳
I'll drink to that
This was the original use to tonic water, but as medicine improved tonic water lost this use.
Anecdotal evidence (in moderation) it helps relieve anxiety also.
Watch how to drink
As a recently-graduated doctor (I'm still completing board exams so I'm not working in a clinical setting yet), I found this video extremely informative! There's so much to learn in med school that we're not taught things that are overly complicated and not well-understood, so I've never actually seen anything about how anti-malarials work (in either malaria or autoimmune disease).
Hank, you never fail to astound me with how well you understand everything and can explain it in every possible field. Even in videos on topics that I am supposed to be an "expert" in, I always learn something from you. You are truly the renaissance man/polymath of the 21st century!
You missed the Zinc. Hydroxychloroquine needs to work with Zinc Ion before it's acting well. Remember, both German and Korea used Zinc together and have a very low death rate.
Or if the patient already has a high zinc level.
Geez, and I thought I was the only one who would mention that. Glad others have caught it.
Not everyone uses zinc with it
It’s called a zinc ionophore.
muricans dont follow recommendations like a korean or german. there’s that too
My mother has an autoimmune disease and has been on chloroquine for many years. Now, she is unable to get the medicine she needs to stay healthy.
I'm so sorry. People with existing conditions should get therapeutic drugs at a higher priority.
I may be part of this group here in the next couple of weeks
All thanks to Trump making a false declaration about chloroquine... The USA really needs to get rid of that uneducated, incompetent fool.
MitZu yeah it really upsets me.
@@audeamus7388 Oh that was him? Figures...
My friend who has Lyme disease just got cutoff from her hydorxychoroquine, the medicine that was basically saving her life. The reason she was cutoff from it is because more and more stuff is talking about its positive effects on COVID-19. So to hear that it's not even confirmed and some stuff even says it's not helping at all, is extremely frustrating. She is going to be going through hell thanks to this.
I’m very sorry that this has happened to your friend unfortunately selfish ass people aren’t listening to the government which spreads it more and makes people sick
@@ndnsdmksjsjdn5798 ah you cant get it without a prescription so it would be selfish doctors prescribing it for themselves, family and friends. You cant go out and just buy some...
Trump said it works.
Trump PROMISED it works.
Now, the gov is clamoring to prove him right (if at all possible), and I wouldn't be surprised if big brother has told INS companies to determine who is low on lists and revoke their meds. (I said I wouldn't be surprised, I doubt they have though)
Paul W, I take it for lupus and can’t get it either. It’s very frustrating that people that really need it can’t get it because the moron in the Whitehouse opens up his big mouth before it’s proven to really work.
@@kenblaese8719 You're misinformed.
I was disappointed to not see one of the more likely mechanisms mentioned clearly. Hydroxychloroquine is a Zn ionophore, which means it helps Zn cross the cell wall. Zn then interferes with the viral replication process. When time is of the essence, you take your best guess AND work on the trials to answer the questions.
Same
Yes, they really should have added in that mechanism, especially because it's been used in concert with Zinc by many doctors so far for this very reason. But maybe they didn't want it to sound too promising or have the video be too long or "boring"? I have no idea why they wouldn't add that information though, honestly. Seems a bit biased.
So far the American doctors are reporting no deaths what so ever from hundreds put on this treatment. Some recovering in 5 days.
@@centpushups it's important to note how the study was conducted. Most people recover from the virus in about 5-7 days without treatment.
As a lupus suffered who has used this medication for over a decade, thank you for the best explanation as to why this medication helps me so much. If this medicine works for COVID19 I would be thrilled but the unnecessary stockpiling has made my life and other regular users fraught with fear of shortages. It has added a layer of fear to this pandemic because we are also vulnerable to the virus. I appreciate a scientific approach over the current political fights.
The worry over toilet paper shortages is what caused the toilet paper shortage.
4:28, this antigen was very happy.
What about Gin & Chloroquine? Okay I'll show my way out.
It’s worth one or five just to make sure
Plymouth Gin, of course ;)
No you won't. There is a pandemic out there.
@Johann some premium tonic waters have more and you can get tonic sauce with fairly high quinine. I have made my own tonic which was so good but took a lot of work. You can also boost it up with quinine powder.
Quinine and Gin kept Malaria at bay.
Thanks for the supplied info guys! Much appreciated in these times.
Very well done, like always. Thanks guys! Keep up the great work.
"its like tryna kill a fly with a hand grendade" lol
Yeah I'll take the collateral damage if I have a large desert centipede in my presence. We both dying. Idc. Lmaoo
It's a wonderful analogy.
Bruh I literally died when I heard that lol
4wolves czcams.com/video/25uMbGTA6PM/video.html
@@KaentukiTheFuki The Giant Tropical Centipede Share There territories with tarantulas. Dubstep* Dubstep*
thank you for keeping me and everyone else educated during this trying time. it really helps :)
You guys drop a video like this (such high quality-no sarcasm here) in just THREE days!!
This episode is more in depth than my dental school pharmacology class on antimalarials. Learned about quinine and when to use it but nothing about how it works on the body’s cells.
Thank you!
Im following your channel, good one! Didn't knew you had a biology background
If you want a really in-depth look at it and the French study that was performed, chubbyemu put out a fantastic video on it (he's an ER/toxicology doctor)
Here you go. This is the good info on Chloroquine and SARS-CoV-2. Studies are flawed, by not including the active ingredient.
czcams.com/video/U7F1cnWup9M/video.htmlm30s
Go watch MedCram update 27/28.
My word! If you had the time to learn more in school then you wouldn't have time to put it into practice, and all health professionals are expected to become acquainted with new developments.
Among the more subtle effects of COVID-19: modestly inferior lighting quality in SciShow videos. :-) (Glad you're taping from home - you're a hero, Hank!)
@@wisdom9091 erm... No. Don't spread pseudoscience
Hank Green really turning green
@@wisdom9091 Uhh, what?
Finally my quart of gin and tonic a day comes in handy
Cheers!
I hope you're drinking the good stuff! 💯 🥛
I thought gin makes you sin tho.....😁💬
It has always been handy
🍸
Beat me to the joke, but yeah, might as well -- if it doesn't work, at least we'll die drunk and happy.
Thank you to you sprrading good information with related sources and thank you to all these researchers and their effort on this.
Thank You for continuing to produce great content videos. As informative as always.
Note able also is that some people who depend on hydro chloroquine for life threatening conditions are having trouble getting it for no good reason
They've actually had no supply problems they are worried that they could, but pharmaceutical wise it's a dirt cheap and easy to make drug.
@@VioletDeathRei - Americans with lupus, RA and other autoimmune diseases are finding their prescriptions for hydrochloroquine have been cancelled, despite the fact that America currently has an overabundance of the drug. India has a stockpile in case of a major malaria outbreak, and Trump blackmailed Modi into handing it over. The so-called "supply" problem is a problem specific to America though, as patients in other countries are not reporting any problems. And those American patients are not being offered temporary alternatives, like steroids, either. This suggests US "healthcare" companies are using Trump's pronouncements as an excuse to save money by not paying for the drug.
@@tavdy79 Sounds more like lobbying and corporate bull then supply issues, banks did the same with small business stimulus loans, said they couldn't give them out until the government eased restrictions placed on them.
There is plenty of the drug and it's not that expensive to make, it's often taken just as a precaution when in high malaria areas.
If you can't get it then someone is holding you hostage to get something, it's not people are buying it all up or something.
Right, keeping people alive is "no good reason". Here's your sign.
@@VioletDeathRei and from the reports I've read, the president ordered millions of extra doses what, two weeks ago. He even had to threaten India's Modi to get them to produce in ship more.
In Germany there have been experimental treatments for terminal cases based on blood plasma transfusion from recovered patients. I know of two cases where that saved the patient.
That stands to reason. Using any plasma proteins from the illness will encourage the body to recognize the virus and its effects more readily. It's time that people thought outside the box on this one, which is kinda how Immunotherapy began to start with.
In a similar vein (get it ... vein) I believe there are attempts to clone the antibodies found in recovered patients. My guess is that it's a longshot, but it's worth a shot.
So it's just antibodiesthat are being transferred granting passive acquired immunity. No long term immunization
yeah, I heard about it as well from my friend who work as a doctor, but I think abusing such thing from recovered patients to cure all the infected is just insane, the person not even in a good condition to make such blood donation
Hank, you are really good at communicating. Thank you for the videos you do.
Germs: exists
Immune systems: Nuke it
Body: I'm I a joke to you.
it's a fight for your life
You guys are a treasure. Thank you for explaining a complex topic that the media tries to cover in 15 seconds.
“Some people are WAAY too excited about this”
Best way to put it.
you mean Elon Musk
Including my own parents.
That includes thousands of doctors. Ummmm...
@hawkturkey If it really were a miracle lifesaving cure, it would have a much more noticeable impact on fatality numbers.
US czcams.com/video/25uMbGTA6PM/video.html
Thank you! I was looking for solid information.
I’m a clinical pharmacist and I can vouch that the info in this video is accurate. I commend you guys for just informing people responsibly. Thank you!
Being part of the global biology research community, a lot of people I know (including me) are amazing about all the recent COVID-19 research breakthroughs. Diagnostic tests have been developed and distributed within weeks, drug screening has led to first clinical trials (using Ebola or HIV drugs) and vaccine trials have already been planned and enrolled people (I just published a video about COVID-19 research breakthroughs). Let's see how effective hydroxychloroquine will turn out to be!
@Xeno Phon their may be some ego stroking involved, but research is mainly money driven
I'm amaze by the speed at which we are getting information about a new disease.
@Xeno Phon citation needed. You say controlled research is more effective? Show me. As far as I understand human nature, we are all self-interested and will do amazing things to benefit ourselves and our families. That kind of motivation will drive someone to out in long hours towards a goal. I have a hard time believing that someone standing over your proverbial shoulder directing you what to study and research yields better results. This line of reasoning sounds like something politically driven. Tell me, are you some sort of authoritarian, ideologically? Prove me wrong.
You want science to be engineering. Engineering is ok, but we need science too.
NICE 💯✔
Killing a fly with a hand grenade.
I'd donate money for that research study.
Watch the fly get away, lol.
@Hugh Jones There was an old Popeye cartoon where he destroyed his home entirely, ridding himself of a pesky mosquito...
@@khatharrmalkavian3306 If you throw the grenade, there's a reasonable chance of that. Just don't land it too close to the fly and you should be good, though.
If you change fly to mosquito then I'm in.
You forgot to mention most people who take this drug also take zinc and other vitamins with it to it’s not just one drug
So, perhaps its the zinc and vitamins that works, not the malaria drug? See the problem of not having a double-blind study with proper numbers and controls?
Actually you are correct zinc is what stops the virus from being able to use cells to reproduce. Hydroxychloroquine allows zinc to pass through cell membranes easier and disrupt the RNA to copy itself. This has been studied in vitro successfully.
@@judychurley6623 It does not work without zinc. So far the American doctors are reporting no deaths what so ever from hundreads put on this treatment. Some recovering in 5 days.
@@centpushups they may have recovered anyway. Often when using meds not in a double blinded trial, there is bias in patient selection and other factors that make those results suspect. The only way to tell for sure is with well constructed clinical trials. There is currently a world wide trial with this drug and other treatments with vast numbers of patients. We will know for sure, be patient
@@centpushups Controlled study, peer-reviewed, or it didn't happen.
Excellent episode! Very good writing, awesome research!
Hi Hank, I would like to say a heartfelt thank you for doing this timely and relevant video during this period of pandemic paranoia. I am one of those people who are really hoping that Hydroxychloroquine can both treat and and have a prophylaxis effect on this virus that's making life so different nowadays. The reason I'm so vested in this hope is that I'm already on the medication for an autoimmune disorder called antiphospholipid syndrome. For me what this drug has been shown to do is to reduce the combination of two autoantibodies ability to attack certain lipids present in the cell linings of amongst other cells, the linings of all my blood vessels, heart etc. And it also actively deactivates platelets so that they are not floating around just looking for a fight when none really exists. On the topic of blindness, this drug also requires annual testing for those on long term therapy by a ophthalmologist to ensure that retinal toxicity isn't working it's way toward blinding the patient.
So yeah once again thank you, not only for this video, but for making scishow and all the offshoot channels also. You rock!
I'm shocked you didn't talk about how hydroxychloroquine is a zinc ionophore and zinc inhibits rna-dependent rna polymerase
They made a whole video on that
ABSOLUTELY! Agenda driven. SiShow is all up deep into Vaccine makers asses.
czcams.com/video/U7F1cnWup9M/video.html
@@linkin543210 Essentially it's a proven fact that hydroxychloroquine allows zinc to enter into the cell and it is also a proven fact that zinc inhibits the enzyme that enables replication of covid-19 in test tube. therefore, one theoretical mechanism is using the drug to prevent replication of Covid-19. Not 100% proven but atleast worthy of mention since it is talked about in medical community (I'm a doctor)
"It's called a 'cytokine storm'. It's basically the immune system equivalent of trying to kill a fly with a hand grenade. And it's the collateral damage from that that ends up killing the person." Great description.
hey... bro... thank u for this video . Ur video is really easy to understand.
Nurse here. That was interesting AF.
Thank you - that was heroically sobering! 🥰
I don’t know if it works or not but nobodies talking about the side effects of HCQS. and yes I take HCQS daily for lupus and even at low doses I get temporary colour blindness and other tons of side effects.
How often and how many mg's per day to you take it. A Covid-19 patient only takes 500mg a day for 5 to 10 days.
@@seanbogan9364 A Covid-19 patient takes nothing unless he's an idiot
Doesn’t it take around 3 years to properly carry out a clinical study?
Normally it takes about 5 years, last time I checked. However, in crisissituations right now we can cut that time down to 12-18 months because we're setting up more and bigger clinical trails than under "normal" situations.
At least
Inovio Pharma expects to have a finished vaccine by November, but I'm not sure if that meant having clinical trials completed or not... hmm
There are international studies (testing meds in treating covid19 patients) that put all their data into a shared data base basically in real time that is then analysed pretty much in real time as well and can have first results in a matter of weeks. They will also change out the substances pretty quickly if they are found to not have an effect, though quickly probably means a month or so.
It's already approved worldwide for other diseases, so your doc can still prescribe it off label.
Well, the French doctor released an abstract for a new hydroxychloroquine study today with 1056 patients. It has a larger sample size, but there was no control group, and it wasn't peer-reviewed.
@Jonathan Williams I'd say the opposite is true. Now it is absolutely vital to perform a randomized study, and it is unethical to not establish the truth.
@@MrGksarathy Just make sure to tell the people that die in your control group that they died an ethical death...
Gautam Sarathy outrageous suggestion
@Jonathan Williams I know full well what a control group is, BUT the real unethical thing that was done was the politicians hyping up hydroxychloroquine as a miracle cure before proper studies could be done.
@@gwcrispi We don't even know whether the difference is a matter of life or death.
Why does he always remind me of the scientist in the Simpsons movie ...
He is designed after Simpsons
Omg yeah never noticed it before but he does look like a young Dr Frink. Lmao!
hank GAGGJJITTEBIBBITY green
This kind of unbiased, factual content is just what the world needs right now. Thank you for your service.
Thanks, Hank. :-) You stay safe out there too.
The one thing I learned from House:. It's never Lupus
Or leishmaniasis...except for young Doctor Chase 😄😄
I don't understand this but my mom has lupus take this medicine along with 30 other pills A-day Lupus is no joke
Inside the show, it makes sense. Outside of it, as someone facing a diagnosis of what is likely Lupus, I don't need to hear it. Nor do the current Lupus patients clicking this video for information on why they can't get their life saving medication.
@@bcoit55 Same. I genuinely hate this joke. People with lupus tend to get misdiagnosed for years as its a difficult disease to discover with lots of unusual symptoms and this its never lupus thing influences young doctors to overlook lupus.
For those who dont know, early lupus causes extreme fatigue, aches and terrible joint pains and sleepiness and disproportionately hits women over men and black people over white or Asian people and generally manifests early in life. So historically doctors who have faced issues with believing female pain is hysterical and straight up not believing black peoples pain can look and young black women and straight up dismiss lupus
Also shoutout to all the Americans with lupus who are struggling to get the immunosurpresent drugs that prevent organ failure as this crisis means America is stockpiling all hydrocloroquine it can get its hands on
@@bcoit55 It's no joke my wife died from lupus.
Finally, a well reasoned, non-automatic hit piece on a possible solution.
let me guess, anything noting how dangerously something so unproven was being promoted by someone who as it turns out doesn't know the difference between a bacteria and virus, was a hit piece.
@@damien4197 no, it's called "multiple informal trials and anecdotal evidence point to this stuff having more of an impact than nothing at all, and so Trump decided to point it out and push the CDC/FDA towards verifying these claims, while giving some people a bit of hope."
@@darkfur18 no, it's called nothing of the sort, the man literally does not know that antibiotics are not used for treating a virus, so what you attribute to him is clearly beyond him. He didn't push for trials, he told people to go out and take it. You are evil, I wont be seeing the inanity of any response.
@@damien4197 I never said he had any scientific backing behind his statements, and he clearly wasn't claiming to, what with the whole "It might work, it might not" thing. More than likely he was just quoting some random article about "a promising study" and using big words to make it seem like he was more in control of the situation. It's just funny how this kinda thing always backfires on you guys. It's really gotta be quite embarrassing.
But yes, just call me evil. Don't try to understand why no matter what you guys do you keep failing so hard.
@@damien4197 The TDS is strong with this one
Can you do an episode on Folding@Home? I've had my home gaming computer working non stop since COVID19 got super serious. Lots of science going on through Stanford University!
Appreciate everything you all are doing to educate and inform us all.
Helpful. Thank-your for providing non-biased information.
C'mon, Hank: one has to take zinc along with HCQ to work effectively...
The Medcram channel makes the case that hydroxychloroquine makes a pore in the cell membrane that allows Zn2+ to enter the cells. For some reason, Zinc interferes with viral replication, which would be one reason these drugs could work better than anti-inflammatories which would also dampen cytokine storms.
Trump and his spawn have stock in the pharma that makes hydroxychloroquine. It’s all about money!!
I believe they also said Quercetin facilitates Zinc. Medcram is a channel worth watching.
@@connienelsonslc In the Trump case, they own shares in a mutual fund, which happens to own a few shares of at least one manufacturer. If you or I own mutual fund shares, that is likely true of us as well (it is, apparently, for me) though I suspect neither of us have political office. However, key point: hydroxychloroquine is a *generic* drug. Many companies make it, some of the biggest are in India, and the barriers to another company coming in and making the drug, taking business away from Trump's investment, are quite low. Although he has the POTUS "bully pulpit," Trump is not the only person advocating this treatment and indeed he is just echoing stuff he read. This is a nothing burger.
@@connienelsonslc less than $2 a day for 5 days, makes $10. Profit after costs, maybe $5? With the rest of the world as their competition since HCQ is generic?
Great explanation. Thanks for sharing.
I feel like the answers are much simpler than it appears and I feel like the answer is right in front of us.
7:22 Kudos for saying “non-human animals.”
Didn't even notice but so correct.
Triggers all the trump supporters that probably dont even watch these science vids lol
@@thricefan89 the only people saying these drugs are objectively bad are the idiots on your side.
@@DiamondSan7 lol my side? Objectively bad?
Google science. Its for your own good
@@thricefan89 Google "how to read English" because I didn't say your side is objectively bad. I said most media outlets on your side touts these drugs as objectively bad.
Thank you for this video! I’ve had many patients argue with me about this “miracle drug.” If these meds were a cure we would be using them. I know people are scared, I practice in NYC, and they are rightfully so because this is scary. We are doing the best we can with what we have. There’s is a way for people to help and that’s by staying home when possible or social distancing when you have to go out. Doctors are doing our part so please do yours. Stay safe.
I don know about ny but here in toronto the majority of of colleagues are STAY HOME as well, while passing out these prescriptions illegal to friends and family (published college of physicians here)Meanwhile not wanting to give patients or even trying these type of a meds and letting patients die.
NY leads the nation in CFR from C-19, no wonder.
Great information, thanks!
Fantastic. Many thanks.
If I had money, you'd get some of it. I know that's not helpful, but I'm spreading the word, sharing your videos...Well done, guys
Kinda missing one of the more important theories of how Hydroxychloroquine fights the virus: It allows zinc to be taken up by cells, and the presence of zinc disrupts RNA replication; meaning the virus is unable to create more copies of itself. This could be an important key factor into explaining why certain trials with Hydroxychloroquine didn't appear to have any positive results, while others (especially those who report using zinc alongside the treatment) have reported extremely high recovery rates.
Thanks--that was very interesting. Would OTC zinc supplements work, or is there another way they delivered the zinc?
@@richardefriend From the existing science, zinc supplements on their own don't do anything (unless you have a zinc deficiency), you need a zinc ionophore for your cells to uptake more zinc that results in the RNA replication disruption.
That actually makes _alot of sense!_
@@richardefriend There are ionophores in green tea that might help. There are papers on this. Look up the information carefully to be sure.
@@rahn45 Thanks, I'll look into it. It's nice to get a reply that isn't infected with TDS (Trump Derangement Syndrome). Politics should steer clear of medical research. Although I can fully understand why Trump's almost $100 indirect interest in the maker of Hydroxychloroquine, on which he stands to make hundreds and hundreds of cents, might be misinterpreted by someone infected by TDS.
Do one on plasma therapy from cured people from covid-19.
Have they started clinical trials? I thought it was just theoretical at this point. It certainly has a lot of potential, and since there is already a huge population of recovered patients, it may even be feasible, although probably not until the curve has been significantly flattened.
I heard in news they are trying it here in India.
Clinical trials also going on in John Hopkins. US FDA permission in "compassionate case" now on case by case by case basis
Italy also has trials going and Germany is ready to be cleared to start next week with giving patients plasma. There is a GREAT video on youtube about plasma therapie and antibodies, but it is in german... summed up: plasma therapie is promising but not as easy as we would think. There are challenges and things to figure out but it could potentially close a gap until we have the vaccine.
Wayy to expensive and timw consuming
A family member of mine who had a severe case of covid-19, was first treated with chloroquine and it did not improve his state. The doctors then switched to Cortisone which was the way to go and finally helped him.
Great video, keep up the good work
I have a feeling a certain medication if proven effective is about to go up in price!
Not necessarily. All the patents expired so generics can be produced. Somebody would be happy to move the price down below the idiots trying to inflating it. Which is according to some reports the core of the problem and why there is so much criticism against chloroquine. There are institutions that have a lot to loose if chloroquine helps to treat covid19 (I don't believe that conspiracy theory personally, but I can't discount it completely either)
@@musashi939 I've been taking qualaquin 324mg for years to relax night cramps in my calves and toes (works in just a few minutes for that). Medicare refuses to pay for it bc I don't have malaria. 30 pills cost 235$, generic. But 30 pills last me quite a while since I only take 1 when necessary.
Yep, it already has started to.
Yes? That's supply and demand... That's how everything works lol
Sulpha drugs like chloroquine were highly researched before the discovery of antibiotics. Almost a century later, as bacteria grow resistant and many of the worst diseases are viral, the focus is shifting back. Although they can have weird side effects, sulpha drugs have seen a wide variety of applications against viral infection (including HIV) and many other diseases.
This is very helpful, thank you !
I correspond with a researcher that works with CBD. He was trying to explain how it could help, but Google Translate was failing us. This explanation of reducing inflammation and shifting the Ph levels really helps me to understand what he was saying.
Thank you.
Whoa. Excellent summary of a very difficult and complicated subject (treating Covid-19). Very courageous!! Keep up the great work!! 👍
Thank you for this thorough and easy to understand description of these drugs and what we know about how they work!
It's tough out there in the politicized world where people have knee-jerk reactions to topics of all sorts based on their partisan politics, its totally poisonous and disheartening.
I hope that these drugs work and many of the anecdotes are promising, BUT it is important to wait for the results of clinical randomized double blind studies. *Even if the drugs end up working* it is still irresponsible to push them before they have been more thoroughly studied, but OTOH to dismiss them outright is just silly.
Could you guys also talk about the supposed combination with z-pack? Its apparently effective along side Hydroxychloroquine as a way to combat pneumonia associated with severe COVID-19 cases (anecdotally of course)
The zinc addition is the French formula that was mentioned. The addition of antiretrovirals is American, IIRC. So if you hear one thing, you can tell what country, or vice versa. But that may change as researchers compare notes and check each others results.
Hey there - you'll see a comment from SciShow a little higher up in the comments noting that the American Heart Association has issued a warning, and it includes the hydroxychloroquine/azithromycin combo.
@@mgm.al3mry "Trust the science, not the scientists" How is that supposed to work?
Did he mention that the doctors who have claimed success with hydrochloroquine, have said they used it along with zinc? And without the zinc, they say, the effect is not as good.
It does not work without zinc. So far the American doctors are reporting no deaths what so ever from hundreads put on this treatment. Some recovering in 5 days.
@@centpushups It has shown to work with zinc and an antibiotic czcams.com/video/Eha_XjGNKj4/video.html
centpushups the problem is that until there is a large double blind study with control groups, you don’t know that the treatment did anything. It’s entirely possible to recover in five days without treatment.
I don't think he even mentioned zinc. As you said many doctors are having success with HCQ + zinc + vitamin C + Z pack. I think the zinc is key. HCQ, like quercetin which is common in food, transports zinc into our cells. Phytic acid, from grains, rice, beans, nuts, etc., blocks zinc absorption. Fortunately vitamin C block the bad effects of phytic acid. Meat eaters get sufficient zinc. It might be, as a preventative, that we should just have some vitamin C whenever we eat meat.
If enough of us build immunity by adding vitamin C, that could result in herd immunity needed to stop this pandemic and prevent the spread to the vulnerable.
@@centpushups To be fair, the patients that died were just considered to have dropped out the trial and many studies show no improvement from treatment. Not sure why people are taking it as gospel that it's very effective.
Thank you for an objective analysis! Super helpful!
Very nice job as usual.
Meanwhile, a SERMO survey reported that HCQ has been widely used by both Spanish and Italian physicians to treat covid-19 patients. And accidentally, they are among the countries with the highest case fatality rate.
Yes because they are desperate 😔
incidently?
@@sigmund5 accidentally, as an ironic "by chance"
SciShow is always coming through with the awesome informed knowledgeable response to current events. Thank you, Hank and team!
As someone who has tried Hydroxychloroquine (Plaquenil) for my rheumatoid arthritis, I have to say that it is a severely harsh drug on the body. I hope that scientists can find other medicines to help because some people will not be able to tolerate it. It causes other horrible side effects besides the potential blindness and heart problems. I challenge anyone who is/was trying to pressure doctors into prescribing them this drug preventively to google the side effects of this medicine. Personally, I was physically ill during taking it and for several days after I discontinued the use of this medicine. This medicine has helped a lot of people and has the potential to help with many ailments, as Hank said, but there are people who need this medicine for their chronic autoimmune conditions that are having trouble getting it now. I'm really worried about them. Not only are the immune-compromised more at risk for this novel coronavirus, if they can't get their medicine they will likely have their conditions flare-up. It just adds insult to injury really. Please keep those people in mind. Here's to hoping things get better soon! #StayHome #ProtectEssentialWorkers #TogetherWeQuarantineApart
Amazing. Very well explained.
Thanks for comprehensively providing information about hydroxychloroquine while keeping it intriguing till the last minute!
I saw a cool video by ChubbyEmu on this too, Thanks for helping shed light as usual, SciShow =D
I saw the same video. Between these two videos, it should be painfully obvious why it's necessary for more and better research to be conducted.
Cells At Work Season 2...
As always, amazing video. I always appreciate your scientific rigor while sticking with more “layperson” language. As a scientist myself, it’s very difficult to maintain that balance. Love you guys! Stay safe!
Thank you so much for shedding light on this topic! I am in professional school, and I asked my immunology professor why we are using a antimalarial drug to treat a virus-he couldn’t get past the politics and refused to speak on it at all! I just want to be educated and informed, so thank you for taking on this hot topic.
@Sheiby brown.Because either hydroxycloroquine or remdesvir ,the so called 'antimalarial drug ' prevents the binding of ncov2 protein spikes to ace2 receptors present in human lungs.