Flibanserin (female viagra)
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- čas přidán 13. 09. 2024
- *Flibanserin: A Breakthrough for Hypoactive Sexual Desire Disorder*
Flibanserin is the first medication approved in August 2015 for treating Hypoactive Sexual Desire Disorder (HSDD) in pre-menopausal women. Initially developed as an antidepressant, Flibanserin is classified as a multifunctional serotonin agonist antagonist (MSAA).
*Mechanism of Action:*
Flibanserin works by rebalancing neurotransmitters that influence sexual desire. It acts as a 5-HT1A agonist and a 5-HT2 antagonist, increasing dopamine and norepinephrine (responsible for sexual excitement) while decreasing serotonin (responsible for sexual inhibition).
*Dosage:*
- 100 mg orally once per day at bedtime
- Discontinue after 8 weeks if no response
*Common Side Effects:*
- Dizziness
- Nausea
- Fatigue
- Sedation or insomnia
- Hypotension
*FDA Warning:*
- Flibanserin combined with alcohol intake increases the risk of severe hypotension and syncope.
- Contraindicated with strong or moderate CYP3A4 inhibitors.
- Contraindicated in patients with hepatic impairment.
*Reference:*
- Lexicomp
- Prework by Dr. Dahshan
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