The longevity sirtuin - what you need to know about SIRT6
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- čas přidán 26. 07. 2024
- SPONSOR: Longevity.Technology - www.longevity.technology/?utm...
Sirtuins are highly conserved proteins that are involved in a variety of important cellular processes such as DNA repair, metabolism and circadian rhythms. The mammalian sirtuins (SIRT1-7) are a family of proteins that carry out NAD+-dependent protein deacylation and mono-ADP-ribosylation. These modifications on proteins can influence their stability, localisation within a cell and activity.
In the late 90s interest in sirtuins bloomed as it was found yeast lived 30% longer when they had an additional copy of a yeast sirtuin, Sir2. Similar studies have now been performed in mice, but whilst overexpression of SIRT1 in mice does not result in lifespan extension, overexpression of SIRT6 does. This has led to SIRT6 being referred to as the longevity sirtuin. However, there seems to be some sex- and mouse strain-dependent differences. So, in the remainder of the video, we will discuss what you need to know about SIRT6 including it's proposed cellular activities, it's association with longevity and how SIRT6 activation using allosteric activators could have future therapeutic potential.
TIMESTAMPS:
Intro - 00:00
Sirtuins - 00:45
SIRT1, SIRT6 and longevity - 03:00
SIRT6 and DNA damage - 08:30
Activating SIRT6 - 09:50
Additional thoughts - 11:45
#longevity #science #latestresearch #TSSS
REFERENCES:
Roichman, A., Elhanati, S., Aon, M.A. et al. Restoration of energy homeostasis by SIRT6 extends healthy lifespan. Nat Commun 12, 3208 (2021). doi.org/10.1038/s41467-021-23...
Regulation of SIRT6 protein levels by nutrient availability - doi.org/10.1016/j.febslet.200...
Regulation of SIRT1 protein levels by nutrient availability - doi.org/10.1016/j.febslet.200...
Kanfi, Y., Naiman, S., Amir, G. et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483, 218-221 (2012). doi.org/10.1038/nature10815
Sirtuin activators and inhibitors: Promises, achievements, and challenges - doi.org/10.1016/j.pharmthera....
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species - doi.org/10.1016/j.cell.2019.0...
Huang, Z., Zhao, J., Deng, W. et al. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol 14, 1118-1126 (2018). doi.org/10.1038/s41589-018-01...
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So is SIRT6 my new favourite protein? Hmmm, of course not, p53 all the way, but it's up there, maybe top 10 :D
You're making p53 jealous
top 2
I find it interesting that men benefit more than women. If true in humans it might just equal everything out being men on average die before women. Therefore might make it to where a lifelong couple might have a better chance at leaving the world together after being together even longer. Kind of poetic.
Not too biochemical. We like biochemical.
Maybe you should do a list of things that activate Sirtuin 1 to 7. I want to look young for a very long time. Living longer healthier life
You need to put all your video talks into a book. You have an incredible future ahead.
Thank you. What a gift you have to take complex research papers and make them so much more accessible!
Thank you for doing this. This is very superior to most CZcams discussions of longevity.
Awesome video as always! I’m currently taking fucoidan, quercetin, and fisetin daily because I think there’s good evidence these molecules extend healthy human lifespan at proper doses and it turns out there’s pretty good evidence that all 3 may be SIRT6 activators which would partially explain why they can extend healthy human lifespan.
Fucoidan does so many interesting things. I take it for anti-autoimmunity and NLRP3 inhibition - really helps with the 'aches and pains'. But studying it can be problematic as it varies in size and composition from different sources and seaweed extracts can also contain stuff like dieckol and fucoxanthin.
Most SIRT6 activators, fucoidan included, are at "in vitro" stage. Is there any in vivo or clinical trial SIRT6 activator study?
@@rhyothemisprinceps1617 Good points. Dr. Vera Gorbunova’s team has been studying fucoidan for many years and I believe Vera’s team has a new paper on fucoidan scheduled to be published in September 2021. We’re honored to have Vera on our Scientific Advisory Board longevityplan.com/about_us
@@user-mq9ml9jg5v See my reply to Rhyothemis princeps 😉
@Brent Nally What is your source for the fisetin? And I’m curious as to why daily and not pulsed like they did in J Kirkland’s studies at Mayo- the “hit and run” approach to knock out senescent cells?
What's the story with fucoidan as a sirt 6 activator?
I’m curious also Do Not age put their Sirt6 Activator on the market.
Yes, what is the story? And what are the side effects of taking fucoidan?
You are totally my hero!
Excellent talk! I love your graphics!
I am creating a seminar presentation over the sirt6/NAD+ pathway right now and this was a very helpful overview! Thank you :)
Very dynamic and graphic video! Thank you so much :)
Great video ! The only advice would be to better your diction
because I had to switch subs on
Amazing and informative, as usual
You can activate sirtuin 6 with cyanidin which is found in red cabbage and cherries.
Elderberries have the most
@@juliahello6673 they contain too much oxalates so they aren’t suitable for everyone.
Thank you for the analysis
longevity technology is the perfect procrastination website for me xd
If you are a teacher, as she is, you have to put it in some illustration on a class blackboard.
thanks for all this interesting information
Another great video. If you take a Sirt6 activator, is it essential that your NAD+ levels are at a 'healthy' level to make the effort worthwhile?
Have you read anything about Fucoidan as a SIRT6 activator?
This was an excellent video and very much appreciated! Thanks!
Would you say Sirt6 is a senolytic or is Sirt6 under expression a marker of cellular senescence?
Is it possible to activate fisetin, quercetin and fucoiden with piperine like resveratrol supposedly is? Are there any other activators you would recommend to increase the efficacy and bio availability of these supplements? Thanks!
Have you thought about looking at bloodresult variations and aging? E.g markers of inflammation, blood urea, WBC, RBC etc and their changes over time. How they indicate internal aging and what we can do about it?
helpful video
Question: Being from mixed parents...could one parents genes be latent and could NMN bring them out of latency? I'm asking because of incredible results I'm getting nfrom NMN incuding white hair regaining colour which starts off the same colour as my mums hair, hazel, where mine was always really dark brown.
I have a question about NAD+. People get infusions of NAD+ as boutique designer medical service, but even if you did that weekly, is that NAD+ reaching and influencing your cells? Or is that infusion just wasted cash?
Similarly, does taking MNM or NAD+ benefit a person and work as hoped for anti-aging?
I’m dubious but also hopeful and curious.
I read that Fucoidan interact with Sirt-6…
What is your take on it?
Since DR (or CR) are said to function by activating Sirtuin genes, does that mean that female test subjects respond less to DR than males?
Also, at the present time, is it believed that resveratrol has any health benefits at all?
What about Urolithin A and Fucoidan as SiRT6 activators?
my mum has been taken the donotage SRIT6 and she got extremely exhausted, as a result was not able to work and not able to cope with the daily routine ,,,,i advised her to stop and see what happens and guess what she gradually recovered and back to normal routine ,,,,,NOW i don't know a thing about science but i know what it did to my mum..... if you ask me this is some dangerous staff
No side effects for me of any kind from their sirt 6 activator.
Interesting subject. I wonder how this could potentially effect the longevity of Werner Syndrome patients ?
How did you learn to draw like that?
Is your job related to it?
Thankyou so much. Really useful explanation. Which natural compounds activate Sirtuin 6?
Someone said red cabbage and cherries.
I have wondered about something for a long time - - butyrate is a general HDAC inhibitor; sirtuins are HDACs. What's up with that?
As far as i was aware, butyric acid is more a class I HDAC inhibitor, with sirtuins being class III. But on from your point, sirtuin inhibitors are being researched for treating other diseases, so yeah, i think it is still unclear what is going on and likely tissue/disease-specifc
How does one benifit from this? Buy it at the local store.
Can I buy it on Amazon?
are you familiar with Ray Peat's writings?
This is genius. The influence on DNA to affect anti-aging is fascinating. ❤️ This is going to make a lot of people wealthy.
for those of us with hearing deficits the voice used in these videos is not conducive hearing the material accurately regardless of how informative the presentation.
Dr.Cheekey is an alien obviously with that intelligence.
So, like a set of spanners, each for a certain sized bolt. 🔧🔧🔧
Can u make video about that new study saying Ageing process is unstoppable ?? want to know whats your take on that.
I retweeted a really good twitter thread discussing the paper and the actual findings that I'd recommend you checking out. Not sure yet if i will cover as a video
@@TheSheekeyScienceShow i am not a tweeter user, can u gimme link or smth ? idk how to search for it. ps Thnx a lot
@@LuciousKage From Eleanor's Twitter: twitter.com/statto/status/1405569768665530369
My goto channel when for scientific uncoloured longetivity content. Thank you
Are there any Sirt6 activators currently commercially available
@@Zuluknob
I'm thinking that you are correct about the seaweed, which I know about.
I was hoping there were others
Black elderberry extract, brown seaweed
@@mesosuavee5498
Thanks
@@Zuluknob As far as I know, quality fucoidan (sourced from Japan/Australia with non-chemical extraction method) is never cheap.
Donotage.org are selling sirt6 activator.
In being tied to CR, I wonder how IF (including in different patterns / durations) would affect SIRT6 activation.... possibly coupled with various 'supplements' (e.g. NAD precursors). How easy is it to measure levels of SIRT6?
Intermittent fasting, exercise and keto diet can definitely activate SIRT6
i have L-Ornithine Alpha ketogluterate.
I❤️💜❤️🔥💓you. no joke. #bachelorsinbiology.
Can you eat something to further activate SIRT6?
Elderberries are the best.
Red beets Pomegranate
@@markveen1373 arionberry is more potent i guess.
And not eat as she says fasting activates it. I don’t know if it’s more time restricted feeding or true fasting as she didn’t mention how long one must go.
Hyarulonic acid.
Cyanidin and Delphinidin activate sirt-6
Do you have a bad microphone?
It's too pa8nful for me to try to listen to your videos.
I think I would like them if the audio was better.
"Graphical Abstract" - memes enter academia.
SATUINS OR SITUTINS? Pronunciation please.
Sir-too-inns
@@TheSheekeyScienceShow lol
SiRT6
Could you tell us which supplements activates Sirtuin 6?
Olive oil (oleic acid
); I do a shot with powdered parsley (apigenin) every day.
Arugula, buckwheat, capers, celery, chilies, cocoa, coffee, extra virgin olive oil, garlic, green tea, kale, Medjool dates, parsley, red endive, red onion, red wine, soy, strawberries, turmeric and walnuts are sirtuin activators.
D-Ribose, berberine, methylene blue, Japanese knotweed, Piceatannol (3,3',4,5 transtetrahydroxystilbene), 2,3,5,4' tetrahydrooxystilbene-2-0-*-D-glucoside(THSG)polygonum multiflorum (he-shou-wu), and maybe polygala-tenuifolia, Cistanche, Yuan Zhi, Chinese club moss, etc.
Why haven't researchers done an in-vivo, randomized, placebo controlled study of fucoidan plus an NAD precursor looking at synergistic longevity benefits?
Are you sirtuin about that?
Nyuk nyuk nyuk.
Great video…love it when you go “bio-chemical”!….no apologies needed….
I would suggest giving more credit to the lab groups, authors, institutions, and journals. These studies are often progressions of earlier studies by the same labs and principal researchers and not one off studies. It's not that hard to give credit where it's due.
Heavy British accent makes it TOUGH to understand! No tea and crumpets here.
Hard understanding her accent and cadence.
What are you talking about? Mabye English is not your first language?
Elderberry