Vineet Sir treated my 23 year old sister stage 4 lung cancer for around 2 years..... Vineet sir is a gem & very knowledgeable & kind. He is going to be the best oncologist in India.
Thanks a lot for very good information. You r doing great job. Because so many women's doesn't have knowledge. I m beautician nd I have my own beauty parlour in Mumbai. I have seen so many my clients those having Brest cancer... I have seen their sadness
Doctor I really need your help. 2 months ago my sister was diagnosed lymphoma in breast and lymph nodes in armpit. In 2020 she's diagnosed calcification on same breast and operation was done. In the same year again she's diagnosed bowel cancer, operated and removed 8 inches. At the moment she's taking targeted therapy and immune therapy. She really wants to remove her breast.She should or shouldn't remove her breast. please give your valuable advice. Thank you.
Very informative vedio doctor.. even my doctor couldn't explain .. about my treatment so deep.. ur a god sent angel.. im a stage 4 ER PR positive with skeletal metastasis .. its been 2 years now.. my last 3 pet scan shows no tumor. complete metabolic response and im on letrozole and ribociclib.. Doctor is therr any chance of stopping these drugs because my quality of life is becoming horrible due to this drug.. im into a clean diet exercise yoga and other alternative therapy im jus 36 and wish to have a second baby..kindly respond. . Im awaiting for your response. . God bless you doctor 🙏 ❤
Hi... You need to take this drug indefinitely. Do not stop it. Pregnancy might not be possible for you right now but research is going on, maybe it might become possible in future. Currently survival is more important than second child
Thank you so much doctor for your time.. indeed ur an angel because I never seen any doctor taking time to explain patient concerns.. God bless you doctor 🙏
Thanks a lot Sir, You a serving the nation in this way of awareness.Pl let me what are tests required for healthy person to know that he is not in grip of cancer
Sir, this video is very informative, my wife 44 years old, had breast cancer 3 years back, relapsed with spread to bone on july 2023z After palbace and letrozole along with SBRT and last PET WAS CLEAR. Now so we need every 6 months PET SCAN? Or once in a year?
Hey .my mum has same how was your wife now hope she is doing great,i hope for fast recovery.. can you let me know how these medicines affect the overall health and how much tumor shrink we can expect it from .
Very nice explanation sir. I am doing research on molecular subtypes of BC. Please also make a video on molecular subtypes (based on gene expression) with respect to their medicine 💊
Thank❤🌹🙏 you sir aapke videos se bahot madat milti hai 🌹🙏stage 3 breast cancer hua tha 🙏🙏yesterday ko stool me se blood aa raha tha 🙏🙏ye konsa indication hai🌹🙏🌹🙏
“My mother (57) has been diagnosed with metastatic stage 4 Breast cancer (ER+,PR-,Her2- score1)which has spread to her (Brain, Lung, Liver and Bone) as of 8/2/24. She’s getting Paclitaxel Chemo 9times once a week(3 are done” She started getting radiation in November and December 2023 ( radiation to back bone,breast, and brain)at that time spread of Ca was limited, Then later she was on target therapy(Palbociclib) &hormone therapy(Letrozole) taking this accelerated the disease then got a PET CT and got to know it has spread to Liver also. Please suggest if treatment is right or wrong
Sir In case pr is positive in core Needle biopsy and negative in surgical specimen. Which report is reliable and what will be treatment plan. Please make one video on this topic Thanks and regards
Can grade 3 invasive breast cancer ( modified Bloom richardson grade ) T3 N0 M0 . ER + , PR + , her 2 negative. Bcs done Can be treated without chemotherapy
Informative video sir Sir meri mom ko CA Breast metastatic hai 12weekly Paclitaxel inj done last cycle 3august 2023 with monthly zoldronic acid continue after chemo palbociclib and letrozole continue but at present new petcity report 20march 2024 cancer shows in 0.2 in liver Dr.. suggested stopped palbociclib or letrozole and started injection fulventrast 500mg quartely with combination of tab capecitabine 500 ....plz Suggested sir which one is better chemo /palbociclib+letrozole /injection fulventrast+capecitabine plz sir reply or any no.. for query
@drvineetgovindagupta mere sister ko 1 week se target Therapy and hormon therapy calrahahe..pls sir bataye mera sister cure ho sakta ha??or next bone se kaha spread karega??
Dr Vineet, very nice and kind of you. However, why is it that for a young lady below 40, who has high PR & ER Positivity and negative HER, who is in Stage 2, is being recommended Chemotherapy first ? Is it because she is young ? Why Medical & Surgical Oncologist have different views on it ?
Thank you sir bahot hi easy karake bataya. Maze ER PR positive breast cancer huaa tha. Meri surgery aur chemo ho gaya hai. Abhi main 3 sal se tamoxifen le rahi hu aur har 3 mouth main ek injection leti hu Luprodex 11.25mg. Mera treatment Tata hospital Mumbai main chal raha hai. Jo main treatment le rahi hu oh sahi hai kya. Please sir guide me. Thank you
Meri mom ka bhi same treatment chal rha h chemo radiation ho gya hai ab zelodrolic acid Monthly aur luprodex 11 25mg 3 month with tamoxifen 1 tab daily bataya hai.
Sir I am impressed to see your video n wants to know whether target therapy can be discountinued if pet scan is normal since last18months I am patient of hormone breast cancer since2006 Please guide me
Hello sir, Meri mother ko 5 sak pahle 4th stage cancer diagnose hua tha. Unko palbace and letrozole diya 5 sal tak. Uske bad August 23 se everolimus and exmestans de rahe the. January 24 se everolimus side effects ki wazh se bnd kr di keval exmestane chal Rahi hai. Kya koi or ilaj h kya? Unko bones me bhi spread h.
Sir, I can share all pet ct reports. Could you please share your email id? Sbse phle left breast and lungs me tha. Vocal cord bhi paralysed ho gye the. Palbace lene k bad lungs me se to remove ho gya. By the time bones me bhi ho gya h. Paabace had stopped working then doctor recommended everolimous and exmestane. But everolimous was stopped after 4 months due to the severe side effects. Now she is taking only exmestane.
Scrape Cytology Report - * Mature Squamous Cells * Sprace Inflammatory Cells * No Dysplastic Cells Or Fungal Elements Seen Sir Please Bataya Report Main Kya He 🙏🙏
Sir my mother has stage 4. Dr.adviced us to go for hormontherapy including ribociclib** . But RIBOCICLIB COST around 60k per month.which is not affordable for us for a long time is there any alternative of this tablet.or i can get help from any government associations.pls let me know as soon as possible.
Sir mai 19 years ki hu mere left breast ka size thoda bada hai or pain bhi hota hai or meri neck se arm Tak pain rahta hai kya mujhe censer hai please sir bataiye 😢
But sir ek bhod bda confusion h esa kahte h ki chemotherepy cencer cell ko body me kahi bhi ho kill krta h to only harmone therepy kese effective hogi please help me sir bhot bada confusion h mujhe😢🙏
Sir after breast cancer treatment ke baad 3 months check up mei Dr ne bola tha ki ultrasound aur blood test karne ke liye report me thoda sa bone week Aya kya kuch problem hai
Sir. My mother is stage 4 BC (left breast, LN, Bone, lung) patient. Harmone positive. 1st line Letrozole + palbace. 2nd line Fulvestrant + piqray 3rd line Everolimus + exemestane. Then Chemo paclitaxel single agent 10 cycles. And today pet CT show decrease with inactive metabolic activity in bones. Now suggested to take tamoxifen And have chemo break. Please suggest if taking tamoxifen right now is valid And suggested? Or should continue paclitaxel??
How much time interval this treatment worked for her cancer you pls tell me ! my mom is one same 1st line of treatment as your and always terrified and worried .....I hope for speed recovery of your mom🕉️❤️
Sir meri mother ko breast cancer h ER-PR positive h aur sir heart ka ejection fraction 30-35% h doctor bol rahe h aise me surgery aur chemo nahi kar sakte kya ye sahi h sir Please guide 🙏🙏
Respected Sir Very nice vedio Can we expect 5 years survival in liver metastasis breast cancer ER +(7/8) Pr.. Negative Her 2 negative Ki 67.. Non contributory (biopsy from liver) Patient age 50 Asymmetric Pls suggest
Vineet Sir treated my 23 year old sister stage 4 lung cancer for around 2 years..... Vineet sir is a gem & very knowledgeable & kind. He is going to be the best oncologist in India.
Konsa ca tha aapki sister ko bhai mari wife ko squamous cell carcinoma alk positive h stege 4th h tab.alectinib 600mg bd le rhi h
@@ashutoshvyas885EGFR positive
@@hemantsharma4182 sir meri mom k bhi treatment sir se hi chal raha 2022 se ..egfr positive hi h meri mom k bhi . Abhi Kasi h apki sister?
What were symptoms for your sister? Please tell me .
आप की vlog se सब ladies main Possitiv vibes आय gi. Again Thank u so much
Thank you so much,Doctor. As a cancer survivor, your video is really helpful and highly appreciated 👏 👍 🙏🙏
Simplified, YOUR MANNER OF PROVIDING INFORMATION JUSTIFIES THE SAYING, "" DOCTORS ARE EXTENSION OF GOD."" MAY U LIVE LONG WITH PEACE.
Thanks a lot for very good information. You r doing great job. Because so many women's doesn't have knowledge. I m beautician nd I have my own beauty parlour in Mumbai. I have seen so many my clients those having Brest cancer... I have seen their sadness
Dr veenit sb G your experience with this subject is very very nice 👍👍👍👍👍👍
Thanks and welcome
Thank u sir ur information about breast cancer means alot for me mujhe same yahi hua hai aap ki baateon se mujhe mere answer mil gaye hai.
Thank U very much sir.May Allah bless you😊
Very nice sir bhaut accha samjaya
We cannot find this kind of detailed information anywhere else. It’s easy to understand and very helpful. Thank you very much 🌷
Very helpful video, thank you for explaining elaborately.
Doctor I really need your help. 2 months ago my sister was diagnosed lymphoma in breast and lymph nodes in armpit. In 2020 she's diagnosed calcification on same breast and operation was done. In the same year again she's diagnosed bowel cancer, operated and removed 8 inches. At the moment she's taking targeted therapy and immune therapy. She really wants to remove her breast.She should or shouldn't remove her breast. please give your valuable advice. Thank you.
Such a positive information video this is 🙏
Thank you Doctor. You explain no well and decrease anxiety. God bless.
Thanks sir aap buat badiya se samjati ho
Thank you Sir, very good information
Ur way of explaining is so gud sir
Thanks sir
Apki bato se himmat milti he
Thanks a lot Doctor, gained lot of courage from your detailed explanation. God bless you, doing very good job .
Very informative and easy to understand
brautiful explained sir👍Thank you🙏🏻it really helped us.
It's my pleasure
Thanku sir for this video I m mcb patient in er pr postive
Thank you so much Dr. Sahab. It is really very informative
Useful information
thanks a lot dr you are such a great doctor, very informative video ❤
Very informative.
Excellent sir
Thankyou sir for the detailed explanation
Thank you sir itni acchi jankari ke liye
Thank you Dr. Gupta sir is jankari kay liye mujhe bhi 4th stage Cancer ho gayi hai
Kha tk spread h apko
Good suggestion dr
Thankyou sir for information
Thankyou sir,will connect Asap
Very informative vedio doctor.. even my doctor couldn't explain .. about my treatment so deep.. ur a god sent angel.. im a stage 4 ER PR positive with skeletal metastasis .. its been 2 years now.. my last 3 pet scan shows no tumor. complete metabolic response and im on letrozole and ribociclib.. Doctor is therr any chance of stopping these drugs because my quality of life is becoming horrible due to this drug.. im into a clean diet exercise yoga and other alternative therapy im jus 36 and wish to have a second baby..kindly respond. . Im awaiting for your response. . God bless you doctor 🙏 ❤
Hi... You need to take this drug indefinitely. Do not stop it.
Pregnancy might not be possible for you right now but research is going on, maybe it might become possible in future. Currently survival is more important than second child
Drug doses can be adjusted if side effects are troublesome. Talk to your oncologist or connect to us via number in video descripiton
Thank you so much doctor for your time.. indeed ur an angel because I never seen any doctor taking time to explain patient concerns.. God bless you doctor 🙏
@@sabithats6835hey hope you doing well.. can I contact you my mom diagnosed with same ?
@@sabithats6835what signa you saw after taking these my doctor has prescribed letrozole and palbociclib
Hi sir ., my mother is suffer from breast cancer . Can you pls sugges..step
And how she can recover.
Your reply is very helpful for me.
Very nice 🎉
Sir make e video on gastric MALT lymphoma and it's effective treatments and further management.
Nice information
Thank you sir
Thank you sir.. It was very informative..
Sir,,make more video this topic and new medicine and treatment
Thanks a lot Sir, You a serving the nation in this way of awareness.Pl let me what are tests required for healthy person to know that he is not in grip of cancer
Sir, this video is very informative, my wife 44 years old, had breast cancer 3 years back, relapsed with spread to bone on july 2023z After palbace and letrozole along with SBRT and last PET WAS CLEAR. Now so we need every 6 months PET SCAN? Or once in a year?
There is no fixed guideline in this, it depends on patient health and disease biology. Your doctor will decide
Hey .my mum has same how was your wife now hope she is doing great,i hope for fast recovery.. can you let me know how these medicines affect the overall health and how much tumor shrink we can expect it from .
How are you now ..my mom diagnosed with same skeletal metastatis and breast cancer can this medicine work to shrink the tumor even in years
@@sakshampathak9019 she is doing good, howz your mom now?
@@user-rf8qv2ys3e we started medicine about a month ago
Great Sir
Thank you sir you r next to god
Sirji❤❤
Thanks sir
Pls,,sir make more video this topic
Thanx doctor ❤
thanks Drsab
How long Harmon therpy need after stage 2 surgery.Its all informative.
Thanks for details.
7-10 years
Very nice explanation sir. I am doing research on molecular subtypes of BC. Please also make a video on molecular subtypes (based on gene expression) with respect to their medicine 💊
Thank❤🌹🙏 you sir aapke videos se bahot madat milti hai 🌹🙏stage 3 breast cancer hua tha 🙏🙏yesterday ko stool me se blood aa raha tha 🙏🙏ye konsa indication hai🌹🙏🌹🙏
Aapne doctor ko consult Kiya?
Sir, my mother taking Letroz 2.5 and Kryxana(Ribociclib),
Sir,Ribociclib are 2 brand name available kryxana and kisqali which is better?sir
Er pr postive cancer me servival rate badane ke liye best medicine jo effective ho plz suggest kijiye
“My mother (57) has been diagnosed with metastatic stage 4 Breast cancer (ER+,PR-,Her2- score1)which has spread to her (Brain, Lung, Liver and Bone) as of 8/2/24. She’s getting Paclitaxel Chemo 9times once a week(3 are done”
She started getting radiation in November and December 2023 ( radiation to back bone,breast, and brain)at that time spread of Ca was limited,
Then later she was on target therapy(Palbociclib) &hormone therapy(Letrozole) taking this accelerated the disease then got a PET CT and got to know it has spread to Liver also. Please suggest if treatment is right or wrong
It is a complicated case. Repeat biopsy with genetic testing should help. Connect via number in video description
Sir
In case pr is positive in core Needle biopsy and negative in surgical specimen. Which report is reliable and what will be treatment plan. Please make one video on this topic
Thanks and regards
Usually PR won't lead to change in therapy
Can grade 3 invasive breast cancer ( modified Bloom richardson grade ) T3 N0 M0 .
ER + , PR + , her 2 negative.
Bcs done
Can be treated without chemotherapy
From where bcs done ?
Thx sir
Tnks sir
Informative video sir
Sir meri mom ko CA Breast metastatic hai 12weekly Paclitaxel inj done last cycle 3august 2023 with monthly zoldronic acid continue after chemo palbociclib and letrozole continue but at present new petcity report 20march 2024 cancer shows in 0.2 in liver Dr.. suggested stopped palbociclib or letrozole and started injection fulventrast 500mg quartely with combination of tab capecitabine 500 ....plz
Suggested sir which one is better chemo /palbociclib+letrozole /injection fulventrast+capecitabine plz sir reply or any no.. for query
Difficult to answer this question without seeing all reports... Contact via number in video description
Dear sir plz bataye ki temoxifine lene ke baad bahoot thkan lgti ese na le to eski jagah kya le
Pls sir,,make video for metastatic breast cancer to tibia bone only...Hormon positive breast cancer..pls,,sir
Yehi video hai
@drvineetgovindagupta mere sister ko 1 week se target Therapy and hormon therapy calrahahe..pls sir bataye mera sister cure ho sakta ha??or next bone se kaha spread karega??
@@vlogwithsoha2960same qqqq
Dr Vineet, very nice and kind of you. However, why is it that for a young lady below 40, who has high PR & ER Positivity and negative HER, who is in Stage 2, is being recommended Chemotherapy first ? Is it because she is young ? Why Medical & Surgical Oncologist have different views on it ?
Younger patients with breast cancer have more aggressive cancers. Even they can avoid chemo if genetics of the cancer are favourable
Thank you sir bahot hi easy karake bataya. Maze ER PR positive breast cancer huaa tha. Meri surgery aur chemo ho gaya hai. Abhi main 3 sal se tamoxifen le rahi hu aur har 3 mouth main ek injection leti hu Luprodex 11.25mg. Mera treatment Tata hospital Mumbai main chal raha hai. Jo main treatment le rahi hu oh sahi hai kya. Please sir guide me. Thank you
You can connect via number in video description
Meri mom ka bhi same treatment chal rha h chemo radiation ho gya hai ab zelodrolic acid Monthly aur luprodex 11 25mg 3 month with tamoxifen 1 tab daily bataya hai.
Can you give me your contact no jisse me aapke ilaj aur aap hamare ilaj ke bare me jaan sake
Sir fir bhi muje radiotherapy diya
ER -ve
PR -ve
HER 2neu -ve
Kya line of treatment hoga sir.
My mother she is 76 and she was harmonal +ve what kind of treatment she sutable plz answer my question recently she was diagonised cancer
Sir need your online consultation.
Sir I am impressed to see your video n wants to know whether target therapy can be discountinued if pet scan is normal since last18months
I am patient of hormone breast cancer since2006
Please guide me
It depends on the type and stage of cancer
Where did it spreaded in 2006?
How are you now ..my mom diagnosed with same skeletal metastatis and breast cancer can this medicine work to shrink the tumor even in years
Hello sir,
Meri mother ko 5 sak pahle 4th stage cancer diagnose hua tha. Unko palbace and letrozole diya 5 sal tak. Uske bad August 23 se everolimus and exmestans de rahe the. January 24 se everolimus side effects ki wazh se bnd kr di keval exmestane chal Rahi hai. Kya koi or ilaj h kya? Unko bones me bhi spread h.
Dear
Let me know which organ was involved in stage 4 breast cancer in your Mother
Dear
Pls share stage 4 me disease kaha kaha gayi thi
Sir, I can share all pet ct reports. Could you please share your email id?
Sbse phle left breast and lungs me tha. Vocal cord bhi paralysed ho gye the. Palbace lene k bad lungs me se to remove ho gya. By the time bones me bhi ho gya h. Paabace had stopped working then doctor recommended everolimous and exmestane. But everolimous was stopped after 4 months due to the severe side effects. Now she is taking only exmestane.
Scrape Cytology Report -
* Mature Squamous Cells
* Sprace Inflammatory Cells
* No Dysplastic Cells Or Fungal Elements Seen
Sir Please Bataya Report Main Kya He 🙏🙏
Sir my mother has stage 4.
Dr.adviced us to go for hormontherapy including ribociclib** . But RIBOCICLIB COST around 60k per month.which is not affordable for us for a long time is there any alternative of this tablet.or i can get help from any government associations.pls let me know as soon as possible.
Yes you can aplly
CM fund
Pm fund
Doctor Brest cancer ki kounshi janch karwaani par ye pata chale ga ki cancer hai
Sir ek short video on Oligomestatic breast cancer please?
It is a complex topic. Get in touch via number in video description
Sir advance tnbc curable hota h kya?? (With lung metastasis)
Depends on genetics of the tumor. Connect via number in video description
Sir mai 19 years ki hu mere left breast ka size thoda bada hai or pain bhi hota hai or meri neck se arm Tak pain rahta hai kya mujhe censer hai please sir bataiye 😢
I'm not a doctor dear but my sister is also a BC survivor
...I suggest you to go and do petscan .stage bahot tezi se badhti hai iski.
Unhe bhi starting symptom yhi thi then bone .
Sir Stage 4 Her2 positive breast cancer main clinical trial chal raha hain kya ??
Brest Cancer brain me chala Gaya hai. To tretment kya honga pls reply
Sir mera husband ko limphoma censar huo h kya hm baby plane kr sakte h
Doctor, can high SGPT elevate CEA observed value.
It is possible
Please i need second opinion from you.
Could you please share your details with us for cancer case cure from you.
Because i am from Maharashtra.
Use number in video description
Sir, when you talking about survival rate? It is again relapse rate?
Both are important
❤❤❤❤of u sir meri sister 4th stage he dna effective nehi hue redio Or opration nehi kie to chalega😢
Stage 4 mein surgery compulsory nahi hai. Video description mein number se sampark karo
But sir ek bhod bda confusion h esa kahte h ki chemotherepy cencer cell ko body me kahi bhi ho kill krta h to only harmone therepy kese effective hogi please help me sir bhot bada confusion h mujhe😢🙏
Bhut achi video sir please myeloma patient ke liya koi new treatment aya hai mein aap ke paas aya tha rply
Watch our multiple myeloma video from channel page
Sir her 2 positive may 17 chemos karani hai?
Sir after breast cancer treatment ke baad 3 months check up mei Dr ne bola tha ki ultrasound aur blood test karne ke liye report me thoda sa bone week Aya kya kuch problem hai
leiomyosarcoma, it had been spread to the liver from gastro intestine.
Is it curable?
How much risk of life is involved in this?
Sir, Please reply....
Sir triple negative breast cancer par banae video please
Jald hi
सर, मुझे हारमोन पॉजिटिव ब्रेस्ट कैंसर है 2 स्टेज का 15 दिन हुए सर्जरी हुई है , 5 लिम्फ नोड रिमूव हुए हैं क्या मुझे कीमो थेरेपी की जरूरत है
Kha par karye ho
Thanks 🙏🏻 Iam worried about my sister metastatic Brest cancer spread in bone diagnosed in last fifteen days back kindly advise
Connect via number in video description
Sir nuroindocrine tumor patient father aur mother
Ban sakte han.
Baby ko hone me risk hai kya.
Usually no. But need to discuss with your oncologist
Sir, you talked about hormonal therapy, so for how long do these medicines have to be taken in stage 2 breast cancer
5-7 years
@@drvineetgovindagupta ok sir thanks
Name of hospital please 😊
Sir mera rectal Cancer permanent colostomy bag lega h kya hyhe hut skta h kya ji please batana ji aapki badi meherbani hogi
Depend karta hai. Sabmein nahi
My mother jas been given 3 chemo than after debulking surgery another 3 chemo is now being given olaparib.
Yes this is recommended in ovarian cancer
Dr sab mera er pr positive n ihc 2 negitive hee 2nd stage heee avi chemo chal rahahee
95% cure rate
सर पुरुषो के breast कैंसर में जिनका er, pr पॉजिटिव और her two नेगेटिव है उनको tamoxifen दिया जा रहा है. इनको और क्या करना चाहिए.
Sir. My mother is stage 4 BC (left breast, LN, Bone, lung) patient. Harmone positive.
1st line
Letrozole + palbace.
2nd line
Fulvestrant + piqray
3rd line
Everolimus + exemestane.
Then
Chemo paclitaxel single agent 10 cycles. And today pet CT show decrease with inactive metabolic activity in bones.
Now suggested to take tamoxifen And have chemo break.
Please suggest if taking tamoxifen right now is valid And suggested? Or should continue paclitaxel??
How much time interval this treatment worked for her cancer you pls tell me ! my mom is one same 1st line of treatment as your and always terrified and worried .....I hope for speed recovery of your mom🕉️❤️
@@sakshampathak9019 she was diagnosed on Feb 2021.
I wish for your mother's good health. God bless brother.
@@kushagrasingh518 thank you bro ..take care of yourself and your mother too...❤️❤️
Sir meri mother ko breast cancer h ER-PR positive h aur sir heart ka ejection fraction 30-35% h doctor bol rahe h aise me surgery aur chemo nahi kar sakte kya ye sahi h sir
Please guide 🙏🙏
Sir please reply
Hi. For ER PR + Hormone therapy can be done with good outcome even with heart failure. Connect via number in video description
Respected Sir
Very nice vedio
Can we expect 5 years survival in liver metastasis breast cancer
ER +(7/8)
Pr.. Negative
Her 2 negative
Ki 67.. Non contributory (biopsy from liver)
Patient age 50
Asymmetric
Pls suggest
Yes, median survival as of 2024 is more than 5 years