How telomere shortening affects aging

It’s believed that telomeres play a role in aging. When telomeres become too short, it triggers our body’s DNA damage response, signaling our cells to undergo senescence or apoptosis (cell death). Telomeres shorten with each cell division because of the structure of DNA itself, called the ‘end replication problem’.
This is part of a short series of videos where we explore telomeres, telomere length and telomerase, as well as the impacts they have on our health.
Chapters:
00:10 What is the Hayflick limit?
00:40 What are telomeres?
01:03 What is the end replication problem?
02:19 How does telomerase prevent telomere shortening?
Watch the next video on the links between telomerase and aging: • The links between telo...
Missed the previous video on what telomeres are and how they protect our cells? • What are telomeres and...
RepeatDx is a leading clinical laboratory for telomere length testing. You can find out more on our website: repeatdx.com/
Follow us on Twitter: / repeatdx
References
1. Bartlett, Zane, "The Hayflick Limit". Embryo Project Encyclopedia (2014-11-14). ISSN: 1940-5030 embryo.asu.edu/handle/10776/8237.
2. Lingner, J., Cooper, J. P. & Cech, T. R. Telomerase and DNA end replication: no longer a lagging strand problem? Science 269, 1533-1534 (1995).
3. Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).

[@mikelwallstaff6905]

Absolutely the best quality video you could ask for. Thank you very much! :D However, I would be even happier to see longer deep dive videos, of course. lol ;)

[@repeatdx3637]

Thanks - glad it was helpful!

[@wwayimran6911]

very helpful visualization

[@repeatdx3637]

Thanks - glad it's helpful!

[@LoLPhuocDat]

Thanks for this video! I was pretty confused about telmerase.

[@repeatdx3637]

Thank you! Glad it was helpful!

[@medboy520]

Really great representation...
Keep teaching ❤️

[@repeatdx3637]

Thank you!