Hematology | Polycythemias
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- čas přidán 25. 07. 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be teaching you about polycythemias. We hope you enjoy this lecture and be sure to support us below!
References:
● Oxford Languages (2021) languages.oup.com/google-dict...
● NatBoardMCQ (2015) [Quiz] www.natboardmcqs.com/hematolog...
● Hong-MouShih Journal of the Formosan Medical Association. Physiology and pathophysiology of renal erythropoietin-producing cells (2018) www.sciencedirect.com/science...
● VIVO Pathophysiology (2018) [digital image] www.vivo.colostate.edu/hbooks/...
● Blood doping (2017) [digital image] www.sports247.my/blood-doping...
● JAK STAT pathway [digital image] www.researchgate.net/figure/J...
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● Sabatine MS. Pocket Medicine: the Massachusetts General Hospital Handbook of Internal Medicine. Philadelphia: Wolters Kluwer; 2020.
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#ninjanerd #Polycythemias #Hematology
You're a gift to humankind
As someone facing the prospect of a dx of PV (just had blood work including JAK2 drawn today) and a recently retired ICU RN, your presentation was outstanding. It puts it all in perspective. You're an outstanding teacher!
Zach, you are the BEST!!!
Great video! You have all the specific videos I can't find anywhere else. Good quality and great explanation! Thank you ninja nerds. I found your videos right before my first hematology test. The coagulation cascade and anemia videos saved me! Keep up the great work.
I never bored to your lecture ..how much long it would...
Thank you. Your lectures are my absolute favorite..
Why does this video has so many clicks but much less thumbs up? Guys PLEASE give the videos thumbs up, this channel deserves it by far more than any other!
People watch the video multiple times but can only like it once...
Thank you. I’ve learned a lots from every lecture you shared. You’re the best 👍
Indeed so great,,,, you are a blessing to medical students
Awesome, concise, precise and productive!
I'm a fan of your channel since my undergrad days and now, I plan on binge watching your videos before I start medical school to give me a headstart on the basics cuz you give the most detailed yet concise explanations. Thank you for this. You really are a blessing 🥰
Excellent video as always! Thank you very much for your content!
Good gifted human. I am overwhelmed with your concept. Big thanks.
as someone who had a stroke 2yrs ago due to polycythemia (so diagnosed at time of stroke) this gives me new avenues of cause to explore.. Underwent bone marrow tests that proved -ve (so not primera).. have been told ever since it was "transient", despite 5 tablets a day not reducing BP.. will be back at my GP next week.... Thankyou very much
thank you for your excellent explanations!
Top-notch conceptual correlation and beautifully crafted and articulated video.
Thank you so much.
14/JAN/2022, Friday, 12:20pm IST
you are amazing! thank you for all your wonderful vids!
This was Zack's pathway.. amazingly explained 👏 👌 👍
You are getting me through nursing school! Thank you so much!
Me too
I was just diagnosed with PV and this is the most informative explanation I've found. Thanks!
You have me hooked on these videos. Brings med back to ANATOMY & PHSILOLGY in NURSING CLASSES. THANK YOU. YOU HAVE MADE IS TEALLY SO EASY TO LEARN. 9:23. 7-14'2023
This is a great video, so happy I found you.
I owe so much to u.... U are a blessing for medical students.... God bless u and may u get aalll the happiness ....💗💗💞💞
Great teacher SIr.. Excellent! If one has polcythemia (secondary) From trt , and does not get rid of some blood. How long will it take to get back to a normal hemoglobin and hematacrit if they get off of trt. Thanks
Grateful and very empathetic and attractive explanation
Prof., Rrahman FERIZI
This topic made no sense to me until now! Thank you!
Your lectures saves lives. .trust me 👍👍
thanks for the video, this help me for my study in turkeys hematology.
Just great, u just injected the topic in mind.
Great job! Do one on Essential Thrombocythemia please
Love how you explain things..great teacher
Xn
I had Polycythemia and had to get a phlebotomy about once a month, because my Hemoglobin was around 55 g/dl and my Doctor ordered it.
Finally I wondered about people with Anemia that were short of red-blood-cells analogously like an opposite to Polycythemia!
Then I looked up the foods that people with Anemia do not eat because they are iron blockers.
Many of these foods are called Oxalate's and absorb Iron. So then I started eating these foods (with Oxalate s) abundantly and after a
few weeks I had my Hemoglobin checked by my Doctor and my Hemoglobin was down to 16 g/dl and now over a year later my Hemoglobin is still 16 g/dl. That is a drop of 39 g/dl’s in a very short time and it held good. Sometimes just a simple procedures are workable.
Of course I believe that my mental procedures, meditations & thoughts had something added to this procedure that was synergy related that made it more effective.
Make it clear that I am not prescribing
anything to anyone, but expressing my own thoughts and experience.
However I would recommend that medical personnel investigate this.
Cordially, Robert Shrewsbury
Thanks for the information.. May I know if your RBC was also on higher side and reduced with hemoglobin too?
Also may I know which Oxalate foods did you take up like beans or nuts?
@@mangeshgadhave6791 My hard-drive went bad and I lost some of the data on the particular oxalates, but I used a lot of them.
I suspect that oxalic acid diluted to a Ph of say 6 may also work? I used to use oxalic acid in the assay laboratory to absorb iron from my ore, so it would assay better. However I would never do any such a thing without having my hemoglobin checked by a competent medical person, because this could be dangerous if one goes too fat and become anemic!?
@@robertshrewsbury9344 Thanks for the quick reply. Definitely I'm relying on food only and not laboratory things but just curious to know does it help in lowering RBC's too as my RBC's are still bit on higher side 6.05 even after phlebotomy every 3 months?
My rest of the medical reports are normal so just trying to fix this with diet.
@@mangeshgadhave6791 hi how are you now
Perfect explanation sir 😊Thanku
You are such a genius, God bless your brain!
Now I get it! Thank you!
Thank you very much, may God bless. You really make me understood through your well elaborated lecture. Thank you🙏
At one time i got really sick and had blood work done at the ER. O had high hematocrit and high bilirubin, still never found out why but i was drinking alcohol a whole lot
i hope there will be a subtitle that was made by you guys, not just by the youtube cause some words are not right, and its make me confuse. thank you. i love ninja nerd
Perfect video!!
Just loved it
Ur teaching skills are just perfect ❤
He forgot to mention other causes an increase of red blood cells or secondary polycitemia Vera like the use of Anabolic steroids, smoking reduces the oxigen capacity and so is sleep Apnea.
Thank you 🙏🏻. Your the best 👍👍
This was helpful really I’m not a med student but I was just told I have Polycythemia secondary, but what happens if someone has both polycythemia and Antiphospholipid antibody syndrome?
Best in the business💕
You are very good at what you doing
Perfect!
very good thank you
Thanks alot. May Allah bless u
Thanks a lot sir 🙏
Than you for your help😊
As a PA-C now you will routinely see elevated counts in RBC from your men on TRT. Teach all providers the difference between PCV and erythrocytosis.
thank u so much sir
Extraordinary.
allways You r the best.. alot of thank🌹🌹🌹🌹🌹🌹🌹
Thanks so much
Thanks sir
You are special man!
Been battling secondary polycythemia for 2 years now and this video really helped my understanding. I think my best solution is focusing on hydration now and your other "Approach to Polycythemis" helped me with that. Thank you!!
Yeah keep yourself hydrated , take one to two 80 mg aspirin daily and donate blood every 2 months and you will be fine.
He forgot to mention other causes an increase of red blood cells or secondary polycitemia Vera like the use of Anabolic steroids, smoking reduces the oxigen capacity and so is sleep Apnea.
I've been fighting this for almost 2 years now it's still unclear on how I got this my hematologist still will not give me any answers why is that ? I have been experiencing hip and joint pain ! It really irritates me that he won't give me any answers on my condition he just suggests I speak to my PCP ! Why can't he answery questions ? Just saying
@@chrisoliver9442 What are those actual symptoms of this? I'm researching on it because my rbc is slightly higher ( Only 0.4 than normal range) & I feel extreme cold sensitivity which seems intolerant to me with breathing problem like chest pain while taking deep breath.
@@chrisoliver9442 hey how are you now did you find out anything
What percentage of population with the JAK2V617F mutation do not go on to develop a myeloproliferative neoplasm?
Thank you 💚💚💚
I had Polycythemia/cancer and my g/dl's was 62 g/dl's instead of 16 and I had to get a pint of blood (Phlebotomy) drained out of me a lot. So I started taking oxalate foods until my hemoglobin was back down to normal at 16 g/dl's Strawberries are good oxalated, but so is rhubarb, but I thought rhubarb was too much Oxalate, so I stuck with strawberries. I am aware that too much oxalic can also be harmful.
Wonderful 👍
Thank you sir❤
From India (Bihar)❤❤
A lot of love to you😘😍
polycythemia can result from excessive intake in which of the following?cobalt,copper,iron,phosphate or manganese
Enjoyed🤟🤟🤟
What is the increase of RBC with normal epo levels caused by?
I have secondary polycythemia and one of the probable causes given was my recently diagnosed severe sleep apnea and smoking.
My Apnea Hypopnea Index (AHI) was 92 (average of 92 apneas/hr in sleep with a desat over 4% causing an arousal). This was most likely ongoing for years. After several phlebotomy sessions over 2 months (500 cc of blood removed each weekly session), the RBC count dropped into a safe level.
Hello @dannybau,
May I know if you still need to do the phlebotomy? What was your highest count of your RBC's ?
How are you doing nowadays ? Are you still on a CPAP ?
How it result in bleeding if viscosity is high??plz tell
You are like a scholarship to me🖤😄
Thankyou ❤
I love you Man ❤️
Hallo Ninja does excessive use of diuretics and inadequate fluid intake cause secondary polycythemia?
I'm doing homework and one of the questions asked me to identify any assessment findings that indicate Hypoxia. One of the findings was a ruddy purplish color. I chose this as part of my answer and was marked wrong. The feedback said ruddy purplish color can indicate COPD or Congestive heart failure and is caused by Polycythemia. So I guess in a way I was still wrong because polycethemia can result from the body responding to hypoxia? Okay I think I just answered my own question. Basically patient can have normal oxygen saturation levels and have an off color. I need to look at pictures for a side by side comparison.
Sir cor pulmonale causes increase in epo?
Actually in PV, the WHO criteria requires seeing "panmyelosis" in the bone marrow - an increase in all three lineages made by the myeloid stem cell. So someone with PV will have high red blood cells and/or high platelets and/or high hemoglobin and/or high granulocytes. High leukocytes in PV confers a higher risk of thrombosis per the WHO MIPPS-PV risk stratification algorithm. Btw, I really appreciate you talking about Secondary Polycythemia. I'm trying hard to find something to educate patients who have this - but patient guides or videos for secondary are sorely lacking.
Cool .
Best Ninja in world
Love you 😎
Sir can we say polycythemia also occur in anemia
My all in all
Thanku so much 💓 💖 💗
I've had 2 cancer doctors. One said we will blame it on your mild sleep apnea, the other doctor said, is not a cancer, I'm on 81mg aspirin. When I checked my patient portal, one said polycythemia vera and then one said secondary but I'm in stage 2 kidney disease and my family doctor didn't tell me. So now I'm going to another cancer doctor for 3rd opinion. I itch after a shower, I burn up, shortness of breath sometimes, I'll sweat at nights sometimes. Heat about takes me out in the summer. I can tell when I have way to much blood and I'm thinking about just donating blood to get those levels down.
Have you had a bone marrow biopsy or have you been tested for the mutations?
Why are they not doing regular CBCs for you?
Polycythemia Vera is considered a blood cancer or chronic leukemia.
Find someone who will test you for those things and monitor your blood counts as all of your symptoms are saying PV.
@@rlove3222thanks for your concern, around here, it's hard to find good doctors that will listen to you. I've been on top of oncologist after oncologist. My hubby has a great oncologist that recently came back to work after breaking his leg, he's going to look over every blood panel I've had going back 1 yr. And to the recent blood work I've had, but he will repeat every blood panel, he will probably do a bone marrow biopsy. If he does a run around with me, I'll just stop going to a doctor all together. I've been dealing with this problem for a long time, my CBC will be elevated sometimes and I rarely get infections. But it's showing my red blood cell count will go up and down. I'm all over the place and I'm becoming more frustrated cause of how I'm being tossed around. I want to have high hopes for this oncologist but when you have been done so shitty, you don't know what to expect. Hopefully I'll have answers soon.
Looking at the description of your symptoms you MAY have polycythemia ( elevated RBC) so for your peace of mind, pls, get CBC blood test -- the hemoglobin, hematocrit and RBC count must be elevated all the time then your doctor may evaluate you for further testing, for diagnosis.
He may order a jak2 mutation blood test, if this test turns out negative then you don't have polycythemia vera if it's positive the you have it.
If a jak2 mutation test is negative then you won't need a bone marrow test, BUT if you've had any blood clots with a negative jak2, then the doctor may order a bone marrow test.
I've had all testing including a bone marrow. I've got Polycythemia Vera. My jak2 is positive.
@@Jenny420ky oh I see, I'm sorry. Hope you're managing it well.
sir bring video on leukemia ,lymphoma ! plz
What's the blood test that would show EPO in high levels? Thanks.
Erythropoeitin test
The one and only 🤟🏿
Could you confirm polycythemeia only by peripheral blood smear ?
Great video, Thanks
The video can not be downloaded
Interesting lecture, but I would add as a contributor to secondary polycycthemia - testosterone, especially for those receiving testosterone replacement therapy.
What is this exactly
How can a patient have an increased chance of bleeding if the patient can clot so quickly?
I currently have polycythemia. I have recently had a JAK2 test performed. During my phlebotomies it would take over an hour to remove a unit of blood due to the clotting of the needle and tubes. I'd continually have to have a new line placed in my arm.
Hey, dont know if you'll get this but the increased proliferation of red blood cells causes the platelets to also proliferate and increase in number in a way to sorta keep up with the RBCs. This does lead to increased clotting however the extra platelets dont always work well and thus fail to clot which in turn leads to increased bleeding. Hope this helps. :)
@@justyouraveragetosser9265 yes it does... thank you for the explanation 👍🙂
Why bleeding occurs despite increase in megakaryocytes
God bless you
great❤🙏🏽❤️🔥
If there is an increased propensity to clot then why should there be increased bleeding/an increased prothrombin time?? I am confused. Can you please reply to explain?
Thank.you.so.much.sir.
Thank. Sir doctor for more share okey
I want to ask for high sugar doc pls. Okey.
Hey dude.. I wanna ask.. I have been checked for JAK II and its said normal and no mutation.. But my RBC production is upnormal.. So this condition can called primary or secondary??
Check for epo level if its normal then might be it is idiopathic erythrocytosis ( primary type features)
@@babumanu895 are facing this issue?
Can’t there also be secondary due to Spleen not removing RBC.
Why there is bleeding?
Is it still polycythemia if it's the white cells and platelets that are high??
So mine is caused by taking testosterone for hypogonadism. Is that primary or secondary?
Secondary due to medications. I had to have a bone marrow biopsy and tests for the mutations. I had a TIA almost 9 years ago and am treated with phlebotomies and aspirin.