Expert Insights on MAS: sJIA/AOSD and Macrophage Activation Syndrome

An Interactive Case-Based Discussion - MAS in Rheumatology
During this webcast archive, Dr. Scott Canna and Dr. Alexei Grom discussed diverse mechanisms and clinical presentations in patients with suspected MAS, approaches for the timely diagnosis of MAS, and considerations for appropriate treatment and management strategies.
Available for AMA/ANCC/ABS credit - click the PPCME link in our bio to access!

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Is the increased IFN-gamma production ISG15-induced (ISG15/CD11a/IFN-g) and thus independent of Il-12 receptor chain upregulation,- or IL-12-induced with upregulation of both IL12RB1 and IL12RB2?
This question is interesting because there have been cases of macrophage activation syndrome/lymphohistiocytosis also in patients with IL12RB1 deficiency (MSMD) who also display decreased perforin expression and decreased clearance of viral pathogens as well as decreased FAS/FASL-dependent apoptosis, triggered from viral infection. And, of course, these patients exhibit an abolished IL-12/IFN-gamma circuit.