New Treatment for Neuroendocrine Tumors

Neuroendocrine tumors (NETS) grow in hormonal glands in the lungs, stomach, pancreas, or gut. Some produce hormones that damage your digestive system or blood sugar. Lutathera treats NETS by slowing down or stopping tumor growth.
Find out more at: uvahealth.com/services/imagin...
Transcript
Matthew Reilly, MD:
One of the therapies that I use more commonly with neuroendocrine tumor patients is a class of therapies called peptide receptor radionucleotide therapy, or PRRT. Within that class, Lutathera, which is also known as lutetium 177 Lu DOTA-TATE, is an approved therapy approved in 2018 for patients with well differentiated metastatic neuroendocrine tumors.
Jeri Pugh, RN:
PRRT is used specifically for neuroendocrine cancer, also known as carcinoide cancer. And what that is is that is a cancer that develops cells in your body called neuroendocrine cells, which create hormones in the body. Essentially, it is a medication that's been specifically designed to bind to target sites on tumors, peptide receptors. And then the medication enters those cells and releases radiation over time, which then kills those tumors.
Lale Kostakoglu Shields, MD, MPH:
It gets internalized into the tumor, and allows this radiation to cause damage to tumor cell with an ultimate goal of a tumor shrinkage, control, progression. So it's a relatively highly safe treatment and effective treatment in disease control.
Matthew Reilly:
About one in five patients will see more of a response with tumor shrinkage. But for the most part, what we see is significant benefit in terms of stopping the tumor from growing, for what can be years, and overall benefit in survival.
Jeri Pugh:
So it also really improves their quality of life, as well as reduces the risk of that progressing. It turns an active progressing growing disease into more of a chronic stable disease state.
Lale Kostakoglu Shields:
Altogether, it's an eight month treatment. It consists of four cycles, separated approximately two months from one another. Patient arrives at Nuclear Medicine early in the morning. And it takes usually five hours to complete the treatment. So it's a full day out-patient treatment for each cycle.
Jeri Pugh:
The treatment itself is provided in Nuclear Medicine Clinic. So with the Nuclear Medicine radiologist, also our outstanding team of certified Nuclear Medicine technologists who actually handle the radioactive medication and provide the imaging.
Matthew Reilly:
When I take care of patients with neuroendocrine tumors, what we're often talking about is that this, unlike some cancers where we're very aggressively approaching patients with chemotherapy, we're really taking more of a longer game approach where we want to control the tumor and keep them doing well for ideally years to come.

[@latasha3472]

This will be my second round of this treatment. I was stable for two years after my first round

[@peruthbiryabarema981]

Where are you found how can some one in Rwanda found you to help them

[@0Deirdre]

If you were diagnosed with 2 x 16mm lung nodules and operated 7 months later, would you still have need for treatment if you still had carcinoid syndrome symptoms or would the removal of the grade 2 have negated the need for anything other than standard follow up?

[@monicark2030]

Thank you for the information, I have NET in my stomach,my state is indolent, but Oncolgy say there's no chemo for it, or radiotherapy

[@manlingz8784]

How are you going rn?

[@monicark2030]

@@manlingz8784 I am experiencing low stomach digestion, my stomach hurts a lot, I got an endoscopy scheduled for July, after it I need to make a new exam, in order to check how slowly my stomach empties, as eating my meals gives me pain, due to Atrophic gastritis

[@63demeter]

Since one year and half, my wife is enduring a NET of the lung (LCNEC) 30% mixed with ADK 70%, class pT3N2M0 therefore grade IIIB, which was treated first by surgery and chemotherapy with Cisplatine and navelbine (3 treatments). Three months later recurrence of the tumor (NE cells) treated by radiotherapy (32 sessions) and Carboplatine plus epotoside (4 treatments): good results at the first month of monitoring, but two months later the PET-scan shows again lymph-nodes on the other side of the mediastin (right side). What can we do? Her oncologist propose the same drugs plus immunotherapy for 6 treatments and follow-up. What could be the other possibilities of treatment I could submit, to her pratician?
Thank you for your advice.

[@yorselrus1996]

Someone help this man. I'm praying for your wife and you. I hope everything is getting better

[@creativecreationsclub7972]

I need this assp for my mom. What can I do?

[@marijanakomatinovic4236]

Same case with my mom. Have you found any information or made any progress on treatments for your mom?

[@creativecreationsclub7972]

@@marijanakomatinovic4236 She died 2 weeks ago😭

[@marijanakomatinovic4236]

@@creativecreationsclub7972 I am really sorry to hear this. I hope you have good people around to support you. Take care of yourself for your mom.

[@creativecreationsclub7972]

@@marijanakomatinovic4236 Thank you.

[@kathygillman5450]

Creativecreatioms I am so sorry! I have stage 3 4 of the same and am not getting txment like above either. Prayers for healing your heart!

[@bettina_s]

I need this for my mother but the damn Oncologist does not want to give it to her, that doctor is a psycho, im gonna report her if she won't write a referral for nuclear medicine clinic.

[@yorselrus1996]

I pray your mother get the necessary care to defeat this. My 48 y/o wife living with Lupus was just diagnosed for this a few hours ago. I can't stop crying. I can't imagine life without her. I'm more concerned with how much the grand babies love her and it's terrifying thinking about it.