Anxiety Relief: Reduces Stress with St. John's Wort- Thomas DeLauer
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- čas přidán 19. 02. 2017
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St. John’s Wort is also known as hypericum perforatum. It is a flowering plant that has been used for thousands of years as a medicinal herb. Key uses are as an antidepressant and an anti-inflammatory. Widely used around the world today for mild to moderate depression. There are many studies that support the use of SJW for these purposes, however understanding exactly how it is working is still under way today. SJW has been shown to help reduce biomarkers of stress, which ties into both depression and inflammation.
Depression and Stress: Chronic stress can lead to depression symptoms, including anxiety, fatigue, sleeping trouble and loss of appetite. It is also known to lead to cognitive impairment, harming memory ability and mental functioning. There are many ways that SJW has been shown to help reduce depression. Below are just a few of the ways the SJW is able to help reduce biomarkers of stress. Depression is thought to be caused by an interruption in brain neurochemistry, particularly from a deficiency of neurotransmitters, including acetylcholine, serotonin, dopamine and norepinephrine. SJO increases the availability of serotonin, dopamine and norepinephrine in the brain. These help to improve your mood, reducing symptoms of depression. Hypericin and hyperforin are thought to be two of the most important components of SJW that reduce depression symptoms.
Hypericin stimulate capillary blood flow and inhibit the enzymes MAO-A and MAO-B. These enzymes are involved in the degradation of the neurotransmitters listed above. It also helps to regulate dopamine levels and action potentials caused by neurotransmitters. Hyperforin is a reuptake inhibitor, making it so neurotransmitters such as serotonin and dopamine are able to create a greater response. This reuptake inhibition does not work the same way that traditional antidepressants work. Rather than blocking 5-HT receptors, SJW results in increased concentrations of sodium and calcium. By making it so that the gradient between the neuron and the synaptic cleft is lesser, reuptake of monoamine neurotransmitters is decreased. It also increases the number of 5-HT receptors, showing possible long-term therapeutic benefit to supplementation. Chronic stress causes interruption of the hypothalamo-pituitary-adrenal (HPA) axis, leading to an overproduction of glucocorticosteroids.
St. John’s Wort has been shown to inhibit genes critical to chronic inflammation. These include the pro-inflammatory cyclooxygenase-2, inducible nitric oxide synthase and interleukin-6. Nitric oxide (NO) synthase is an enzyme that catalyzes the creation of nitric oxide from L-arginine. In areas with inflammation, large quantities of NO exist. In healthy amounts this leads to the removal of organisms causing the inflammation. However, these can become toxic over time, such as with chronic inflammation. Prolonged high concentrations of nitric oxide can lead to tissue damage.
In one study it was found that the reduction of inducible nitric-oxide synthase was due to transcriptional inhibition.This study showed that the supplementation of SJW could help to treat chronic inflammatory conditions, such as chronic stress.
How Much to Take: For those with depression an initial dose would be 300 mg three times daily. Following this initial dose, most will decrease to 300 to 600 mg daily. St. John’s Wort can interfere with a number of different medications, including but not limited to birth control pills, antidepressants and blood thinners, so be sure to talk to your doctor if you are currently on any medications.
References:
1. Mechanism of St. John’s Wort extract...
www.academia.edu/25991149/Mech...
2. Anti-inflammatory actions of St. John’s Wort….
www.ncbi.nlm.nih.gov/pubmed/1...
3. St. John’s Wort’s cortisol reducing effect on the brain..
www.greenmedinfo.com/article/s...
4. Chapter 11: Medical Attributes of St. John’s Wort
www.ncbi.nlm.nih.gov/books/NB...
5. St. John’s Wort may relieve negative effects of stress on spatial working memory…
www.ncbi.nlm.nih.gov/pubmed/2...
Thank you, no wonder I felt so much better when I was taking St John's Wort everyday! I actually felt like I could focus better mentally which is typically challenging for me.
My health has gone downhill greatly over the last 10 years from stress. About 3 years ago it caused my heart to completely stop and now I have a pacemaker keeping me alive. I have been put on blood pressure medication and then taken off of it, then anti-anxiety medication and taken off of it, and now my 5 cardiologists are simply puzzled. I have taken specialized tests, to find out why I have bradycardia and tachycardia and heart failure. I am now left to believe that it has something to do with what this video is talking about.
Some of my specialists have said that I am constantly in a fight or flight mode. My body over produces adrenaline for no reason. My resting heart rate is typically 90 beats per minute. My pacemaker constantly records all of my heart activity, each time I go have it checked, I find that my heart stops beating on its own around three thousand times per month. No that's not a typo.
I feel as though I am left to figure this out on my own, because it has been a developing problem for so long. I no longer take any prescription medicine. But I would like to try some natural stuff. I quit my full-time job, and took a less stressful part time job, because it was literally killing me. I am starting a regimen of St John's Wort combined with some other goodies, and maybe I will live to see 50.
In short, stress can kill you. I was declared dead on 11 different ER visits, until I got suited with a pacemaker. And that was before I was 40 years old. I'm a non-smoker, and I used to walk or hike 5 to 7 miles a day, etc.
Don't live to work, turn it around and stop to smell the daisies - or you will be pushing them up.
Alex McCarthy st.johns wort,for me works as effective as Valium,maybe even better,the other herb you should try though in a tincture is hawthorn berry,it works wonders for your problem and drink cayenne pepper 1 tsp in hot water 3 times a day,it's called food for the heart
@ROTTEN POLITICIANS Did you try It?
@Shlomo Shekelberg Eliminate wheat, dairy and sugar. Read the book, Wheat Belly.
Hey Alex thanks for your personal experiences I hope you are well and the doctors saying your body’s in a fight or flight state constantly I feel the same stay well Alex
Have you tried Ashwagandha and other adaptogens for stress and anxiety?
Great video, thanks Thomas. I just recently started taking St. John’s Wort and it’s changed my life almost immediately. I was diagnosed with ADD as a child and I’ve found that I was often too depressed to finish things, or to just do things in general. But now it’s like my mood are way better and because of that I’m not afraid or put off of going about a task like tiding, interacting with the people sharing where I live etc, which were real problems. Now I just do it. I suffered from SAD as well but now it doesn’t seem to effect me anymore.
this is best video on youtube explaining how st johns wort work..and how ssri medications work...thanks a lot
Hey Thomas! Would be really interesting if you did a video that explains how neurotransmitters are made in the body, the different steps going from amino acids to neurotransmitters and the components needed to make the process! Have a good one and take care!!
Thank you Thomas, your videos are incredibly helpful and well presented.
Thanks taking this instead of the medication the therapist was going to prescribe. Thank you so much!
Thank you for sharing your knowledge.
I would also like to see more videos on stress, my wife seems to let or have stress build up and affect her. Great video
fantastic video I have been using St. John's Work for a week now and I am already feeling much better. I started to fill better after I took my pill, I felt like a cloud had been lifted from. Thank you for sharing .
Do you take the tablet in the morning or in the evening. Thanks
Really? Where can I buy it online as I am not in the States? Thanks
Sue Guerrieri did you really feel a difference right after taken it?- I'm an addict, 3 days sober but the mental battle is over powering so any response will do.
You Igit I have taken it and then stopped. And then just yesterday bought it and have already noticed a difference. The mental battle is hard for sure. Try this. At Walmart for less than $5 - hope your battle gets easier.
@@saraahm5605 Amazon
Thomas thank you for this comprehensive outlook on this amazing herb! Now I know how and why it helps by keeping the neurotransmitters sticking around. Thank you!
Awesome video! Awesome dude! In my next incarnation I want to look just like you, Thomas! Thanks for sharing your great wisdom and personality!
This vid is super comprehensive solid delivery my guy!!🔥💪
Thank you Thomas
One of your best videos
Im about to see a doctor and your video has really helped me understand what could be going on for me - thanks
Thanks for being factual and positive about st. John's warts. 🙂😘
can you do a video on mental toughness and emotional resilience?? the best way to interact with stress thank you .
Damn good explanation and delivery. One video watched and subscribing 👍🏽
excellent. a friend needs this
you are awesome man! thanks
thank you thank you thank you !
Very good video!
Wow! Great information.
Thomas you are awesome, I am suffering from low mood and anxiety during menopause and feel stressed from the symptoms, I am going to give St Johns Wort a try and update you on the result
Did it help?
great info!
Nice video! Thanks!
Works for me.
Thank you sooo soo much coz you are really educating us.
Would you please complete with the stress topic and break down the relationship between adrenal fatigue, the ceruloplasmin and the copper levels ( copper toxicity) . And the relationship between copper and iron.
I appreciate that you write your video in the description box .
Awesome 👏
This video is excellent and so well executed. The information you provided is thorough and sound. I always like to know the reasons behind why herbs work & this information provided just that for St. John’s Worth. Thank you!
I was taking st johns wort for 2 months and I thought it wasnt working that much then I stopped and I feel horrible now. Just ordered some more because after watching many videos e read some researches I find out it actually works but is not gonna make you feel super euphoric and happy, will just make you feel ok in your daily life. I will start taking again as soon as it arrives
How are you now?
Any exercise advice? You're in good shape.
So St. Johns will help keep my serotonin, dopamine and norepinephrine levels up?
Yes but they will keep accumulating be VERY CAREFUL!!
I am buying a bottle tomorrow morning!!!! 💯
love this video. Is it OK to take st Johns wort with iron supplements and vitamin c?
nice thanks man
Thanks for the great video! I combine St. John's Wort (nourishes the nervous system) with Skullcap (relaxes he nerves), it's a great combination.
brilliant Miguel well done 👍,do you find the st John's wort is stimulating moreso?I've never taken it myself.thank you
@miguel horth Doses of both?? You still take both?
Great video explaining stress/depression connection. Please make a video on how to deal with adrenal burnout.
Very nice video
Can you do a video on Amino Acids & Interment Fasting! Does Aminos Affect The Fasting Stage?!
great vid, but have to say just looking at him made me feel better
adam last Look at girls bro. You are a guy.
St Johns works amazingly well
But some research shows it affect ur eyes in sunlight . Do you have some issues with ur eyes ?
I would like you to expand on dosage and minimum / maximum period if any that the supplement should be taken.
Current research shows that St. John’s wort (Hypericum perforatum) is not a strong MAO inhibitor.The antidepressant activity of the herb was initially hypothesized to be due to MAO inhibition, but further research has shown that neither St. John’s wort extracts nor their key chemical compounds are significant MAOIs.
Tons of research that shows St. John's Wort is very effective as well
Great video I was on the fence about purchasing St John's Wort
Now I'm gonna try it out ...also question can st. John's Wort be taken with other Nootropics like Aricetam?
Thomas, what brand of St. John's Wort do you recommend?
Any chance of a video on cleansing products that dont contain parabutens? Rolls ons and soap etc
This video is very informative. Most brands of St John's Wort does not have 5% hyperforin. Where can I purchase a quality and safe brand with the 5%?
I think stress has been a large part of me being overweight and not food
How often should I use it and for how long?
can you do a video on niacin
I come from a long line of stress, anxiety, and depression in my family. Could you do a video on how much a part heridity plays in these maladies?
I think it simply the family stresses each other out by passing along the wrong ways to deal with stress. I know for my family noone deals with their stress they pass it onto someone else and manipulate each other into helping. Everyone plays the victim.
Speaking as someone who has a BA in psychology and who comes from a family with a strong history of mental illnesses, family genetics are not as big of a factor as the learned behaviors and environmental factors. Sure, you can be more susceptible because of your biology, but the triggers come from outside you. The most effective treatments for depression and anxiety are therapeutic interventions and changing your environment.
Mines heritary my dad was the same suffered with really bad nerves they called it then . He was on diazapan for years back in the 70s . I'm now the same but they won't give me diazapan even to take now and again and zoloft was horrendous.
You should do organic tart cherry next
Very informative, also seems to have a lot of benefits. Also do you know how long you should take St John's wort? And it have any side effects?
You need to take it for at least a couple of weeks(2-4) to see an effect. When you begin taking it you can feel anxious, headaches, dizzy, diahrrea, stuff like that. It also makes the skin more sensitive for sunlight so be careful with your sun exposure. Also DO NOT combine with a synthetic ssri! You'll get serotonin syndrome which can be deadly.
I have a pituitary tumor in my brain which causes high prolactin and high cortisol. I have daily anxiety attacks. I can barely ride in a car. I want to try this but I’m scared this might make me worse because of my high hormone levels. 🤔
Love this video and all the great information in it. I know that I have inflammation in my body and I suffer from MDD-Major Depressive Disorder, along with being hypothyroid and have a hormone imbalance, and as a result my body is in constant fight or flight and I have gained 40 lbs out of nowhere and cannot lose it. However, I would love to stop taking my anti depressant and use something like St. John's Wort. I'm just wondering if it's something I could start taking while I'm weaning myself off of my anti depressant?
SUZIJ5 I think St.Johns wort would definitely nudge in the right direction out of medication, but I would rely solely on it.
DO NOT TAKE ST JOHNS WORT WITH SYNTHETIC SSRI'S! That will cause serotonin syndrome, which can be deadly!
What about a video on auto-immune diseases? Like AS or RA. With these diseases there is obviously a lot of inflammation ,and is there a way to reverse this? Instead of taking TNFs? I am sure stress and an unhealthy gut could cause these diseases?
Matt, you are probably never going to read this but if you do, please keep talking about St-Johns wort and the capillaries, blood flow, sodium and calcium and the brain. I think this is my issue.
In addition to the photosensitivity I've heard there can be an effect on the eyes if used over the long-term?
I have a avm on my brain had a stroke 5 years ago age 30 , will st John's wort be ok to use with avm?
What are the contra indications for St John’s Wart ? I am taking some medicine for my heart . Also, I heard something about calcium, iron and magnesium.
I have just started taking 600mg and hope it will help ! I was awake since 4am this morning !!!
Another thing what brand do you recommended? Natures valley? And can anytake this that just wants to feel better all around? How long does it take to work
2 to 4 weeks. Just know that you're taking a natural ssri, so ask yourself if you need it.
I like your information what did you study?
Can someone with bipolar II take this? I stopped all the prescriptions meds due to side effects.
I combine it with a soluble vitamin complex and quality omega 3 and two pills instead of one. If I don't do all this I am tortured by severe hypochondriac anxiety attacks. With this remedy, I can at least have a more or less normal life, although the anxiety is still there but mildly. Taking antidepressants meant help but at the same time battling all kind of side effects like weight gain, constipation, restless legs etc..
Great video, but what about St. Jihn's Wort and men's libido?
They Thomas! I was hoping you'd have some insight into Heart Palpitations and what could possibly be a factor with those, if not connected with heart disease. I'm 27, very healthy and work out regularly but I've been dealing with palpitations for 5+ years. I'm currently seeing a cardiologist and have been doing tests. So far, everything looks great. Strong healthy heart but I still get these moments where my heart seems to "hiccup" in my chest. Mostly after a workout, or at night/morning when I'm most relaxed. If you could, I'd love for you to make a video targeting some of the causes as to why a young, healthy person could be experiencing this. I'm now taking magnesium and vitamin D supplements (found out I was very low in vitamin D) and I'm working on my anxiety but I still get them every now and then and I know a LOOOOT of people my age do too. It would be incredibly helpful and inspiring to get your take on the subject for a lot of us who experience this.
Kelly Vawter stop taking any pre-workout supplements that might help..
Kelly Vawter cut caffeine and all sugar
I was 25 when I started with palpitations, I've been on medication for almost 20 years!
Magnesium works for heart palpitations.
I also get heart palpitations from St johns wort...worth investigating
Is it safe for people who have had alcohol problems and potentially have damaged gaba and seratonin receptors etc?
Idk.. st john s wort or 5htp? Which to try? Which is better?
I take Bisoprolol -,25 g for my heart rate. It flutters .
Also a décontractant muscular for my back - it’s has magnesium, vit B, copper , selenium and potassium .
I’ve heard and read that you shouldn’t take these while being on birth control! I’m currently taking these whilst being on the pill! Do you think this will effect me much as in it will reduce the effectiveness of the pill? At the moment i choose to be on birth control and also I choose to be take St.John wort as they do help me a lot due to anxiety and stress and feeling down! These tablets help me a lot! Is anyone else taking these whilst being on the pill? If so, would you say it effects being on the pill much? Has it increased the risk of you getting pregnant?
I bought some with dandelion extract it helps if it has dandelion which is for acute depression and mood.
Thank you for sharing this.❤
what brand of it should i use... where can i buy it
I occassionally take Rizatriptan for migraine . Can i take st johns wort as long as i dont take migraine medicine often ?
Is it ok to take with someone with Adrenal exhaustion? I have low cortisol for most of the day
I wonder the same. Did you try it?
I think it's the HPA Axis, not Access
Is it normal to feel exhausted, shaky and anxious when your first start taking it?
It can increase anxiety in some cases, as well as boost your hear rate.
don,t take high doses i take 140 once daily
Hi i also would like to try st johns wort yet I heard a side effect of possibly developing cataracts...?
That's a load of BS🤦🏻♂️
What can you say about melatonin?
How to know if you have adrenal fatigue? I feel like shit and unproductive. I used to drink something with caffeine in it daily and now am taking a break.. already 7 days without caffeine. Can i just take st johns wort and see if it works?
There is no test for adrenal fatigue man.
How do you prevent drowsiness while taking st John's wort? Would it be advisable to take it before bedtime? Is 600 mg enough for low mood?
Do you still have questions
@@brendfan do you have answers for those questions? They still appear to be there. I will be looking out for your answers.
@@Chak17 I drink caffeine during the day. I personally take the last one mid afternoon. I use 900 mg
@@brendfan thank you for your reply. Does SJW really work for you - it is so confusing: so many seem to swear by it and so many say the contrary. At the end of the day I suppose it is if you believe and have faith that it will work and you thereby give it the power to do so. Indeed that is the placebo phenomenon. I really would like to use something natural without the side effects and withdrawal issues. So really just wondering about your experience and hoping it might help me to navigate mine. Thank you
@@Chak17 it is definitely not placebo, it just takes a few weeks to start working fully so you have to be patient. At the end of the day the side effects are minimal so what do you have to lose trying it out . I would buy some and then report back in 8 weeks even though I felt differences much earlier than the eight week mark
So where do you find this St. John's Wort. Is it a over the counter sort of vitamin?
Depends on where you are, different countries regulate it differently. My best bet would be to check online
If you live in the USA, Walmart and your local pharmacy like cvs and Walgreens will have it in the supplements aisle
Health food stores and pharmacies in U.K.
Vitamin? It's not a vitamin 🤦🏻♂️
@@jcbanbury health food stores carry it. It is considered a supplement.
So if it makes neurons activate that normally aren't activated I can imagine that some feelings/thoughts/experiences come into conciousness that might have been unprovoked for a long time?Could lead to positive and negative consequences for you mood and mental
wellbeing I guess.
What about long term use
I had a nurse tell me to quit taking St. John's wort that it would kill my kidneys that sam e how right is this.
Barbara VunCannon Ask her to back up with a sources.
I started taking it 2 months back due to PMS depression..and I feel so much better..and instead of taking serotonin I thought this is a better option.My question is how long can one have it ? Does it have any side effects besides interacting with some medication.
did you tried antidepressants first or you directly started SJW...has it any side effects and after how long it begin to start working for you?how much you were taking it?
@@ahmedfraz8324 I used to be on antidepressants. Trust me that should be your last resort try st John's wort first. Just be patient though . I did notice results pretty quickly but nothing significant for about four weeks
@@ahmedfraz8324 if you have any other questions just reply and I'll be glad to answer with my anecdotal experiences
@@brendfanHi , how are y now? Do y continue taking SJW? Is it functioning? Do y recommend?
@@gmc202 I'm doing great and I recommend trying it just give it a few weeks to start working
So if I started consuming St. John's Wort to relief anxiety, would it be more of a preventative measure? Like, I'm taking this now so I'd be less likely to experience anxiety later? Or could this be something I can take while experiencing an anxiety attack to help calm down? Like, I'm having anxiety right now, I'm going to take this to calm down.
Qamon23 it takes tow months to kick in
Any concern with taking St Johns Wart and Holy Basil together?
Both are brilliant. Take St. John's Wort in the morning and Holy Basil in the evening. I've been taking both with no problems.
Wait but sodium and calcium in high doses are linked to kidney stones , if I'm correct I those are the 2 components that make up kidney stones
Is there a withdrawal from it
You look like Nathan from uncharted 4 lol
You should mention that those using anticoagulants should never use SJW. This goes for warfarin, Xeralto, Rivaxored, etc etc. It will negatively impact the efficacy of the anticoagulant.
You really shouldn’t take SJW if you’re taking any medication you rely on. It decreases the effectiveness of so many medications due to it’s action in the liver
STW can be additionally suplemented together with 5-HTP and Tyrosine to increase its effects
Not with 5htp cause of seretonin syndrome
Extremely dangerous combination. Do NOT take 5-htp while taking SJW, as you greatly increase your risk for serotonin syndrome.
😢 this is me
If im going to drink a beer. Do you not take any st johns wort that day? Due to the serotonin already raised by beer.
400th like!
can you take Lexapro and saint john wort together
Not a good idea from what I'm reading
Grayson Guice NO supplements with any SSRI’s.
No don't do that
"Seratonin" ?
Can someone answer my questions on this? pleaseee