husbands new birthday 12/12/19 cart-t at UCLA west la CT/Pet 2 times NO CANCER find. Dr Larson & great stuff she created new life for my husband, THANK YOU !!
Im suffer suffering from this Horrible disease, and CAR T CELL THERAPY AND IMMUNE THERAPY are amazing options. I live in NORTHERN CALIFORNIA (SACRAMENTO). Besides UCLA, are there any other Trial, Hospital, or Clinic that will do it treatment. I need this treatment ASAP!.
i am an oncology nurse, it is amazing scientific treatment. 10 years back, i never thought about this kind of Tx, now i can image all kind of cancer can be treated without suffering for the future.
My dad battled stage 4 lymphoma for a year with aggressive chemos, 2 days prior to do his CAR T cell therapy he caught Covid, which he battled for months to get approval in the end he couldn’t undergo the therapy with Covid, in 2 weeks when he almost beat Covid, the tumor in his brain was too far advanced RIP 2/24/22 😔 He was so close, all because my coworker was forced to work with Covid which gave it to me, he knew my situation and to give a me heads up about positives, my boss didn’t give a dam and didn’t tell me til 2 days later 😔
Amazing, I haven’t watched anything so interested and at the same time understanding very little of it, since it is at such a high medical language. Go on with this amazing work there are people who really need this! You are heroes.
@@jordanwelty6582 Apologies for any unintentional or undue slight to the great nation of Israel. Please note my salute to Gideon Gross and Zelig Eshar at the Weizmann Institute of Israel, for developing first generation CAR-Ts. 🙂
There are several tips for treating incontinence at home Try Kegel exercises- which involve flexing the same muscles you use to stop the urinary flow. Consider using losing weight if you are overweight excess belly fat puts pressure on the bladder and the pelvic muscles. Shedding a few pounds if you are overweight can help restore your bladder control. See if you can train your bladder - put off going to bathroom. Try to delay urinating by 10 minutes and build up to 20 minutes etc. Try magnesium and vitamin D Use Quiting smoking. Nicotine can irritate the bladder. (I read these and why they work on Nilah control plan site )
Great video. Quick question. Why can’t we get better simulating treatment and measure the possibility of resistance of the patients cancer in vitro. That way you could know ahead of time what patients would get resistant and which would respond.
Sami Khal can you tell where you started treatment ? My son is starting at the National Cancer Institution at Bethesda Maryland. Looking into other Cancer centers for best results. Thank you
Im suffer suffering from this Horrible Disease, and CAR T CELL THERAPY AND IMMUNE THERAPY are amazing options. I live in NORTHERN CALIFORNIA (SACRAMENTO). Besides UCLA, are there any other Trial, Hospital, or Clinic that will do it treatment. I need this treatment ASAP!. Thxs.
planestrainsandautomobile Our son 33 yrs old with a very rare cancer found help Sarah Canon Cancer Center in Nashville Tennessee after NCI was not able to except him in their trials CAR T CELL Trial . I hope you will research them and wish you all the hope and perseverance it takes to battle cancer 🙏
@@emilyhunt2129 - I wish you well, also. What is Troubling is that most of all these Hospitals and Clinics want you to go through all these other weaker Drugs and fail those before they will consider you for CAR T CELL OR IMMUNE THERAPY. Very UNFAIR!
Kind of confused, at 4:45 you show an Ig (clearly with the forked Hc and Lc) but unlike most B-cell membrane bound IgM's this one has a CD28 and CD3-zeta chain domain (features commonly found in T-cells (not B-cells)). Why is that?
Does anyone know, how does the car T cells specifically target only cancer cells? How do they avoid killing normal tissue? For example with breast cancer, how does it target cancerous cells while leaving normal breast tissue alone?
The CART cells only bind to cells that has either CD19 or CD22 protein receptors in their cellular membrane. Only particular cancer cells and the B cells have this protein receptors, therefor CAR T cells only binds to those leaving normal tissues alone.
@@joeamrine7450 No worries dear! No, I am still a student at the moment, I am getting a specialty in the field of genetic engineering and have a keen interest in gene therapy as such as CAR T cells. If you feel like I can help you, I’d be happy to provide you some information or insights.
Have any clinical trials been conducted with CAR-T cells targeting solid tumours such as Osteosarcoma? My son was diagnosed with Osteosarcoma in June 2018, and since then he has had limb salvage surgery & multiple rounds of aggressive pre- and post-surgery chemotherapy. Sadly he has had a few relapses since his treatment finished earlier this year, and his recent PET scan in November 2019 has detected multiple tumours throughout his body, including in his lungs. He is now back on chemotherapy, and we are now resigned to the fact that the chemotherapy is just a short term solution. We have read up on CAR-T cell immunotherapy, which seems to be quite effective, and would be very grateful if you could advise whether this may be an option in treating our son's diagnosis. If not, are you aware of any other treatments available? Thanking you very much in advance.
@@emilyhunt2129 Only on clinical trials. Texas Children's Cancer Hospital is offering anti-GD2 CAR combined with Interkeukin-7 in a phase-1 trial. Also, University of Texas MD Anderson is offering 'Allogeneic natural killer cells', also in a phase-1 trial.
@@blackhawkedu1 There are some biomarkers that can, in certain cases, be bloodborne. This isn't the majority of cases though and they aren't in high concentrations until later stages typically, making it hard to detect unless pancreatic cancer is suspected from the get go
husbands new birthday 12/12/19 cart-t at UCLA west la
CT/Pet 2 times NO CANCER find.
Dr Larson & great stuff
she created new life for my husband, THANK YOU !!
Im suffer suffering from this Horrible disease, and CAR T CELL THERAPY AND IMMUNE THERAPY are amazing options. I live in NORTHERN CALIFORNIA (SACRAMENTO). Besides UCLA, are there any other Trial, Hospital, or Clinic that will do it treatment. I need this treatment ASAP!.
i am an oncology nurse, it is amazing scientific treatment. 10 years back, i never thought about this kind of Tx, now i can image all kind of cancer can be treated without suffering for the future.
Very clear and informational talk!
My dad battled stage 4 lymphoma for a year with aggressive chemos, 2 days prior to do his CAR T cell therapy he caught Covid, which he battled for months to get approval in the end he couldn’t undergo the therapy with Covid, in 2 weeks when he almost beat Covid, the tumor in his brain was too far advanced RIP 2/24/22 😔
He was so close, all because my coworker was forced to work with Covid which gave it to me, he knew my situation and to give a me heads up about positives, my boss didn’t give a dam and didn’t tell me til 2 days later 😔
Excellent Presntation ! thank you from Egypt
Amazing, I haven’t watched anything so interested and at the same time understanding very little of it, since it is at such a high medical language. Go on with this amazing work there are people who really need this! You are heroes.
Thank you for all Sarah Larson.
Excellent presentation! Thank you so much for all of your hard work!!!
Excellent lecture
Thank you for a clear and concise presentation
You're all unsung heros! Dr. Larson, this presentation is amazing! Thank you!
Well Israel as they discovered and developed this therapy.. but yes its wonderful
@@jordanwelty6582 Apologies for any unintentional or undue slight to the great nation of Israel. Please note my salute to Gideon Gross and Zelig Eshar at the Weizmann Institute of Israel, for developing first generation CAR-Ts. 🙂
They're not Heroes you see how much they charge you for that
@@jordanwelty6582It was Japan, not Israel who discover the CAR T therapy.
@@payaltrivedi5914it was discovered by Japan
Is this recommended for HPV 16 & 18 Head & Neck cancer, which is not a blood type cancer like leukemia and lymphoma
There are several tips for treating incontinence at home
Try Kegel exercises- which involve flexing the same muscles you use to stop the urinary flow.
Consider using losing weight if you are overweight excess belly fat puts pressure on the bladder and the pelvic muscles. Shedding a few pounds if you are overweight can help restore your bladder control.
See if you can train your bladder - put off going to bathroom. Try to delay urinating by 10 minutes and build up to 20 minutes etc.
Try magnesium and vitamin D
Use Quiting smoking. Nicotine can irritate the bladder.
(I read these and why they work on Nilah control plan site )
awsome presentation!
Great video. Quick question. Why can’t we get better simulating treatment and measure the possibility of resistance of the patients cancer in vitro. That way you could know ahead of time what patients would get resistant and which would respond.
Thank you for the info. Very well done.
Using a retrovirus as a vector is genius.
Are any facilities doing this in Oklahoma.
I'm starting CAR-T for CLL 11/20/19
Best of luck
Where are doing it
Hello Sami where are you starting it. We are looking for places for my father...
thanks in advance
Sami Khal can you tell where you started treatment ? My son is starting at the National Cancer Institution at Bethesda Maryland. Looking into other Cancer centers for best results. Thank you
How exciting! Great work, thank you so much for sharing with us
Outstanding......👍
Im suffer suffering from this Horrible Disease, and CAR T CELL THERAPY AND IMMUNE THERAPY are amazing options. I live in NORTHERN CALIFORNIA (SACRAMENTO). Besides UCLA, are there any other Trial, Hospital, or Clinic that will do it treatment. I need this treatment ASAP!. Thxs.
planestrainsandautomobile Our son 33 yrs old with a very rare cancer found help Sarah Canon Cancer Center in Nashville Tennessee after NCI was not able to except him in their trials CAR T CELL Trial . I hope you will research them and wish you all the hope and perseverance it takes to battle cancer 🙏
@@emilyhunt2129 - I wish you well, also. What is Troubling is that most of all these Hospitals and Clinics want you to go through all these other weaker Drugs and fail those before they will consider you for CAR T CELL OR IMMUNE THERAPY. Very UNFAIR!
can you explain how it response toCD13&CD 10
Does this work for bilineage leukemia aka mixed phenotype leukemia?
Can you get this therapy even if your cancer has spread to the bone marrow
very nice
Kind of confused, at 4:45 you show an Ig (clearly with the forked Hc and Lc) but unlike most B-cell membrane bound IgM's this one has a CD28 and CD3-zeta chain domain (features commonly found in T-cells (not B-cells)). Why is that?
great explanation 👌🏻🤩
Does anyone know, how does the car T cells specifically target only cancer cells? How do they avoid killing normal tissue? For example with breast cancer, how does it target cancerous cells while leaving normal breast tissue alone?
The CART cells only bind to cells that has either CD19 or CD22 protein receptors in their cellular membrane. Only particular cancer cells and the B cells have this protein receptors, therefor CAR T cells only binds to those leaving normal tissues alone.
@@inahwiththeh_ thank you! Can I ask do you work in this field? I have some ideas from a genetics perspective
@@joeamrine7450 No worries dear! No, I am still a student at the moment, I am getting a specialty in the field of genetic engineering and have a keen interest in gene therapy as such as CAR T cells. If you feel like I can help you, I’d be happy to provide you some information or insights.
Well done. Very informative
Have any clinical trials been conducted with CAR-T cells targeting solid tumours such as Osteosarcoma? My son was diagnosed with Osteosarcoma in June 2018, and since then he has had limb salvage surgery & multiple rounds of aggressive pre- and post-surgery chemotherapy. Sadly he has had a few relapses since his treatment finished earlier this year, and his recent PET scan in November 2019 has detected multiple tumours throughout his body, including in his lungs. He is now back on chemotherapy, and we are now resigned to the fact that the chemotherapy is just a short term solution. We have read up on CAR-T cell immunotherapy, which seems to be quite effective, and would be very grateful if you could advise whether this may be an option in treating our son's diagnosis. If not, are you aware of any other treatments available? Thanking you very much in advance.
Ritesh M Dadlani Have you found any help in finding CAR-T Cell treatment for your son?
@@emilyhunt2129 Only on clinical trials. Texas Children's Cancer Hospital is offering anti-GD2 CAR combined with Interkeukin-7 in a phase-1 trial. Also, University of Texas MD Anderson is offering 'Allogeneic natural killer cells', also in a phase-1 trial.
16:25 future targets and other cells ?
numbers are just unprecendented! I know the future of oncology is immunotherapy. Thank you for your job!
Can it cures completely carcinomas
а есть ссылка чтоб с переводом посмотреть?
Why is it so hard to fight pAncreatic cancer ?
Mostly because it is asymptomatic until stage III/IV. At this point the tumor impedes on the hepatic artery and it cannot be surgically removed.
@@emilefortier1688does a blood analysis can detect a pancreatic cancer?
@@blackhawkedu1 There are some biomarkers that can, in certain cases, be bloodborne. This isn't the majority of cases though and they aren't in high concentrations until later stages typically, making it hard to detect unless pancreatic cancer is suspected from the get go
22:18 Suicide gene (Safety off switch)
Its biriefullll
King 😚💋❤🙌
Wat about auto transplant
Regulatory T-cells are natures off-switch.
25
4:40
10:43
too bad such a hi tech explanation with out clear crisp audio.
23
What means 23?
8.01
19:18
So we just gonna act like this isnt the exact same thing that happened in the movie I AM LEGEND?
Corona virus
Fit
No
Z
.
CAR-T cells… is this a designer drug?
Hot doc.
Dude I love Sarah what’s ur number
6:08 Inactivated HIV (cannot replicate)
ok... serious question...... is she single? :D
Good question
Nope