Neuron resting potential mechanism | Nervous system physiology | NCLEX-RN | Khan Academy
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- čas přidán 6. 09. 2024
- Created by Matthew Barry Jensen.
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Neurons understanding how neurons work.
Neuron ko ye pehle se yaad q nahi q usko apna function nahi yaad q humy yaad karwana parh rha hai😢
I owe Khan academy my life tbh
Isn't the equilibrium potential for Potassium ~-90 mV, derived via Nernst equation?
This perfectly encompassed all the concepts I've been piecing together from lecture notes. No other videos that I could find touch on the specific details this thoroughly. Thank you!
Omg, thank you so much. I finally feel like I understand this concept. Thank you Khan Academy!
Nice explanation of how the electrochemical gradient is the combined diffusion and electrical gradient
Best explanation I have ever seen in my life ❤❤❤
Sir u r saying that 70 mV is the potential at which membrane will be in equilibrium but in our book it says that at this potential inside will be more negative than outside then how it is in equilibrium if inside is more negative for equilibrium negative positive ions should be equal in concentration
This is the best video on resting membrane potential- particularly because it explains the mechanism of Nernst potential for all types of ions. Thank you so much for this lucid explanation!
@5:40 ish, you said that 3 Na+ have left and only 2 K+ have entered, ergo, the net ion charge has dropped from 3+ to 2+, therefore, another K+ would have to enter the cell through the 'leak channels,' yet you are saying that a K+ will now leave the cell to equalise this supposed increase in K+ concentration....
Anyone else see the issues here?
the net ionic charge has dropped from 3+ to 2+ and apparently needs to drop to 1+ to equalise....as opposed to more Cl- coming in to equalise (if we are to conclude that the cell wants a 0 ion charge, we theoretically need 2 x Cl- to equalise our now 2 x K+.
How do we conclude the ionic charge that the cell requires for optimal functioning?
A brief hint may be that our hunter gatherer ancestors and even our ancestors of 200 years ago had, according to some sources, 300x more potassium in their diets, on average, than the average people of our modern world and simultaneously 300x less sodium.
A more conservative estimate is a 1:16 ratio of Sodium to Potassium as compared with todays' 1.36:1 ratio
optimisingnutrition.com/the-effect-of-minerals-on-hunger-and-satiety/
www.health.harvard.edu/heart-health/sodiumpotassium-ratio-important-for-health
Wow. Crystal clear concepts
if the sodium-potassium pump puts 2 potassium ions in and the potassium channels are roughly equal in potassium in and potassium out, what stops the neuron from becoming fuller and fuller of potassium so the membrane potential is constantly changing due the there always being 2 more and 2 more potassium ions being added?
oh boy, the way you say potassium.
oh boy, the way he say "dribbeling"
It's like the Na+/K+ ATPase is an electrolytic cell generating a separation of charges, and the leak channels are galvanic cells driving the free energy change back up to 0.
Curious about the dietary sodium intake of the people who's bodies they observed cells functioning this way was.
Guessing their sodium levels were through the roof
amazing video
How OA-s contribute to RMP if the membrane is not permeable to them ? let's say only OA-s exsit with gradient differnce in bothe sides. With a voltage meter can you measure the " -5mv" out?
What happen to RMP if intracellular potassium concentration reduce to the value of extracellular potassium concentration?
Good to a certain extent. I get so lost in the words though. It's really quite annoying. Like the video is annoying and this whole subject is annoying. How do we know all this stuff about neurons anyway???
😅
I think the relevant equation describing actions of electrochemical and chemical potentials is this:
ΔG = ΔG°′ + RT lnQ[Cin]^n/[Cout]^n + nZFΔΨ
the organic anions would not cause a membrane potential since the membrane is impermeable to them
The equilibrium potentials were incorrect. For K+ it is 90 Mv and for Na+ it is 62 mV.
For K+ it´s 80 to 85 mV
for K+ = 92 mV
Great video :D
... you're not Sal, he gets so damn excited! Its so good to listen too... but still made a good video...
I just think Sal should do them all hahahaha :D :P
Thanks a bundle :)) It was a lot helpful, this whole membrane potential topic had got me a bit (more than a bit I guess) confused, so thanks again.
There's a subtitle error in 8:42 in portuguese (Brazil). It says "potássio" instead of "sódio"
Erro de legenda.
This is great except for one wrong bit of data. The extracellular space ECS is exquisitely small. IT is 40nm-110nm across (20% of tissue volume). 20nm for synapses. This means that ECS Na+, Cl- and Ca2+ dynamical scarcity can play a role in action potential dynamics over certain timescales, depending on geometry and activity. The intracellular space is comparatively huge (80% of tissue volume).
Colin Hales Yeah but I guess Extracellular fluid is also quite dynamic and it's concentrations changing due to proximity with blood circulation. Maybe therefore it doesn't affect much to the ECS than neuron itself.
SNC doesn't have much extracellular matrix, so I agree. But in the peripheric nervous system he would be right due to the presence of endoneurium (connective tissue)
At 6:30 he said that no net movment is found, yet he said the action potential is -60mV !! How is this ??
I don't like how you say potassium.. Nevertheless, I learned a lot from this. Thanks!
Are the leak channels only for K+ to go through? Or can the other ions e.g. OA- go through as well?
OA- can't leave through the membrane. The leak channels only allow K+ and the other ions to permeate.
Thanks for the help! Well said :)
thanks a lot u saved me
Awesome
i did not understand anything :((
need help or late ?
need help or late (2)
Toshienla Longchar it’s too late, thank you 🙏🏻 😂❤️
@@reemal.3658 😂 yeah 3 years no kidding..not that I would've been able to help u either 😅
Toshienla Longchar 🤣🤣