Mechanism of Action of Salbutamol (MOA of Albuterol / Ventolin) | Mechanism of Action of Salbutamol

#salbutamol #mechanismofactionofsalbutamol #beta2agonist
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The mechanism of action of Salbutamol can be explained in the following five steps:
Salbutamol binds to beta-2 adrenergic receptors present in the smooth muscles of the airways.
This binding leads to the activation of the enzyme adenylate cyclase, which converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP).
Increased levels of cAMP activate protein kinase A (PKA), which in turn phosphorylates myosin light chain kinase (MLCK) and inhibits its activity.
As a result, the concentration of intracellular calcium decreases, leading to the relaxation of the smooth muscles of the airways and bronchodilation.
This relaxation of the airway smooth muscles increases the diameter of the airways and improves airflow to the lungs, providing relief from symptoms of bronchoconstriction such as wheezing, coughing, and shortness of breath.

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Drop comments of what more you want me to cover about this topic I will make a separate video for it

[@LALITMATHUR-xf2cb]

Good

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Thank you so much

[@vedantikasalunkhe5000]

Great explanation ☺️

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[@contentwordsmiths7818]

Good information 👏👏👏

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[@dsk8787]

Well done 🎉

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[@thesareexpress]

Very well explained ❤

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[@kakashi675]

which book is this explaination from ?

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Essentials of Pharmacology by Dr. KD Tripathi

[@hancemsokwa1813]

How does it affect potassium levels?

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It decreases the K levels in serum

[@user-qe5pz2dy9t]

@@learnmedicinebydr.nikitaso the potassium is going out of the smooth muscle cell or into the cell?