Pharmacological Actions of Prostaglandins, Prostacycline, Thromboxane & Leukotrienes (Autacoids - 7)

Pharmacological Actions of Prostaglandins, Prostacycline, Thromboxane & Leukotrienes (Autacoids - 7) by Dr. Shikha Parmar
The prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids having diverse hormone-like effects in animals. Prostaglandins have been found in almost every tissue in humans and other animals. They are derived enzymatically from the fatty acid arachidonic acid.
Prostaglandins are powerful locally acting vasodilators and inhibit the aggregation of blood platelets. Through their role in vasodilation, prostaglandins are also involved in inflammation. They are synthesized in the walls of blood vessels and serve the physiological function of preventing needless clot formation, as well as regulating the contraction of smooth muscle tissue. Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet aggregation. Their name comes from their role in clot formation (thrombosis).
Description Source: Wikipedia

[@shubhamkorades1707]

Best teacher of pharmacology with best notes....keep uploading mam we love your content

[@DrShikhaParmarClasses]

Thanks a lot for your motivating comments to do better.

[@vaseemunnisa4737]

​@@DrShikhaParmarClassesp 7:28

[@Coffeeeee230]

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[@DrShikhaParmarClasses]

Thank you very much Dear for liking the videos.

[@diptikashyap9532]

Nice lecture ma'am ❤❤

[@aadinarayanareddy4787]

❤ super

[@DrShikhaParmarClasses]

Thanks for liking

[@080prankurchaudhary9]

Mam why pge2 is bronchodilator ?

[@DrShikhaParmarClasses]

PGE2 is a physiological prostaglandin produced by activation of COX-1. It is a potent bronchodilator. It is a bronchodilator. We can’t question this.
Asthma may be caused due to an imbalance between bronchoconstrictors PGF2α, PGD2, TXA2, Leukotrienes AND bronchodilators PGE2, PGI2.
All these autacoids are produced on regular basis in our body and a balance exists between them.
Asthma arises when the balance is disturbed.
Like balance between sympathetic and parasympathetic regulated heart rate.
If parasympathetic starts dominating it causes bradycardia
If sympathetic stars dominating it causes tachycardia

[@080prankurchaudhary9]

@@DrShikhaParmarClasses thankyou so much mam❤️