Diabetes 6, Glucosuria, polyuria, thirst
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- čas přidán 2. 07. 2013
- Polyuria occurs as a result of an osmotic diuresis. This is a diuresis that occurs for osmotic reasons. Diuresis means an abnormally large volume of urine is produced. When the level of glucose in the blood increases there is an equivalent increase in the concentration of glucose in glomerular filtrate. The quantity of glucose the renal tubules are able to reabsorb is limited. In health, when blood glucose levels are normal, all of the glucose in the filtrate is reabsorbed; this means physiologically there is no glucose at all in urine. However, when glucose glomerular filtrate levels are abnormally high it cannot all be reabsorbed. This will result in glucose passing straight through the tubule into the urine.
Thank you so much Dr Campbell. Sincerely, a very stressed nursing student...
Im sorry you are put under stress in order to become a nurse.
+Dr. John Campbell It's ok, I get stressed out by exams in general. But they're over now and I passed them all which is what matters :)
Excellent, well done.
Thank you Dr. Campbell ,studying for a Nursing final and Diabetes/DKA is one of the concepts.Our instructors didn't do a good job explaining it.You have helped me grasp it in such a short amount of time!
thank you very much ! the best explanation i have heard last 7 years !
Holy crap. This was such a great and simple explanation! Thank you so much John, definitely subscribing.
Wish I was taught like this in my nursing days😔. Thank you very much sir! You are really a great 👨🏫! May God continue to bless you. India 🇮🇳
Thanks Doctor Campbell it was nicely explained… easy to understand !!!
Thank you Dr. Campbell!
Thank you. Makes a lot of sense to me and I'm a lay person. It really helps when you understand the whys. I've been low carb for 15 months and it only took 3 months to control my diabetes with diet alone.
Great explanation. Thanks.
Gah. Thank you. Taking a test in pharmacology for drugs in diabetes & I understood so much because of this. I really appreciate it. Like a LOT. You've got a new subscriber! (:
Dynamite video, thanks so much!
You made me happy to learn. Now I really understand. Thank you.
Thank you so much Sir for this video!
Excellent overview of glucosuria!
thanks doctor,,, god bless you !
Thank sooo much. 1st time i have been cleard the basic concept.thanks dr. John.
Hi Dr. Campbell. Thank you so much for this video. Polyuria is absolutely the #1, most prevalent sign of hyperglycemia in diabetes patients-- and there are no videos on The Internet about it (except, of course, yours).
I know you made this a long time ago, and you've moved on to focusing on Covid. But one thing is a little deceptive in your diagram. From my understanding, 90% of glucose is reabsorbed in the proximal convoluted tubule through SGLT 2 transporters, and the other 10% is reabsorbed through SGLT 1 transporters in the descending loop of Henle.
Nonetheless, a great explanation-- and a much needed one!
ITS GREAT LECTURE N MANY PEOPLES WILL BE BENEFITED. THANK YOU VERY MUCH DR. JOHN
Thankyou very much for your clear explanations Dr John Campbell. I am so grateful, for your detailed and understandable teaching, which is helping me with revision for my nursing degree.
thank you ..answered alot of questions that i had ,,,,,u are a master thanks from africa
Thank you!
Thank you for the explanation to grasp the concept of polyuria. Very helpful!!
U are great!
really helpful thanks
Thank you so much!!
Thank you so much! I now understand
thank you! this made it so easy
Thank you so much. You are a born teacher .
thank u so much doctor
Thanks Doc
Thank u so much sir
Brilliant
you are brilliant.. thank you so much!!!
Great video, very informative and helpful! Damn, 2.5 m subs!
plz explain the diff b/w Tm n renal threshold..
wow wow really thank you very much now its very easy for me
Can the ADH function properly when you have high bloodsugar? Since the glucose itself is an osmotic molecule, should'nt ADH be completely useless when suffering of diabetes type 2 and hyperglycemia?
*You Did Not Choose To Be Classified As Diabetic, But You Can Choose To Fight Back Against Diabetes* 💪
outstanding !! i really hope my lecturer was like you !
if that happends, maybe i will be smarter LOL
Well i just tested my urine with a normal blood glucose test strip which i use for my T1D which is usually for blood glucose testing i am not sure if it tests the same way as a usual urine tester but it shows as HI and my blood sugar was 10, but i have just a had a big chinies takeaway tonight so that could indicate that it has been very high before the insulin took effect, i am am going to wait until i am down to 5 mmol s and after two urination's see what it says at that point, but if it is high when i test it while it is 5mmols would that indicate?
I would just also like say that this was a very interesting and informative and very well presented video that was easy to listen to because it was clear and direct, thank you
If in any doubt, get your HbA1C checked
Good teaching
awesome
Hey Dr Campbell, I have a question regarding your video. Considering that the glomerular filtrate sees a low water potential due to the presence of glucose, does this mean that water from blood in surrounding capillaries of the tubules will enter the glomerular filtrate via osmosis?
The concentration of glucose in the filtrate will not be higher than the concentration in the blood, so there will not be a glucose induced osmotic gradient from the blood into the filtrate. However, the presence of glucose in the filtrate will reduce the volumes of water reabsorbed from the tubule back into the blood.
Dr. John Campbell can I know why it will reduce the amount of water that is reabsorbed
THANK YOU
The reason of glycosuria in diabetes is low threshold or defect in glucose absorption in pct ???
Sir isn't the glucose would reabsorb from PCT instead of loop of henle
Damn you are good
How do I heal from renal Glucosuria?? Thanks in advance
You need to lower the blood levels of glucose down to physiological levels.
@ ALALALALALALALA, anti-diuretic hormone has no function here. I think it only function to prevent diuresis when glucose is not involved. In DM, more water is absorb in the Nephron to wash out concentration of glucose within the nephron itself. Since water absorption is greater than reabsorption to blood circulation and that is why dehydration occurs.
+rea arines The dehydration in DM occurs as a rest of the osmotic diuresis. As the concentrations of glucose in the glomerular filtrate are raised in hyperglycaemia, the amounts of glucose present can exceed the renal threshold of about 11mmol / L. This means glucose is present along the length of the tubules, and as glucose is an osmotic molecule, more water is therefore osmotically retained in the nephron. This results in reduced reabsorption from the nephron, back in to the blood. As a result more water enters the renal pelvis, and the urine, meaning less is left in the body. This causes dehydration and thirst. This is not related to the ADH mechanism.
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He looks like morrissey 😆
APPRECIATED DR.JOHN LIVE LONG, GOD BLESS YOU.
Hey! Have you thought about the Hamilton Diabetes Reversal Protocol? (search on google) I have heard some interesting things about the results in lowering Blood sugars and my mate got cool resultsafter trying it.
I have never understood that clear about this topic brfore...Thankyou