53. Exploring Predictors of Ketamine Response in Adolescent Treatment-Resistant Depression

Ketamine has proved effective as a rapid-acting antidepressant agent, but treatment is not effective for everyone (approximately a quarter to a half of patients). Some adult studies have begun to investigate predictors of ketamine’s antidepressant response, but no studies have examined this in adolescents with depression.
Methods: We conducted a secondary data analysis of adolescents who participated in a randomized, single-dose, midazolam- controlled crossover trial of ketamine for adolescents with treatment-resistant depression. We examined the relationship between 19 exploratory demographic and clinical variables and depression symptom improvement (using the Montgomery- A ̊ sberg Depression Rating Scale [MADRS]) at 1 and 7 days postinfusion.